Use of the terms "Wellbeing" and "Quality of Life" in health sciences: A conceptual framework

Background and Objectives: The assessment of wellbeing is a top priority in health sciences. The aim of this paper is to review the history of the concept of wellbeing and “Quality of Life” (QoL), and to understand the theories and assumptions that guided this field in order to provide a conceptual framework that may eventually facilitate the development of a formal synset (grouping of synonyms and semantically similar terms) of health-related wellbeing Methods: The history of the concept of wellbeing and QoL was reviewed in order to provide a conceptual framework. Results: Huge differences exist on the definition of “Wellbeing” and its relationship with QoL, “Happiness” and “Functioning” in the health context. From a dimensional perspective, health related wellbeing could be regarded as an overarching construct characterised by asymmetrical polarity, where “wellbeing” embeds the concept of “ill-being” as “health” incorporates de concept of “disease”. Conclusions: A common conceptual framework of these terms may eventually facilitate the development of a formal synset of health-related wellbeing. This terminological clarification should be part of a new taxonomy of health-related wellbeing based on the International Classification of Functioning, Disability and Health (ICF) framework that may facilitate knowledge transfer across different sectors and semantic interoperability for care management and planningThe research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement numbers 223071 (COURAGE in Europe) and 282586 (ROAMER), from the Instituto de Salud Carlos III-FIS research grant number PS09/00295, and from the Spanish Ministry of Science and Innovation ACI-Promociona (ACI2009-1010 and ACI- 2011-1080). The study was supported by the Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos II

Bases biológicas de la esquizofrenia : aspectos neuroquímicos y neuroanatómicos

La investigación en el campo de la esquizofrenia ha propuesto múltiples factores relacionados con su etiología y su clínica: psicológicos, víricos, metabólicos, anatomopatológicos, bioquímicos, genéticos y ambientales. Entre las alteraciones en los sistemas de neurotransmisión, la disfunción dopaminérgica y serotoninérgica son las más consistentes a lo largo de la literatura; su interrelación con otros neurotransmisores, como la noradrenalina GABA y el glutamato, y también con algunos neuropéptidos, debería aproximarnos a una visión más integrada de la función cerebral. Los estudios neuroanatómicos han mostrado dilatación ventricular y disminución del volumen de los lóbulos frontal y temporal en algunos pacientes. Las alteraciones detectadas se localizan especialmente en estructuras temporolímbicasResearch on schizophrenia has revealed a number of factors related to its etiology and its clinics: psychological, virological, metabolic, pathological, biochemical, genetic and environmental. Amongst the neurotransmitter systems disorders, dopamine and serotonin dysfunction are the most frequently mentioned in the literature; their interplay with other neurotransmitter substances, such as noradrenaline, GABA and glutamate, and also with some neuropeptides, should provide us a more integrated view of brain function. Neuroanatomical data have revealed ventricular enlargement and diminished frontal and temporal lobe volume in some patients. These findings are concentrated particularly in temporolimbic structure

The way we look at our own body really matters! Body-related attentional bias as a predictor of worse clinical outcomes after a virtual reality body exposure therapy

Body-related attentional bias (AB) experienced by anorexia nervosa (AN) patients has been associated with body image disturbances and other eating disorders (ED)-related symptoms. The aim of this study was to assess whether the body-related AB reported by AN patients before a virtual reality (VR)-based body exposure therapy predicted worse clinical outcomes after treatment. Thirteen AN outpatients participatedin the study. AB was recorded using an eye-tracker incorporated in a VR-Head Mounted Display. Results showed that AN patients attended to their weight-related body parts for longer and more frequently than to their non-weight-related body parts. Statistically significant (p<.05) negative and positive correlations between pre-intervention bodyrelated AB measures and the difference between pre- and post-assessment fear of gaining weight, body dissatisfaction, and body appreciation measures were also found. Showing higher body-related AB before the intervention marginally predicted a lower reduction of fear of gaining weight (p =.08 and p=.07) and body dissatisfaction (p = .05 and p=.06) at post-treatment, and significantly predicted a lower increase of body appreciation scores after the intervention (p<.001). Results suggest that body-related AB may reduce the efficacy of VR-based body exposure therapy in patients with A

Eye-Tracking and Virtual Reality-based Attentional Bias Modification Training to Improve Mirror Exposure Therapy: preliminary findings from a multiple case study with Anorexia Nervosa patients

Attentional bias modification training (ABMT) is an effective technique for reducing the dysfunctional body-related attentional bias (AB) that may be responsible for reducing the effectiveness of mirror exposure therapy (MET), which has been proposed as an effective treatment for anorexia nervosa ( AN). This multiple-case study provides evidence of the usefulness of incorporating ABMT into virtual reality ( VR) and eye-tracking (ET)-based MET to improve its efficacy in the treatment of four female adolescents with AN. Over five exposure sessions, patients were immersed in a virtual environment and were embodied in a real-size body virtual avatar reflected in a mirror that gradually increased body mass index (BMI) until reaching a healthy BMI in the last session. In every session, the participants completed the ABMT followed by the MET. This augmentation of MET using VRET-based ABMT achieved promising results for targeting AN symptomatology by reducing body dissatisfaction, drive for thinness, weight-related body parts anxiety, body checking behaviors, fear of gaining weight, and anxiety, and increasing body appreciation. Two patients who did not show a reduction in fear of gaining weight during the sessions also showed high anxiety levels, which could have affected its reduction. To advance this preliminary study and evaluate the effectiveness of incorporating ABMT into MET, a controlled clinical trial will be conducted

An Attentional bias modification task, through virtual reality and eye-tracking technologies, to enhance the treatment of anorexia nervosa

Mirror exposure therapies (METs) have been shown to be effective in reducing body image disturbances through the habituation process. Virtual reality (VR) combined with eye-tracking techniques can provide innovative solutions to some of METs' limitations reported with patients with anorexia nervosa (AN), especially the negative influence of body-related attentional bias (AB). This pilot study aimed to assess the preliminary efficacy of a new VR-based AB modification task (ABMT) among healthy women and the procedure's user experience. AB levels towards weight- and non-weight-related body parts, using complete fixation time (CFT) and number of fixations (NF), were assessed throughout the ABMT procedure (300 trials). The user experience was evaluated at the end of the procedure. The results showed that VR-based ABMT was effective in reducing AB significantly after 150 trials for both CFT- and NF-based measures, although 225 trials were necessary to get the same result for women with an NF initially more oriented towards weight-related body parts. Overall, the software received a 'C-rating' on a scale from 'A' (most usable) to 'F' (least usable). These results provide evidence of the opportunity to use a VR-based ABMT procedure to reduce AB and improve existing treatments for AN

Attentional Bias Modification Training Based on Virtual Reality and Eye Tracking in Anorexia Nervosa Patients

Anorexia nervosa (AN) patients exhibit attentional bias (AB) related to the body, which is the tendency to pay greater attention to weight-related body areas compared to non-weight-related ones. This phenomenon has been linked to elevated levels of body dissatisfaction (BD) and may potentially reduce the effectiveness of body exposure therapy. The purpose of this pilot study is to assess the efficacy of a single session of a new body-related AB modification task (ABMT) that combines virtual reality with eye tracking in patients with AN. The goals of the ABMT are to reduce body-related AB by balancing attention between weight and non-weight-related body areas and to reduce BD levels. Twenty-three adolescent patients with AN were embodied in a virtual avatar and immersed in a virtual environment where they completed the ABMT. Body-related AB measures and BD levels were assessed before and after the training. A paired samples t-test showed statistically significant differences between pre-assessment and post-assessment; the complete fixation time on weight-related body parts was reduced and BD levels decreased. The initial evidence of the efficacy of this ABMT has important clinical implications, since AB and BD are considered risk factors for developing and maintaining eating disorder symptomatology among patients with AN

Modification of Body-Related Attentional Bias through Virtual Reality and Eye-Tracking in Healthy Participants: Implications for Anorexia Nervosa Treatments

Cognitive biases have a significant impact on the etiology and treatment of eating disorders (EDs). These biases, including selective attentional bias (AB) to disliked body parts, may reinforce concerns about body shape, fear of gaining weight and body image disturbances and may contribute to dietary restriction and restraint. Decreasing AB could reduce core symptoms in anorexia nervosa (AN). This study represents a preliminary exploration aiming to assess whether AB towards weightrelated (WR) and non-weight-related (NW) body parts could be reduced through an AB modification task in a virtual reality (VR) environment in healthy participants. A total of 54 female participants, aged 22.98 ± 1.89, were recruited. The task consisted of directing the participants’ attention towards all body parts equally in a VR setting. Eye-tracking (ET) measurements (complete fixation time [CFT] and number of fixations [NF]) were made before and after the task. The results showed a significant reduction of the AB in the two groups with an initial AB towards WR body parts or towards NW body parts. Participants showed a tendency to more balanced (non-biased) attention after the intervention. This study provides evidence of the usefulness of AB modification tasks in a non-clinical sample

Oncogenic regulation of tumor metabolic reprogramming

Development of malignancy is accompanied by a complete metabolic reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key oncogenic pathways converge to adapt the metabolism of carbohydrates, proteins, lipids and nucleic acids to the dynamic tumor microenvironment, conferring a selective advantage to cancer cells. Therefore, metabolic properties of tumor cells are significantly different from those of non-transformed cells. In addition, tumor metabolic reprogramming is linked to drug resistance in cancer treatment. Accordingly, metabolic adaptations are specific vulnerabilities that can be used in different therapeutic approaches for cancer therapy. In this review, we discuss the dysregulation of the main metabolic pathways that enable cell transformation and its association with oncogenic signaling pathways, focusing on the effects of c-MYC, hypoxia inducible factor 1 (HIF1), phosphoinositide-3-kinase (PI3K), and the mechanistic target of rapamycin (mTOR) on cancer cell metabolism. Elucidating these connections is of crucial importance to identify new targets and develop selective cancer treatments that improve response to therapy and overcome the emerging resistance to chemotherapeutics

ChainRank, a chain prioritisation method for contextualisation of biological networks

Advances in high throughput technologies and growth of biomedical knowledge have contributed to an exponential increase in associative data. These data can be represented in the form of complex networks of biological associations, which are suitable for systems analyses. However, these networks usually lack both, context specificity in time and space as well as the distinctive borders, which are usually assigned in the classical pathway view of molecular events (e.g. signal transduction). This complexity and high interconnectedness call for automated techniques that can identify smaller targeted subnetworks specific to a given research context (e.g. a disease scenario)

Direct evidence of the presence of cross-linked Aβ dimers in the brains of Alzheimer's disease patients

Brain-derived amyloid-β (Aβ) dimers are associated with Alzheimer´s disease (AD). However, their covalent nature remains controversial. This feature is relevant, as a covalent cross-link would make brain-derived dimers (brain dimers) more synaptotoxic than Aβ monomers and would make them suitable candidates for biomarker development. To resolve this controversy, we here present a three-step approach. First, we validated a type of synthetic cross-linked Aβ (CL Aβ) dimers, obtained by means of the photo-induced cross-linking of unmodified proteins (PICUP) reaction, as well-defined mimics of putative brain CL Aβ dimers. Second, we used these PICUP CL Aβ dimers as standards to improve the isolation of brain Aβ dimers and to develop state-of-the-art mass spectrometry (MS) strategies to allow their characterization. Third, we applied these MS methods to the analysis of brain Aβ dimer samples allowing the detection of the CL [Aβ(6-16)]2 peptide comprising a dityrosine cross-link. This result demonstrates the presence of CL Aβ dimers in the brains of patients with AD and opens up avenues for establishing new therapeutic targets and developing novel biomarkers for this disease