Decision Making on Fuzzy Soft Simply* Continuous of Fuzzy Soft Multi-Function

Real world applications are dealing now with a huge amount of data, especially in the area of high dimensional features. In this article, we depict the simply*upper, the simply*lower continuous, we get several characteristics and other properties with respect to upper and lower simply*-continuous soft multifunctions. We also investigate the relationship between soft-continuous, simply*- continuous multifunction. We also implement fuzzy soft multifunction between fuzzy soft topological spaces which is Akdag’s generation of the notion. We are introducing a new class of soft open sets, namely soft simply*open set deduce from soft topology, and we are using it to implement the new approximation space called soft multi-function approach space. Simply*space for approximation based on a simply*open set. The world must adopt modern studies in order to confront epidemics. Accordingly, we presented a new decision proposal in this article, compared our proposed approach to the soft relationship introduced by approximation of Xueyou, and concluded that our approach is better. We also used our proposal in the medical application that was studied in this paper

Association between Temperature and Relative Humidity in Relation to COVID-19

The aim of this study is to determine the association between temperature and humidity in relation to COVID-19 above 3°C. This was carried out in the cities of Bandung and Surabaya which have temperatures of about 22°C to 31°C. Data was analyzed using descriptive analysis and the Pearson and Spearman correlation for normally and abnormally distributed data. The results showed that there was no association between people under monitoring (ODP)/close contact, patients under surveillance (PDP)/suspect, and COVID-19 confirmed cases in relation to the temperature and humidity in Bandung and Surabaya. Furthermore, there was no relationship between temperature and humidity with ODP, PDP, and COVID-19 Confirmed cases in both cities, because they had a comfortably wet category (RH > 70%). This results are expected to provide information to the government that weather cases in Indonesia (temperatures around 26°C–30°C with humidity > 60%) do not affect the spread of COVID-19. In addition, it is expected that further studies would be carried out on other factors that influence the spread of COVID-19 in Indonesia, for example, how the level of alternating flow in and/or out of the population into an area

Automated Quantification of Neuropad Improves Its Diagnostic Ability in Patients with Diabetic Neuropathy.

PublishedResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tNeuropad is currently a categorical visual screening test that identifies diabetic patients at risk of foot ulceration. The diagnostic performance of Neuropad was compared between the categorical and continuous (image-analysis (Sudometrics)) outputs to diagnose diabetic peripheral neuropathy (DPN). 110 subjects with type 1 and 2 diabetes underwent assessment with Neuropad, Neuropathy Disability Score (NDS), peroneal motor nerve conduction velocity (PMNCV), sural nerve action potential (SNAP), Deep Breathing-Heart Rate Variability (DB-HRV), intraepidermal nerve fibre density (IENFD), and corneal confocal microscopy (CCM). 46/110 patients had DPN according to the Toronto consensus. The continuous output displayed high sensitivity and specificity for DB-HRV (91%, 83%), CNFD (88%, 78%), and SNAP (88%, 83%), whereas the categorical output showed high sensitivity but low specificity. The optimal cut-off points were 90% for the detection of autonomic dysfunction (DB-HRV) and 80% for small fibre neuropathy (CNFD). The diagnostic efficacy of the continuous Neuropad output for abnormal DB-HRV (AUC: 91%, P = 0.0003) and CNFD (AUC: 82%, P = 0.01) was better than for PMNCV (AUC: 60%). The categorical output showed no significant difference in diagnostic efficacy for these same measures. An image analysis algorithm generating a continuous output (Sudometrics) improved the diagnostic ability of Neuropad, particularly in detecting autonomic and small fibre neuropathy.National Institute of Health (NIH)Juvenile Diabetes Research Foundation (JDRF

Gabapentin for chronic pelvic pain in women (GaPP2):a multicentre, randomised, double-blind, placebo-controlled trial

BackgroundChronic pelvic pain affects 2–24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology.MethodsWe performed a multicentre, randomised, double-blind, placebo-controlled randomised trial in 39 UK hospital centres. Eligible participants were women with chronic pelvic pain (with or without dysmenorrhoea or dyspareunia) of at least 3 months duration. Inclusion criteria were 18–50 years of age, use or willingness to use contraception to avoid pregnancy, and no obvious pelvic pathology at laparoscopy, which must have taken place at least 2 weeks before consent but less than 36 months previously. Participants were randomly assigned in a 1:1 ratio to receive gabapentin (titrated to a maximum dose of 2700 mg daily) or matching placebo for 16 weeks. The online randomisation system minimised allocations by presence or absence of dysmenorrhoea, psychological distress, current use of hormonal contraceptives, and hospital centre. The appearance, route, and administration of the assigned intervention were identical in both groups. Patients, clinicians, and research staff were unaware of the trial group assignments throughout the trial. Participants were unmasked once they had provided all outcome data at week 16–17, or sooner if a serious adverse event requiring knowledge of the study drug occurred. The dual primary outcome measures were worst and average pain scores assessed separately on a numerical rating scale in weeks 13–16 after randomisation, in the intention-to-treat population. Self-reported adverse events were assessed according to intention-to-treat principles. This trial is registered with the ISRCTN registry, ISCRTN77451762.FindingsParticipants were screened between Nov 30, 2015, and March 6, 2019, and 306 were randomly assigned (153 to gabapentin and 153 to placebo). There were no significant between-group differences in both worst and average numerical rating scale (NRS) pain scores at 13–16 weeks after randomisation. The mean worst NRS pain score was 7·1 (standard deviation [SD] 2·6) in the gabapentin group and 7·4 (SD 2·2) in the placebo group. Mean change from baseline was −1·4 (SD 2·3) in the gabapentin group and −1·2 (SD 2·1) in the placebo group (adjusted mean difference −0·20 [97·5% CI −0·81 to 0·42]; p=0·47). The mean average NRS pain score was 4·3 (SD 2·3) in the gabapentin group and 4·5 (SD 2·2) in the placebo group. Mean change from baseline was −1·1 (SD 2·0) in the gabapentin group and −0·9 (SD 1·8) in the placebo group (adjusted mean difference −0·18 [97·5% CI −0·71 to 0·35]; p=0·45). More women had a serious adverse event in the gabapentin group than in the placebo group (10 [7%] of 153 in the gabapentin group compared with 3 [2%] of 153 in the placebo group; p=0·04). Dizziness, drowsiness, and visual disturbances were more common in the gabapentin group.InterpretationThis study was adequately powered, but treatment with gabapentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effects than placebo. Given the increasing reports of abuse and evidence of potential harms associated with gabapentin use, it is important that clinicians consider alternative treatment options to off-label gabapentin for the management of chronic pelvic pain and no obvious pelvic pathology.FundingNational Institute for Health Research

Integrated motor drives: state of the art and future trends

With increased need for high power density, high efficiency and high temperature capabilities in Aerospace and Automotive applications, Integrated Motor Drives (IMD) offers a potential solution. However, close physical integration of the converter and the machine may also lead to an increase in components temperature. This requires careful mechanical, structural and thermal analysis; and design of the IMD system. This paper reviews existing IMD technologies and their thermal effects on the IMD system. The effects of the power electronics (PE) position on the IMD system and its respective thermal management concepts are also investigated. The challenges faced in designing and manufacturing of an IMD along with the mechanical and structural impacts of close physical integration is also discussed and potential solutions are provided. Potential converter topologies for an IMD like the Matrix converter, 2-level Bridge, 3-level NPC and Multiphase full bridge converters are also reviewed. Wide band gap devices like SiC and GaN and their packaging in power modules for IMDs are also discussed. Power modules components and packaging technologies are also presented

Asymptotic behavior of a certain third order differential equation

In order to introduce the investigation contemplated in this thesis, let us consider the differential equation d3y d2y dyz3 ____+ z2___(b0 + blzm) + z - (c0 + clzm) dz3 dz2 dz+ (d0 + dlzm + d2z2m) y = 0Here, m is an arbitrary positive integer and the variable z is complex as are the constantsbi,ci (i=0,1) and di (i=0,1,2) with d2≠0. It is also assumed that the difference of no two roots of the indicial equation about z = 0 is congruent to zero modulo m.Ball State UniversityMuncie, IN 47306Thesis (M.S.)--Ball State University, 1983