7 research outputs found
Hawaiian Dream Girl
Photograph of Gilda Gray; Illustration of women dancing on beachhttps://scholarsjunction.msstate.edu/cht-sheet-music/12603/thumbnail.jp
When The Clouds Of War Roll By
Soldiers fighting on the ground; Planes fighting in the cloudshttps://scholarsjunction.msstate.edu/cht-sheet-music/12879/thumbnail.jp
When the clouds of war roll by
Gift of Dr. Mary Jane Esplen.Piano vocal [instrumentation]Ev'ryone's excited [first line]When the clouds roll by [first line of chorus]C [key]Moderato [tempo]Popular song [form/genre]Battle clouds [illustration]Rayner Dalhelm & Co. Music Printers & Engravers Chicago, Ill. [lithographer]Publisher's advertisement on back cover [note
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
In horses, graying with age is an autosomal dominant trait associated with a high incidence of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is caused by a 4.6-kb duplication in intron 6 of STX17 (syntaxin-17) that constitutes a cis-acting regulatory mutation. Both STX17 and the neighboring NR4A3 gene are overexpressed in melanomas from Gray horses. Gray horses carrying a loss-of-function mutation in ASIP ( agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses. The Gray horse provides a notable example of how humans have cherry-picked mutations with favorable phenotypic effects in domestic animals