103 research outputs found
Exploring the options for fuelwood policies to support poverty alleviation policies: Evolving dimensions in South Africa
Access to secure and affordable energy supplies is widely acknowledged as a critical foundation for sustainable development; inadequate access exacerbates household poverty. In the developing world poor households are frequently reliant upon fuel wood for all or most of their energy needs. However, national poverty alleviation policies commonly do not consider fuelwood within their strategies, and similarly, energy policies rarely consider the poverty alleviation potential of a comprehensive fuelwood strategy. Consequently, synergies between poverty alleviation and energy policies—with fuelwood (and its derivates) as the bridge—are needed. This paper discusses this potential using South Africa as a case example. The current policy environment that either favours or hinders a linkage between the poverty and energy sectors and policy options and strategies available to develop such links, are discussed
Pancreatic (pro)enzymes treatment suppresses BXPC-3 pancreatic Cancer Stem Cell subpopulation and impairs tumour engrafting
Cancer stem cells (CSCs) subpopulation within the tumour is responsible for metastasis and cancer
relapse. Here we investigate in vitro and in vivo the effects of a pancreatic (pro)enzyme mixture
composed of Chymotrypsinogen and Trypsinogen (PRP) on CSCs derived from a human pancreatic
cell line, BxPC3. Exposure of pancreatic CSCs spheres to PRP resulted in a significant decrease of
ALDEFLUOR and specific pancreatic CSC markers (CD 326, CD 44 and CxCR4) signal tested by flow
cytometry, further CSCs markers expression was also analyzed by western and immunofluorescence
assays. PRP also inhibits primary and secondary sphere formation. Three RT2 Profiler PCR Arrays
were used to study gene expression regulation after PRP treatment and resulted in, (i) epithelialmesenchymal
transition (EMT) inhibition; (ii) CSCs related genes suppression; (iii) enhanced expression
of tumour suppressor genes; (iv) downregulation of migration and metastasis genes and (v) regulation
of MAP Kinase Signalling Pathway. Finally, in vivo anti-tumor xenograft studies demonstrated high
anti-tumour efficacy of PRP against tumours induced by BxPC3 human pancreatic CSCs. PRP impaired
engrafting of pancreatic CSC’s tumours in nude mice and displayed an antigrowth effect toward
initiated xenografts. We concluded that (pro)enzymes treatment is a valuable strategy to suppress the
CSC population in solid pancreatic tumours
The biogeography of South African terrestrial plant invasions
Thousands of plant species have been introduced, intentionally and accidentally, to South Africa from many parts of the world. Alien plants are now conspicuous features of many South African landscapes and hundreds of species have naturalised (i.e. reproduce regularly without human intervention), many of which are also invasive (i.e. have spread over long distances). There is no comprehensive inventory of alien, naturalised, and invasive plants for South Africa, but 327 plant taxa, most of which are invasive, are listed in national legislation. We collated records of 759 plant taxa in 126 families and 418 genera that have naturalised in natural and semi-natural ecosystems. Over half of these naturalised taxa are trees or shrubs, just under a tenth are in the families Fabaceae (73 taxa) and Asteraceae (64); genera with the most species are Eucalyptus,Acacia, and Opuntia. The southern African Plant Invaders Atlas (SAPIA) provides the best data for assessing the extent of invasions at the national scale. SAPIA data show that naturalised plants occur in 83% of quarter-degree grid cells in the country. While SAPIA data highlight general distribution patterns (high alien plant species richness in areas with high native plant species richness and around the main human settlements), an accurate, repeatable method for estimating the area invaded by plants is lacking. Introductions and dissemination of alien plants over more than three centuries, and invasions over at least 120 years (and especially in the last 50 years) have shaped the distribution of alien plants in South Africa. Distribution patterns of naturalised and invasive plants define four ecologically-meaningful clusters or “alien plant species assemblage zones”, each with signature alien plant taxa for which trait-environment interactions can be postulated as strong determinants of success. Some widespread invasive taxa occur in high frequencies across multiple zones; these taxa occur mainly in riparian zones and other azonal habitats,or depend on human-mediated disturbance, which weakens or overcomes the factors that determine specificity to any biogeographical region
A Molecular Phylogeny of the Chalcidoidea (Hymenoptera)
Chalcidoidea (Hymenoptera) are extremely diverse with more than 23,000 species described and over 500,000 species estimated to exist. This is the first comprehensive phylogenetic analysis of the superfamily based on a molecular analysis of 18S and 28S ribosomal gene regions for 19 families, 72 subfamilies, 343 genera and 649 species. The 56 outgroups are comprised of Ceraphronoidea and most proctotrupomorph families, including Mymarommatidae. Data alignment and the impact of ambiguous regions are explored using a secondary structure analysis and automated (MAFFT) alignments of the core and pairing regions and regions of ambiguous alignment. Both likelihood and parsimony approaches are used to analyze the data. Overall there is no impact of alignment method, and few but substantial differences between likelihood and parsimony approaches. Monophyly of Chalcidoidea and a sister group relationship between Mymaridae and the remaining Chalcidoidea is strongly supported in all analyses. Either Mymarommatoidea or Diaprioidea are the sister group of Chalcidoidea depending on the analysis. Likelihood analyses place Rotoitidae as the sister group of the remaining Chalcidoidea after Mymaridae, whereas parsimony nests them within Chalcidoidea. Some traditional family groups are supported as monophyletic (Agaonidae, Eucharitidae, Encyrtidae, Eulophidae, Leucospidae, Mymaridae, Ormyridae, Signiphoridae, Tanaostigmatidae and Trichogrammatidae). Several other families are paraphyletic (Perilampidae) or polyphyletic (Aphelinidae, Chalcididae, Eupelmidae, Eurytomidae, Pteromalidae, Tetracampidae and Torymidae). Evolutionary scenarios discussed for Chalcidoidea include the evolution of phytophagy, egg parasitism, sternorrhynchan parasitism, hypermetamorphic development and heteronomy
State of the world’s plants and fungi 2020
Kew’s State of the World’s Plants and Fungi project provides assessments of our current knowledge of the diversity of plants and fungi on Earth, the global threats that they face, and the policies to safeguard them. Produced in conjunction with an international scientific symposium, Kew’s State of the World’s Plants and Fungi sets an important international standard from which we can annually track trends in the global status of plant and fungal diversity
Book Reviews
The impact of electricity development, desires and dilemmasTanja WintherBerghahn Books: New York and Oxford, 2008274 p
Recommended from our members
Finally breaking the barriers: South African case study on LPG use by low-income urban households
Paper presented at the Istanbul Pre-conference workshop on "Clean Cooking Fuels", 16-17 Jun
Recommended from our members
The use of liquefied petroleum gas by South African low-income urban households: a case study
At the end of 2005 and in 2006, the Western Cape suffered extended blackouts. The cuts came as a shock and customers were loud in their criticism of Eskom and the City of Cape Town's failure to provide a reliable electricity supply. The utility Eskom's
responses included the introduction of an aggressive Demand Side Management (DSM) programme with the goal of saving electricity and reducing the need to shed customers. In Khayelitsha, Cape Town, the DSM programme entailed an exchange
and subsidy programme: households were encouraged to swop their two-plate electric stoves for Liquid Petroleum Gas (LPG) stoves. This intervention is the subject of this paper. The results of the study were analysed in terms of the socio-economic
characteristics of the sample interviewed, multiple fuel use and transition trends in households in urban areas, changes in behaviour in electricity and LPG use, changing perceptions of LPG and the impact of the intervention. Previous studies in household energy use showed that people perceived LPG to be dangerous saying that it posed a greater danger to the household than paraffin since
it might explode. Surprisingly, during the electricity power cuts in 2006, people in low-income communities, readily accepted LPG stoves in great numbers and a year later, up to 89% of the households surveyed, reported still using LPG for cooking.
Perioperative management of transthoracic oesophagectomies. Fundamentals of interdisciplinary care and new approaches to accelerated recovery after surgery
Locally advanced carcinomas of the oesophagus require multimodal treatment. The core element of curative therapy is transthoracic en bloc oesophagectomy, which is the standard procedure carried out in most specialized centres. Reconstruction of intestinal continuity is usually achieved with a gastric sleeve, which is anastomosed either intrathoracically or cervically to the remaining oesophagus. This thoraco-abdominal operation is associated with significant postoperative morbidity, not least because of a vast array of pre-existing illnesses in the surgical patient. For an optimal outcome, the careful interdisciplinary selection of patients, preoperative risk evaluation and conditioning are essential. The caseload of the centres correlates inversely with the complication rate. The leading surgical complication is anastomotic leakage, which is diagnosed endoscopically and usually treated with the aid of endoscopic procedures. Pulmonary infections are the most frequent non-surgical complication. Thoracic epidural anaesthesia and perfusion-orientated fluid management can reduce the rate of pulmonary complications. Patients are ventilated protecting the lungs and are extubated as early as possible. Oesophagectomies should only be performed in high-volume centres with the close cooperation of surgeons and anaesthesia/intensive care specialists. Programmes of enhanced recovery after surgery (ERAS) hold further potential for the patient's quicker postoperative recovery. In this review article the fundamental aspects of the interdisciplinary perioperative management of transthoracic oesophagectomy are described
- …