Percutaneous or mini-invasive surgical radiofrequency re-ablation of atrial fibrillation: Impact on atrial function and echocardiographic predictors of short and long-term success.

Objectives The aim of this study was to compare percutaneous catheter ablation vs. minimally invasive surgical ablation, evaluating the impact of repeated ablation on atrial function, and evaluating predictors of atrial fibrillation (AF) recurrence. Background When AF ablation fails, re-ablations are required in up to 40% of patients to treat recurrent arrhythmia; surgical ablation is more effective than catheter ablation. Methods Thirty-two patients with failed prior catheter ablation and referred for a second ablation (18 catheter and 14 surgical) were included in a descriptive observational study. Left atrial volumes, strain, and strain rate were measured with 2D speckle tracking echocardiography at baseline and 6 months after the procedures to assess left atrial functions. Patients received up to 1 year of clinical and Holter follow-up. Results At the 12-month follow-up, catheter ablation was effective in 56% and surgical ablation in 72% of patients (OR 2 (CI 0.45–8.84), p 0.36). Left atrial booster function was similar in all patients, but left atrial reservoir function was more impaired in those patients who underwent surgical ablation. Left atrial booster function was predictive of arrhythmia recurrence after both catheter and surgical ablation: late diastolic strain rate (LASRa) cut-off ≤ -0.89 s–1 (sensitivity 88%, specificity 70%, AUC 0.82) and ≤ -0.85 s–1 (sensitivity 60%, specificity 100%, AUC 0.82), respectively. Conclusion Surgical ablation has a more negative impact on LA reservoir function despite being slightly more effective in arrhythmia suppression. LA booster function is not significantly impaired by either procedure. LA booster function predicts arrhythmia elimination after a re-ablation (catheter or surgical)

BAG3 Genetic Cardiomyopathy May Overlap Fulminant Myocarditis Clinical Findings.

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Risk scores' performance and their impact on operative decision‑making in left‑sided endocarditis: a cohort study

Theaccuracy of contemporary risk scores in predicting perioperative mortality in infective endocarditis (IE) remains controversial. The aim is to evaluate the performance of existent mortality risk scores for cardiovascular surgery in IE and the impact on operability at high-risk thresholds. A single-center retrospective review of adult patients diagnosed with acute left-sided IE undergoing surgery from May 2014 to August 2019 (n = 142) was done. Individualized risk calculation was obtained according to the available mortality risk scores: EuroScore I and II, PALSUSE, Risk-E, Costa, De Feo-Cotrufo, AEPEI, STS-risk, STS-IE, APORTEI, and ICE-PCS scores. A cross-validation analysis was performed on the score with the best area under the curve (AUC). The 30-day survival was 96.5% (95%CI 91-98%). The score with worse area under the curve (AUC = 0.6) was the STS-IE score, while the higher was for the RISK-E score (AUC = 0.89). The AUC of the majority of risk scores suggested acceptable performance; however, statistically significant differences in expected versus observed mortalities were common. The cross-validation analysis showed that a large number of survivors (> 75%) would not have been operated if arbitrary high-risk threshold estimates had been used to deny surgery. The observed mortality in our cohort is significantly lower than is predicted by contemporary risk scores. Despite the reasonable numeric performance of the analyzed scores, their utility in judging the operability of a given patient remains questionable, as demonstrated in the cross-validation analysis. Future guidelines may advise that denial of surgery should only follow a highly experienced Endocarditis Team evaluation

The impact of feedback type regarding behavior on shaping spending credit-card behavior

Treball de Fi de Grau en Economia. Curs 2013-2014Tutor: Gert CornelisenPayment methods have been proven to affect spending behavior. More precisely, when/nindividuals use credit cards tend to overspend and to underestimate their past expenses. However, there is little research about the role that the additional services provided by financial institution have in shaping consumption patterns. This paper analyze how one of these services –the text message that banks send to their clients each time they make a payment using a credit card– affects spending control. A review of the previous literature is considered, and an experiment is hold to show support for the proposed theoretical framework. Our findings suggest that the information stated in these SMS are a source of variance in the overall expenses

The impact of feedback type regarding behavior on shaping spending credit-card behavior

Treball de Fi de Grau en Economia. Curs 2013-2014Tutor: Gert CornelisenPayment methods have been proven to affect spending behavior. More precisely, when/nindividuals use credit cards tend to overspend and to underestimate their past expenses. However, there is little research about the role that the additional services provided by financial institution have in shaping consumption patterns. This paper analyze how one of these services –the text message that banks send to their clients each time they make a payment using a credit card– affects spending control. A review of the previous literature is considered, and an experiment is hold to show support for the proposed theoretical framework. Our findings suggest that the information stated in these SMS are a source of variance in the overall expenses

Does Quality of Life in Survivors of Surgery for Acute Left-Sided Infective Endocarditis Differ from Non-Endocarditis Patients?

Surgery for left-sided infective endocarditis (IE) has been demonstrated to improve patients' survival rates but information about quality of life (QoL) after surgery is scarce. The aim of this study was to assess the postoperative outcomes and QoL after surgery for IE patients compared to patients undergoing cardiac surgery for non-IE indications. Adult patients with definite acute left-sided IE were matched 1:1 to patients who underwent cardiac surgery for non-endocarditic purposes from 2014 to 2019. QoL was assessed using the SF-36 survey at the last follow-up. A total of 105 patients were matched. The IE group had higher rates of preoperative stroke (21% vs. 7.6%, p = 0.005) and higher stages of NYHA class (p < 0.001), EuroSCORE II (12.3 vs. 3.0, p < 0.001) and blood cell count abnormalities (p < 0.001). The IE group had higher incidence of low cardiac output syndrome (13.3% vs. 4.8%, p = 0.029), dialysis (10.5% vs 1.0%, p = 0.007) and prolonged mechanical ventilation (16.2% vs. 2.9%, p = 0.002) after surgery. At the last follow-up, subcomponents of the SF-36 QoL survey were not different between the groups. Patients who underwent cardiac surgery for IE demonstrated a higher risk profile with a higher rate of postoperative complications. Once recovered from the acute phase of the disease, the reported QoL at follow-up was comparable to that of matched cardiac patients operated for non-IE purposes

Comprehensive characterization of modern industrial Argentinian paints for improved chronological painting attribution

Throughout the twentieth century, the paint industry developed a multitude of new binding media, pigments and additives that improved the appearance, ease of application, and performance of modern industrial paints. Depending on when and where they were first manufactured, and when they were introduced into paint formulations, some of these new paint components could conceivably be chronological markers useful in assigning attribution to specific artists or in the study of forgeries. The aim of this study was to develop a systematic methodology for characterizing organic and inorganic materials in modern paints, and search for potential chronological markers. Colored reference paints manufactured by local companies in Argentina from the 1940s and 1950s were studied with a multi-analytical approach that included Fourier-transform infrared spectroscopy, gas chromatography coupled with mass spectrometry, Raman spectroscopy, X-ray diffraction, X-ray fluorescence and scanning electron microscopy with energy dispersive X-ray analysis. A wide range of compounds was identified due to the complementarity use of the analytical techniques. Historical references, patents, books, and scientific publications about the materials used in that time period provided invaluable information in establishing tentative timelines for modern paint components. This investigation was part of a broader interdisciplinary investigation of Concrete Art, an international art movement of the beginning of the twentieth century, which took place in Argentina and other nearby countries during the 1940s and 1950s. To prove the concept, a micro-sample from “Obra N° 171” by Raúl Lozza was analyzed. Organic and inorganic fractions were studied and the information collected was correlated with developed timelines to support the authentication process. Ultimately, the information from this study may also have a direct impact on the key areas of material characterization, aging behavior, and conservation of works of art made from these products.Fil: Castellá, Florencia. Universidad Nacional de San Martín. Escuela de Hábitat y Sostenibilidad;Fil: Pérez Estebanez, Marta. Universidad Complutense de Madrid; EspañaFil: Reinoso, Maria Elba. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schilling, Michael. Getty Conservation Institute; Estados UnidosFil: Khanjian, Herant. Getty Conservation Institute; Estados UnidosFil: Learner, Tom. Getty Conservation Institute; Estados UnidosFil: Fernandez Niello, Jorge Oscar. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; ArgentinaFil: Tascon, Marcos. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; ArgentinaFil: Marte, Fernando. Universidad Nacional de San Martín. Escuela de Hábitat y Sostenibilidad

Characterizing the performance of the NIRC2 vortex coronagraph at W. M. Keck Observatory

International audienceThe NIRC2 vortex coronagraph is an instrument on Keck II designed to directly image exoplanets and circumstellar disks at mid-infrared bands L′ (3.4–4.1 μm) and Ms (4.55–4.8 μm). We analyze imaging data and corresponding adaptive optics telemetry, observing conditions, and other metadata over a three-year time period to characterize the performance of the instrument and predict the detection limits of future observations. We systematically process images from 359 observations of 304 unique stars to subtract residual starlight (i.e., thecoronagraphic point-spread function) of the target star using two methods: angular differential imaging (ADI) and reference star differential imaging (RDI). We find that for the typical parallactic angle (PA) rotation of our data set (∼10°), RDI provides gains over ADI for angular separations smaller than 0 25. Furthermore, we find a power-law relation between the angular separation from the host star and the minimum PA rotation required for ADI to outperform RDI, with a power-law index of −1.18 ± 0.08. Finally, we use random forest models to estimate ADI and RDI post-processed detection limits a priori. These models, which we provide publicly on a website, explain 70%–80% of the variance in ADI detection limits and 30%–50% of the variance in RDI detection limits. Averaged over a range of angular separations, our models predict both ADI and RDI contrast to within a factor of 2. These results illuminate important factors in high-contrast imaging observations with the NIRC2 vortex coronagraph, help improve observing strategies, and inform future upgrades to the hardware

Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning.

Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulation of splicing machinery components and splicing regulatory factors in browned adipose tissue from patients, with upregulation of a few genes encoding RNA-binding proteins potentially involved in splicing regulation. These changes were also observed in cell culture models of human brown adipocyte differentiation, confirming a potential involvement of splicing in the cell-autonomous control of adipose browning. The coordinated changes in splicing are associated with a profound modification in the expression levels of splicing-driven transcript isoforms for genes involved in the specialized metabolism of brown adipocytes and those encoding master transcriptional regulators of adipose browning. Splicing control appears to be a relevant component of the coordinated gene expression changes that allow human adipose tissue to acquire a brown phenotype