Axial and transverse deep‐water sediment supply to syn‐rift fault terraces: insights from the West Xylokastro Fault Block, Gulf of Corinth, Greece

Deep‐water syn‐rift systems develop in partially‐ or transiently‐linked depocentres to form complicated depositional architectures, which are characterised by short transport distances, coarse grain sizes, and a wide range of sedimentary processes. Exhumed systems that can help to constrain the tectono‐stratigraphic evolution of such systems are rare or complicated by inversion tectonics. Here, we document a mid‐Pleistocene deep‐water syn‐rift system fed by Gilbert‐type fan deltas in the hangingwall of a rift margin fault bounding the West Xylokastro Horst block, on the southern margin of the Gulf of Corinth, Greece. Structural and stratigraphic mapping combined with digital outcrop models permit observations along this syn‐rift depositional system from hinterland source to deep‐water sink. The West Xylokastro Fault hangingwall is filled by two distinct sediment systems; an axial system fed by coarse‐grained sediment gravity flows derived from fault‐tip Gilbert‐type fan deltas and a lateral system dominated by mass transport deposits fed from an evolving fault‐scarp apron. Abrupt changes in stratigraphic architecture across the axial system are interpreted to record changes in relative base level, sediment supply and tectonics. Locally, depositional topography and intra‐basinal structures controlled sediment dispersal patterns, from bed‐scale infilling of local rugose topography above mass transport complexes, to basin‐scale confinement from the fault scarp apron. These acted to generate a temporally and spatially variable, heterogeneous stratigraphic architecture throughout the basin‐fill. The transition of the locus of sedimentation from a rift margin to a fault terrace through the syn‐sedimentary growth of a basinward fault produced regressive surfaces updip, which manifest themselves as channels in the deep‐water realm and acted to prograde the system. We present a new conceptual model that recognises coeval axial and transverse systems based on the stratigraphic architecture around the West Xylokastro fault block that emphasises the lateral and vertical heterogeneity of rift basin‐fills with multiple entry points

Quantifying faulting and base level controls on syn-rift sedimentation using stratigraphic architectures of coeval, adjacent Early-Middle Pleistocene fan deltas in Lake Corinth, Greece

Quantification of allogenic controls in rift basin‐fills requires analysis of multiple depositional systems because of marked along‐strike changes in depositional architecture. Here, we compare two coeval Early‐Middle Pleistocene syn‐rift fan deltas that sit 6 km apart in the hangingwall of the Pirgaki‐Mamoussia Fault, along the southern margin of the Gulf of Corinth, Greece. The Selinous fan delta is located near the fault tip and the Kerinitis fan delta towards the fault centre. Selinous and Kerinitis have comparable overall aggradational stacking patterns. Selinous comprises 15 cyclic stratal units (ca. 25 m thick), whereas at Kerinitis 11 (ca. 60 m thick) are present. Eight facies associations are identified. Fluvial and shallow water facies dominate the major stratal units in the topset region, with shelfal fine‐grained facies constituting ca. 2 m thick intervals between major topset units and thick conglomeratic foresets building down‐dip. It is possible to quantify delta build times (Selinous: 615 kyr; Kerinitis: >450 kyr) and average subsidence and equivalent sedimentation rates (Selinous: 0.65 m/kyr; Kerinitis: >1.77 m/kyr). The presence of sequence boundaries at Selinous, but their absence at Kerinitis, enables sensitivity analysis of the most uncertain variables using a numerical model, ‘Syn‐Strat’, supported by an independent unit thickness extrapolation method. Our study has three broad outcomes: (a) the first estimate of lake level change amplitude in Lake Corinth for the Early‐Middle Pleistocene (10–15 m), which can aid regional palaeoclimate studies and inform broader climate‐system models; (b) demonstration of two complementary methods to quantify faulting and base level signals in the stratigraphic record—forward modelling with Syn‐Strat and a unit thickness extrapolation—which can be applied to other rift basin‐fills; and (c) a quantitative approach to the analysis of stacking patterns and key surfaces that could be applied to stratigraphic pinch‐out assessment and cross‐hole correlations in reservoir analysis

Impact of generic alendronate cost on the cost-effectiveness of osteoporosis screening and treatment

Introduction: Since alendronate became available in generic form in the Unites States in 2008, its price has been decreasing. The objective of this study was to investigate the impact of alendronate cost on the cost-effectiveness of osteoporosis screening and treatment in postmenopausal women. Methods: Microsimulation cost-effectiveness model of osteoporosis screening and treatment for U.S. women age 65 and older. We assumed screening initiation at age 65 with central dual-energy x-ray absorptiometry (DXA), and alendronate treatment for individuals with osteoporosis; with a comparator of "no screening" and treatment only after fracture occurrence. We evaluated annual alendronate costs of $20 through$800; outcome measures included fractures; nursing home admission; medication adverse events; death; costs; quality-adjusted life-years (QALYs); and incremental cost-effectiveness ratios (ICERs) in 2010 U.S. dollars per QALY gained. A lifetime time horizon was used, and direct costs were included. Base-case and sensitivity analyses were performed. Results: Base-case analysis results showed that at annual alendronate costs of $200 or less, osteoporosis screening followed by treatment was cost-saving, resulting in lower total costs than no screening as well as more QALYs (10.6 additional quality-adjusted life-days). When assuming alendronate costs of$400 through $800, screening and treatment resulted in greater lifetime costs than no screening but was highly cost-effective, with ICERs ranging from$714 per QALY gained through $13,902 per QALY gained. Probabilistic sensitivity analyses revealed that the cost-effectiveness of osteoporosis screening followed by alendronate treatment was robust to joint input parameter estimate variation at a willingness-to-pay threshold of$50,000/QALY at all alendronate costs evaluated. Conclusions: Osteoporosis screening followed by alendronate treatment is effective and highly cost-effective for postmenopausal women across a range of alendronate costs, and may be cost-saving at annual alendronate costs of $200 or less. © 2012 Nayak et al

Spatial variability in depositional reservoir quality of deep-water channel-fill and lobe deposits

Initial porosity and permeability in deep-water systems are controlled by primary sedimentary texture and mineralogy. Therefore, understanding the sedimentary processes that control changes in primary texture is critical for improved reservoir quality predictions. A well-constrained, exhumed submarine lobe in the Jaca Basin, and a submarine channel-fill element in the Aínsa Basin, northern Spain, were studied to characterize the depositional reservoir quality in axial to marginal/fringe positions. Construction of architectural panels and strategic sampling enabled analysis of the spatial changes in textural properties, and their relationship to reservoir quality distribution. Samples were analyzed in thin-section to establish how depositional processes inferred from outcrop observations affect textural properties. Results show that high-density turbidites are concentrated in lobe- and channel-axis positions and exhibit good depositional reservoir quality. Lobe off-axis deposits contain high- and low-density turbidites and have moderate depositional reservoir quality. Conversely, low-density turbidites dominate lobe fringe and channel-margin positions and have relatively poor depositional reservoir quality. There is a sharp decrease in depositional reservoir quality between the lobe off-axis and lobe fringe due to: 1) an abrupt increase in matrix content; 2) an abrupt decrease in sandstone amalgamation; and 3) a decrease in grain-size. There is an abrupt increase in depositional reservoir quality from channel margin to channel axis corresponding to: 1) an increase in total sandstone thickness and amalgamation; 2) an increase in grain-size, 3) a decrease in matrix content. Rates of change of key properties are up to two orders of magnitude greater between channel-fill sub-environments compared to lobe sub-environments. Spatial variability in properties of discrete architectural elements, and rates of changes, provides input to reservoir models during exploration, appraisal, and development phases of hydrocarbon fields

CAM therapies among primary care patients using opioid therapy for chronic pain

<p>Abstract</p> <p>Background</p> <p>Complementary and alternative medicine (CAM) is an increasingly common therapy used to treat chronic pain syndromes. However; there is limited information on the utilization and efficacy of CAM therapy in primary care patients receiving long-term opioid therapy.</p> <p>Method</p> <p>A survey of CAM therapy was conducted with a systematic sample of 908 primary care patients receiving opioids as a primary treatment method for chronic pain. Subjects completed a questionnaire designed to assess utilization, efficacy and costs of CAM therapies in this population.</p> <p>Results</p> <p>Patients were treated for a variety of pain problems including low back pain (38.4%), headaches (9.9%), and knee pain (6.5%); the average duration of pain was 16 years. The median morphine equivalent opioid dose was 41 mg/day, and the mean dose was 92 mg/day. Forty-four percent of the sample reported CAM therapy use in the past 12 months. Therapies utilized included massage therapy (27.3%, n = 248), chiropractic treatment (17.8%, n = 162), acupuncture (7.6%, n = 69), yoga (6.1%, n = 55), herbs and supplements (6.8%, n = 62), and prolotherapy (5.9%, n = 54). CAM utilization was significantly related to age female gender, pain severity income pain diagnosis of neck and upper back pain, and illicit drug use. Medical insurance covered chiropractic treatment (81.8%) and prolotherapy (87.7%), whereas patients primarily paid for other CAM therapies. Over half the sample reported that one or more of the CAM therapies were helpful.</p> <p>Conclusion</p> <p>This study suggests CAM therapy is widely used by patients receiving opioids for chronic pain. Whether opioids can be reduced by introducing such therapies remains to be studied.</p

Interpretation of ambiguous situations: evidence for a dissociation between social and physical threat in Williams syndrome

There is increasing evidence that Williams syndrome (WS) is associated with elevated anxiety that is non-social in nature, including generalised anxiety and fears. To date very little research has examined the cognitive processes associated with this anxiety. In the present research, attentional bias for non-social threatening images in WS was examined using a dot-probe paradigm. Participants were 16 individuals with WS aged between 13 and 34 years and two groups of typically developing controls matched to the WS group on chronological age and attentional control ability respectively. The WS group exhibited a significant attention bias towards threatening images. In contrast, no bias was found for group matched on attentional control and a slight bias away from threat was found in the chronological age matched group. The results are contrasted with recent findings suggesting that individuals with WS do not show an attention bias for threatening faces and discussed in relation to neuroimaging research showing elevated amygdala activation in response to threatening non-social scenes in WS

Use of an Anaerobic Chamber Environment for the Assay of Endogenous Cellular Protein-Tyrosine Phosphatase Activities

Protein-tyrosine phosphatases (PTPases) have a catalytic cysteine residue whose reduced state is integral to the reaction mechanism. Since exposure to air can artifactually oxidize this highly reactive thiol, PTPase assays have typically used potent reducing agents to reactivate the enzymes present; however, this approach does not allow for the measurement of the endogenous PTPase activity directly isolated from the in vivo cellular environment. Here we provide a method for using an anaerobic chamber to preserve the activity of the total PTPase complement in a tissue lysate or of an immunoprecipitated PTPase homolog to characterize their endogenous activation state. Comparison with a sample treated with biochemical reducing agents allows the determination of the activatable (reducible) fraction of the endogenous PTPase pool

Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking

Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine. We have shown previously that a deletion of the α2-subunit results in an absence of sensitisation to cocaine. Objective We investigated the reinforcing properties of cocaine in GABAA α2-subunit knockout (KO) mice using an intravenous self-administration procedure. Methods α2-subunit wildtype (WT), heterozygous (HT) and KO mice were trained to lever press for a 30 % condensed milk solution. After implantation with a jugular catheter, mice were trained to lever press for cocaine (0.5 mg/kg/infusion) during ten daily sessions. Responding was extinguished and the mice tested for cue- and cocaine-primed reinstatement. Separate groups of mice were trained to respond for decreasing doses of cocaine (0.25, 0.125, 0.06 and 0.03 mg/kg). Results No differences were found in acquisition of lever pressing for milk. All genotypes acquired self-administration of cocaine and did not differ in rates of self-administration, dose dependency or reinstatement. However, whilst WT and HT mice showed a dose-dependent increase in lever pressing during the cue presentation, KO mice did not. Conclusions Despite a reported absence of sensitisation, motivation to obtain cocaine remains unchanged in KO and HT mice. Reinstatement of cocaine seeking by cocaine and cocaine-paired cues is also unaffected. We postulate that whilst not directly involved in reward perception, the α2-subunit may be involved in modulating the “energising” aspect of cocaine’s effects on reward-seeking

Experimental delayed-choice entanglement swapping

Motivated by the question, which kind of physical interactions and processes are needed for the production of quantum entanglement, Peres has put forward the radical idea of delayed-choice entanglement swapping. There, entanglement can be "produced a posteriori, after the entangled particles have been measured and may no longer exist". In this work we report the first realization of Peres' gedanken experiment. Using four photons, we can actively delay the choice of measurement-implemented via a high-speed tunable bipartite state analyzer and a quantum random number generator-on two of the photons into the time-like future of the registration of the other two photons. This effectively projects the two already registered photons onto one definite of two mutually exclusive quantum states in which either the photons are entangled (quantum correlations) or separable (classical correlations). This can also be viewed as "quantum steering into the past"