An in vitro method to study the effects of hematopoietic regulators during immune and blood cell development

In adults, hematopoiesis occurs in bone marrow (BM) through a complex process with differentiation of hematopoietic stem cells (HSCs) to immune and blood cells. Human HSCs and their progenitors express CD34. Methods on hematopoietic regulation are presented to show the effects of the chemokine, stromal-derived growth factor (SDF)-1Î and the neuropeptide, substance P (SP). SDF-1Î production in BM stroma causes interactions with HSCs, thereby retaining the HSCs in regions close to the endosteum, at low oxygen. Small changes in SDF-1Î levels stimulate HSC functions through direct and indirect mechanisms. The indirect method occurs by SP production, which stimulates CD34+ cells, supported by ligand-binding studies, long-term culture-initiating cell assays for HSC functions, and clonogenic assays for myeloid progenitors. These methods can be applied to study other hematopoietic regulators

To What Extent do Fiscal Regimes Equalize Opportunities for Income Acquisition Among Citizens?

This project employs the theory of equality of opportunity, described in Roemer's book (Equality of Opportunity, Harvard University Press, 1998), to compute the extent to which tax-and-transfer regimes in ten countries equalize opportunities among citizens for income acquisition. Roughly speaking, equality of opportunity for incomes has been achieved in a country when it is the case that the distributions of post-fisc income are the same for different types of citizen, where a citizen's type is defined by the socioeconomic status of his parents. Intuitively, a country will have equalized opportunity if the chances of earning high (or low) income are equal for citizens from all family backgrounds. Of course, pre-fisc income distributions, by type, will not be identical, as long as the educational system does not entirely make up for the disadvantage that children, who come from poor families face, but the tax-and-transfer system can play a role in rectifying that inequality. We include, in our computation, two numbers that summarize the extent to which each country's current fiscal regime achieves equalization of opportunities for income, and the deadweight loss that would be incurred by moving to the regime that does.

ICT Competencies in Eight Mayan-speaking Communities of Mexico: Preliminary Findings

The skills related to the use of information and communication technologies (ICT) were examined in this study within the context of eight communities with a high degree of vulnerability and diversity. The objectives of the study were: a) to conduct a diagnosis of thirteen competencies related to the use of ICT in eight Mayan-speaking communities in the state of Yucatan, Mexico, and b) to examine such variables as gender, marital status, and the education level of their parents. in relation to the degree of ICT among these youth. The findings indicate that there are differences in the use of technology among the eight communities that participated in the study. Specifically, it was found that the greatest social inequality associates to the lowest performance in the thirteen skills related to ICT. Research also discovered that gender and the marital status of the subjects, as well as the schooling of their parents, related to the ICT competencies. The findings of the study will add more values to ICT related research, especially in the socioeconomic status of the indigenous community and/or some of their personal backgrounds. It could also be used to design training strategies to overcome the most pressing needs of the subjects in the area of ICT

Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres

Neural crest cells have broad migratory and differentiative ability that differs according to their axial level of origin. However, their transient nature has limited understanding of their stem cell and self-renewal properties. While an in vitro culture method has made it possible to maintain cranial neural crest cells as self-renewing multipotent crestospheres (Kerosuo et al., 2015), these same conditions failed to preserve trunk neural crest in a stem-like state. Here we optimize culture conditions for maintenance of avian trunk crestospheres, comprised of both neural crest stem and progenitor cells. Our trunk-derived crestospheres are multipotent and display self-renewal capacity over several weeks. Trunk crestospheres display elevated expression of neural crest cell markers as compared to those characteristic of ventrolateral neural tube or mesodermal fates. Moreover, trunk crestospheres express increased levels of trunk neural crest-enriched markers as compared to cranial crestospheres. Finally, we use lentiviral transduction as a tool to manipulate gene expression in trunk crestospheres. Taken together, this method enables long-term in vitro maintenance and manipulation of multipotent trunk neural crest cells in a premigratory stem or early progenitor state. Trunk crestospheres are a valuable resource for probing mechanisms underlying neural crest sternness and lineage decisions as well as accompanying diseases.Peer reviewe

Parent Satisfaction with Outpatient Pediatric Endoscopy Procedures at University of New Mexico Children\u27s Hospital

As a part of endoscopy quality improvement (EQI) project, we decided to measure parent satisfaction about pediatric endoscopy service at University of New Mexico Children\u27s Hospital

To what extent do fiscal regimes equalize opportunities for income acquisition among citizens?.

This paper employs the theory of equality of opportunity, described in Roemer’s book (Equality of Opportunity, Harvard University Press, 1998), to compute the extent to which tax-and-transfer regimes in 11 countries equalize opportunities among citizens for income acquisition. Roughly speaking, equality of opportunity for incomes has been achieved in a country when it is the case that the distributions of post-fisc income are the same for different types of citizen, where a citizen’s type is defined by the socio-economic status of his parents. Intuitively, a country will have equalized opportunity if the chances of earning high (or low) income are equal for citizens from all family backgrounds. Of course, pre-fisc income distributions, by type, will not be identical, as long as the educational system does not entirely make up for the disadvantage that children, who come from poor families face, but the tax-and-transfer system can play a role in rectifying that inequality. We include, in our computation, two numbers that summarize the extent to which each country’s current fiscal regime achieves equalization of opportunities for income, and the deadweight loss that would be incurred by moving to the regime that does.Fiscal regimes; Equal opportunities; Income acquisition;

To what extent do fiscal regimes equalize opportunities for income acquisition among citizens?

This project employs the theory of equality of opportunity, described in Roemer’s book (Equality of Opportunity, Harvard University Press, 1998), to compute the extent to which tax-and-transfer regimes in ten countries equalize opportunities among citizens for income acquisition. Roughly speaking, equality of opportunity for incomes has been achieved in a country when it is the case that the distributions of post-fisc income are the same for different types of citizen, where a citizen's type is defined by the socioeconomic status of his parents. Intuitively, a country will have equalized opportunity if the chances of earning high (or low) income are equal for citizens from all family backgrounds. Of course, pre-fisc income distributions, by type, will not be identical, as long as the educational system does not entirely make up for the disadvantage that children, who come from poor families face, but the tax-and-transfer system can play a role in rectifying that inequality. We include, in our computation, two numbers that summarize the extent to which each country’s current fiscal regime achieves equalization of opportunities for income, and the deadweight loss that would be incurred by moving to the regime that does

To what extent do fiscal regimes equalize opportunities for income acquisitions among citizens?

This project employs the theory of opportunity, described in Roemer''s book (Equality of Opportunity, Harvard University Press, 1998), to compute the extent to which tax-and-transfer regimes in ten countries equalize opportunities among citizens for income acquisition. Roughly speaking, equality of opportunity for incomes has been achieved in a country when it is the case that the distributions of post-fisc income are the same for different types of citizen, where a citizen''s type is defined by the socio-economic status of his parents. Intuitively, a country will have equalized opportunity if the chances of earning high (or low) income are equal for citizens from all family backgrounds. Of course, pre-fisc income distributions, by type, will not be identical, as long as the educational system does not entirely make up for the disadvantage that children, who come from poor families face, but the tax-and-transfer system can play a role in rectifying that inequality. We include, in our computation, two numbers that summarize the extent to which each country''s current fiscal regime achieves equalization of opportunities for income, and the deadweight loss that would be incurred by moving to the regime that does

Conteúdos em Áudio: o Uso do Podcast como Recurso Educacional na Disciplina de Histologia

Increased use of online tools and digital media along with the speed in which information becomes available over the last few years, asks for adaptations on the educational environments. Recently, due to restrictions imposed by the Covid-19 pandemic, the world has witnessed profound changes in the educational scenario, with a real disruption in the teaching-learning process, which has forcibly been mediated by digital interfaces. In the present work, an experience will be presented, within the scope of education carried out in other classrooms, and also carried out in a Dentistry course at a Brazilian public university. A podcast, with 20 episodes, was implemented as a complementary educational resource, in the Histology discipline. The podcast was made available on the Spotify platform and associated with an Instagram account for dissemination and placement of materials, such as summaries and photos from the course's slide bank. At the end of the school year, a form had been sent to assess the perception of students that listened to the podcast. The project reached 1,262 people, including 14 foreigners. From 87 participants who answered the form, 89.7% noticed a great improvement in their subject understanding and 96.6% rated the content as excellent. The results bring a successful experience during emergency remote teaching, reinforcing the possibility of adopting new digital technologies, which can privilege distant activities and with the potential to generate greater engagement and autonomy for students.    Keywords: Learning. Technology. Podcast. Histology.O crescente uso de ferramentas online e mídias digitais e a velocidade com a qual as informações tornam-se disponíveis ao longo dos últimos anos, vêm requerendo adaptações dos ambientes educacionais. Recentemente, devido às restrições impostas pela pandemia de Covid-19, o mundo presenciou profundas mudanças no cenário educacional, havendo uma verdadeira disruptura no processo de ensino e aprendizagem, que passou forçosamente a ser mediado pelas interfaces digitais. No presente trabalho será apresentada uma experiência, no âmbito das educações realizadas em outras presencialidades, desenvolvida em um curso de Odontologia de uma universidade pública brasileira, durante o período de pandemia. Um podcast, com 20 episódios, foi implementado como recurso educacional complementar, na disciplina de Histologia. O podcast foi disponibilizado na plataforma Spotify e associado a uma conta no Instagram para divulgação e veiculação de material, como resumos e fotos do banco de lâminas da disciplina. Ao término do ano letivo foi enviado um formulário para avaliar a percepção dos estudantes usuários do podcast. O projeto alcançou 1.262 pessoas, incluindo 14 estrangeiros. Dos 87 participantes que responderam o formulário, 89,7% perceberam grande melhora no entendimento da matéria após ouvir o podcast e 96,6% classificaram o conteúdo como excelente. Os resultados trazem uma experiência exitosa durante o ensino remoto emergencial, reforçando a possibilidade da adoção de novas tecnologias digitais, que possam privilegiar atividades à distância e com potencial de gerar maior engajamento e autonomia dos estudantes.   Palavras-chave: Aprendizagem. Tecnologia. Podcast. Histologia

To what extent do fiscal regimes equalize opportunities for income acquisition among citizens?

This paper employs the theory of equality of opportunity, described in Roemer’s book (Equality of Opportunity, Harvard University Press, 1998), to compute the extent to which tax-and-transfer regimes in 11 countries equalize opportunities among citizens for income acquisition. Roughly speaking, equality of opportunity for incomes has been achieved in a country when it is the case that the distributions of post-fisc income are the same for different types of citizen, where a citizen’s type is defined by the socio-economic status of his parents. Intuitively, a country will have equalized opportunity if the chances of earning high (or low) income are equal for citizens from all family backgrounds. Of course, pre-fisc income distributions, by type, will not be identical, as long as the educational system does not entirely make up for the disadvantage that children, who come from poor families face, but the tax-and-transfer system can play a role in rectifying that inequality. We include, in our computation, two numbers that summarize the extent to which each country’s current fiscal regime achieves equalization of opportunities for income, and the deadweight loss that would be incurred by moving to the regime that does.Publicad