Le cycle peint du Grand Siège de Malte au château de La Cassagne ou l’émergence d’un modèle iconographique

Cet article propose de porter un regard nouveau sur l’œuvre exécutée par Matteo Perez d’Aleccio dans la salle du grand conseil du palais magistral de La Valette à Malte, à la fin du xvie siècle. Le grand Siège de Malte de 1565 tel qu’il y fut peint, se déploie en un cycle de plusieurs épisodes montrant chacun un moment clef de l’événement. L’artiste prit l’initiative de reproduire cet ensemble au moyen de la gravure qu’il publia sous forme de recueil en 1582. La gravure, medium privilégié du fait de son caractère mobile, allait alors constituer un outil de diffusion du cycle tel qu’il fut définit par d’Aleccio. Or, le retour à l’emploi de la peinture constaté au château de La Cassagne dans le Gers, où le chevalier Bertrand de Luppé Garrané reproduisit le cycle, permet de conférer à l’œuvre de d’Aleccio le caractère de modèle iconographique.In this article, we propose a new approach to the works produced by Matteo Perez d’Aleccio in the Throne Room of the Grandmaster’s Palace in Valletta, Malta, in the late sixteenth century. The cycle consists of a series of wall paintings, each representing a salient episode of the 1565 Great Siege of Malta. The artist made the choice to engrave the paintings and publish a collection of the reproductions in 1582. Due to its essentially mobile character, engraving had a privileged status and was then about to contribute to the circulation of the painted cycle by d’Aleccio. Besides, the cycle was reproduced in the Château de La Cassagne, located in Gers in the French Pyrenees. It was painted by Knight Bertrand de Luppé Garrané, thus transforming d’Aleccio’s frescoes into an iconographic model

Artistic commissions and patronage by the knights of the Order of Malta in the langue of Provence. 17th - 18th centuries

Le chevalier de l’Ordre de Malte est à la fois un religieux et un militaire, formé aux arts de la guerre sur terre comme en mer. La « Religion », l’Ordre de Saint-Jean de Jérusalem, possède de nombreux biens sur le territoire français, lui conférant la particularité d’être un véritable État dans l’État. L’Ordre répartit ses possessions en Langue, dont la Langue de Provence couvrant la France méridionale constitue sa première fondation historique. Les chevaliers sont alors tenus de passer des commandes artistiques pour embellir ces biens qu’ils administrent. Certains font à cet égard figure d’esthètes en s’intéressant de près aux cercles artistiques locaux, que ceux-ci soient académiques ou non. Réalisée à partir des grands exemples connus en Langue de Provence, cette étude consiste d’abord à analyser et à définir, selon une approche sociologique, les pratiques de la commande artistique des chevaliers. Dans un second et troisième temps, il s’agit plusspécifiquement de saisir les enjeux iconographiques et stylistiques des réalisations. Enfin, les systèmes d’échanges artistiques entre Malte et la Langue de Provence sont observés. Ceux-ci témoignent du rôle des chevaliers dans l’émergence de nouvelles représentations concernant leur Ordre et son île. Cette thèse cherche à comprendre les mécanismes qui sous-tendent l’exercice du mécénat et leurs répercussions sur l’ensemble d’une production artistique.A knight of the Order of Malta was both a monastic and a soldier trained in the arts of land and sea warfare. The “Religion” – the Order of Saint John of Jerusalem – owned much property in France, thereby earning the quality of State within a State. The Order divided its possessions into Langues, of which the Langue of Provence covering southern France was aninitial foundation. The knights had the duty to commission works of art to embellish the properties they governed. Some of them showed true aestheticism and took great interest in local artistic circles, academic or otherwise. This paper starts by taking some well-known works in the Langue of Provence to analyse and describe the practice of artistic commission by the knights from a sociological standpoint. It goes on go discuss more specifically the iconographic and stylistic features of the works and then examines the systems of art exchanges between Malta and the Langue of Provence which highlight the part played by the knights in the development of new representations of their Order and its island. The thesis aims to gain insight into the underlying mechanisms at work in the practice of patronage and their impact on artistic output as a whole

Impact of the mutational load on the virological response to a first-line rilpivirine-based regimen.

ObjectivesTo determine how the load of rilpivirine-resistant variants (mutational load) influences the virological response (VR) of HIV-1-infected patients to a rilpivirine-based first-line regimen.Patients and methodsFour hundred and eighty-nine patients infected with HIV-1 whose reverse transcriptase gene had been successfully resistance genotyped using next-generation sequencing were given a first-line regimen containing rilpivirine. Variables associated with the VR at 12 months were identified using a logistic model. The results were used to build a multivariate model for each mutational load threshold and the R2 variations were analysed to identify the mutational load threshold that best predicted the VR.ResultsThe mutational load at baseline was the only variable linked to the VR at 12 months (P  < 0.01). The VR at 12 months decreased from 96.9% to 83.4% when the mutational load was >1700 copies/mL and to 50% when the mutational load was > 9000 copies/mL. The threshold of 9000 copies/mL was associated with the VR at 12 months with an OR of 36.7 (95% CI 4.7-285.1). The threshold of 1700 copies/mL was associated with the VR at 12 months with an OR of 7.2 (95% CI 1.4-36.8).ConclusionsThere is quantifiable evidence that determining a mutational load threshold can be used to identify those patients on a first-line regimen containing rilpivirine who are at risk of virological failure. The clinical management of HIV-infected patients can be improved by evaluating the frequency of mutant variants at a threshold of < 20% together with the plasma HIV-1 viral load at the time of resistance genotyping

Persistent headaches one year after bacterial meningitis: prevalence, determinants and impact on quality of life

International audienceBackground: Little is known on headaches long-term persistence after bacterial meningitis and on their impact on patients' quality of life.Methods: In an ancillary study of the French national prospective cohort of community-acquired bacterial meningitis in adults (COMBAT) conducted between February 2013 and July 2015, we collected self-reported headaches before, at onset, and 12 months (M12) after meningitis. Determinants of persistent headache (PH) at M12, their association with M12 quality of life (SF 12), depression (Center for Epidemiologic Studies Depression Scale) and neuro-functional disability were analysed.Results: Among the 277 alive patients at M12 87/274 (31.8%), 213/271 (78.6%) and 86/277 (31.0%) reported headaches before, at the onset, and at M12, respectively. In multivariate analysis, female sex (OR: 2.75 [1.54-4.90]; p < 0.001), pre-existing headaches before meningitis (OR: 2.38 [1.32-4.30]; p < 0.01), higher neutrophilic polynuclei percentage in the CSF of the initial lumbar puncture (OR: 1.02 [1.00-1.04]; p < 0.05), and brain abscess during the initial hospitalisation (OR: 8.32 [1.97-35.16]; p < 0.01) were associated with M12 persistent headaches. Neither the responsible microorganism, nor the corticoids use were associated with M12 persistent headaches. M12 neuro-functional disability (altered Glasgow Outcome Scale; p < 0.01), M12 physical handicap (altered modified Rankin score; p < 0.001), M12 depressive symptoms (p < 0.0001), and M12 altered physical (p < 0.05) and mental (p < 0.0001) qualities of life were associated with M12 headaches.Conclusion: Persistent headaches are frequent one year after meningitis and are associated with quality of life alteration

Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease

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One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study

Trial registration: ClinicalTrial.Gov identification number NCT01730690.International audienceIntroduction: COMBAT is a prospective, multicentre cohort study that enrolled consecutive adults with community-acquired bacterial meningitis (CABM) in 69 participating centres in France between February 2013 and July 2015 and followed them for 1 year.Methods: Patients aged at least 18 years old, hospitalised with CABM were followed during their hospitalisation and then contacted by phone 12 months after enrolment. Here we present the prevalence of sequelae at 12 months in a subgroup of patients with meningococcal meningitis.Results: Five of the 111 patients with meningococcal meningitis died during initial hospitalisation and two died between discharge and 12 months, leaving 104 patients alive 1 year after enrolment, 71 of whom provided 12-month follow-up data. The median age was 30.0 years and 54.1% of the patients had no identified risk factor for meningitis. More than 30% reported persistent headache, more than 40% were not satisfied with their sleep and 10% had concentration difficulties. Hearing loss was present in about 15% of the patients and more than 30% had depressive symptoms. About 13% of the patients with a previous professional activity had not resumed work. On the SF-12 Health Survey, almost 50% and 30% had physical component or mental component scores lower than the 25th percentile of the score distribution in the French general population. There was a non-significant improvement in the patients' disability scores from hospital discharge to 12 months (p = 0.16), but about 10% of the patients had residual disability.Conclusions: Although most patients in our cohort survive meningococcal meningitis, the long-term burden is substantial and therefore it is important to ensure a prolonged follow-up of survivors and to promote preventive strategies, including vaccination