Resolved young binary systems and their disks

We have conducted a survey of young single and multiple systems in the Taurus-Auriga star-forming region with the Atacama Large Millimeter Array (ALMA), substantially improving both the spatial resolution and sensitivity with which individual protoplanetary disks in these systems have been observed. These ALMA observations can resolve binary separations as small as 25--30 AU and have an average 3$\sigma$ detection level of 0.35 mJy, equivalent to a disk mass of $4 \times 10^{-5}$ M$_{\odot}$ for an M3 star. Our sample was constructed from stars that have an infrared excess and/or signs of accretion and have been classified as Class II. For the binary and higher order multiple systems observed, we detect $\lambda = 1.3$ mm continuum emission from one or more stars in all of our target systems. Combined with previous surveys of Taurus, our 21 new detections increase the fraction of millimeter-detected disks to over 75% in all categories of stars (singles, primaries, and companions) earlier than spectral type M6 in the Class II sample. Given the wealth of other information available for these stars, this has allowed us to study the impact of multiplicity with a much larger sample. While millimeter flux and disk mass are related to stellar mass as seen in previous studies, we find that both primary and secondary stars in binary systems with separations of 30 to 4200 AU have lower values of millimeter flux as a function of stellar mass than single stars. We also find that for these systems, the circumstellar disk around the primary star does not dominate the total disk mass in the system and contains on average 62% of the total mass.Comment: 30 pages, 12 figures, to be published in the Astrophysical Journa

Four years (2011–2015) of total gaseous mercury measurements from the Cape Verde Atmospheric Observatory

Mercury is a chemical with widespread anthropogenic emissions that is known to be highly toxic to humans, ecosystems and wildlife. Global anthropogenic emissions are around 20 % higher than natural emissions and the amount of mercury released into the atmosphere has increased since the industrial revolution. In 2005 the European Union and the United States adopted measures to reduce mercury use, in part to offset the impacts of increasing emissions in industrialising countries. The changing regional emissions of mercury have impacts on a range of spatial scales. Here we report 4 years (December 2011–December 2015) of total gaseous mercury (TGM) measurements at the Cape Verde Observatory (CVO), a global WMO-GAW station located in the subtropical remote marine boundary layer. Observed total gaseous mercury concentrations were between 1.03 and 1.33 ng m−3 (10th, 90th percentiles), close to expectations based on previous interhemispheric gradient measurements. We observe a decreasing trend in TGM (−0.05 ± 0.04 ng m−3 yr−1, −4.2 % ± 3.3 % yr−1) over the 4 years consistent with the reported decrease of mercury concentrations in North Atlantic surface waters and reductions in anthropogenic emissions. The decrease was more visible in the summer (July–September) than in the winter (December–February), when measurements were impacted by air from the African continent and Sahara/Sahel regions. African air masses were also associated with the highest and most variable TGM concentrations. We suggest that the less pronounced downward trend inclination in African air may be attributed to poorly controlled anthropogenic sources such as artisanal and small-scale gold mining (ASGM) in West Africa

Resolved Young Binary Systems and Their Disks

We have conducted a survey of young single and multiple systems in the Taurus–Auriga star-forming region with the Atacama Large Millimeter Array (ALMA), substantially improving both the spatial resolution and sensitivity with which individual protoplanetary disks in these systems have been observed. These ALMA observations can resolve binary separations as small as 25–30 au and have an average 3σ detection level of 0.35 mJy, equivalent to a disk mass of 4 × 10^(−5) M⊙ for an M3 star. Our sample was constructed from stars that have an infrared excess and/or signs of accretion and have been classified as Class II. For the binary and higher-order multiple systems observed, we detect λ = 1.3 mm continuum emission from one or more stars in all of our target systems. Combined with previous surveys of Taurus, our 21 new detections increase the fraction of millimeter-detected disks to over 75% in all categories of stars (singles, primaries, and companions) earlier than spectral type M6 in the Class II sample. Given the wealth of other information available for these stars, this has allowed us to study the impact of multiplicity with a much larger sample. While millimeter flux and disk mass are related to stellar mass as seen in previous studies, we find that both primary and secondary stars in binary systems with separations of 30–4200 au have lower values of millimeter flux as a function of stellar mass than single stars. We also find that for these systems, the circumstellar disk around the primary star does not dominate the total disk mass in the system and contains on average 62% of the total mass

Nicotine dependence and biochemical exposure measures in the second trimester of pregnancy

Introduction: The Heaviness of Smoking Index (HSI) is validated to measure nicotine dependence in nonpregnant smokers, and in these smokers, mean salivary and serum cotinine levels are related by a ratio of 1.25. However, as nicotine metabolism increases during gestation, these findings may differ in pregnancy. We investigated the validity of HSI in pregnancy by comparing this with 3 biochemical measures; and in a search for a less-invasive cotinine measure in pregnancy, we also explored the relationship between mean blood and salivary cotinine levels. Methods: Cross-sectional analyses using baseline data from the Smoking, Nicotine, and Pregnancy Trial. Participants were 16–46 years old, 12–24 weeks gestation, smoked more than 5 cigarettes per day and had exhaled carbon monoxide (CO) readings of at least 8 ppm. Linear regression was used to examine correlations between HSI and blood cotinine, and salivary cotinine and exhaled CO. Correlation between blood and salivary cotinine was investigated using linear regression through the origin. Results: HSI scores were associated with blood cotinine (R2 = 0.20, n = 662, p < .001), salivary cotinine (R2 = 0.11, n = 967, p < .001), and exhaled CO (R2 = 0.13, n = 1,050, p < .001). Salivary and blood cotinine levels, taken simultaneously, were highly correlated (R2 = 0.91, n = 628, p < .001) and the saliva:blood level ratio was 1.01 (95% CI 0.99–1.04). Conclusions: Correlations between HSI and biochemical measures in pregnancy were comparable with those obtained outside pregnancy, suggesting that HSI has similar validity in pregnant smokers. Salivary and blood cotinine levels are roughly equivalent in pregnant smokers

Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery : Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds

Objectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6-3.2), low-moderate (LMDAS≥3.2-4.19), high-moderate (HMDAS 4.2-5.1) and high (HDAS>5.1). Results: Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. Conclusions: There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients.Peer reviewedFinal Published versio

Structural conversion of an oxazolidine ligand upon treatment with copper(I) and (II) halides; structural, spectral, theoretical and docking studies

In this work, the 2-(2-(pyridin-2-yl)oxazolidin-3-yl)ethanol (AEPC) ligand was prepared under solvent free conditions using ultrasonic irradiation, before reaction with a Cu(NO3)2/KSCN mixture, CuCl2 and CuI, the products of which were characterized by elemental analysis, UV-Vis, FT-IR spectroscopy and single-crystal X-ray diffraction. The X-ray analyses results revealed that AEPC, after reactions with the three copper(I/II) halides, gave structures ([Cu(DEA)Cl2] ( 2 ), DEA = diethanolamine, [Cu(BHEG)2] ( 3 ), BHEG = bis(2-hydroxyethyl)glycinato), however it retains its structure on treatment with Cu(NO3)2/KSCN mixture ([Cu(AEPC)(NCS)2] ( 1 )). The geometrical parameters for the complexes were compared with the Cambridge Structural Database (CSD) and coordination modes for thiocyanate ion were extracted. In the crystal structure of 1 , the copper ion has a distorted square-pyramidal geometry and a CuNpyN2NCSNtertOalc environment in which the AEPC acts as NN'O-donor in a facial coordination mode. In the crystal structure of 2 , the copper ion has a Cu(Nsec)(Oalc)2Cl2 environment and distorted square-pyramidal geometry in which the DEA ligand is coordinated as a mer-NO2-donor. The copper ion in 3 has a CuN2O4 environment and distorted octahedral geometry. The ability of these compounds to interact with the nine biomacromolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS and Top II) was investigated by Docking calculations and compared with that of doxorubicin. The thermodynamic stability of 1 and its isomer and also charge distribution patterns were studied by DFT and NBO analysis, respectively.PostprintPeer reviewe

The Lantern Vol. 27, No. 2, Spring 1959

• The Case for a Stratified Society • Education Courses • Some Thoughts for God\u27s Thinking Creatures • Sawdust to the Oats? • To Change the Things I Can... • Vignette • I Meet Goliath • Reverie and Reminiscence • On Flight • In Defense of Jazz • A Description • Line of Retreat • Alan Lomax and the American Folk Song • Dawn Stillness • Seasons • Two Poems • Despair • Too Late • Education • For All Practical Purposes He Was Bald • Contrast • I Belong to the Sea • Waves • Love • The Glory and the Dreamhttps://digitalcommons.ursinus.edu/lantern/1077/thumbnail.jp

The Profumo affair in popular culture: The Keeler Affair (1963) and ‘the commercial exploitation of a public scandal’

This article demonstrates that the Profumo affair, which obsessed Britain for large parts of 1963, was not simply a political scandal, but was also an important cultural event. Focussing on the production of The Keeler Affair, a feature film that figured prominently in contemporary coverage of the scandal but which has been largely overlooked since, the article shows that this film emerged from a situation in which cultural entrepreneurs, many of them associated with the satire boom, sought to exploit the scandal for financial gain. Many Profumo-related cultural products found an audience, and thus formed an integral part of, and helped to shape public attitudes towards, the Profumo affair. However, these products did not go uncontested, and resistance to them, and especially to the idea that Keeler might benefit materially from her role in the scandal, speak to concerns about cultural mediations of sex, politics and humour in early-1960s Britain