Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia sobre la serialización de los medicamentos y los procesos de mezclado

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

ObjectivesCARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.MethodsIn total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC &gt; 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis.ResultsIn total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5).ConclusionThis study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3

Ha estallado la paz. continuación

Proyecto de Educación para la Paz iniciado el año anterior con un estudio de Latinoamérica y que para este curso gira en torno al conocimiento del continente africano y la construcción de juguetes no bélicos. Los objetivos son: crear actitudes pacifistas; sensibilizar al alumnado a través de la solidaridad, la cooperación, la aceptación de otras culturas, razas, etc; y fomentar sentimientos de respeto, valorando y considerando las diferentes formas de ser y pensar de las personas. La experiencia parte de la realidad concreta y cercana de los alumnos para alcanzar otras realidades más amplias y alejadas. Se utiliza para ello una metodología activa y participativa, en la que el profesorado actúa como orientador y estimulador, centrada en los agrupamientos pequeños para el trabajo de campo con reparto individual de tareas; y de clase, para la puesta en común, el debate, análisis de resultados y búsqueda de soluciones. Como primera fase se realiza un estudio de 'El Tercer Mundo: Africa' a través de coloquios, debates, murales, fiestas y exposiciones; y para la segunda fase se confeccionan juguetes no bélicos y se adaptan juguetes de tablero para hacerlos no competitivos y que puedan ser usados por los más pequeños. La evaluación se centra, sobre todo en la adquisición de actitudes y conductas y no tanto en el desarrollo de contenidos..Madrid (Comunidad Autónoma). Consejería de Educación y CulturaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

Stability and storage of medicines: challenge-based learning for the correct preservation of medicines by the population

El proyecto, enfocado en la estabilidad y conservación de los medicamentos, pretende facilitara a los alumnos el aprendizaje de la materia Tecnología Farmacéutica II impartida en cuarto curso del grado de Farmacia, aproximando los conocimientos adquiridos a la identificación, análisis y resolución de problemas sanitarios reales, mediante la utilización de una metodología de aprendizaje basado en retos.The project, focused on the stability and preservation of medications, aims to facilitate students learning the subject Pharmaceutical Technology II taught in the fourth year of the Pharmacy degree, bringing the knowledge acquired to the identification, analysis and resolution of real health problems , by using a challenge-based learning methodology.Fac. de FarmaciaFALSEsubmitte

Activación de la inteligencia mediante la música y las artes plásticas usando bits

El proyecto consiste en la estimulación temprana del cerebro de los niños de Educación Infantil, con lo que se pretende incidir en la disminución de las dificultades de aprendizaje y en el fracaso escolar. Los objetivos son apoyar el potencial de aprendizaje de los niños y elevar su autoestima; facilitar la construcción del aprendizaje mediante asociación y razonamiento de lo conocido; crear ambientes comunicativos y segurizantes; provocar deseos, emociones e intenciones; inducir inquietudes expresividades y encuentros. La metodología consiste en presentar a los niños bits de inteligencia que se agrupan en series relacionadas y que se cambian cada quince días según los contenidos del curriculo. Por otro lado, se realizan audiciones de música precedidas de informaciones de carácter cultural. El sistema de bits de inteligencia se aplica también al área de Conocimiento del Medio en el tercer ciclo de Primaria. Las actividades consisten, además de las unidades didácticas propias de las distintas áreas de Educación Infantil, y algunas de Primaria, en la construcción de instrumentos sencillos y la utilización artístico-musical de material de desecho. Otras actividades son las audiciones acompañadas de láminas, transparencias, musicogramas y visionado de vídeos y la utilización de material multimedia. La evaluación de la metodología empleada responde a los estímulos del niño, a la guía de la profesora y a una mayor atención, concentración y dirección de la motivación. Es una herramienta eficaz para la adquisición de vocabulario para niños que no leen, desarrolla la creatividad del niño y el aprendizaje de otras materias.Madrid (Comunidad Autónoma). Consejería de EducaciónMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

Evaluation of the short- and long-term effectiveness and safety of fully covered self-expandable metal stents for drainage of pancreatic fluid collections: results of a Spanish nationwide registry

[Background and Aims]: Initial reports suggest that fully covered self-expandable metal stents (FCSEMSs) may be better suited for drainage of dense pancreatic fluid collections (PFCs), such as walled-off pancreatic necrosis. The primary aim was to analyze the effectiveness and safety of FCSEMSs for drainage of different types of PFCs in a large cohort. The secondary aim was to investigate which type of FCSEMS is superior.[Methods]:This was a retrospective, noncomparative review of a nationwide database involving all hospitals in Spain performing EUS-guided PFC drainage. From April 2008 to August 2013, all patients undergoing PFC drainage with an FCSEMS were included in a database. The main outcome measurements were technical success, short-term (2 weeks) and long-term (6 months) effectiveness, adverse events, and need for surgery.[Results]: The study included 211 patients (pseudocyst/walled-off pancreatic necrosis, 53%/47%). The FCSEMSs used were straight biliary (66%) or lumen-apposing (34%). Technical success was achieved in 97% of patients (95% confidence interval [CI], 93%-99%). Short-term- and long-term clinical success was obtained in 94% (95% CI, 89%-97%) and 85% (95% CI, 79%-89%) of patients, respectively. Adverse events occurred in 21% of patients (95% CI, 16%-27%): infection (11%), bleeding (7%), and stent migration and/or perforation (3%). By multivariate analysis, patient age (>58 years) and previous failed drainage were the most important factors associated with negative outcome.[Conclusions]: An FCSEMS is effective and safe for PFC drainage. Older patients with a history of unsuccessful drainage are more likely to fail EUS-guided drainage. The type of FCSEMS does not seem to influence patient outcome