Achieving convergence in galaxy formation models by augmenting N-body merger trees

Accurate modeling of galaxy formation in a hierarchical, cold dark matter universe requires the use of sufficiently high-resolution merger trees to obtain convergence in the predicted properties of galaxies. When semi-analytic galaxy formation models are applied to cosmological N-body simulation merger trees, it is often the case that those trees have insufficient resolution to give converged galaxy properties. We demonstrate a method to augment the resolution of N-body merger trees by grafting in branches of Monte Carlo merger trees with higher resolution, but which are consistent with the pre-existing branches in the N-body tree. We show that this approach leads to converged galaxy properties

Mechanical design of an affordable adaptive gravity balanced orthosis for upper limb stroke rehabilitation

In this paper, a novel design of a non-powered orthosis for upper limb stroke rehabilitation is reported. Its design exploits the gravity balancing theory. Designed for home-based use, it is the first affordable, passive design to incorporate an assistive level that can be adaptively varied within a closed-loop control scheme. This allows the device to be integrated with a dual robotic and electrical stimulation control scheme, to thereby enable full exploitation of the motor relearning principles which underpin both robotic therapy and Functional Electrical Stimulation (FES) based stroke rehabilitation. This embeds the potential for more effective treatment. The article focuses on the mechanical design of the non-powered orthosis, providing detailed design, dynamic analysis and evaluation. Publisher statement: “This is an Accepted Manuscript of an article published by Taylor & Francis in Mechanics Based Design of Structures and Machines on 14 June 2015, available online: http://www.tandfonline.com/10.1080/15397734.2015.1054513

Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound Treatment at 1.5 T: A Retrospective Study on Treatment- and Patient-Related Parameters Obtained From 52 Procedures

Objective: To present a retrospective analysis of patient- and sonication-related parameters of a group of patients treated with a transcranial magnetic resonance imaging (MRI)-guided focused ultrasound (tcMRgFUS) system integrated with a 1.5-T MRI unit. Methods: The data obtained from 59 patients, who underwent the tcMRgFUS procedure from January 2015 to April 2019, were retrospectively reviewed for this study. The following data, among others, were mainly collected: skull density ratio (SDR), skull area (SA), number of available transducer elements (Tx), and estimated focal power at target (FP). For each of the four different treatment stages, we calculated the number of sonication processes (S-n), user-defined sonication power (S-p), effective measured power (S-mp), sonication duration (S-d), user-defined energy (E), effective measured energy (E-m), maximum temperature (T-max), and MR thermometry plane orientation. Furthermore, the time delay between each sonication (S-t) and the total treatment time (T-t) were recorded. Results: Fifty-two patients (40 males and 12 females; age 64.51 +/- SD 11.90 years; range 26-86 years), who underwent unilateral Vim thalamotomy (left = 50, 96.15%; right = 2, 3.85%) for medication-refractory essential tremor (n = 39; 78%) or Parkinson tremor (n = 13; 22%) were considered. A total of 1,068 (95.10%) sonication processes were included in our final analysis (average S-n per treatment: 20.65 +/- 6.18; range 13-41). The energy released onto the planned target was found to decrease with the SDR for all temperature ranges. A positive correlation was observed between the slope of T-max vs. E-m plot and the SDR (R-2 = 0.765; p < 0.001). In addition, the T-max was positively correlated with SDR (R-2 = 0.398; p < 0.005). On the contrary, no significant correlation was found between SDR and SA or Tx. An analysis of the MR thermometry scanning plane indicated that, at our site, the axial and the coronal planes were used (on average) 10.4 (SD +/- 3.8) and 7.7 (SD +/- 3.0) times, respectively, whereas the sagittal plane was used only 2.5 (SD +/- 3.0) times per treatment. Conclusion: Our results confirm the factors that significantly influence the course of a tcMRgFUS procedure even when a 1.5-T MRI scanner is used for procedure guidance. The experience we gained in this study indicates that the SDR remains one of the most significant technical parameters to be considered in a tcMRgFUS procedure. The possibility of prospectively setting the sonication energy according to the presented curves of energy delivery as a function of SDR for each treatment stage could provide a further understanding and a greater awareness of this emerging technology

Resectable and borderline resectable pancreatic ductal adenocarcinoma: Role of the radiologist and oncologist in the era of precision medicine

The incidence and mortality of pancreatic ductal adenocarcinoma are growing over time. The management of patients with pancreatic ductal adenocarcinoma involves a multidisciplinary team, ideally involving experts from surgery, diagnostic imaging, interventional endoscopy, medical oncology, radiation oncology, pathology, geriatric medicine, and palliative care. An adequate staging of pancreatic ductal adenocarcinoma and re-assessment of the tumor after neoadjuvant therapy allows the multidisciplinary team to choose the most appropriate treatment for the patient. This review article discusses advancement in the molecular basis of pancreatic ductal adenocarcinoma, diagnostic tools available for staging and tumor response assessment, and management of resectable or borderline resectable pancreatic cancer

Capacitance study of thin film SnO2:F/p-type a-Si:H heterojunctions

Abstract We characterized SnO 2 :F/p-type a-Si:H heterojunctions by current-voltage (I-V) and capacitance-voltage (C-V) measurements at room temperature to determine the junction parameters. Samples with circular geometry and different diameters were characterized. The current scales with the junction area, and the current density J as a function of the voltage V is a slightly asymmetric curve with a super-linear behaviour (cubic law) for high voltages. Using a transmission line model valid for devices with circular geometry, we studied the effects of the SnO 2 :F resistivity on the measured capacitance when the SnO2:F layer works as an electrical contact. The measured C-V curve allows us to determine junction parameters as doping of p-type a-Si:H, built-in potential and depletion width for the heterojunction with the smallest diameters, demonstrating that for these samples the TCO effects can be neglected. We compared theoretical and measured data to explain qualitatively the transport mechanism in this heterojunction

Extracting the three- and four-graviton vertices from binary pulsars and coalescing binaries

Using a formulation of the post-Newtonian expansion in terms of Feynman graphs, we discuss how various tests of General Relativity (GR) can be translated into measurement of the three- and four-graviton vertices. In problems involving only the conservative dynamics of a system, a deviation of the three-graviton vertex from the GR prediction is equivalent, to lowest order, to the introduction of the parameter beta_{PPN} in the parametrized post-Newtonian formalism, and its strongest bound comes from lunar laser ranging, which measures it at the 0.02% level. Deviation of the three-graviton vertex from the GR prediction, however, also affects the radiative sector of the theory. We show that the timing of the Hulse-Taylor binary pulsar provides a bound on the deviation of the three-graviton vertex from the GR prediction at the 0.1% level. For coalescing binaries at interferometers we find that, because of degeneracies with other parameters in the template such as mass and spin, the effects of modified three- and four-graviton vertices is just to induce an error in the determination of these parameters and, at least in the restricted PN approximation, it is not possible to use coalescing binaries for constraining deviations of the vertices from the GR prediction.Comment: 10 pages, 5 figures; v2: an error corrected; references adde

dexterous gripper for in hand manipulation with embedded object localization algorithm

Abstract Since the last decade, thanks to the spreading of the concept of Industry 4.0 and Smart Factory, more and more companies have started to investigate the robotic field looking for reliable solutions aiming at improving the efficiency of assembly lines. Promising technologies are connected to the speeding up of production stages like fast algorithms for object localization, as well as dexterous grippers for manipulation and assembly. Nowadays, most of the solutions for pick and place tasks involve the use of robotic grippers for grasping objects, while robotic manipulators are responsible for their accurate placements. Focusing on the grippers, although their simple structure can be appreciated, it greatly reduces their in-hand manipulation abilities, making unfeasible the twists of grasped objects and their release in a desired pose. As consequence, the efficiency of the pick and place operation is reduced since several adjustments of the robotic arm are required to accomplish the task. In this paper, a novel dexterous gripper coupled with a vision system algorithm for object localization and pose estimation are presented, and their performances in manipulating different objects are discussed. The designed gripper has a symmetrical structure with two finger modules, each one consisting in a couple of linear actuators arranged mutually orthogonal, so the translations in two axis, namely y and z directions, are allowed. As terminal part of each finger there is a revolute joint to whom is attached a fingertip modelled according to the shape of the target objects and easily replaceable. The embedded vision system algorithm adopted estimates position and orientation of the objects on a flat surface, and it coordinates the gripper placement to grasp them. The case study of the handling of a Spanish fan is presented and discussed in details