Use of regional climate model simulations as input for hydrological models for the Hindukush-Karakorum-Himalaya region

The most important climatological inputs required for the calibration and validation of hydrological models are temperature and precipitation that can be derived from observational records or alternatively from regional climate models (RCMs). In this paper, meteorological station observations and results of the PRECIS (Providing REgional Climate for Impact Studies) RCM driven by the outputs of reanalysis ERA 40 data and HadAM3P general circulation model (GCM) results are used as input in the hydrological model. The objective is to investigate the effect of precipitation and temperature simulated with the PRECIS RCM nested in these two data sets on discharge simulated with the HBV model for three river basins in the Hindukush-Karakorum-Himalaya (HKH) region. Six HBV model experiments are designed: HBV-Met, HBV-ERA and HBV-Had, HBV-MetCRU-corrected, HBV-ERABenchmark and HBV-HadBenchmark where HBV is driven by meteorological stations data, data from PRECIS nested in ERA-40 and HadAM3P, meteorological stations CRU corrected data, ERA-40 reanalysis and HadAM3P GCM data, respectively. Present day PRECIS simulations possess strong capacity to simulate spatial patterns of present day climate characteristics. However, also some quantitative biases exist in the HKH region, where PRECIS RCM simulations underestimate temperature and overestimate precipitation with respect to CRU observations. The calibration and validation results of the HBV model experiments show that the performance of HBV-Met is better than the HBV models driven by other data sources. However, using input data series from sources different from the data used in the model calibration shows that HBV-Had is more efficient than other models and HBV-Met has the least absolute relative error with respect to all other models. The uncertainties are higher in least efficient models (i.e. HBV-MetCRU-corrected and HBV-ERABenchmark) where the model parameters are also unrealistic. In terms of both robustness and uncertainty ranges the HBV models calibrated with PRECIS output performed better than other calibrated models except for HBV-Met which has shown a higher robustness. This suggests that in data sparse regions such as the HKH region data from regional climate models may be used as input in hydrological models for climate scenarios studies

Meaning above the head: combinatorial constraints on the visual vocabulary of comics

“Upfixes” are “visual morphemes” originating in comics where an element floats above a character’s head (ex. lightbulbs or gears). We posited that, similar to constructional lexical schemas in language, upfixes use an abstract schema stored in memory, which constrains upfixes to locations above the head and requires them to “agree” with their accompanying facial expressions. We asked participants to rate and interpret both conventional and unconventional upfixes that either matched or mismatched their facial expression (Experiment 1) and/or were placed either above or beside the head (Experiment 2). Interpretations and ratings of conventionality and face–upfix matching (Experiment 1) along with overall comprehensibility (Experiment 2) suggested that both constraints operated on upfix understanding. Because these constraints modulated both conventional and unconventional upfixes, these findings support that an abstract schema stored in long-term memory allows for generalisations beyond memorised individual items

Transdiagnostic factors predicting the 2-year disability outcome in patients with anxiety and depressive disorders

Background: Both anxiety and depressive disorders are associated with significant long-term disability. Since experienced impairments vary between patients independent of diagnosis and disease severity, identifying transdiagnostic factors that predict the course of disability may provide new targets to reduce disability. This study examines transdiagnostic factors predicting the 2-year disability outcome in patients with anxiety and/or depressive disorders (ADD), focusing on potentially malleable factors.Methods: Six hundred fifteen participants with a current diagnosis of ADD from the Netherlands Study of Depression and Anxiety (NESDA) were included. Disability was assessed at baseline and after 2 years of follow-up, using the 32-item WHODAS II questionnaire. Transdiagnostic predictors of 2-year disability outcome were identified using linear regression analysis.Results: In univariable analyses, transdiagnostic factors associated with the 2-year disability outcome were locus of control (standardized β = -0.116, p = 0.011), extraversion (standardized β = -0.123 p = 0.004) and experiential avoidance (standardized β = 0.139, p = 0.001). In multivariable analysis, extraversion had a unique predictive value (standardized β = -0.143 p = 0.003). A combination of sociodemographic, clinical and transdiagnostic variables resulted in an explained variance (R2) of 0.090). The explained variance of a combination of transdiagnostic factors was 0.050.Conclusion: The studied transdiagnostic variables explain a small but unique part of variability in the 2-year disability outcome. Extraversion is the only malleable transdiagnostic factor predictive of the course of disability independent of other variables. Due to the small contribution to the variance in the disability outcome, the clinical relevance of targeting extraversion seems limited. However, its predictive value is comparable to that of accepted disease severity measures, supporting the importance of looking beyond using disease severity measures as predictors. Furthermore, studies including extraversion in combination with other transdiagnostic and environmental factors may elucidate the unexplained part of variability of the course of disability in patients with ADD.</p

Climatic variability and periodicity for upstream sub-basins of the Yangtze river, China

The headwaters of the Yangtze River are located on the Qinghai Tibetan Plateau, which is affected by climate change. Here, treamflow trends for Tuotuohe and Zhimenda sub-basins and relations to temperature and precipitation trends during 1961–2015 were investigated. The modified Mann–Kendall trend test, Pettitt test, wavelet analysis, and multivariate correlation analysis was deployed for this purpose. The temperature and precipitation significantly increased for each sub-basin, and the temperature increase was more significant in Tuotuohe sub-basin as compared to the Zhimenda sub-basin. A statistically significant periodicity of 2–4 years was observed for both sub-basins in different time spans. Higher flow periodicities for Tuotuohe and Zhimenda sub-basin were found after 1991 and 2004, respectively, which indicates that these are the change years of trends in streamflows. The influence of temperature on streamflow is more substantial in Tuotuohe sub-basin, which will ultimately impact the melting of glaciers and snowmelt runoff in this sub-basin. Precipitation plays a more critical role in the Zhimenda streamflow. Precipitation and temperature changes in the headwaters of the Yangtze River will change the streamflow variability, which will ultimately impact the hydropower supply and water resources of the Yangtze Basin. This study contributes to the understanding of the dynamics of the hydrological cycle and may lead to better hydrologic system modeling for downstream water resource developments

Preverbs: an introduction

The notion ‘preverb’ is a traditional descriptive notion in Indo-European linguistics. It refers to morphemes that appear in front of a verb, and which form a close semantic unit with that verb. In many cases, the morpheme that functions as a preverb can also function without a preverbal context, often as an adverb or an adposition. Most linguists use the notion ‘preverb’ as a cover term for preverbal words and preverbal prefixes. The preverb may be separated from the verb whilst retaining its close cohesion with the verb, which is called ‘tmesis’. It may also develop into a bound morpheme, that is, a prefix inseparable from the verb, with concomitant reduction of phonological form in some cases. If the preverb has become a real prefix, we may use the more specific notion of ‘complex verb’, whereas we take the notion ‘complex predicate’ to refer generally to multi-morphemic expressions with verbal valency. That is, we make a terminological distinction between complex predicates and complex verbs. The latter are multi-morphemic, but behave as single grammatical words

The Influence of Long-Acting Somatostatin Analogs on 68 Ga-DOTATATE Uptake in Patients With Neuroendocrine Tumors

Purpose A high SUVmax tumor-to-liver ratio (TLR) of 68Ga-DOTATATE can be used to select patients with neuroendocrine tumors (NETs) for peptide receptor radionuclide therapy (PRRT). In addition, an SUVmax TLR ≥ 8.1 is associated with increased progression-free survival in NET patients treated with somatostatin analogs (SSAs). To avoid a theoretical interaction, several guidelines recommend performing PET/CT just before the monthly administration of long-acting SSAs. We aimed to investigate the effect of SSA on the SUVmax of 68Ga-DOTATATE in patients with NET and to identify independent predictors for high SUVmax TLR. Patients and Methods For this retrospective study, 192 68Ga-DOTATATE PET/CT scans of 165 patients without (n = 115) and with (n = 77) SSA (octreotide or lanreotide) in the 3 months before PET/CT were collected and reviewed. The effect of SSA on SUVmax values was analyzed by a maximum likelihood mixed model. Results Patients with SSA had a significantly higher median SUVmax TLR than patients without SSA (4.7 [IQR], 3.1-7.7) versus 3.2 [IQR, 2.0-5.4]; P < 0.001). Multivariable logistic regression analysis showed that SSA use was an independent predictor for SUVmax TLR ≥ 8.1 (odds ratio, 2.91; 95% confidence interval, 1.26-6.72; P = 0.012). Conclusions Our data suggest that higher SSA concentrations do not have a negative effect on 68Ga-DOTATATE uptake in tumor lesions. In addition, we found that only SSA use was associated with SUVmax TLR ≥ 8.1. Our results are consistent with previously conducted studies and in line with the recently published guideline that suggests that the relatively recent use of SSA does not necessitate any delay in 68Ga-DOTATATE PET/CT imaging

Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion

Negative affect in healthy populations regulates the appraisal of demanding situations, which tunes subsequent effort mobilization and adjustments in cognitive control. In the present study, we hypothesized that dysphoria in depressed individuals similarly modulates this adaptation, possibly through a neural mechanism involving serotonergic regulation. We tested the effect of dysphoria induced by acute tryptophan depletion (ATD) in remitted depressed patients on conflict adaptation in a Simon task. ATD temporarily lowers the availability of the serotonin precursor L-Tryptophan and is known to increase depressive symptoms in approximately half of remitted depressed participants. We found that depressive symptoms induced by ATD were associated with increased conflict adaptation. Our finding extends recent observations implying an important role of affect in regulating conflict-driven cognitive control

A simple view of linguistic complexity

Although a growing number of second language acquisition (SLA) studies take linguistic complexity as a dependent variable, the term is still poorly defined and often used with different meanings, thus posing serious problems for research synthesis and knowledge accumulation. This article proposes a simple, coherent view of the construct, which is defined in a purely structural way, i.e. the complexity directly arising from the number of linguistic elements and their interrelationships. Issues of cognitive cost (difficulty) or developmental dynamics (acquisition) are explicitly excluded from this theoretical definition and its operationalization. The article discusses how the complexity of an interlanguage system can be assessed based on the limited samples SLA researchers usually work with. For the areas of morphology, syntax and the lexicon, some measures are proposed which are coherent with the purely structural view advocated, and issues related to their operationalization are critically scrutinized