Urban Welfare-to-Work Transitions in the 1990s: Patterns in Six Urban Areas

This report focuses on patterns of welfare use and employment for welfare leavers for central counties in each of six metropolitan areas

The triple decomposition of a fluctuating velocity field in a multiscale flow

A new method for the triple decomposition of a multiscale flow, which is based on the novel optimal mode decomposition (OMD) technique, is presented. OMD provides low order linear dynamics, which fits a given data set in an optimal way and is used to distinguish between a coherent (periodic) part of a flow and a stochastic fluctuation. The method needs no external phase indication since this information, separate for coherent structures associated with each length scale introduced into the flow, appears as the output. The proposed technique is compared against two traditional methods of the triple decomposition, i.e., bin averaging and proper orthogonal decomposition. This is done with particle image velocimetry data documenting the near wake of a multiscale bar array. It is shown that both traditional methods are unable to provide a reliable estimation for the coherent fluctuation while the proposed technique performs very well. The crucial result is that the coherence peaks are not observed within the spectral properties of the stochastic fluctuation derived with the proposed method; however, these properties remain unaltered at the residual frequencies. This proves the method’s capability of making a distinction between both types of fluctuations. The sensitivity to some prescribed parameters is checked revealing the technique’s robustness. Additionally, an example of the method application for analysis of a multiscale flow is given, i.e., the phase conditioned transverse integral length is investigated in the near wake region of the multiscale object array

International Trade Decisions of the Federal Circuit: 2006 Cases and Highlights of 2003-2005

Over the past four years, the United States Court of Appeals for the Federal Circuit (“Federal Circuit”) has, as it has done since its establishment in 1982, exercised its jurisdiction under 28 U.S.C. § 1295(a)(5) to review decisions of the United States Court of International Trade (“CIT”) regarding U.S. regulation of international trade. While trade cases currently make up only about six percent of the docket of the Federal Circuit, decisions in these cases can have a significant discernable impact on the day-to-day investigation and regulation of trade matters of the three U.S. agencies featured most prominently in the trade decisions of the Federal Circuit—United States Customs and Border Protection (“Customs”), the United States Department of Commerce (“Commerce”), and the United States International Trade Commission (“ITC” or “Commission”)—and on the parties involved in trade disputes before these agencies. This article covers all cases decided by the Federal Circuit in 2006, and selected cases from 2003-2005, dealing with international trade matters from tariff classification to investigations of dumping and subsidies, and jurisdictional issues related to appeals of these matters. A significant number of the cases that arrive at the Federal Circuit from the CIT are accompanied by a complex history—sometimes described as “a long and tortuous path”—and the case summaries below highlight the major holdings of each case within the context of this history and the unique fact patterns encompassing each case

International Trade Decisions of the Federal Circuit: 2006 Cases and Highlights of 2003-2005

Over the past four years, the United States Court of Appeals for the Federal Circuit (“Federal Circuit”) has, as it has done since its establishment in 1982, exercised its jurisdiction under 28 U.S.C. § 1295(a)(5) to review decisions of the United States Court of International Trade (“CIT”) regarding U.S. regulation of international trade. While trade cases currently make up only about six percent of the docket of the Federal Circuit, decisions in these cases can have a significant discernable impact on the day-to-day investigation and regulation of trade matters of the three U.S. agencies featured most prominently in the trade decisions of the Federal Circuit—United States Customs and Border Protection (“Customs”), the United States Department of Commerce (“Commerce”), and the United States International Trade Commission (“ITC” or “Commission”)—and on the parties involved in trade disputes before these agencies. This article covers all cases decided by the Federal Circuit in 2006, and selected cases from 2003-2005, dealing with international trade matters from tariff classification to investigations of dumping and subsidies, and jurisdictional issues related to appeals of these matters. A significant number of the cases that arrive at the Federal Circuit from the CIT are accompanied by a complex history—sometimes described as “a long and tortuous path”—and the case summaries below highlight the major holdings of each case within the context of this history and the unique fact patterns encompassing each case

CD44 and tumor-derived extracellular vesicles (TEVs) : possible gateway to cancer metastasis

Cancer metastasis, the final stage of tumor progression, is a complex process governed by the interplay of multiple types of cells and the tumor microenvironment. One of the aspects of this interplay involves the release of various factors by the tumor cells alone or by forcing other cells to do so. As a consequence of these actions, tumor cells are prepared in favorable conditions for their dissemination and spread to other sites/organs, which guarantees their escape from immunosurveillance and further progression. Tumor-derived extracellular vesicles (TEVs) represent a heterogeneous population of membrane-bound vesicles that are being actively released by different tumors. The array of proteins (i.e., receptors, cytokines, chemokines, etc.) and nucleic acids (i.e., mRNA, miR, etc.) that TEVs can transfer to other cells is often considered beneficial for the tumor’s survival and proliferation. One of the proteins that is associated with many different tumors as well as their TEVs is a cluster of differentiation 44 in its standard (CD44s) and variant (CD44v) form. This review covers the present information regarding the TEVs-mediated CD44s/CD44v transfer/interaction in the context of cancer metastasis. The content and the impact of the transferred cargo by this type of TEVs also are discussed with regards to tumor cell dissemination

Current status of in vitro differentiation of stem cells into gametes

From an evolutionary point of view, the gametes are the cells in the body that matter the most as they are the ones who transmit their genes to the next generation ensuring continuation of the species. Being able to generate mature oocytes in vitro is of great interest. Oocytes are the key to totipotency and are able to reprogram somatic cells in approximately one day. In addition, in contrast to a clump of pluripotent stem cells, once the developmental program has started, fertilized oocytes develop into a clump of cells with positional information and the possibility to differentiate into both the embryonic and the extraembryonic lineages that form a complete developing and viable organism. How to instruct pluripotent stem cells to become oocytes in vitro is still unclear and even though the first steps to obtain mouse oocytes have recently been successfully demonstrated, inducing meiosis progression and folliculogenesis in vitro are still far from being understood and have not yet been accomplished. In humans, the specific molecular niche that leads to correct oogenesis is less understood. Here, we discuss the current status of in vitro differentiation of human pluripotent stem cells into gametes, in particular to oocytes

Side Effects of National Immunization Program: E-Governance Support Toward Elders' Digital Inclusion

In response to the coronavirus pandemic, the European Union (EU) governments develop policies to regulate exclusive health protection actions that consider societal needs with the emphasis on elders. Given that the EU vaccination strategy uses a centralized ICT-based approach, there is little guidance on how seniors are included in national immunization programs (NIP). In this paper, we addressed a knowledge gap of the side effects of e-governance of NIP for the elderly. To fill this gap, we identified 40 side effects by analyzing online textual opinions (tweets, comments, articles) that express public perception regarding the results of the Polish NIP implementation to seniors' digital inclusion, categorized them into 8 categories and assign them to four e-governance functions. The main contribution of this paper is a better understanding of the digital divide and to provide guidelines for government policy improvement