An Evaluation of Innovation Within a Post-Acquisition Life Science Organization: Text and Case Study

The pharmaceutical industry is rooted in the ability to research, develop, market, and distribute safe and effect drugs that meet the need of patients. In many cases pharmaceutical companies attempt to accelerate their drug development efforts by acquiring other companies for their pipeline; however, there may be missed opportunities to protect, foster, and metabolize a core asset throughout the acquisition process: innovation. The following capstone, presented as a single case study, focuses on innovation retention and protection through the lens of an acquired organization. While plenty of research has been conducted to prescribe how companies can become more innovative, this capstone explores practical methods for protecting existing innovative assets while reviewing challenges and opportunities through an organizational dynamics lens. The overall goal of this paper is to establish a suggest framework for protecting innovation in order to maximize organizational effectiveness

SU(3) Latent Heat and Surface Tension from Tree Level and Tadpole Improved Actions

We analyze the latent heat and surface tension at the SU(3) deconfinement phase transition with tree level and tadpole improved Symanzik actions on lattices with temporal extent $N_\tau = 3$ and 4 and spatial extent $N_\sigma/ N_\tau = 4$, 6 and 8. In comparison to the standard Wilson action we do find a drastic reduction of cut-off effects already with tree level improved actions. On lattices with temporal extent $N_\tau=4$ results for the surface tension and latent heat obtained with a tree level improved action agree well with those obtained with a tadpole improved action. A comparison with $N_\tau=3$ calculations, however, shows that results obtained with tadpole action remain unaffected by cut-off effects even on this coarse lattice, while the tree level action becomes sensitive to the cut-off. For the surface tension and latent heat we find $\sigma_I/ T_c^3 = 0.0155~(16)$ and $\Delta\epsilon/T_c^4 = 1.40~(9)$, respectively.Comment: 11 pages, LaTeX2e File, 3 Postscript figure

Structural validation of a realistic wing structure: the RIBES test article

Several experimental test cases are available in literature to study and validate fluid structure interaction methods. They, however, focus the attention mainly on replicating typical cruising aerodynamic conditions forcing the adoption of fully steel made models able to operate with the high loads generated in high speed facilities. This translates in a complete loss of similitude with typical realistic aeronautical wing structures configurations. To reverse this trend, and to better study the aerolastic mechanism from a structural point of view, an aeroelastic measurement campaign was carried within the EU RIBES project. A half wing model for wind tunnel tests was designed and manufactured replicating a typical metallic wing box structure, producing a database of loads, pressure, stress and deformation measurements. In this paper the design, manufacturing and validation activities performed within the RIBES project are described, with a focus on the structural behavior of the test article. All experimental data and numerical models are made freely available to the scientific community

Improved Actions for QCD Thermodynamics on the Lattice

Finite cut-off effects strongly influence the thermodynamics of lattice regularized QCD at high temperature in the standard Wilson formulation. We analyze the reduction of finite cut-off effects in formulations of the thermodynamics of $SU(N)$ gauge theories with three different $O(a^2)$ and $O(a^4)$ improved actions. We calculate the energy density and pressure on finite lattices in leading order weak coupling perturbation theory ($T\rightarrow \infty$) and perform Monte Carlo simulations with improved $SU(3)$ actions at non-zero $g^2$. Already on lattices with temporal extent $N_\tau=4$ we find a strong reduction of finite cut-off effects in the high temperature limit, which persists also down to temperatures a few times the deconfinement transition temperature.Comment: 20 pages, 3 Postscript figure

Two-photon excitation selective plane illumination microscopy (2PE-SPIM) of highly scattering samples: Characterization and application

In this work we report the advantages provided by two photon excitation (2PE) implemented in a selective plane illumination microscopy (SPIM) when imaging thick scattering samples. In particular, a detailed analysis of the effects induced on the real light sheet excitation intensity distribution is performed. The comparison between single-photon and twophoton excitation profiles shows the reduction of the scattering effects and sample-induced aberrations provided by 2PE-SPIM. Furthermore, uniformity of the excitation distribution and the consequent improved image contrast is shown when imaging scattering phantom samples in depth by 2PE-SPIM. These results show the advantages of 2PE-SPIM and suggest how this combination can further enhance the SPIM performance. Phantom samples have been designed with optical properties compatible with biological applications of interest. © 2013 Optical Society of America

Improved techniques in data analysis and interpretation of potential fields: examples of application in volcanic and seismically active areas

Geopotential data may be interpreted by many different techniques, depending on the nature of the mathematical equations correlating specific unknown ground parameters to the measured data set. The investigation based on the study of the gravity and magnetic anomaly fields represents one of the most important geophysical approaches in the earth sciences. It has now evolved aimed both at improving of known methods and testing other new and reliable techniques. This paper outlines a general framework for several applications of recent techniques in the study of the potential methods for the earth sciences. Most of them are here described and significant case histories are shown to illustrate their reliability on active seismic and volcanic areas

2D Continuous Wavelet Transform of potential fields due to extended source distributions

AbstractWe analyse the real Continuous Wavelet Transform 2D (CWT2D) of potential fields for the investigation of potential field singularities. We focus our attention to extended geological sources, in order to verify the reliability of this method with realistic fields. 3D space-scale representation (3D Scalogram) related to synthetic models were generated, showing the Wavelet Transform Modulus Maxima (WTMM) at each scale. The WTMM are related to the shape of the source, so defining some sort of source boundary analysis through the CWT. Wavelets of different order may help to gain resolution and define source features. Selecting a range of scales where the sources behave as if they are approximately isolated, the depth to the source may be estimated basing on the property that the lines joining the modulus maxima of the wavelet coefficients at different scales (WTMML) intersect each other at the edges of the causative body. Therefore, it is possible to manage the information contained in the wavelet transform of fields related to extended sources. In the real case of the anomaly gravity map of the Vesuvius area (Italy), we estimated the depth of the Mesozoic carbonate basement in the Pompei Basin. We showed also how the WTMML information can be integrated to that of another multiscale method, the Depth from Extreme Points (DEXP) transformation, which is also related to the source density distribution of a given region

UAV BLOCK GEOREFERENCING and CONTROL by ON-BOARD GNSS DATA

Unmanned Aerial Vehicles (UAV) are established platforms for photogrammetric surveys in remote areas. They are lightweight, easy to operate and can allow access to remote sites otherwise difficult (or impossible) to be surveyed with other techniques. Very good accuracy can be obtained also with low-cost UAV platforms as far as a reliable ground control is provided. However, placing ground control points (GCP) in these contexts is time consuming and requires accessibility that, in some cases, can be troublesome. RTK-capable UAV platforms are now available at reasonable costs and can overcome most of these problems, requiring just few (or none at all) GCP and still obtaining accurate results. The paper will present a set of experiments performed in cooperation with ARPA VdA (the Environmental Protection Agency of Valle d'Aosta region, Italy) on a test site in the Italian Alps using a Dji Phantom 4 RTK platform. Its goals are: a) compare accuracies obtainable with different calibration procedures (pre- or on-the-job/self-calibration); b) evaluate the accuracy improvements using different number of GCP when the site allows for it; and c) compare alternative positioning modes for camera projection centres determination, (Network RTK, RTK, Post Processing Kinematic and Single Point Positioning)