On the Origin of the Dark Gamma-Ray Bursts

The origin of dark bursts - i.e. that have no observed afterglows in X-ray, optical/NIR and radio ranges - is unclear yet. Different possibilities - instrumental biases, very high redshifts, extinction in the host galaxies - are discussed and shown to be important. On the other hand, the dark bursts should not form a new subgroup of long gamma-ray bursts themselves.Comment: published in Nuovo Ciment

Factor analysis of the spectral and time behavior of long GRBs

A sample of 197 long BATSE GRBs is studied statistically. In the sample 11 variables, describing for any burst the time behavior of the spectra and other quantities, are collected. The application of the factor analysis on this sample shows that five factors describe the sample satisfactorily. Both the pseudo-redshifts coming from the variability and the Amati-relation in its original form are disfavored.Comment: In GAMMA-RAY BURSTS 2007: Proceedings of the Santa Fe Conferenc

Factor analysis of the long gamma-ray bursts

We study statistically 197 long gamma-ray bursts, detected and measured in detail by the BATSE instrument of the Compton Gamma-Ray Observatory. In the sample 10 variables, describing for any burst the time behavior of the spectra and other quantities, are collected. The factor analysis method is used to find the latent random variables describing the temporal and spectral properties of GRBs. The application of this particular method to this sample indicates that five factors and the \REpk spectral variable (the ratio of peak energies in the spectrum) describe the sample satisfactorily. Both the pseudo-redshifts inferred from the variability, and the Amati-relation in its original form, are disfavored.Comment: 5 pages, acceptod to A&

A trip in voice phytotheraphy: TRPA1 ion channel as a target for bioactive compounds in herbal remedies for voice care

Voice is the sound we produce to communicate meanings and ideas and has a capital importance in human social development. Herbs have been used for voice care since ancient times and many herbal remedies are still in use, both as folk medicine and as sources of botanicals used in commercial products. In Europe Sisymbrium officinale (L.) Scop (the "singers'plant\u201d) is the most popular herbal remedy for voice care, but many other plants are employed in phytopreparations. The mechanisms of action of these botanicals include anti-bacterial, anti-inflammatory, mucolytic, antinociceptive and other general activities; nevertheless, mechanisms that could be specifically referred to voice are often unknown. We collected information on plants used worldwide for voice care; the plants have been organized in a database (Herbs for Voice Database) and classified according to the bioactive compounds, their molecular targets and the pathologies they are recommended for. The data were analyzed with the aim to identify some possible common mechanism of action and the molecular targets involved. The analysis of data shows that an important pathway involves the somatosensory TRPA1 (Transient Receptor Potential Ankyrin type 1) ion channel, a well-known mediator of irritation, inflammatory and neurogenic pain. Agonists of this ion channel have been identified in 27 over 44 plants, corresponding to 61,3% of the plants in the database. Also TRPM8 (Transient Receptor Potential Melastatin type 8), involved in the perception of coolness, was identified among the molecular targets. This finding reinforces the hypothesis that these somatosensory ion channels could be involved in relevant mechanisms of action of these traditional remedies and open new perspectives in the rational study of voice phytopharmacology and therapy. This research was funded by FONDAZIONE CARIPLO (Milano, I), University of Milano (I) and Conservatorio di Musica G. Verdi (Milano, I), grant number 2017-1653

Herbs for voice database : developing a rational approach to the study of herbal remedies used in voice care

Herbs have been used for voice care since ancient times and many herbal remedies are still in use in every geographical areas and cultures, both as traditional medicine and as sources of botanicals used in commercial products. Many of these plants are used as extracts and other phytopreparates, and a full phytochemical analysis is sometimes incomplete or lacking. The mechanisms of action of these botanicals include antibacterial, antiinflammatory, mucolytic, and other general activities; nevertheless, mechanisms that could be specifically referred to voice are often unknown, as well as the corresponding molecular targets and therefore a rational approach in the use of these remedies is hard to be applied by phoniatricians. To address this problem, we collected information on plants used for voice care from several different geographical areas, using both literature data and a pool of contributors from an international network of artistic phoniatrics and vocologists. The plants have been organized in a database (Herbs for Voice Database) and classified according to the natural compounds contained in them, their molecular targets and the pathologies they are recommended for. This first database contains 44 plants, 101 phytocompounds, and 32 recognized molecular targets. The distribution of herbs and phytocompounds according to the botanical families, their known biological activity, traditional uses, and molecular targets were analyzed. In particular, data analysis shows that the somatosensory and pain receptor Transient Receptor Potential Ankyrin 1 ion channel is targeted by a large number of different phytochemicals contained in the herbs for voice, and could therefore be involved in a mechanism of action common to many plants

Time-resolved spectral correlations of long-duration Gamma-Ray Bursts

For a sample of long GRBs with known redshift, we study the distribution of the evolutionary tracks on the rest-frame luminosity-peak energy Liso-Ep' diagram. We are interested in exploring the extension of the `Yonetoku' correlation to any phase of the prompt light curve, and in verifying how the high-signal prompt duration time, Tf, in the rest frame correlates with the residuals of such correlation (Firmani et al. 2006). For our purpose, we analyse separately two samples of time-resolved spectra corresponding to 32 GRBs with peak fluxes >1.8 phot cm^-2 s^-1 from the Swift-BAT detector, and 7 bright GRBs from the CGRO-BATSE detector previously processed by Kaneko et al. (2006). After constructing the Liso-Ep' diagram, we discuss the relevance of selection effects, finding that they could affect significantly the correlation. However, we find that these effects are much less significant in the Liso x Tf-Ep' diagram, where the intrinsic scatter reduces significantly. We apply further corrections for reducing the intrinsic scatter even more. For the sub-samples of GRBs (7 from Swift and 5 from CGRO) with measured jet break time, we analyse the effects of correcting Liso by jet collimation. We find that (i) the scatter around the correlation is reduced, and (ii) this scatter is dominated by the internal scatter of the individual evolutionary tracks. These results suggest that the time, integrated `Amati' and `Ghirlanda' correlations are consequences of the time resolved features, not of selection effects, and therefore call for a physical origin. We finally remark the relevance of looking inside the nature of the evolutionary tracks.Comment: 11 pages, 6 figures, 4 tables. Submitted to MNRAS (Sept 8th), after referee comment

Effectiveness of Different Analytical Methods for the Characterization of Propolis : a Case of Study in Northern Italy

Propolis is used as folk medicine due to its spectrum of alleged biological and pharmaceutical properties and it is a complex matrix not still totally characterized. Two batches of propolis coming from two different environments (plains of Po Valley and the hilly Ligurian\u2013 Piedmont Apennines) of Northern Italy were characterized using different analytical methods: Spectrophotometric analysis of phenols, flavones and flavonols, and DPPH radical scavenging activity, HPLC, NMR, HSPME and GC\u2013MS and HPLC\u2013MS Orbitrap. Balsam and moisture content were also considered. No statistical differences were found at the spectrophotometric analysis; balsam content did not vary significantly. The most interesting findings were in the VOCs composition, with the Po Valley samples containing compounds of the resins from leaf buds of Populus nigra L. The hills (Appennines) samples were indeed characterize by the presence of phenolic glycerides already found in mountain environments. HPLC\u2013Q-Exactive-Orbitrap\uae\u2013MS analysis is crucial in appropriate recognition of evaluate number of metabolites, but also NMR itself could give more detailed information especially when isomeric compounds should be identified. It is necessary a standardized evaluation to protect and valorize this production and more research on propolis characterization using different analytical techniques