sensitivity analysis

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Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022

Up to 27 May 2022, Portugal has detected 96 confirmed cases of monkeypox. We describe 27 confirmed cases (median age: 33 years (range: 22–51); all males), with an earliest symptom onset date of 29 April. Almost all cases (n = 25) live in the Lisbon and Tagus Valley health region. Most cases were neither part of identified transmission chains, nor linked to travel or had contact with symptomatic persons or with animals, suggesting the possible previously undetected spread of monkeypox.info:eu-repo/semantics/publishedVersio

Adoção de sistemas de integração lavoura-pecuária-floresta (ILPF) em São Paulo.

Este estudo objetivou caracterizar a adoção dos sistemas de integração no Estado de São Paulo e identificar demandas. Uma amostra de 175 propriedades rurais, sendo 66 adotantes de sistemas de Integração Lavoura-Pecuária (ILP), 24 adotantes de sistemas de Integração PecuáriaFloresta (IPF) e 85 não adotantes de sistemas integrados, compôs a base de dados analisados por meio de estatística descritiva e teste qui-quadrado (x2) de Pearson. Os resultados indicam que os adotantes de sistemas ILP possuem maior experiência com atividades agrícolas, participação mais frequente em cooperativas agrícolas, palestras e dias de campo, bem como recebem mais orientação técnica. O acesso ao crédito rural e o uso mais frequente de mecanismos para gestão do risco climático e econômico estão associados ao componente agrícola do ILP. O fator escala de produção explica propriedades rurais mais extensas e estrutura mais robusta de máquinas agrícolas. A adoção dos sistemas IPF encontra-se em fase experimental nas propriedades rurais. Esses adotantes contam com outra fonte de renda, o que os confere maior flexibilidade para testar o sistema, em sua maioria, implantado de forma escalonada na área de pastagem e com recursos próprios. Predominam propriedades rurais menores, com relevo mais ondulado, solos arenosos, rebanhos menores e concentrados nas fases de cria/recria, além de maior diversificação da produção.bitstream/item/214315/1/AdocaoSistemasIntegracao.pd

Postoperative outcomes in oesophagectomy with trainee involvement

BACKGROUND: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. METHODS: Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. RESULTS: Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). CONCLUSION: Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery

Implementing ecological intensification in fish farming : definition and principles from contrasting experiences

Ecological intensification is a new concept in agriculture that addresses the double challenge of maintaining a level of production sufficient to support needs of human populations and respecting the environment in order to conserve the natural world and human quality of life. This article adapts this concept to fish farming using agroecological principles and the ecosystem services framework. The method was developed from the study of published literature and applications at four study sites chosen for their differences in production intensity: polyculture ponds in France, integrated pig and pond polyculture in Brazil, the culture of striped catfish in Indonesia and a recirculating salmon aquaculture system in France. The study of stakeholders' perceptions of ecosystem services combined with environmental assessment through Life Cycle Assessment and Emergy accounting allowed development of an assessment tool that was used as a basis for co-building evolution scenarios. From this experience, ecological intensification of aquaculture was defined as the use of ecological processes and functions to increase productivity, strengthen ecosystem services and decrease disservices. It is based on aquaecosystem and biodiversity management and the use of local and traditional knowledge. Expected consequences for farming systems consist of greater autonomy, efficiency and better integration into their surrounding territories. Ecological intensification requires territorial governance and helps improve it from a sustainable development perspective

Curcumin and rutin down-regulate cyclooxygenase-2 and reduce tumor-associated inflammation in HPV16-transgenic mice

Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. Materials and Methods: Six-week - old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16(-/-) no treatment, n=12; HPV16(+/-) no treatment, n=13; HPV16(+/-) rutin, n=12; HPV16(+/-) curcumin, n=13. HPV16-induced skin lesions and their inflammatory infiltrates were studied histologically. COX2 expression was assessed immunohistochemically. Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). Curcumin led to dermal and epidermal scores of 10.5 and 4.5. Both compounds reduced leukocytic infiltration, but neither prevented epidermal dysplasia. Conclusion: COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. However, this was not sufficient to block carcinogenesis, calling for additional studies focused on combination therapies