Multiple beam antenna system

Using a computer program which plots beams from antennas located on synchronous satellites onto the earth's surface, several circular and elliptical reflectors were analyzed for pattern coverage. The reflectors considered were circular paraboloid and elliptical shaped

Investigation of foamed metals for application on space capsules annual report, 29 jun. 1963 - 15 aug. 1964

Foamed metal development for space capsules - brazing, variable density beam, thermal testing, mechanical tests, and machinin

Scale-dependence of Non-Gaussianity in the Curvaton Model

We investigate the scale-dependence of f_NL in the self-interacting curvaton model. We show that the scale-dependence, encoded in the spectral index n_{f_NL}, can be observable by future cosmic microwave background observations, such as CMBpol, in a significant part of the parameter space of the model. We point out that together with information about the trispectrum g_NL, the self-interacting curvaton model parameters could be completely fixed by observations. We also discuss the scale-dependence of g_NL and its implications for the curvaton model, arguing that it could provide a complementary probe in cases where the theoretical value of n_{f_NL} is below observational sensitivity.Comment: 14 pages, 5 figures, Eq.(10) correcte

Space Trajectory Error Analysis Program (STEAP) for halo orbit missions. Volume 2: Programmer's manual

The six month effort was responsible for the development, test, conversion, and documentation of computer software for the mission analysis of missions to halo orbits about libration points in the earth-sun system. The software consisting of two programs called NOMNAL and ERRAN is part of the Space Trajectories Error Analysis Programs. The program NOMNAL targets a transfer trajectory from earth on a given launch date to a specified halo orbit on a required arrival date. Either impulsive or finite thrust insertion maneuvers into halo orbit are permitted by the program. The transfer trajectory is consistent with a realistic launch profile input by the user. The second program ERRAN conducts error analyses of the targeted transfer trajectory. Measurements including range, doppler, star-planet angles, and apparent planet diameter are processed in a Kalman-Schmidt filter to determine the trajectory knowledge uncertainty

Inhomogeneous non-Gaussianity

We propose a method to probe higher-order correlators of the primordial density field through the inhomogeneity of local non-Gaussian parameters, such as f_NL, measured within smaller patches of the sky. Correlators between n-point functions measured in one patch of the sky and k-point functions measured in another patch depend upon the (n+k)-point functions over the entire sky. The inhomogeneity of non-Gaussian parameters may be a feasible way to detect or constrain higher-order correlators in local models of non-Gaussianity, as well as to distinguish between single and multiple-source scenarios for generating the primordial density perturbation, and more generally to probe the details of inflationary physics.Comment: 16 pages, 2 figures; v2: Minor changes and references added. Matches the published versio

Gravity and non-gravity mediated couplings in multiple-field inflation

Mechanisms for the generation of primordial non-Gaussian metric fluctuations in the context of multiple-field inflation are reviewed. As long as kinetic terms remain canonical, it appears that nonlinear couplings inducing non-gaussianities can be split into two types. The extension of the one-field results to multiple degrees of freedom leads to gravity mediated couplings that are ubiquitous but generally modest. Multiple-field inflation offers however the possibility of generating non-gravity mediated coupling in isocurvature directions that can eventually induce large non-Gaussianities in the metric fluctuations. The robustness of the predictions of such models is eventually examined in view of a case study derived from a high-energy physics construction.Comment: 14 pages, 3 figures, invited review for CQG issue on non-linear cosmolog

Heparin-binding and patterns of virulence for two recombinant strains of Sindbis virus

AbstractE2 is an important determinant of Sindbis virus neurovirulence. Increased heparan sulfate (HS) binding is associated with rapid clearance of viremia and usually with decreased virulence. However, substitution of histidine for arginine at E2-157 (R157H) or glutamate for lysine at E2-159 (K159E) produces viruses with decreases in heparin-Sepharose binding and increases in viremia but different levels of binding to HS-expressing cells and virulence phenotypes in newborn CD-1 mice (Byrnes, A.P., Griffin, D.E., 2000. Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia and slower clearance from the circulation. J. Virol. 74, 644–651). To identify mechanisms of virulence, R157H and K159E were studied in newborn CD-1 and BALB/c mice. Subcutaneous inoculation of R157H caused 100% and K159E 60% mortality in 2-day-old CD-1 mice. R157H caused 25% and K159E no mortality in 2-day-old BALB/c mice. R157H and K159E replicated similarly at the site of inoculation with the same level of viremia, but clearance was slower in CD-1 than BALB/c mice. R157H replicated better than K159E in the central nervous system (CNS) after subcutaneous and intracerebral inoculation and in undifferentiated neurons. These studies show a genetic restriction of replication in newborn BALB/c mice, and that amino acid substitutions affecting binding to proteoglycans may differ in importance for CNS infection and viremia

Dysbetalipoproteinaemia-clinical and pathophysiological features

Objectives. Dysbetalipoproteinaemia (type III hyperlipidaemia, broad-beta disease) is a highly atherogenic genetic disorder of lipoprotein metabolism. It presents with a severe mixed hyperlipidaemia in which the ratio of total cholesterol to triglycerides is typically 2:1. There is a high incidence of atherosclerotic complications and severe hypertriglyceridaemia may cause pancreatitis. Highly effective therapy is available and affected families also benefit from genetic counselling.We present a review of our experience with dysbetalipoproteinaemia at the lipid clinic of Groote Schuur Hospital to enhance awareness of this serious condition, for which the index of suspicion should be raised.Design. Retrospective review of case records, 1969- 2001.Setting. Lipid clinic of Groote Schuur Hospital, Cape Town.Subjects. Patients with dysbetalipoproteinaemia diagnosed by the presence of cholesterol-enriched very-low-density lipoproteins (VLDL) and/or dyslipidaemia associated with homozygosity for apolipoprotein E2 or carriers of the apoE2 (Arg 145 →Cys) mutation.Results. One hundred and five patients were identified, 55 of whom were male and 50 female. The age at presentation was 48.8 ± 11.1 years (mean, standard deviation). Total cholesterol was 12.0 ± 5.5 mmol/l and plasma triglycerides 8.3 ± 9.8 mmol/1. The ratio (by mass) of cholesterol to triglycerides within VLDL was 0.52 ± 0.17, while VLDL cholesterol to plasma triglycerides was 0.33 ± 0.09. Fifty patients were E2 homozygotes while 22 carried the apoE2(Arg→ 145 Cys) mutation. Palmar crease xanthomas occurred in 20% of patients, cutaneous xanthomas in 18%, and tendon xanthomas in 13%. Coronary artery disease was found in 47% of patients and peripheral vascular disease in 20%. Fibrates were the most commonly used hypolipidaemic agents (48%), while 31% of patients received combination therapy with a fibrate and statin. Statin monotherapy was used in 11% of patients and a few patients were treated with niacin or required no drug therapy. The treated cholesterol was 5.7 ± 2.4 mmol/1, with plasma triglycerides of 2.7 ± 1.9 mmol/1. Conclusions. Dysbetalipoproteinaemia is a highly atherogenic disorder and is extremely responsive to therapy. A significant proportion of dysbetalipoproteinaemia locally is caused by the apoE2(Arg→ 145 Cys) mutation and is therefore dominantly inherited. This mutation is particularly prevalent in the black community where dysbetalipoproteinaemia may be undiagnosed in many patients. Patients with severe mixed hyperlipidaemia or clinical stigmata of dyslipidaemia should be assessed at a lipid clinic for a specific diagnosis and initiation of therapy.

Generation of helical magnetic fields from inflation

The generation of helical magnetic fields during single field inflation due to an axial coupling of the electromagnetic field to the inflaton is discussed. We find that such a coupling always leads to a blue spectrum of magnetic fields during slow roll inflation. Though the helical magnetic fields further evolve during the inverse cascade in the radiation era after inflation, we conclude that the magnetic fields generated by such an axial coupling can not lead to observed field strength on cosmologically relevant scales.Comment: 4 pages, 1 figure; Contribution to the proceedings of the International Conference on Gravitation and Cosmology (ICGC), Goa, India, December, 201