2,367 research outputs found
On the evolution of an entangled lepton-neutrino pair
The evolution of the entangled muon-neutrino system emerging from charged
pion decay is explored both in vacuum and in matter. The study is based on a
Weisskopf-Wigner type wave-packet description. Explicit formulae are derived
displaying modulation and attenuation of the oscillations due to additional
time scales characterising the production process. The case of neutrinos
disentangled due to the detection of the muon is also considered
Signatures from an extra-dimensional seesaw model
We study the generation of small neutrino masses in an extra-dimensional
model, where right-handed neutrinos are allowed to propagate in the extra
dimension, while the Standard Model particles are confined to a brane.
Motivated by the fact that extra-dimensional models are non-renormalizable, we
truncate the Kaluza-Klein towers at a maximal extra-dimensional momentum. The
structure of the bulk Majorana mass term, motivated by the Sherk-Schwarz
mechanism, implies that the right-handed Kaluza-Klein neutrinos pair to form
Dirac neutrinos, except for a number of unpaired Majorana neutrinos at the top
of each tower. These heavy Majorana neutrinos are the only sources of lepton
number breaking in the model, and similarly to the type-I seesaw mechanism,
they naturally generate small masses for the left-handed neutrinos. The lower
Kaluza-Klein modes mix with the light neutrinos, and the mixing effects are not
suppressed with respect to the light-neutrino masses. Compared to conventional
fermionic seesaw models, such mixing can be more significant. We study the
signals of this model at the Large Hadron Collider, and find that the current
low-energy bounds on the non-unitarity of the leptonic mixing matrix are strong
enough to exclude an observation.Comment: 17 pages, 3 figures, REVTeX4. Final version published in Phys. Rev.
Effective communications on invasive alien species: Identifying communication needs of Swedish domestic garden owners
Invasive alien species threaten biodiversity with domestic gardens acting as a major pathway for the introduction of alien species. Even though the Nordic region is not currently a hotspot for biological invasions, the number of invasions in the Nordic area has been predicted to increase due to climate change. Given a time lag between introduction and invasion, many non-invasive horticultural alien species already introduced into gardens may become invasive in the future. This study aimed to identify the communication needs of Swedish garden owners regarding their management of invasive alien species. A survey among domestic garden owners, informed by topic specialists and local area experts, and interviews with garden owners were conducted in three different bio-climatic areas in a latitudinal gradient across Sweden. The questions targeted invasive alien species and their relations to biodiversity loss and climate change, as well as measures taken to control these species. Analysing the survey data collected in relation to measures taken to control invasive species, Bayesian Additive Regression Tree (BART) modelling was used to identify geographically varying communication needs of the domestic garden owners. In all study areas, the garden owners' measures taken to control invasive alien species were correlated with their strength of beliefs in having experienced local biodiversity loss. A majority of the garden owners were, moreover, uncertain about the impact of climate change on the invasiveness of alien species. In addition, the garden owners' capacity for identifying invasive alien species was often in need of improvement, in particular with respect to the species Impatiens glandulifera, Reynoutria japonica and Rosa rugosa. The results suggest that the evidence-based guidelines for effective communications we developed, have the potential to help communicators meet the local communication needs of garden owners across Sweden, in relation to the management of invasive alien garden species
Testing matter effects in propagation of atmospheric and long-baseline neutrinos
We quantify our current knowledge of the size and flavor structure of the
matter effects in the evolution of atmospheric and long-baseline neutrinos
based solely on the analysis of the corresponding neutrino data. To this aim we
generalize the matter potential of the Standard Model by rescaling its
strength, rotating it away from the e-e sector, and rephasing it with respect
to the vacuum term. This phenomenological parametrization can be easily
translated in terms of non-standard neutrino interactions in matter. We show
that in the most general case, the strength of the potential cannot be
determined solely by atmospheric and long-baseline data. However its flavor
composition is very much constrained and the present determination of the
neutrino masses and mixing is robust under its presence. We also present an
update of the constraints arising from this analysis in the particular case in
which no potential is present in the e-mu and e-tau sectors. Finally we
quantify to what degree in this scenario it is possible to alleviate the
tension between the oscillation results for neutrinos and antineutrinos in the
MINOS experiment and show the relevance of the high energy part of the spectrum
measured at MINOS.Comment: PDFLaTeX file using JHEP3 class, 25 pages, 7 figures included.
Accepted for publication in JHE
EURONU WP6 2009 yearly report: Update of the physics potential of Nufact, superbeams and betabeams
Many studies in the last ten years have shown that we can measure the unknown
angle theta13, discover leptonic CP violation and determine the neutrino
hierarchy in more precise neutrino oscillation experiments, searching for the
subleading channel nue -> numu in the atmospheric range. In this first report
of WP6 activities the following new results are reviewed: (1) Re-evaluation of
the physics reach of the upcoming generation of experiments to measure theta13
and delta; (2) New tools to explore a larger parameter space as needed beyond
the standard scenario; (3) Neutrino Factory: (a) evaluation of the physics
reach of a Nufact regards sterile neutrinos; (b) evaluation of the physics
reach of a Nufact as regards non-standard interactions; (c) evaluation of the
physics reach of a Nufact as regards violation of unitarity; (d) critical
assessment on long baseline tau-detection at Nufact; (e) new physics searches
at a near detector in a Nufact; (4) Beta-beams: (a) choice of ions and location
for a gamma = 100 CERN-based beta-beam; (b) re-evaluation of atmospheric
neutrino background for the gamma = 100 beta-beam scenario; (c) study of a two
baseline beta-beam; (d) measuring absolute neutrino mass with beta-beams; (e)
progress on monochromatic beta-beams; (5) Update of the physics potential of
the SPL super-beam. Eventually, we present an updated comparison of the
sensitivity to theta13, delta and the neutrino mass hierarchy of several of the
different proposed facilities.Comment: 2009 Yearly report of the Working Package 6 (Physics) of the EUROnu
FP7 EU project. 55 pages, 21 figures
Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium
BACKGROUND: Delirium is associated with an increased risk of incident dementia and accelerated progression of existing cognitive symptoms. Reciprocally, dementia increases the risk of delirium. Cerebrospinal fluid (CSF) concentration of the dendritic protein neurogranin has been shown to increase in early Alzheimer's disease (AD), likely reflecting synaptic dysfunction and/or degeneration. OBJECTIVE: To elucidate the involvement of synaptic dysfunction in delirium pathophysiology, we tested the association between CSF neurogranin concentration and delirium in hip fracture patients with different AD-biomarker profiles, while comparing them to cognitively unimpaired older adults (CUA) and AD patients. METHODS: The cohort included hip fracture patients with (n = 70) and without delirium (n = 58), CUA undergoing elective surgery (n = 127), and AD patients (n = 46). CSF was collected preoperatively and diagnostically in surgery and AD patients respectively. CSF neurogranin concentrations were analyzed in all samples with an in-house ELISA. Delirium was assessed pre-and postoperatively in hip fracture patients by trained investigators using the Confusion Assessment Method. Hip fracture patients were further stratified based on pre-fracture dementia status, delirium subtype, and AD fluid biomarkers. RESULTS: No association was found between delirium and CSF neurogranin concentration (main analysis: delirium versus no delirium, p = 0.68). Hip fracture patients had lower CSF neurogranin concentration than AD patients (p = 0.001) and CUA (p = 0.035) in age-adjusted sensitivity analyses. CONCLUSION: The findings suggest that delirium is not associated with increased CSF neurogranin concentration in hip fracture patients, possibly due to advanced neurodegenerative disease and age and/or because synaptic degeneration is not an important pathophysiological process in delirium
Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus
BACKGROUND: Patients with idiopathic normal pressure hydrocephalus (iNPH) have reduced cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ) and α- and β-cleaved soluble forms of amyloid precursor protein (sAPPα and sAPPβ). The aims of this study were to examine if changes could also be seen in the CSF for secreted metabolites of APP-like protein 1 (APLP1) and to explore the prognostic value of amyloid-related CSF biomarkers, as well as markers of neuronal injury and astroglial activation, as regards to clinical outcome after shunt surgery. METHODS: Twenty patients diagnosed with iNPH, 10 improved and 10 unchanged by shunt surgery, and 20 neurologically healthy controls were included. All patients were examined clinically prior to surgery and at 6-month follow-up after surgery using the iNPH scale. Lumbar puncture was performed pre-operatively. CSF samples were analyzed for neurofilament light (NFL), Aβ isoforms Aβ38, Aβ40 and Aβ42, sAPPα, sAPPβ, APLP1 β-derived peptides APL1β25, APL1β 27 and APL1β 28 and YKL40 by immunochemical methods. RESULTS: The concentrations of all soluble forms of APP, all Aβ isoforms and APL1β28 were lower, whilst APL1β25 and APL1β27 were higher in the CSF of iNPH patients compared to controls. There was no difference in biomarker concentrations between patients who improved after surgery and those who remained unchanged. CONCLUSIONS: The reduced CSF concentrations of Aβ38, Aβ40, Aβ42, sAPPα and sAPPβ suggest that APP expression could be downregulated in iNPH. In contrast, APLP1 concentration in the CSF seems relatively unchanged. The increase of APL1β25 and APL1β27 in combination with a slight decreased APL1β28 could be caused by more available γ-secretase due to reduced availability of its primary substrate, APP. The data did not support the use of these markers as indicators of shunt responsiveness
CXCL13 in patients with facial palsy caused by varicella zoster virus and Borrelia burgdorferi: a comparative study
High cerebrospinal fluid (CSF) concentrations of the chemokine CXCL13 have been associated with Lyme neuroborreliosis (LNB), and have recently been studied as a potential diagnostic marker. It has proven difficult to establish a reliable diagnostic cut-off, possibly in part due to heterogenicity of case–control groups. Our purpose was to investigate CSF CXCL13 concentrations in patients with similar clinical presentations, facial palsy. We retrospectively included patients with facial palsy associated with LNB (n = 21), or varicella zoster virus (VZV) (n = 26). Median CXCL13 concentrations were significantly higher in patients with LNB facial palsy compared to VZV facial palsy. Receiver-operating characteristic analyses yielded an optimal cut-off concentration at 34.5 pg/mL (sensitivity 85.7%, specificity of 84.6%), lower than that in previous studies. Although the analysis has potential, it is still not adequately established that CXCL13 provides additional, clinically useful, diagnostic information over current recommendations
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