Rosai-Dorfman Disease With Pure and Multifocal Cutaneous Lesions: A Case Report

A 52‐year‐old woman developed progressive infiltrated purple and hyperpigmented cutaneous lesions in the face, thighs, armpits, chest, and abdomen evolving forone year. Histopathological examination showed large histiocytes exhibiting intact inflammatory cells in their cytoplasm (emperipolesis). Immunohistochemical analyses showed that the histiocyte population was positive for S100 and CD68, but negative for CD1a. Based on the clinical, histopathological, and immunohistochemical findings, we made the diagnosis of Rosai Dorfman disease (RDD). Our patient didn’t manifest any other extra-cutaneous involvement and all the biological and radiological investigations were normal. This form of pure cutaneous RDD (P-CRDD) with multifocal lesions has been rarely reported. RDD is very rare and hardly recognized in the absence of lymphadenopathy. The diagnosis of this entity involves a combination of histology and immunohistochemistry. To date, there is no standard treatment

Zero-inflated and over-dispersed data models: Empirical evidence from insurance claim frequencies

The main objective of this paper is to model automobile claim frequency by using standard count regression and zero-inflated regression models. The use of the latter model is mainly motivated by its ability to handle the over dispersion and zero-inflation phenomenon. The sample data consist of claims data obtained from one randomly selected automobile insurance company in Tunisia for a single year, 2009, containing beginning drivers and drivers who have had a license for less than three years. Our estimation results show that many exogenous variables can explain the frequency of claims; they are not taken into account in calculating the basic insurance premium. Moreover, the ZI binomial negative regression outperforms the standard count models and the ZI Poisson model in handling zero-inflated and additional over dispersed claim count data

Zero-inflated and over-dispersed data models: Empirical evidence from insurance claim frequencies

The main objective of this paper is to model automobile claim frequency by using standard count regression and zero-inflated regression models. The use of the latter model is mainly motivated by its ability to handle the over dispersion and zero-inflation phenomenon. The sample data consist of claims data obtained from one randomly selected automobile insurance company in Tunisia for a single year, 2009, containing beginning drivers and drivers who have had a license for less than three years. Our estimation results show that many exogenous variables can explain the frequency of claims; they are not taken into account in calculating the basic insurance premium. Moreover, the ZI binomial negative regression outperforms the standard count models and the ZI Poisson model in handling zero-inflated and additional over dispersed claim count data

Multifocal bone tuberculosis simulating metastasis

Abstract Multiple skeletal tuberculosis can be the first sign of tuberculosis. In such cases, physicians should consider tuberculosis diagnosis and take biopsies for anatomopathological evidence to make the correct diagnosis

Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2)

International audienc

Cervicotomy and Sternotomy for Resectin of Cervicothoracic Neuroblastoma in Children

Introduction: We report the case of a 4 years old girl who presenta cervico-thoracic ganglioneuroblastome with none response tochemotherapy and radiotherapyCase presentation: The girl was operated using the CormierDartevelle-Grünenwald incision which helped to remove the tumorcompletely with optimal control of noble elements. The follow upwas uneventful.Conclusion: The Cormier Dartevelle-Grünenwald incision can be agood option in case of big cervico-thoracic malignant tumors

Synthesis, Antibacterial, and Antifungal Activities of Imidazo[2,1-c][1,2,4]triazoles and 1,2,4-Triazolo[4,3-a]pyrimidinones

<div><p></p><p>A straightforward method has been developed for the synthesis of 1-phenyl-imidazo [2,1-c][1,2,4]triazole derivatives <b>5a–j</b> and 1-phenyl-[1,2,4]triazolo[4,3-a]pyrimidinones derivatives <b>6a–g</b> starting from 5-amino-1-phenyl[1,2,4]triazole and p-toluenesulfonic acid (PTSA). This methodology affords a number of 1-phenyl-imidazo [2,1-c][1,2,4]triazoles <b>5a–j</b> and 1-phenyl-[1,2,4]triazolo[4,3-a]pyrimidinones <b>6a–g</b> in reasonable yields and short reaction times. The structures of all new compounds were elucidated using infrared, ¹H and ¹³C NMR, and high-resolution mass spectrometry. Some of the newly synthesized compounds were screened for their antimicrobial activity.</p> <p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Synthetic Communications</i>^® for the following free supplemental resource(s): Full experimental and spectral details.]</p> </div

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy

International audienc

Epidemiological and Phylogeographic Study of Equid Herpesviruses in Tunisia

Equid herpesvirus (EHV) is a contagious viral disease affecting horses, causing illness characterized by respiratory symptoms, abortion and neurological disorders. It is common worldwide and causes severe economic losses to the equine industry. The present study was aimed at investigating the incidence of EHVs, the genetic characterization of Tunisian isolates and a spatiotemporal study, using 298 collected samples from diseased and clinically healthy horses. The global incidence of EHV infection was found to be about 71.81%. EHV2 and EHV5 were detected in 146 (48.99%) and 159 (53.35%) sampled horses, respectively. EHV1 was detected in 11 samples (3.69%); EHV4 was not detected. Co-infections with EHV1-EHV2, EHV1-EHV5 and EHV2-EHV5 were observed in 0.33%, 1.34% and 31.54% of tested horses, respectively. Phylogenetic analyses showed that gB of EHV2 and EHV5 displays high genetic diversity with a nucleotide sequence identity ranging from 88 to 100% for EHV2 and 97.5 to 100% for EHV5. Phylogeography suggested Iceland and USA as the most likely countries of origin of the Tunisian EHV2 and EHV5 isolates. These viruses detected in Tunisia seemed to be introduced in the 2000s. This first epidemiological and phylogeographic study is important for better knowledge of the evolution of equid herpesvirus infections in Tunisia

Isolated traumatic head injury in children: Analysis of 276 observations

<b>Background</b> : To determine predictive factors of mortality among children after isolated traumatic brain injury. <b>Materials and Methods</b> : In this retrospective study, we included all consecutive children with isolated traumatic brain injury admitted to the 22-bed intensive care unit (ICU) of Habib Bourguiba University Hospital (Sfax, Tunisia). Basic demographic, clinical, biochemical, and radiological data were recorded on admission and during ICU stay. <b>Results</b> : There were 276 patients with 196 boys (71&#x0025;) and 80 girls, with a mean age of 6.7 &#177; 3.8 years. The main cause of trauma was road traffic accident (58.3&#x0025;). Mean Glasgow Coma Scale score was 8 &#177; 2, Mean Injury Severity Score (ISS) was 23.3 &#177; 5.9, Mean Pediatric Trauma Score (PTS) was 4.8 &#177; 2.3, and Mean Pediatric Risk of Mortality (PRISM) was 10.8 &#177; 8. A total of 259 children required mechanical ventilation. Forty-eight children (17.4&#x0025;) died. Multivariate analysis showed that factors associated with a poor prognosis were PRISM &gt; 24 (OR: 10.98), neurovegetative disorder (OR: 7.1), meningeal hemorrhage (OR: 2.74), and lesion type VI according to Marshall tomographic grading (OR: 13.26). <b>Conclusion</b> : In Tunisia, head injury is a frequent cause of hospital admission and is most often due to road traffic injuries. Short-term prognosis is influenced by demographic, clinical, radiological, and biochemical factors. The need to put preventive measures in place is underscored