459 research outputs found

    Econometric study of alternative operators' investment decisions

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    Mestrado em Econometria Aplicada e PrevisãoA relação entre a intervenção regulatória, as decisões de investimento dos operadores alternativos e o grau de concorrência nos mercados de comunicações eletrónicas tem sido intensamente discutida. O debate centra-se na possibilidade de obter um compromisso entre concorrência baseada em serviços e concorrência baseada em infraestruturas. A teoria da escada do investimento defende a conciliação destes dois objetivos pela intervenção adequada do regulador. Usando uma base de dados bastante completa e atendendo às fragilidades apontadas a outros estudos conclui-se que a informação sobre o mercado português comprova alguns pressupostos teóricos associados à teoria da escada do investimento: (i) a criação de condições para que os operadores alternativos entrem no mercado é um passo importante para que invistam em infraestrutura, e (ii) o regulador possui instrumentos para neutralizar o custo de oportunidade criado ao investimento em infraestruturas pelos lucros da concorrência baseada em serviços. O investimento em redes de fibra ótica pelos operadores alternativos é também considerado, avaliando os determinantes deste investimento e o respetivo efeito no nível de cobertura de uma área geográfica. É dada particular atenção à obtenção de uma especificação adequada para o modelo. Conclui-se que é preferível utilizar um modelo a duas partes em detrimento de um modelo a uma parte, pois os conjuntos de determinantes da decisão de investir numa área geográfica e da decisão relativa ao nível de cobertura a atingir nessa área não são idênticos. As características demográficas, económicas e sociais intrínsecas às áreas geográficas influenciam significativamente as decisões de investimento dos operadores alternativos.The relation between regulation, the alternative operators' investment decisions and the degree of competition in the markets, has been an important policy issue over time. The discussions on this matter are mostly related with the possibility to achieve service-based competition in the short run, without compromising infrastructure-based competition in the long run. The investment ladder theory argues that both goals are achievable by appropriate regulatory intervention. By using a rich dataset and taking into account flaws pointed out in other studies, the present study finds reasonable evidence that the Portuguese market's data supports theoretical assumptions of the investment ladder theory: (i) creating conditions for alternative operators entering the market is an step in creating conditions for investment in infrastructure; (ii) the regulator has the tools to neutralise the opportunity cost for infrastructure investment created by service-based competition profits. The investment in fibre networks by alternative operators is also taken into consideration, with an evaluation of the investment determinants and their effect on coverage level of alternative operator's fibre networks. Particular attention is given to achieve an appropriate model specification. It is concluded that it is preferable to use a two-part model over a one part-model, which provides evidence that the determinants of the decision to invest in a geographical area are not entirely similar to the determinants of the decision on the coverage level in that area. The present study found that the intrinsic demographic, economic and social characteristics of a given geographical area influence investment decisions of alternative operators

    Pervasive gaps in Amazonian ecological research

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    Pervasive gaps in Amazonian ecological research

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    Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

    Measurement of differential cross sections for top quark pair production using the lepton plus jets final state in proton-proton collisions at 13 TeV

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    National Science Foundation (U.S.

    Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV

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    Many measurements and searches for physics beyond the standard model at the LHC rely on the efficient identification of heavy-flavour jets, i.e. jets originating from bottom or charm quarks. In this paper, the discriminating variables and the algorithms used for heavy-flavour jet identification during the first years of operation of the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, are presented. Heavy-flavour jet identification algorithms have been improved compared to those used previously at centre-of-mass energies of 7 and 8 TeV. For jets with transverse momenta in the range expected in simulated tt‾\mathrm{t}\overline{\mathrm{t}} events, these new developments result in an efficiency of 68% for the correct identification of a b jet for a probability of 1% of misidentifying a light-flavour jet. The improvement in relative efficiency at this misidentification probability is about 15%, compared to previous CMS algorithms. In addition, for the first time algorithms have been developed to identify jets containing two b hadrons in Lorentz-boosted event topologies, as well as to tag c jets. The large data sample recorded in 2016 at a centre-of-mass energy of 13 TeV has also allowed the development of new methods to measure the efficiency and misidentification probability of heavy-flavour jet identification algorithms. The heavy-flavour jet identification efficiency is measured with a precision of a few per cent at moderate jet transverse momenta (between 30 and 300 GeV) and about 5% at the highest jet transverse momenta (between 500 and 1000 GeV)

    Evidence for the Higgs boson decay to a bottom quark–antiquark pair

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    info:eu-repo/semantics/publishe

    Particle-flow reconstruction and global event description with the CMS detector

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    The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic tau decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8 TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions

    Search for heavy resonances decaying to a top quark and a bottom quark in the lepton+jets final state in proton–proton collisions at 13 TeV

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    info:eu-repo/semantics/publishe

    Pseudorapidity and transverse momentum dependence of flow harmonics in pPb and PbPb collisions

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    info:eu-repo/semantics/publishe

    Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

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    BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
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