586 research outputs found
Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts
Dust heating by the interstellar radiation field in models of turbulent molecular clouds
We have calculated the radiation field, dust grain temperatures, and far
infrared emissivity of numerical models of turbulent molecular clouds. When
compared to a uniform cloud of the same mean optical depth, most of the volume
inside the turbulent cloud is brighter, but most of the mass is darker. There
is little mean attenuation from center to edge, and clumping causes the
radiation field to be somewhat bluer. There is also a large dispersion,
typically by a few orders of magnitude, of all quantities relative to their
means. However, despite the scatter, the 850 micron emission maps are well
correlated with surface density. The fraction of mass as a function of
intensity can be reproduced by a simple hierarchical model of density
structure.Comment: 32 pages, 14 figures, submitted to Ap
Effect of implementing a heart failure admission care bundle on hospital readmission and mortality rates: interrupted time series study
This study aimed to evaluate the impact of developing and implementing a care bundle intervention to improve care for patients with acute heart failure admitted to a large London hospital. The intervention comprised three elements, targeted within 24 hours of admission: N-terminal pro-B-type natriuretic peptide (NT-proBNP) test, transthoracic Doppler two-dimensional echocardiography and specialist review by cardiology team. The SHIFT-Evidence approach to quality improvement was used. During implementation, July 2015âJuly 2017, 1169 patients received the intervention. An interrupted time series design was used to evaluate impact on patient outcomes, including 15â618 admissions for 8951 patients. Mixed-effects multiple Poisson and log-linear regression models were fitted for count and continuous outcomes, respectively. Effect sizes are slope change ratios pre-intervention and post-intervention. The intervention was associated with reductions in emergency readmissions between 7 and 90âdays (0.98, 95%âCI 0.97 to 1.00), although not readmissions between 0 and 7âdays post-discharge. Improvements were seen in in-hospital mortality (0.96, 95%âCI 0.95 to 0.98), and there was no change in trend for hospital length of stay. Care process changes were also evaluated. Compliance with NT-proBNP testing was already high in 2014/2015 (162 of 163, 99.4%) and decreased slightly, with increased numbers audited, to 2016/2017 (1082 of 1101, 98.2%). Over this period, rates of echocardiography (84.7â98.9%) and specialist input (51.6â90.4%) improved. Care quality and outcomes can be improved for patients with acute heart failure using a care bundle approach. A systematic approach to quality improvement, and robust evaluation design, can be beneficial in supporting successful improvement and learning
A âHow-Toâ Guide for Designing Judgment Bias Studies to Assess Captive Animal Welfare
Robust methods to assess nonhuman animal emotion are essential for ensuring good welfare in captivity. Cognitive bias measures such as the judgment bias task have recently emerged as promising tools to assess animal emotion. The simple design and objective response measures make judgment bias tasks suitable for use across species and contexts. In reviewing 64 studies published to date, it emerged that (a) judgment biases have been measured in a number of mammals and birds and an invertebrate; (b) no study has tested judgment bias in any species of fish, amphibian, or reptile; and (c) no study has yet investigated judgment bias in a zoo or aquarium. This article proposes that judgment bias measures are highly suitable for use with these understudied taxa and can provide new insight into welfare in endangered species housed in zoos and aquariums, where poor welfare impacts breeding success and, ultimately, species survival. The article includes a âhow-toâ guide to designing judgment bias tests with recommendations for working with currently neglected âexoticsâ including fishes, amphibians, and reptiles
Statistical Assessment of Shapes and Magnetic Field Orientations in Molecular Clouds through Polarization Observations
We present a novel statistical analysis aimed at deriving the intrinsic
shapes and magnetic field orientations of molecular clouds using dust emission
and polarization observations by the Hertz polarimeter. Our observables are the
aspect ratio of the projected plane-of-the-sky cloud image, and the angle
between the mean direction of the plane-of-the-sky component of the magnetic
field and the short axis of the cloud image. To overcome projection effects due
to the unknown orientation of the line-of-sight, we combine observations from
24 clouds, assuming that line-of-sight orientations are random and all are
equally probable. Through a weighted least-squares analysis, we find that the
best-fit intrinsic cloud shape describing our sample is an oblate disk with
only small degrees of triaxiality. The best-fit intrinsic magnetic field
orientation is close to the direction of the shortest cloud axis, with small
(~24 deg) deviations toward the long/middle cloud axes. However, due to the
small number of observed clouds, the power of our analysis to reject
alternative configurations is limited.Comment: 14 pages, 8 figures, accepted for publication in MNRA
British Torture in the 'War on Terror'
Despite longstanding allegations of UK involvement in prisoner abuse during counterterrorism operations as part of the US-led âwar on terrorâ, a consistent narrative emanating from British government officials is that Britain neither uses, condones nor facilitates torture or other cruel, inhuman, degrading treatment and punishment. We argue that such denials are untenable. We have established beyond reasonable doubt that Britain has been deeply involved in post-9/11 prisoner abuse, and we can now provide the most detailed account to date of the depth of this involvement. We argue that it is possible to identify a peculiarly British approach to torture in the âwar on terrorâ, which is particularly well-suited to sustaining a narrative of denial. To explain the nature of UK involvement, we argue that it can be best understood within the context of how law and sovereign power have come to operate during the âwar on terrorâ. We turn here to the work of Judith Butler, and explore the role of Britain as a âpetty sovereignâ, operating under the state of exception established by the US Executive. UK authorities have not themselves suspended the rule of law so overtly, and indeed have repeatedly insisted on their commitment to it. They have nevertheless been able to construct a rhetorical, legal and policy âscaffoldâ that has enabled them to demonstrate at least procedural adherence to human rights norms, while at the same time allowing UK officials to acquiesce in the arbitrary exercise of sovereignty over individuals who are denied any access to appropriate representation or redress in compliance with the rule of law
Trade in the Shadow of Power : Japanese Industrial Exports in the Interwar years
During the interwar years, Japanese industrialisation accelerated alongside the expansion of industrial exports to regional markets. Trade blocs in the interwar years were used as an instrument of imperial power to foster exports and as a substitute for productivity to encourage industrial production. The historiography on Japanese industrialisation in the interwar years describes heavy industries' interests in obtaining access to wider markets to increase economies of scale and reduce unit costs. However, this literature provides no quantitative evidence that proves the success of those mechanisms in expanding exports. In this paper we scrutinise how Japan—a relatively poor country—used colonial as well as informal power interventions to expand regional markets for its exports, especially for the most intensive human capital sector of the industrializing economy
Development and Feasibility of a Smartphone, ECG and GPS Based System for Remotely Monitoring Exercise in Cardiac Rehabilitation
Background Despite its efficacy and cost-effectiveness, exercise-based cardiac rehabilitation is undertaken by less than one-third of clinically eligible cardiac patients in every country for which data is available. Reasons for non-participation include the unavailability of hospital-based rehabilitation programs, or excessive travel time and distance. For this reason, there have been calls for the development of more flexible alternatives. Methodology and Principal Findings We developed a system to enable walking-based cardiac rehabilitation in which the patient's single-lead ECG, heart rate, GPS-based speed and location are transmitted by a programmed smartphone to a secure server for real-time monitoring by a qualified exercise scientist. The feasibility of this approach was evaluated in 134 remotely-monitored exercise assessment and exercise sessions in cardiac patients unable to undertake hospital-based rehabilitation. Completion rates, rates of technical problems, detection of ECG changes, pre- and post-intervention six minute walk test (6 MWT), cardiac depression and Quality of Life (QOL) were key measures. The system was rated as easy and quick to use. It allowed participants to complete six weeks of exercise-based rehabilitation near their homes, worksites, or when travelling. The majority of sessions were completed without any technical problems, although periodic signal loss in areas of poor coverage was an occasional limitation. Several exercise and post-exercise ECG changes were detected. Participants showed improvements comparable to those reported for hospital-based programs, walking significantly further on the post-intervention 6 MWT, 637 m (95% CI: 565â726), than on the pre-test, 524 m (95% CI: 420â655), and reporting significantly reduced levels of cardiac depression and significantly improved physical health-related QOL. Conclusions and Significance The system provided a feasible and very flexible alternative form of supervised cardiac rehabilitation for those unable to access hospital-based programs, with the potential to address a well-recognised deficiency in health care provision in many countries. Future research should assess its longer-term efficacy, cost-effectiveness and safety in larger samples representing the spectrum of cardiac morbidity and severity
Transformations in the law concerning slavery: legacies of the nineteenth century anti-slavery movement
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