Metal Laminated Tooling - A Quick and Flexible Tooling Concept

For the fast manufacturing of complex formed tools Fraunhofer IWS works together with partners from the industry on a constant automation solution for cutting, packaging and adding steel sheet cutouts. With the selection of the most suitable connecting technology, also requirements must be considered to quality, surface quality and the production costs. Deep drawing or stamping tools do not require a complete connection of the single metal sheets. Here, a fast and economical connection is the main objective. Due to simple automation, laser beam welding offers itself as joining process. On the other hand, a temperature-steady connection of the sheet metal lamellas is necessary for injection molds, which can resist the injection pressures.Mechanical Engineerin

TOOLympics II: competitions on formal methods:A Special Issue for TOOLympics 2019

This is the second issue in the new “Competitions and Challenges” (CoCha) theme of the International Journal on Software Tools for Technology Transfer. The new theme was established to support competitions and challenges with an appropriate publication venue. The first issue presented the competition on software testing Test-Comp 2019, which was part of the TOOLympics 2019 event. In this second issue for TOOLympics, we present selected competition reports. The TOOLympics event took place as part of the 25-years celebration of the conference TACAS. The goal of the event was to provide an overview of competitions and challenges in the area of formal methods

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue oxygenation in SSc. Oxygen supply is further reduced by accumulation of extracellular matrix (ECM), which increases diffusion distances from blood vessels to cells. Therefore, severe hypoxia is a characteristic feature of SSc and might contribute directly to the progression of the disease. Hypoxia stimulates the production of ECM proteins by SSc fibroblasts in a transforming growth factor-β-dependent manner. The induction of ECM proteins by hypoxia is mediated via hypoxia-inducible factor-1α-dependent and -independent pathways. Hypoxia may also aggravate vascular disease in SSc by perturbing vascular endothelial growth factor (VEGF) receptor signalling. Hypoxia is a potent inducer of VEGF and may cause chronic VEGF over-expression in SSc. Uncontrolled over-expression of VEGF has been shown to have deleterious effects on angiogenesis because it leads to the formation of chaotic vessels with decreased blood flow. Altogether, hypoxia might play a central role in pathogenesis of SSc by augmenting vascular disease and tissue fibrosis

Effect of natural aging on the chemical composition of norway spruce, fir, and european oak wood.

The chemical composition of a number of naturally aged construction wood samples of spruce, fir and oak was investigated. The content of lignin, polysaccharide, and extractives was determined using wet chemical and chromatographic methods. Differences to non-aged wood samples were found particularly found on oak wood samples with regard to lignin and polysaccharide content as well as to cellulose crystallinity. The composition of wood extractives of aged and non-aged wood samples revealed degradation processes due to oxidation and slight hydrolysis. The investigation showed that the relative content of the structural wood constituents depends on the sample age as well as the conditions they were aged under. The different degradation rates of those structural components may lead to contradictory results regarding their contents at certain degrees of aging. Cellulose crystallinity values are affected by extractives content

Shadow effects in an offshore wind farm - potential of vortex methods for wake modelling

Offshore wind turbines in a wind farm are affected by wakes of upstream turbines and adjacent wind farms depending on the park layout and wind direction. As a result the power output may decrease, while structural loads are increasing. In this research a coupled numerical approach based on multi-body system and free vortex methods is used to simulate shadow effects on the Alpha Ventus wind farm. The AV5 is operating at 12 m/s wind speed at half wake conditions with enabled control system and flexible blades and tower. Results of power output, rotor speed, blade pitch and blade root moment over time and azimuth demonstrate the high impact of the half wake condition on the wind turbine performance and loads

PU.1 controls fibroblast polarization and tissue fibrosis

Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure. By contrast, a hallmark feature of fibroblasts in arthritis is degradation of the extracellular matrix because of the release of metalloproteinases and degrading enzymes, and subsequent tissue destruction. The mechanisms that drive these functionally opposing pro-fibrotic and pro-inflammatory phenotypes of fibroblasts remain unknown. Here we identify the transcription factor PU.1 as an essential regulator of the pro-fibrotic gene expression program. The interplay between transcriptional and post-transcriptional mechanisms that normally control the expression of PU.1 expression is perturbed in various fibrotic diseases, resulting in the upregulation of PU.1, induction of fibrosis-associated gene sets and a phenotypic switch in extracellular matrix-producing pro-fibrotic fibroblasts. By contrast, pharmacological and genetic inactivation of PU.1 disrupts the fibrotic network and enables reprogramming of fibrotic fibroblasts into resting fibroblasts, leading to regression of fibrosis in several organs

COMPARISON OF DIFFERENT DEVICE CONCEPTS TO INCREASE THE OPERATING VOLTAGE OF A TRENCH ISOLATED SOI TECHNOLOGY TO ABOVE 900V

For gate driver ICs in three phase power applications level shifters with more than 900V operating voltage are required. The extension of the voltage rating of an existing trench isolated SOI process was done with different device concepts: Serial stacking of lower voltage devices was evaluated as an alternative approach to conventional quasi-vertical and charge compensated lateral devices which need layout and material modifications. Based on sufficient 900V trench isolation the different device concepts were tested with diodes and transistors. For the usage as level shifters the focus was to achieve the required breakdown voltages with minimum area

Platelet-derived serotonin links vascular disease and tissue fibrosis

Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage

Model Analysis of Time Reversal Symmetry Test in the Caltech Fe-57 Gamma-Transition Experiment

The CALTECH gamma-transition experiment testing time reversal symmetry via the E2/M1 mulipole mixing ratio of the 122 keV gamma-line in Fe-57 has already been performed in 1977. Extending an earlier analysis in terms of an effective one-body potential, this experiment is now analyzed in terms of effective one boson exchange T-odd P-even nucleon nucleon potentials. Within the model space considered for the Fe-57 nucleus no contribution from isovector rho-type exchange is possible. The bound on the coupling strength phi_A from effective short range axial-vector type exchange induced by the experimental bound on sin(eta) leads to phi_A < 10^{-2}.Comment: 5 pages, RevTex 3.

Tailoring the mode-switching dynamics in quantum-dot micropillar lasers via time-delayed optical feedback

Funding: European Research Council under the European Union’s Seventh Framework Program (ERC Grant Agreement No. 615613); German Research Foundation (CRC 787, GRK1558); project EMPIR 14IND05 MIQC2 co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation program.Microlasers are ideal candidates to bring the fascinating variety of nonlinear complex dynamics found in delay-coupled systems to the realm of quantum optics. Particularly attractive is the possibility of tailoring the devices’ emission properties via non-invasive delayed optical coupling. However, until now scarce research has been done in this direction. Here, we experimentally and theoretically investigate the effects of delayed optical feedback on the mode-switching dynamics of an electrically driven bimodal quantum-dot micropillar laser, characterizing its impact on the micropillar’s output power, optical spectrum and photon statistics. Feedback is found to influence the switching dynamics and its characteristics time scales. In addition, stochastic switching is reduced with the subsequent impact on the microlaser photon statistics. Our results contribute to the comprehension of feedback-induced phenomena in micropillar lasers and pave the way towards the external control and tailoring of the properties of these key systems for the nanophotonics community.Publisher PDFPeer reviewe