Three-dimension-printed custom-made prosthetic reconstructions: from revision surgery to oncologic reconstructions

Background The use of custom-made 3D-printed prostheses for reconstruction of severe bone defects in selected cases is increasing. The aims of this study were to evaluate (1) the feasibility of surgical reconstruction with these prostheses in oncologic and non-oncologic settings and (2) the functional results, complications, and outcomes at short-term follow-up. Methods We analyzed 13 prospectively collected patients treated between June 2016 and January 2018. Diagnoses were primary bone tumour (7 patients), metastasis (3 patients), and revision of total hip arthroplasty (3 patients). Pelvis was the most frequent site of reconstruction (7 cases). Functional results were assessed with MSTS score and complications according to Henderson et al. Statistical analysis was performed using Kaplan-Meier and log-rank test curves. Results At a mean follow-up of 13.7 months (range, 6 \u2013 26 months), all patients except one were alive. Oncologic outcomes show seven patients NED (no evidence of disease), one NED after treatment of metastasis, one patient died of disease, and another one was alive with disease. Overall survival was 100% and 80% at one and two years, respectively. Seven complications occurred in five patients (38.5%). Survival to all complications was 62% at two years of follow-up. Functional outcome was good or excellent in all cases with a mean score of 80.3%. Conclusion 3D-printed custom-made prostheses represent a promising reconstructive technique in musculoskeletal oncology and challenging revision surgery. Preliminary results were satisfactory. Further studies are needed to evaluate prosthetic design, fixation methods, and stability of the implants at long-ter

IO9 GEOPLANET Field Trip Guide

This document has been prepared by the University of Padova in collaboration with the University D’Annunzio and the whole consortium of the Erasmus+ Strategic Partnership GeoPlaNet-SP (ref. 2020-1-FR01-KA203-079773) with a more consistent effort from University of Nantes personnel. This Intellectual provide a comprehensive overview of some key sites on the Dolomites similar to geological environments on Mars. The field guide is focused on the Upper Permian sedimentary environment of semi-arid alluvial plains, the Upper Permian Lower-Triassic coastal and shallow marine sequences and the Quaternary periglacial morphologies. The main sites of interest are the Bletterbach Gorge, the San Pellegrino Pass and the Rolle Pass. The guide describes in detail the most important analogies of the sites with specific Martian geological settings and provides geological maps of each site

Pre-Alpine and Alpine deformation at San Pellegrino pass (Dolomites, Italy)

In this work, we present the geological map of the San Pellegrino pass, inserted in the spectacular scenario of the Dolomiti region (Southern Alps, Italy), at a scale of 1:10.000 and accompanied by geological cross-sections. The detailed distinction of lithological thin units allowed to achieve a consistent interpretation of the local structural setting by drawing brittle and ductile Alpine tectonic deformations. The differential deformation and structural styles within the geological map are the result of the different rheological nature of volcanic and sedimentary rocks, as well as of the superimposition of compressional Alpine tectonics over Permo-Mesozoic extensional tectonic phases, and consequent reactivation of inherited structures

Assessment of Neurocognitive Functions, Olfaction, Taste, Mental, and Psychosocial Health in COVID-19 in Adults: Recommendations for Harmonization of Research and Implications for Clinical Practice

Assessment; COVID-19; Guidelines; Neuropsychological functions.Avaluació; COVID 19; Directrius; Funcions neuropsicològiques.Evaluación; COVID-19; Pautas; Funciones neuropsicológicasObjective: To propose a set of internationally harmonized procedures and methods for assessing neurocognitive functions, smell, taste, mental, and psychosocial health, and other factors in adults formally diagnosed with COVID-19 (confirmed as SARS-CoV-2 + WHO definition). Methods: We formed an international and cross-disciplinary NeuroCOVID Neuropsychology Taskforce in April 2020. Seven criteria were used to guide the selection of the recommendations' methods and procedures: (i) Relevance to all COVID-19 illness stages and longitudinal study design; (ii) Standard, cross-culturally valid or widely available instruments; (iii) Coverage of both direct and indirect causes of COVID-19-associated neurological and psychiatric symptoms; (iv) Control of factors specifically pertinent to COVID-19 that may affect neuropsychological performance; (v) Flexibility of administration (telehealth, computerized, remote/online, face to face); (vi) Harmonization for facilitating international research; (vii) Ease of translation to clinical practice. Results: The three proposed levels of harmonization include a screening strategy with telehealth option, a medium-size computerized assessment with an online/remote option, and a comprehensive evaluation with flexible administration. The context in which each harmonization level might be used is described. Issues of assessment timelines, guidance for home/remote assessment to support data fidelity and telehealth considerations, cross-cultural adequacy, norms, and impairment definitions are also described. Conclusions: The proposed recommendations provide rationale and methodological guidance for neuropsychological research studies and clinical assessment in adults with COVID-19. We expect that the use of the recommendations will facilitate data harmonization and global research. Research implementing the recommendations will be crucial to determine their acceptability, usability, and validity

Geometry and stratigraphic relationships of lower Oligocene coral reefs in Lumignano (Berici Hills, northern Italy)

The Cliffs of Lumignano (Northern Italy) are a renowned climbing area, set on the steep walls of lower Oligocene limestones of the Castelgomberto formation which are made mainly of coral boundstone. Lumignano lies approximately on the south-eastern margin of a Cenozoic carbonate platform known as the Lessini Shelf, but the depositional environment of coral reefs is still debated, and it is unclear whether it was a Caribbean-type carbonate platform with a lagoon and steep slope, or a carbonate ramp with coral reefs on the mid ramp. We produced a geological map of the Lumignano area, in which five lithofacies are distinguished and mapped within the Castelgomberto formation. Their spatial distribution and main sedimentological characters outline that landward of coral reefs, a high-energy environment was present and was shallower than the reefs. Seaward of coral reefs, coralline algae and marlstones with bryozoans occur, while no evidence of a slope made of coral rubble was found. Hence, the detailed geological mapping and the documentation of the stratigraphic relationships between lithofacies provided a valuable contribution to the understanding of depositional environments of the lower Oligocene Lessini Shelf. This work also suggests elements for a better definition of the Castelgomberto formation, which could be split in members or lithofacies that can be mapped at a reasonably large scale (1:10000). The coralline algal lithofacies of the Castelgomberto formation is locally indistinguishable from the analogous facies of the underlying Priabona formation, but the boundary between these two units is always marked by an unconformity, which is easy to identify and may be used for the lithostratigraphic definition of the Castelgomberto formation

Submarine Slides During Relative Sea Level Rise: Two Examples from the Eastern Tyrrhenian Margin

Abstract Two extensive mass-failure deposits originated during the late-Quaternary sea level rise on the eastern Tyrrhenian margin. The deposits that failed had markedly different architectures: offshore Cape Licosa, a shelf-margin low-stand wedge failed along its basal downlap surface; in Paola slope basin, extensive failure on the upper slope involved a few-m-thick mud drape and older consolidated units. Regardless of their geometric differences, both failures occurred close to an interval of accelerated lateQuaternary sea-level rise (ca.13.8 cal. kyr BP). This evidence suggests that rapid drowning of unconsolidated sediment resulted in increased water load; enhanced pore pressure played a role in favoring failure

M & L Jaargang 19/5

Anna Bergmans De Sint-Martinusbasiliek van Halle. Reiniging en onderzoek van het interieur. [The Saint Martins basilica in Halle Cleaning and study of the interior.]Karel Breda De restauratieve reiniging van het kerkinterieur (1998-1999). [The cleaning of the church interior.]Hugo VandenBorre De polychromie van het kerkinterieur: inventaris, reiniging en consolidatie. [A church interior and its polychromy: Inventory, cleaning and preservation.]Ingrid Geelen en Wivine Wailliez Enkele beschouwingen over de apostelen: de plaats van de kleur. [A dissertation on the Apostles: the role of colour.]Christian Bodiaux - De gebeeldhouwde zwikken in het koor. Enkele iconografische themas en stijlkenmerken. [The sculptured ensembles in the choir. Iconographical themes and style features.]Summar

Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.

The complement system consists of more than 40 proteins that participate in the inflammatory response and in pathogen killing. Complement inhibitors are necessary to avoid the excessive consumption and activation of this system on host cells. Leptospirosis is a worldwide zoonosis caused by spirochetes from the genus Leptospira. Pathogenic leptospires are able to escape from complement activation by binding to host complement inhibitors Factor H [FH] and C4b-binding protein (C4BP) while non-pathogenic leptospires are rapidly killed in the presence of fresh serum. In this study, we demonstrate that complement control protein domains (CCP) 7 and 8 of C4BP α-chain interact with the outer membrane proteins LcpA, LigA and LigB from the pathogenic leptospire L. interrogans. The interaction between C4BP and LcpA, LigA and LigB is sensitive to ionic strength and inhibited by heparin. We fine mapped the LigA and LigB domains involved in its binding to C4BP and heparin and found that both interactions are mediated through the bacterial immunoglobulin-like (Big) domains 7 and 8 (LigA7-8 and LigB7-8) of both LigA and LigB and also through LigB9-10. Therefore, C4BP and heparin may share the same binding sites on Lig proteins

Design, Implementation, and Evaluation of the Adolescents and Surveillance System for the Obesity Prevention Project

The Adolescents Surveillance System for Obesity prevention (ASSO) Project aimed at developing standardized and web-based tools for collecting data on adolescents’ obesity and its potential determinants. This has been implemented and piloted in the local area of Palermo city, Italy. The aim of the present study is to provide an overview of the Project’s design, implementation, and evaluation, highlighting all the aspects for a potential scale-up of the surveillance system on the whole national territory and abroad, as a sustainable and effective source of data. The overall structure and management, the ASSO-toolkit, the ASSO-NutFit software, and all developed and used procedures for recruiting, training, and data collecting/analyzing are addressed. An interim evaluation has been performed through a feasibility study; a final Project evaluation has been performed reporting the Strengths, Weaknesses, Opportunities, and Threats (SWOT) and the attributes that a surveillance system should have. This article provides a detailed overview of the Project and highlights that ASSO can be considered a valid, logical, coherent, efficient, and sustainable surveillance system that is consistent with countries’ needs and priorities. The system developed by the ASSO Project provides high-quality data and complies with several characteristics typical of a suitable surveillance system. It has a potential of being adopted within the National Health Service and other countries’ Health Services for monitoring adolescents’ obesity and its determinants, such as food intakes, behaviors, physical activity, and fitness profiles

Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.

The complement system consists of more than 40 proteins that participate in the inflammatory response and in pathogen killing. Complement inhibitors are necessary to avoid the excessive consumption and activation of this system on host cells. Leptospirosis is a worldwide zoonosis caused by spirochetes from the genus Leptospira. Pathogenic leptospires are able to escape from complement activation by binding to host complement inhibitors Factor H [FH] and C4b-binding protein (C4BP) while non-pathogenic leptospires are rapidly killed in the presence of fresh serum. In this study, we demonstrate that complement control protein domains (CCP) 7 and 8 of C4BP α-chain interact with the outer membrane proteins LcpA, LigA and LigB from the pathogenic leptospire L. interrogans. The interaction between C4BP and LcpA, LigA and LigB is sensitive to ionic strength and inhibited by heparin. We fine mapped the LigA and LigB domains involved in its binding to C4BP and heparin and found that both interactions are mediated through the bacterial immunoglobulin-like (Big) domains 7 and 8 (LigA7-8 and LigB7-8) of both LigA and LigB and also through LigB9-10. Therefore, C4BP and heparin may share the same binding sites on Lig proteins