Examining the interaction between vertical and horizontal dimensions of state transformation

Two dimensions of state transformation often analysed separately can be identified as vertical authority shifts between different levels of government and horizontal authority transfers between state and non-state domains. This article firstly reviews three existing approaches that highlight links between vertical and horizontal state transformation: multi-level governance, policy networks and sections of the rescaling literature. However, these approaches do not yet provide a framework sufficient to enable a more thorough and detailed examination of the relationship between these two dimensions. The article thus proceeds to develop a multifaceted framework in order to facilitate further research into this relationship, a necessity if we are to understand more fully whether vertical and horizontal authority shifts complement or contradict one another within the transformation of the state's role in governing society and economy

The open method of coordination – effectively preventing welfare state retrenchment?

This article re-examines the division between "optimists" and "pessimists" within the literature on the Open Method of Coordination’s (OMC) effectiveness. Each of those "camps" tends to focus on a different question. "Optimists" are more concerned with the question of whether the OMC exerts an influence on the national level and through which mechanisms, whilst "pessimists" concentrate on the question of whether the OMC can "strengthen" EU social policy and therefore European welfare states. This article combines these two perspectives and argues that the OMC is indeed capable of influencing national policies through the dissemination of ideas and "learning" as the "optimists" stress. However, policy "learning" at the member state level is shaped and constrained by a variety of internal and external pressures. Against the hopes of most of the OMC "optimists", this makes the OMC largely ineffective in preventing welfare state retrenchme

The Resilience of Authoritarian Rule in Syria under Hafez and Bashar Al-Asad

This paper seeks an explanation for the resilience of the Syrian authoritarian regime under Hafez and Bashar Al-Asad. It will be argued that this resilience is to a relevant extent caused by the fact that the regime’s “material” as well as “ideational” forms of power share a common element, if not an underlying principle. This generates their compatibility and congruency and thus produces a convergence of forces which manifests in the regime’s ability to exceed the mere sum of its individual forms of power. It will be demonstrated that this common principle can be conceptualized as a “tacit pact” between unequal parties, with the weaker party under constant threat of exclusion and/or coercion in the event of noncompliance. It will be argued that inherent in the pact is a high level of ambiguity; this, paradoxically, renders it more effective but at the same time also more instable as a tool of domination.authoritarianism, power of command, disciplinary power, hegemony, Middle East

Der Jemen am Scheideweg : Demokratisierung oder Bürgerkrieg

This work concerns the interrelationship between thermodynamic, kinetic and structural aspects of crystal polymorphism. It is both experimental and theoretical, and limited with respect to compounds to substituted monocyclic aromatics. Two polymorphs of the compound m-aminobenzoic acid have been experimentally isolated and characterized by ATR-FTIR spectroscopy, X-ray powder diffraction and optical microscopy. In addition, two polymorphs of the compound m-hydroxybenzoic acid have been isolated and characterized by ATR-FTIR spectroscopy, high-temperature XRPD, confocal Raman, hot-stage and scanning electron microscopy. For all polymorphs, melting properties and specific heat capacity have been determined calorimetrically, and the solubility in several pure solvents measured at different temperatures with a gravimetric method. The solid-state activity (ideal solubility), and the free energy, enthalpy and entropy of fusion have been determined as functions of temperature for all solid phases through a thermodynamic analysis of multiple experimental data. It is shown that m-aminobenzoic acid is an enantiotropic system, with a stability transition point determined to be located at approximately 156°C, and that the difference in free energy at room temperature between the polymorphs is considerable. It is further shown that m-hydroxybenzoic acid is a monotropic system, with minor differences in free energy, enthalpy and entropy. 1393 primary nucleation experiments have been carried out for both compounds in different series of repeatability experiments, differing with respect to solvent, cooling rate, saturation temperature and solution preparation and pre-treatment. It is found that in the vast majority of experiments, either the stable or the metastable polymorph is obtained in the pure form, and only for a few evaluated experimental conditions does one polymorph crystallize in all experiments. The fact that the polymorphic outcome of a crystallization is the result of the interplay between relative thermodynamic stability and nucleation kinetics, and that it is vital to perform multiple experiments under identical conditions when studying nucleation of polymorphic compounds, is strongly emphasized by the results of this work. The main experimental variable which in this work has been found to affect which polymorph will preferentially crystallize is the solvent. For m-aminobenzoic acid, it is shown how a significantly metastable polymorph can be obtained by choosing a solvent in which nucleation of the stable form is sufficiently obstructed. For m-hydroxybenzoic acid, nucleation of the stable polymorph is promoted in solvents where the solubility is high. It is shown how this partly can be rationalized by analysing solubility data with respect to temperature dependence. By crystallizing solutions differing only with respect to pre-treatment and which polymorph was dissolved, it is found that the immediate thermal and structural history of a solution can have a significant effect on nucleation, affecting the predisposition for overall nucleation as well as which polymorph will preferentially crystallize. A set of polymorphic crystal structures has been compiled from the Cambridge Structural Database. It is found that statistically, about 50% crystallize in the crystallographic space group P21/c. Furthermore, it is found that crystal structures of polymorphs tend to differ significantly with respect to either hydrogen bond network or molecular conformation. Molecular mechanics based Monte Carlo simulated annealing has been used to sample different potential crystal structures corresponding to minima in potential energy with respect to structural degrees of freedom, restricted to one space group, for each of the polymorphic compounds. It is found that all simulations result in very large numbers of predicted structures. About 15% of the predicted structures have excess relative lattice energies of <=10% compared to the most stable predicted structure; a limit verified to reflect maximum lattice energy differences between experimentally observed polymorphs of similar compounds. The number of predicted structures is found to correlate to molecular weight and to the number of rotatable covalent bonds. A close study of two compounds has shown that predicted structures tend to belong to different groups defined by unique hydrogen bond networks, located in well-defined regions in energy/packing space according to the close-packing principle. It is hypothesized that kinetic effects in combination with this structural segregation might affect the number of potential structures that can be realized experimentally. The experimentally determined crystal structures of several compounds have been geometry-optimized (relaxed) to the nearest potential energy minimum using ten different combinations of common potential energy functions (force fields) and techniques for assigning nucleus-centred point charges used in the electrostatic description of the energy. Changes in structural coordinates upon relaxation have been quantified, crystal lattice energies calculated and compared with experimentally determined enthalpies of sublimation, and the energy difference before and after relaxation computed and analysed. It is found that certain combinations of force fields and charge assignment techniques work reasonably well for modelling crystal structures of small aromatics, provided that proper attention is paid to electrostatic description and to how the force field was parameterized. A comparison of energy differences for randomly packed as well as experimentally determined crystal structures before and after relaxation suggests that the potential energy function for the solid state of a small organic molecule is highly undulating with many deep, narrow and steep minima.QC 2011052

Optimization of Enzymatic Gas-Phase Reactions by Increasing the Long-Term Stability of the Catalyst

Enzymatic gas-phase reactions are usually performed in continuous reactors, and thus very stable and active catalysts are required to perform such transformations on cost-effective levels. The present work is concerned with the reduction of gaseous acetophenone to enantiomerically pure (R)-1-phenylethanol catalyzed by solid alcohol dehydrogenase from Lactobacillus brevis (LBADH), immobilized onto glass beads. Initially, the catalyst preparation displayed a half-life of 1 day under reaction conditions at 40 °C and at a water activity of 0.5. It was shown that the observed decrease in activity is due to a degradation of the enzyme itself (LBADH) and not of the co-immobilized cofactor NADP. By the addition of sucrose to the cell extract before immobilization of the enzyme, the half-life of the catalyst preparation (at 40 °C) was increased 40 times. The stabilized catalyst preparation was employed in a continuous gas-phase reactor at different temperatures (25-60 °C). At 50 °C, a space-time yield of 107 g/L/d was achieved within the first 80 h of continuous reaction.

Labor Market Policy Decentralization in Germany, the United Kingdom and Italy - Dynamics and Reasons. ACES Working Papers No. 5, 2008

This article argues that welfare-to-work or activation policies, which have been adopted across a range of OECD countries during the last two decades, do not only have led to changes in the substance of the welfare state but also to transformations in its institutional configuration. This institutional transformation includes the spatial reconfiguration of the welfare state, which has given new roles to the supra-national, national, and sub-national levels of government as well as private actors in the management and creation of labor market policies. By bringing institutions into these debates, this article seeks to expand the literature on welfare-to-work and activation as to date authors working on this topic have said very little about the degree, types, and reasons for the spatial re-configuration of welfare-to-work policies across different states. To fill a gap in the literatures on changes in the welfare state and its territorial configuration in particular, we compare trends in the re-configuration of welfare-to-work policies in Italy, Germany and the United Kingdom. We find that there is a cross-national trend, when it comes to the institutional effects of the implementation of activation. These trends bear a tension between decentralization and centralization, as both central and sub-national levels of government have acquired new responsibilities to implement the activation paradigm

Household Sharing for Carbon and Energy Reductions: The Case of EU Countries

As households get smaller worldwide, the extent of sharing within households reduces, resulting in rising per capita energy use and greenhouse gas (GHG) emissions. This article examines for the first time the differences in household economies of scale across EU countries as a way to support reductions in energy use and GHG emissions, while considering differences in effects across consumption domains and urban-rural typology. A country-comparative analysis is important to facilitate the formulation of context-specific initiatives and policies for resource sharing. We find that one-person households are most carbon- and energy-intensive per capita with an EU average of 9.2 tCO2eq/cap and 0.14 TJ/cap, and a total contribution of about 17% to the EU’s carbon and energy use. Two-person households contribute about 31% to the EU carbon and energy footprint, while those of five or more members add about 9%. The average carbon and energy footprints of an EU household of five or more is about half that of a one-person average household, amounting to 4.6 tCO2eq/cap and 0.07 TJ/cap. Household economies of scale vary substantially across consumption categories, urban-rural typology and EU countries. Substantial household economies of scale are noted for home energy, real estate services and miscellaneous services such as waste treatment and water supply; yet, some of the weakest household economies of scale occur in high carbon domains such as transport. Furthermore, Northern and Central European states are more likely to report strong household economies of scale—particularly in sparsely populated areas—compared to Southern and Eastern European countries. We discuss ways in which differences in household economies of scale may be linked to social, political and climatic conditions. We also provide policy recommendations for encouraging sharing within and between households as a contribution to climate change mitigation

Distributional effects of climate change mitigation policies

Climate change scholars generally urge that CO2 emissions need to be cut rapidly if we are to avoid dangerous risks of climate change. However, climate change mitigation policies are widely perceived to have regressive effects — that is, putting a higher financial burden as a proportion of household income on poor than on rich households. This is one of several major barriers to the adoption of effective mitigation policies. They would also have considerable social justice implications requiring significant welfare state responses. We assess the claim that climate change policies have regressive effects by comparing different types of mitigation policies. We will argue that many of these are indeed likely to have regressive distributional implications but that there are several policy options to counteract regressive effects

Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations

<p>Abstract</p> <p>Background</p> <p>In the past decade, an enormous number of new bioprocesses have evolved in the biotechnology industry. These bioprocesses have to be developed fast and at a maximum productivity. Up to now, only few microbioreactors were developed to fulfill these demands and to facilitate sample processing. One predominant reaction platform is the shaken microtiter plate (MTP), which provides high-throughput at minimal expenses in time, money and work effort. By taking advantage of this simple and efficient microbioreactor array, a new online monitoring technique for biomass and fluorescence, called BioLector, has been recently developed. The combination of high-throughput and high information content makes the BioLector a very powerful tool in bioprocess development. Nevertheless, the scalabilty of results from the micro-scale to laboratory or even larger scales is very important for short development times. Therefore, engineering parameters regarding the reactor design and its operation conditions play an important role even on a micro-scale. In order to evaluate the scale-up from a microtiter plate scale (200 μL) to a stirred tank fermenter scale (1.4 L), two standard microbial expression systems, <it>Escherichia coli </it>and <it>Hansenula polymorpha</it>, were fermented in parallel at both scales and compared with regard to the biomass and protein formation.</p> <p>Results</p> <p>Volumetric mass transfer coefficients (k_La) ranging from 100 to 350 1/h were obtained in 96-well microtiter plates. Even with a suboptimal mass transfer condition in the microtiter plate compared to the stirred tank fermenter (k_La = 370-600 1/h), identical growth and protein expression kinetics were attained in bacteria and yeast fermentations. The bioprocess kinetics were evaluated by optical online measurements of biomass and protein concentrations exhibiting the same fermentation times and maximum signal deviations below 10% between the scales. In the experiments, the widely applied green fluorescent protein (<it>GFP</it>) served as an online reporter of protein expression for both strains.</p> <p>Conclusions</p> <p>The successful 7000-fold scale-up from a shaken microtiter plate to a stirred tank fermenter was demonstrated in parallel fermentations for standard microbial expression systems. This confirms that the very economical and time efficient platform of microtiter plates can be very easily scaled up to larger stirred tank fermenters under defined engineering conditions. New online monitoring techniques for microtiter plates, such as the BioLector, provide even more real-time kinetic data from fermentations than ever before and at an affordable price. This paves the way for a better understanding of the bioprocess and a more rational process design.</p

Использование потенциометрического метода для определения микроконцентраций фторид ионов в технологических водах АЭС

Disposable cylindrical shaken bioreactors using plastic bags or vessels represent a promising alternative to stainless steel bioreactors, because they are flexible, cost-effective and can be pre-sterilized. Unlike conventional well-established steel bioreactors, however, such disposable bioreactor systems have not yet been precisely characterized. Thus, the aim of this current work is to introduce a new power input correlation as a potential means to characterize the hydrodynamics of these new systems. A set of rel- evant power input variables was defined and transformed into dimensionless numbers by using the Buckingham’s pi-Theorem. These numbers were then experimentally varied to quantify the relationship among the numbers. A simple correlation was generated for the power input with seven variables. The application of this new correlation was validated using 200 L and 2000 L orbitally shaken bioreactors. In conclusion, the proposed correlation is a useful tool to predict the power input and hydrodynamics during cell cultivation in cylindrical shaken bioreactors of all scales