Laboratory monitoring and antiviral treatment for chronic hepatitis B among routine care patients in the United States

We investigated factors associated with rates of recommended monitoring of chronic hepatitis B (HBV) patients for viral DNA and alanine aminotransferase (ALT), and initiation of antiviral treatment among eligible patients, in a US cohort of patients under routine care. Patients were categorised by treatment indication: definite, equivocal or ineligible. Baseline covariates included demographics, clinical characteristics and specialist care status. \u27Recommended monitoring\u27 was defined ≥1 ALT or HBV DNA test per year. Logit models, univariate then multivariable, were used to evaluate factors associated with monitoring and treatment. Among 3,830 patients, treatment was received by 67.5% (788/1168 patients) in the \u27definite\u27 category, and 34.1% (208/610 patients) in the \u27equivocal\u27 category, of whom 109 moved up to \u27definite\u27 status at some point during follow-up. Sex, age and specialist care were independently associated with receipt of treatment in \u27definite\u27 patients. Routine monitoring rates were high prior to treatment in \u27definite/ treated\u27 patients (ALT: 77%; DNA: 85%) but declined afterwards (ALT 63%; DNA 36%). Rates of monitoring were lower in \u27definite/ untreated\u27 patients (ALT: 48%; DNA: 32%). Among \u27equivocal/ treated\u27 patients, lower age and comorbidity scores were associated with receipt of treatment; ALT monitoring rates were similar before and after treatment initiation (41% and 46%, respectively), while rates of DNA monitoring declined (55% and 29%). Monitoring among \u27treatment ineligible\u27 patients was similar to those in the \u27equivocal\u27 and untreated \u27definite\u27 groups. A large proportion of US HBV patients under routine care did not receive recommended annual laboratory monitoring, especially after initiation of antiviral treatment, and nearly one-third of patients with \u27definite\u27 indications for antiviral therapy remained untreated

EFECTOS DEL ESTRÉS COMBINADO DE ALTA TEMPERATURA Y DEFICIENCIA DE AGUA EN LA FLORACIÓN FEMENINA, MASCULINA Y EL NÚMERO DE GRANOS EN MAÍZ.

Extremely high temperatures and water deficits commonly affect crop productivity worldwide (Prasad et al., 2008; Lobell et al., 2013). The frequency of these events may increase as a result of global warming (Rezaei et al., 2015; IPCC, 2023; Heino et al., 2023) impacting to a greater extent in low latitudes with high probability of heat stress during crop growth and development (Easterling et al., 1997). Feng et al. (2020), in a global analysis, determined that Argentina is among the seven producing countries with the highest probability of occurrence of events with high temperatures and water deficit. Thus, the increase in the frequency and magnitude of heat stress (TS) due to high temperature and water deficit (DH) are among the main abiotic constraints with considerable adverse effects on maize yield (Lobell and Field, 2007; Hatfield et al., 2011). The number of grains (NG) is the component that explains most of the variations in maize yield (Tollenaar et al., 1992). The most critical time for NG determination in maize is around flowering (e.g., Tollenaar et al., 1992; Carrera et al., 2023). In particular, it was shown that the effects of ET on NG reduction were greatest between stigma emission and 15-17 days after stigma emission (Rattalino Edreira and Otegui, 2013; Neiff et al., 2016; Shim et al., 2017), coinciding with the period of maximum susceptibility to DH (Ouattar et al., 1987). Both the occurrence of ET or DH often result in the lag between the anthesis-stigmas interval (Cairns et al., 2013; Trachsel et al., 2016; Wang et al. 2019), leading to NG declines. Episodes of ET often reduce the pollen release period (PLP) and its daily production (Wang, 2019), as well as the % of viable pollen grains (Alam et al., 2017).Las temperaturas extremadamente altas y el déficit hídrico comúnmente afectan la productividad de los cultivos en el mundo (Prasad et al., 2008; Lobell et al., 2013). La frecuencia de estos eventos puede aumentar como resultado del calentamiento global (Rezaei et al., 2015; IPCC, 2023; Heino et al., 2023) impactando en mayor medida en latitudes bajas con alta probabilidad de golpes de calor durante el crecimiento y desarrollo de los cultivos (Easterling et al., 1997). Feng et al. (2020), en un análisis global, determinaron que Argentina se encuentra dentro de los siete países productores que presentan una mayor probabilidad de ocurrencia de eventos con altas temperaturas y déficit hídrico. Así, el aumento de la frecuencia y la magnitud del estrés térmico (ET) por alta temperatura y déficit hídrico (DH) son unas de las principales limitantes abióticas con efectos adversos considerables en el rendimiento de maíz (Lobell y Field, 2007; Hatfield et al., 2011). El número de granos (NG) es el componente que explica en mayor medida las variaciones en rendimiento de maíz (Tollenaar et al., 1992). El momento más crítico para la determinación del NG en maíz es alrededor de su floración (e.g., Tollenaar et al., 1992; Carrera et al., 2023). En particular se demostró que los efectos del ET sobre la reducción en NG fueron mayores entre la emisión de estigmas y 15-17 días posteriores a la misma (Rattalino Edreira y Otegui, 2013; Neiff et al., 2016; Shim et al., 2017), coincidente con el periodo de máxima susceptibilidad al DH (Ouattar et al., 1987). Tanto la ocurrencia de ET o DH a menudo producen el desfase entre el intervalo antesis-estigmas (Cairns et al., 2013; Trachsel et al., 2016; Wang et al. 2019), lo cual conlleva a disminuciones del NG. Episodios de ET a menudo reducen el periodo de liberación de polen (PLP) y su producción diaria (Wang, 2019), como así también el % de granos de polen viables (Alam et al., 2017). Además, se han reportado reducciones del número total de flores pistiladas y disminuciones de estigmas exertos por fuera de las chalas atribuibles a episodios de ET con diferencias genotípicas (Rattalino Edreira et al. 2011; Liu et al., 2020). A menudo, los genotipos con germoplasma tropical han presentado una mayor tolerancia al ET (Rattalino Edreira y Otegui, 2012; Mayer et al., 2016) que los híbridos templados. Sin embargo, gran parte de los híbridos sembrados en el Nordeste Argentino poseen genética de origen templada. Por su parte, el DH durante el PC también produce importantes reducciones en el NG como consecuencia delretraso en la emergencia de los estigmas y el fallo en el cuaje de los granos (i.e., aborto; Westgate y Boyer, 1986; Bassetti y Westgate, 1993). La principal causa de aborto de granos ocurre por la escasez de asimilados hacia los ovarios fecundados (Westgate y Boyer 1986; McLaughlin y Boyer, 2004) que son resultado de las bajas tasas de crecimiento (Andrade et al., 2002; Nagore et al., 2017). Más aún, la aparición y el número total de estigmas y su relación con el porcentaje de cuaje fueron estudiados para estreses individuales por ET (Rattalino et al., 2011), DH (Otegui et al., 1995) y nitrógeno (Rossini et al., 2020), no existiendo estudios a campo que proporcionen información bajo ET*DH y que contrasten genotipos de distinto origen (templado vs. subtropical). La mayoría de los estudios en maíz se han centrado en los efectos del ET y DH como factores de estrés individuales. Sin embargo, varios estudios revelan que los efectos combinados del ET*DH reducen en mayor medida el rendimiento del cultivo maíz respecto a estreses individuales (Neiff et al., 2015; Meseka et al., 2018; Hussain et al., 2019; Nelimor et al., 2019). Además, la tolerancia de híbridos de maíz a estreses individuales no confirió tolerancia al ET*DH combinado (Mittler et al., 2006; Cairns et al., 2013). Por lo tanto, y considerando la escasez de estudios en condiciones de campo que combinen la incidencia de ET*DH y que contrasten genotipos de distinto origen, este trabajo tiene como objetivos: (i) caracterizar la floración masculina (período de liberación, producción y viabilidad de polen) y femenina (número de estigmas totales y exertos), (ii) cuantificar el intervalo antesis-emisión estigmas y (iii)establecer el impacto en el número de granos y su relación con las variables mencionadas

The prevalence and risk of metabolic syndrome and its components among people with posttraumatic stress disorder: A systematic review and meta-analysis

Objective: People with posttraumatic stress disorder (PTSD) have a higher mortality than the general population, mainly due to cardiovascular diseases (CVD). Metabolic syndrome (MetS) and its components are highly predictive of CVD. The aim of this meta-analysis was to describe pooled frequencies of MetS and its components in people with PTSD and to compare MetS prevalences in PTSD versus the general population. Method: Medline, PsycARTICLES, Embase and CINAHL were searched until 02/2015 for cross-sectional and baseline data of longitudinal studies in adults with PTSD. Two independent reviewers conducted the searches and extracted data. Random effects meta-analysis with a relative risk, subgroups and meta-regression analyses were employed. Results: Overall, 9 studies met the inclusion criteria including 9,254 individuals in midlife with PTSD and 6,852 general population controls. The pooled MetS prevalence was 38.7% (95%CI = 32.1%-45.6%; Q = 52.1, p < 0.001; N = 9; n = 9,673; age range = 44-61years). Abdominal obesity was observed in 49.3% (95%CI = 29.7%-69.0%), hyperglycaemia in 36.1% (95%CI = 18.8%-55.6%), hypertriglyceridemia in 45.9% (95%CI = 12.2%-81.9%), low high density-lipoprotein-cholesterol in 46.4% (95%CI = 26.4%-67.0%) and hypertension in 76.9% (95%CI = 67.9%-84.8). The MetS prevalence was consistently high across geographical regions, settings or populations (war veterans or not). Compared with matched general population controls, people with PTSD had an almost double increased risk for MetS (RR = 1.82; 95%CI = 1.72-1.92; p < 0.001). Most analyses were not statistically heterogeneous. Conclusions: MetS is highly prevalent in people with PTSD. Routine screening and multidisciplinary management of medical and behavioral conditions is needed. Future research should focus on how cardio-metabolic outcomes are moderated by clinical and treatment characteristics and genetic factors

Fear of terrorism and preparedness in New York City 2 years after the attacks: Implicatins for disaster planning and research

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48739/1/boscarino_fears of terrorism_2006.pd

Umbilical cord medication in healthy full-term newborns: a before-after uncontrolled quality improvement study

Umbilical cord care can be a stressful practice for parents. Complications of cord care can increase neonatal morbidity and mortality. The extracts of Arnica montana (AM) have been reported to possess antibacterial, anti-inflammatory, antifungal, and immunomodulatory activities. We aim to demonstrate the efficacy of AM on cord detachment and parents’ stress level induced by cord medication in healthy full-term newborns. We enrolled full-term infants with a birth weight ≥ 2500 g in healthy conditions. Cord stumps of infants in the PRE-group were cleaned and dried, while cord stumps of infants in the POST-group were cleaned, dried, and medicated with a natural topic dermo-protective powder containing AM. After discharge, we interviewed parents on the stump status during follow-up visits in a pediatric office at 7 and 14 days of life, or by phone calls after follow-up visits. Long-rank test showed that time of cord separation of newborns in the PRE-group was significantly higher compared to that in the POST-group (p &lt; 0.001). Parents of newborns in the PRE-group were significantly more stressed during cord medication compared to parents in the POST-group (2.0 (1.2 to 2.1) vs 1.0 (0.8 to 1.3), p = 0.011). Multivariate analysis showed a significantly linear relation with group assignment for cord separation (p &lt; 0.001) and parents’ stress during the medication (p = 0.033). Conclusion: The use of a natural topic dermo-protective powder containing AM reduces the time of cord separation, improves parents’ stress level, and reduces the risk of complications

Hemimysis anomala in Lake Ontario food webs: stable isotope analysis of nearshore communities

a b s t r a c t a r t i c l e i n f o Hemimysis anomala, a littoral freshwater mysid native to the Ponto-Caspian region, is the newest invader to the Laurentian Great Lakes basin. Discovered in 2006, they have since been found in all of the Great Lakes (except Lake Superior) and have the potential to offset the dietary energy sink caused by invasive dreissenid mussels (Dreissena bugensis and D. polymorpha) in the littoral zone. We evaluated nearshore food web structure at four sites along Lake Ontario&apos;s north shore spanning a gradient of Hemimysis density to determine: 1) if dominant nearshore food web pathways change seasonally, and 2) whether fish are exhibiting a dietary shift towards consumption of Hemimysis. No Hemimysis were found in any of the 431 fish (alewife Alosa pseudoharengus, round goby Neogobius melanostomus, and yellow perch Perca flavescens) stomachs analysed. We used stable isotopes of carbon ( C of Hemimysis. Our results suggest that Hemimysis are being incorporated into diets of round gobies, alewife and small yellow perch and their reliance on Hemimysis as a dietary component increases with Hemimysis density. As Hemimysis populations continue to establish and stabilize, fish may incorporate this species into their diets at a higher rate

Trends in Cirrhosis and Mortality by Age, Sex, Race, and Antiviral Treatment Status Among US Chronic Hepatitis B Patients (2006-2016)

BACKGROUND: Changing US demographics and evolving chronic hepatitis B (CHB) treatments may affect longitudinal trends in CHB-related complications. We studied trends in the prevalence of cirrhosis (past or present) and incidence of all-cause mortality, stratified by patient age, sex, race, and antiviral treatment status, in a sample from US health care systems. METHODS: Joinpoint and Poisson regression (univariate and multivariable) were used to estimate the annual percent change in each outcome from 2006 to 2016. RESULTS: Among 5528 CHB patients, cirrhosis prevalence (including decompensated cirrhosis) rose from 6.7% in 2006 to 13.7% in 2016; overall mortality was unchanged. Overall rates of cirrhosis and mortality were higher among treated patients, but adjusted annual percent changes (aAPC) were significantly lower among treated than untreated patients (cirrhosis: aAPC +2.4% vs. +6.2%, mortality: aAPC -3.9% vs. +4.0%). Likewise, among treated patients, the aAPC for mortality declined -3.9% per year whereas among untreated patients, mortality increased +4.0% per year. CONCLUSIONS: From 2006 to 2016, the prevalence of cirrhosis among CHB patients doubled. Notably, all-cause mortality increased among untreated patients but decreased among treated patients. These results suggest that antiviral treatment attenuates the progression of cirrhosis and the risk of death among patients with CHB

Terrorism in Australia: factors associated with perceived threat and incident-critical behaviours

<p>Abstract</p> <p>Background</p> <p>To help improve incident preparedness this study assessed socio-demographic and socio-economic predictors of perceived risk of terrorism within Australia and willingness to comply with public safety directives during such incidents.</p> <p>Methods</p> <p>The terrorism perception question module was incorporated into the New South Wales Population Health Survey and was completed by a representative sample of 2,081 respondents in early 2007. Responses were weighted against the New South Wales population.</p> <p>Results</p> <p>Multivariate analyses indicated that those with no formal educational qualifications were significantly more likely (OR = 2.10, 95%CI:1.32–3.35, p < 0.001) to think that a terrorist attack is very or extremely likely to occur in Australia and also more likely (OR = 3.62, 95%CI:2.25–5.83, p < 0.001) to be very or extremely concerned that they or a family member would be directly affected, compared to those with a university-level qualification. Speaking a language other than English at home predicted high concern (very/extremely) that self or family would be directly affected (OR = 3.02, 95%CI:2.02–4.53, p < 0.001) and was the strongest predictor of having made associated changes in living (OR = 3.27, 95%CI:2.17–4.93, p < 0.001). Being female predicted willingness to evacuate from public facilities. Speaking a language other than English at home predicted low willingness to evacuate.</p> <p>Conclusion</p> <p>Low education level is a risk factor for high terrorism risk perception and concerns regarding potential impacts. The pattern of concern and response among those of migrant background may reflect secondary social impacts associated with heightened community threat, rather than the direct threat of terrorism itself. These findings highlight the need for terrorism risk communication and related strategies to address the specific concerns of these sub-groups as a critical underpinning of population-level preparedness.</p

Uncertainty quantification for kinetic models in socio-economic and life sciences

Kinetic equations play a major rule in modeling large systems of interacting particles. Recently the legacy of classical kinetic theory found novel applications in socio-economic and life sciences, where processes characterized by large groups of agents exhibit spontaneous emergence of social structures. Well-known examples are the formation of clusters in opinion dynamics, the appearance of inequalities in wealth distributions, flocking and milling behaviors in swarming models, synchronization phenomena in biological systems and lane formation in pedestrian traffic. The construction of kinetic models describing the above processes, however, has to face the difficulty of the lack of fundamental principles since physical forces are replaced by empirical social forces. These empirical forces are typically constructed with the aim to reproduce qualitatively the observed system behaviors, like the emergence of social structures, and are at best known in terms of statistical information of the modeling parameters. For this reason the presence of random inputs characterizing the parameters uncertainty should be considered as an essential feature in the modeling process. In this survey we introduce several examples of such kinetic models, that are mathematically described by nonlinear Vlasov and Fokker--Planck equations, and present different numerical approaches for uncertainty quantification which preserve the main features of the kinetic solution.Comment: To appear in "Uncertainty Quantification for Hyperbolic and Kinetic Equations

Use of mental health services among disaster survivors: predisposing factors

<p>Abstract</p> <p>Background</p> <p>Given the high prevalence of mental health problems after disasters it is important to study health services utilization. This study examines predictors for mental health services (MHS) utilization among survivors of a man-made disaster in the Netherlands (May 2000).</p> <p>Methods</p> <p>Electronic records of survivors (n = 339; over 18 years and older) registered in a mental health service (MHS) were linked with general practice based electronic medical records (EMRs) of survivors and data obtained in surveys. EMR data were available from 16 months pre-disaster until 3 years post-disaster. Symptoms and diagnoses in the EMRs were coded according to the International Classification of Primary Care (ICPC). Surveys were carried out 2–3 weeks and 18 months post-disaster, and included validated questionnaires on psychological distress, post-traumatic stress reactions and social functioning. Demographic and disaster-related variables were available. Predisposing factors for MHS utilization 0–18 months and 18–36 months post-disaster were examined using multiple logistic regression models.</p> <p>Results</p> <p>In multiple logistic models, adjusting for demographic and disaster related variables, MHS utilization was predicted by demographic variables (young age, immigrant, public health insurance, unemployment), disaster-related exposure (relocation and injuries), self-reported psychological problems and pre- and post-disaster physician diagnosed health problems (chronic diseases, musculoskeletal problems). After controlling for all health variables, disaster intrusions and avoidance reactions (OR:2.86; CI:1.48–5.53), hostility (OR:2.04; CI:1.28–3.25), pre-disaster chronic diseases (OR:1.82; CI:1.25–2.65), injuries as a result of the disaster (OR:1.80;CI:1.13–2.86), social functioning problems (OR:1.61;CI:1.05–2.44) and younger age (OR:0.98;CI:0.96–0.99) predicted MHS utilization within 18 months post-disaster. Furthermore, disaster intrusions and avoidance reactions (OR:2.29;CI:1.04–5.07) and hostility (OR:3.77;CI:1.51–9.40) predicted MHS utilization following 18 months post-disaster.</p> <p>Conclusion</p> <p>This study showed that several demographic and disaster-related variables and self-reported and physician diagnosed health problems predicted post-disaster MHS-use. The most important factors to predict post-disaster MHS utilization were disaster intrusions and avoidance reactions and symptoms of hostility (which can be identified as symptoms of PTSD) and pre-disaster chronic diseases.</p