Reorganization of the Warehouse Activities Processes with the Framing of their Problems and Solutions

Purpose: The aim of this study is to examine and identify goods processing operations in a warehouse and propose a reorganization of tasks to minimize processing time.   Theoretical framework: Current literature highlights the need to reorganize and adapt the operations chain (LOMBA Cédric, 2018). Some areas still need to be studied in depth to improve the supply chain. The literature on warehouse management has not sufficiently studied partial time management or closed-loop time management in the supply chain (CLSC) from goods-in to goods-out. The potential links between the risks of lost time and the management of the quality of the goods handling service have not been studied in depth.   Design/Methodology/Approach: The in-depth analysis of recent international studies published on warehouse management and the supply chain enables us to identify the studies that have the greatest impact on research.   Findings:  The result of this work is the development of a double typology, one linked to the chain of operations and the other to the constraints linked to the CLSC in a warehouse. Tools will be applied to diagnose the constraints and factors adversely goods handling operations.   Research, Practical & Social implications: To help logisticians and researchers, we have proposed an operational reformulation of a warehouse, enriched with a logical framework linking the problems and their potential solutions.   Originality/Value: The article proposes an original vision to improve the spatio-temporal organization of warehouses, by synthesizing its different entities, operations, and processes while presenting all the existing problems and identifying their possible solutions

Selection of the Best Proposal using FAHP: Case of Procurement of IT Master Plan’s Realization

IT master plan, which allows planning and managing the development of the computer systems, derives its importance in the central role of the computer systems in the functioning of organizations. This article focuses on the use of FAHP method for analysis and evaluation of tenders during the awarding of contracts of IT master plan’s realization. For those purposes, a painstaking work was realized for making an inventory of criteria and sub-criteria involved in the evaluation of tenders and for specifying the degrees of preference for each pair of criteria and sub-criteria. To find a provider for the IT master plan’s realization, organizations are increasingly using tendering as the mode of awarding contracts. This paper is an improvement of a previous published paper in which AHP method was used. The goals of this work are to make available to members of tenders committee a decision support tool for evaluating tenders of IT master plan’s realization and endow the organizations with effective IT master plans in order to increase their information systems’ performance

Proposal Decision Support Process for Urban Goods Delivery

This paper proposes a collaborative process to handle demands received by a carrier for urban goods delivery.The purpose of this article is to provide support for carriers analyzing the demands,physical resources,human resources,risks and profitability,in order to decide processing internally or externally a goods delivery demand or rejecting it.Such a process,called CUFP(Collaborative Urban Freight Process),is based on an analysis of urban movements of goods,divided into four stages:Check out of extreme conditions,feasibility study,exploitation study and execution

Growing Capacity in Gifted and Talented Education Through Science, Technology, Engineering, Arts, and Mathematics (STEAM)

A graduate-level gifted and talented education (GTE) course for in-service teachers was revised aiming to prepare teachers to integrate science, technology, engineering, arts, and mathematics (STEAM) education into existing curricula to create challenging learning experiences for students identified as gifted and talented. Two university-based teacher educators in science education and GTE, respectively, engaged in action research in order to develop and refine a semester-long STEAM project in the GTE course to accomplish this goal. In all, two elementary, one Music, and one World History teacher participated. Case study analysis explored the teachers’ approaches to developing STEAM-based lessons to expand their GTE toolkit, as well as teacher-reported effects on their students. The lessons implemented are discussed in light of guidance from reviewed literature, including student-centeredness, inquiry-driven, problem-based, peer interaction, and local contextual relevance

Analisis Yuridis Pertentangan Putusan Mahkamah Agung Nomor 2206 K/Pdt/2012 Dengan Putusan Peninjauan Kembali Nomor 319 PK/Pdt/2015 Tentang Sengketa Perdata Menurut Kitab Undang-Undang Hukum Perdata Dan Undang-Undang Nomor 42 Tahun 1999 Tentang Jaminan Fidusia

Banyak cara memperoleh dan mengalihkan status kepemilikan terhadap benda bergerak, KUHPerdata mengatur tentang cara memperoleh hak milik tersebut melalui jual- beli, penyerahan (levering) dan melalui sita jaminan, adapun jaminan lain yang tidak diatur dalam KUHPerdata diatur secara khusus dalam Undang-Undang lain, khususnya dalam penulisan ini adalah jaminan fidusia, pada kasus sengketa yang didapatkan dari putusan pengadilan yang sudah naik hingga peninjauan kembali diketahui telah terjadi Perjanjian ekspor impor antara eksportir dengan importir. Saat barang masih dalam pengiriman, importir bertindak sebagai penjual dengan menjual barang yang terlampir pada konosemennya kepada pembeli, tanpa mengalihkan konosemen tersebut, pembeli melunasi barang tersebut dengan menjaminkan barang secara fidusia kepada bank untuk barang yang akan diperoleh kemudian, setelah importir menerima barang dari pengangkut, importir langsung mengirim barang hingga gudang pembeli, Diketahui terjadi sengketa antara pembeli, bank penjamin melawan eksportir tanpa melibatkan importir yang hasil putusannya bertentangan. Di tingkat kasasi hakim memutus hak kepemilikan milik eksportir, di tingkat peninjauan kembali, hakim memutus hak kepemilikan barang menjadi milik bank penjamin fidusia, untuk itu penulis tertarik untuk menganalisis hak kepemilikan barang dalam sengketa tersebut secara Yuridis Normatif dengan Studi Kepustakaan berdasarkan KUHPerdata dan Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan Fidusia

Recommended physical activity and intensity levels to reduce excess of body fat amongst Malay female university students in Malaysia

This study aims to determine the type of physical activity that best predicts risk of adiposityamongst Malay female university students residing in Klang Valley, Malaysia. A total of 316female youth aged 18 to 25 years old were recruited for this study. Their physical activities were assessed using Short Questionnaire to Assess Health-Enhancing Physical Activity (SQUASH). Body fat percentage was measured via InBody 270 Body Impedance analyzer machine. Bivariate logistic regression was used to assess the association between physical activities and body fat percentage. Result from this study highlighted that total time per week of commuting (OR = 2.92, 95% CI: 1.18-7.31, p < 0.05) and the activity score of leisure time activities (OR = 2.47, 95% CI: 1.37-5.34, p < 0.05) are able to predict the risk of adiposityamongst Malay female youth.Keywords: youth; physical activity; adiposity; fat percentage; SQUASH.

Challenges of communication system during emergency disaster response in Malaysia: A review

The purpose of this review is to provide the overview of available systems and potentialfuture systems for communication during disaster in Malaysia. Electronic searches in majorsubject loci databases such as MEDLINE (via PUBMED), Ovid, Science Direct, Scopus,IEEE Xplore digital library and Springer are used in conducting the reviews. The majorchallenge is to integrate between readily available communications systems at pre-disaster,during disaster and post-disaster. Therefore, this review will further provide information forthe policy makers, responsible personnel as well as researchers on the vulnerability of thecommunication systems during disaster and the future direction of effective communicationsystem in Malaysia.Keywords: disaster; communication system;GIRN; effective communication system;emergency medicine

Mutation Analysis of Pancreatic Juice and Plasma for the Detection of Pancreatic Cancer

Molecular profiling may enable earlier detection of pancreatic cancer (PC) in high-risk individuals undergoing surveillance and allow for personalization of treatment. We hypothesized that the detection rate of DNA mutations is higher in pancreatic juice (PJ) than in plasma due to its closer contact with the pancreatic ductal system, from which pancreatic cancer cells originate, and higher overall cell-free DNA (cfDNA) concentrations. In this study, we included patients with pathology-proven PC or intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia (HGD) from two prospective clinical trials (KRASPanc and PACYFIC) for whom both PJ and plasma were available. We performed next-generation sequencing on PJ, plasma, and tissue samples and described the presence (and concordance) of mutations in these biomaterials. This study included 26 patients (25 PC and 1 IPMN with HGD), of which 7 were women (27%), with a median age of 71 years (IQR 12) and a median BMI of 23 kg/m2 (IQR 4). Ten patients with PC (40%) were (borderline) resectable at baseline. Tissue was available from six patients (resection n = 5, biopsy n = 1). A median volume of 2.9 mL plasma (IQR 1.0 mL) and 0.7 mL PJ (IQR 0.1 mL, p &lt; 0.001) was used for DNA isolation. PJ had a higher median cfDNA concentration (2.6 ng/μL (IQR 4.2)) than plasma (0.29 ng/μL (IQR 0.40)). A total of 41 unique somatic mutations were detected: 24 mutations in plasma (2 KRAS, 15 TP53, 2 SMAD4, 3 CDKN2A 1 CTNNB1, and 1 PIK3CA), 19 in PJ (3 KRAS, 15 TP53, and 1 SMAD4), and 8 in tissue (2 KRAS, 2 CDKN2A, and 4 TP53). The mutation detection rate (and the concordance with tissue) did not differ between plasma and PJ. In conclusion, while the concentration of cfDNA was indeed higher in PJ than in plasma, the mutation detection rate was not different. A few cancer-associated genetic variants were detected in both biomaterials. Further research is needed to increase the detection rate and assess the performance and suitability of plasma and PJ for PC (early) detection.</p

<i>ATP5PO </i>levels regulate enteric nervous system development in zebrafish, linking Hirschsprung disease to Down Syndrome

Hirschsprung disease (HSCR) is a complex genetic disorder characterized by the absence of enteric nervous system (ENS) in the distal region of the intestine. Down Syndrome (DS) patients have a &gt;50-fold higher risk of developing HSCR than the general population, suggesting that overexpression of human chromosome 21 (Hsa21) genes contribute to HSCR etiology. However, identification of responsible genes remains challenging. Here, we describe a genetic screening of potential candidate genes located on Hsa21, using the zebrafish. Candidate genes were located in the DS-HSCR susceptibility region, expressed in the human intestine, were known potential biomarkers for DS prenatal diagnosis, and were present in the zebrafish genome. With this approach, four genes were selected: RCAN1, ITSN1, ATP5PO and SUMO3. However, only overexpression of ATP5PO, coding for a component of the mitochondrial ATPase, led to significant reduction of ENS cells. Paradoxically, in vitro studies showed that overexpression of ATP5PO led to a reduction of ATP5PO protein levels. Impaired neuronal differentiation and reduced mitochondrial ATP production, were also detected in vitro, after overexpression of ATP5PO in a neuroblastoma cell line. Finally, epistasis was observed between ATP5PO and ret, the most important HSCR gene. Taken together, our results identify ATP5PO as the gene responsible for the increased risk of HSCR in DS patients in particular if RET variants are also present, and show that a balanced expression of ATP5PO is required for normal ENS development.</p