Table 2: Anti-tumor agents for targeting hypoxia-induced CA IX for therapy and diagnosis.

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tumors and reduce the tumor growth establishing the significant role of CA IX in tumorigenesis. Thus, the development of potent antitumor drugs targeting CA IX with minimal toxic effects is important for the target-specific tumor therapy. Recently, several promising antitumor agents against CA IX have been developed to treat certain types of cancers in combination with radiation and chemotherapy. Here we review the inhibition of CA IX by small molecule compounds and monoclonal antibodies. The methods of enzymatic assays, biophysical methods, animal models including zebrafish and Xenopus oocytes, and techniques of diagnostic imaging to detect hypoxic tumors using CA IX-targeted conjugates are discussed with the aim to overview the recent progress related to novel therapeutic agents that target CA IX in hypoxic tumors

Özel sigorta sektöründe hayat dışı branşlardaki müşteri temsilcilerinin iş memnuniyetinin değerlendirilmesi

ÖZETÖZEL SİGORTA SEKTÖRÜNDE HAYAT DIŞI BRANŞLARDAKİ MÜŞTERİ TEMSİLCİLERİNİN İŞ MEMNUNİYETİNİN DEĞERLENDİRİLMESİSigorta sektöründeki müşteri temsilcilerinin iş memnuniyeti bu tezin temel konusudur. Motivasyon ve iş tatmini buradaki önemli iki tutumdur. Günümüzde işyerinde artı değerin oluşumunda çalışanın önemli etkisi olduğu kabul edilmektedir. Sigorta sektörünün de bu artı değere ihtiyacı uzun yıllardır sigorta şirketleri tarafından göz ardı edilmiştir. Acente bazlı satışla birlikte değişik pazarlama yapılanmaları sektörün gelişimine artı değer katmıştır.Çalışmanın ilk bölümü hizmet kavramı ve özelliklerini içermektedir. Ayrıca hizmet sektöründe çalışan personel profil yaklaşımları hakkında bilgi verilmiştir. İkinci bölümde iş tatmini konusu incelenmiştir. Daha sonra memnuniyetin boyutları belirtilmiş ve işyerinde iş tatmini ölçmenin önemi ve yararları değerlendirilmiştir. Üçüncü bölümde sigorta sektörü çeşitli değişkenler yardımıyla incelenmiştir. Ayrıca sektördeki müşteri temsilcilerinin yetersizliği konusunda bilgi verilmiştir. Dördüncü bölümde sigorta sektöründeki 150 müşteri temsilcisine iş memnuniyeti ile ilgili anket yapılmış ve sonuçları istatistiksel olarak irdelenmiştir. ANAHTAR KELİMELER: Hizmet, İş tatmini, Sigorta Sektörü, Müşteri Temsilcisi Ki-kare analizi. ABSTRACTANALYSIS OF THE SATISFACTION OF NON-LIFE CUSTOMER REPRESENTATIVES IN THE PRIVATE INSURANCE SECTORThe employee satisfaction of the customer representatives in the insurance sector is the main subject of this thesis. Motivation and the employee satisfaction are the two important behaviours of this subject. In today’s world, it is obvious that the employee has an important effect in creating positive value for his company. In the private insurance sector, the need for this positive value has been neglected for a long time. Agency based sales and various marketing structurings have added positive value to the emerging insurance sector.The first section includes the concept of service and its peculiarities. It also includes the profile and the approaches of the employees working in the service sector. In the second part of the thesis, employee satisfaction is observed. Then, the dimensions of the satisfaction are stated and the importance and advantages of measuring employee satisfaction in a company are emphasized. In the third part, the insurance sector is observed by the help of various variables. Moreover, the unsufficiency of the customer representatives is emphasized. In the fourth part, a questionary has been applied to 150 customer representatives to measure their satisfaction and the results are analysed statistically.KEYWORDS: Service, employee satisfaction, insurance sector, customer representative, chi-square analysis

Özel sigorta sektöründe hayat dışı branşlardaki müşteri temsilcilerinin iş memnuniyetinin değerlendirilmesi

ÖZEL SİGORTA SEKTÖRÜNDE HAYAT DIŞI BRANŞLARDAKİ MÜŞTERİ TEMSİLCİLERİNİN İŞ MEMNUNİYETİNİN DEĞERLENDİRİLMESİ Sigorta sektöründeki müşteri temsilcilerinin iş memnuniyeti bu tezin temel konusudur. Motivasyon ve iş tatmini buradaki önemli iki tutumdur. Günümüzde işyerinde artı değerin oluşumunda çalışanın önemli etkisi olduğu kabul edilmektedir. Sigorta sektörünün de bu artı değere ihtiyacı uzun yıllardır sigorta şirketleri tarafından göz ardı edilmiştir. Acente bazlı satışla birlikte değişik pazarlama yapılanmaları sektörün gelişimine artı değer katmıştır. Çalışmanın ilk bölümü hizmet kavramı ve özelliklerini içermektedir. Ayrıca hizmet sektöründe çalışan personel profil yaklaşımları hakkında bilgi verilmiştir. İkinci bölümde iş tatmini konusu incelenmiştir. Daha sonra memnuniyetin boyutları belirtilmiş ve işyerinde iş tatmini ölçmenin önemi ve yararları değerlendirilmiştir. Üçüncü bölümde sigorta sektörü çeşitli değişkenler yardımıyla incelenmiştir. Ayrıca sektördeki müşteri temsilcilerinin yetersizliği konusunda bilgi verilmiştir. Dördüncü bölümde sigorta sektöründeki 150 müşteri temsilcisine iş memnuniyeti ile ilgili anket yapılmış ve sonuçları istatistiksel olarak irdelenmiştir. ANAHTAR KELİMELER: Hizmet, İş tatmini, Sigorta Sektörü, Müşteri Temsilcisi Ki-kare analizi. ABSTRACT ANALYSIS OF THE SATISFACTION OF NON-LIFE CUSTOMER REPRESENTATIVES IN THE PRIVATE INSURANCE SECTOR The employee satisfaction of the customer representatives in the insurance sector is the main subject of this thesis. Motivation and the employee satisfaction are the two important behaviours of this subject. In today’s world, it is obvious that the employee has an important effect in creating positive value for his company. In the private insurance sector, the need for this positive value has been neglected for a long time. Agency based sales and various marketing structurings have added positive value to the emerging insurance sector. The first section includes the concept of service and its peculiarities. It also includes the profile and the approaches of the employees working in the service sector. In the second part of the thesis, employee satisfaction is observed. Then, the dimensions of the satisfaction are stated and the importance and advantages of measuring employee satisfaction in a company are emphasized. In the third part, the insurance sector is observed by the help of various variables. Moreover, the unsufficiency of the customer representatives is emphasized. In the fourth part, a questionary has been applied to 150 customer representatives to measure their satisfaction and the results are analysed statistically. KEYWORDS: Service, employee satisfaction, insurance sector, customer representative, chi-square analysis

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

A series of 20 histamine Schiff base was synthesised by reaction of histamine, a well known carbonic anhydrase (CA, E.C 4.2.2.1.) activator pharmacophore, with substituted aldehydes. The obtained histamine Schiff bases were assayed as activators of five selected human (h) CA isozymes, the cytosolic hCA I, hCA II, and hCA VII, the membrane-anchored hCA IV and transmembrane hCA IX. Some of these compounds showed efficient activity (in the nanomolar range) against the cytosolic isoform hCA VII, which is a key CA enzyme involved in brain metabolism. Moderate activity was observed against hCA I and hCA IV (in the nanomolar to low micromolar range). The structure–activity relationship for activation of these isoforms with the new histamine Schiff bases is discussed in detail based on the nature of the aliphatic, aromatic, or heterocyclic moiety present in the aldehyde fragment of the molecule, which may participate in diverse interactions with amino acid residues at the entrance of the active site, where activators bind, and which is the most variable part among the different CA isoforms

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors

A series of new 1,3-diaryltriazene sulfonamides was synthesised by reaction of diazonium salt of metanilamide (3-aminobenzene sulfonamide) with substituted aromatic amines. The obtained new compounds were assayed as inhibitors of four physiologically and pharmacologically relevant human (h) isoforms of carbonic anhydrases (CA, EC 4.2.1.1), specifically, hCA I, hCA II, and hCA VII (cytosolic isoforms), as well as the tumour-associated membrane-bound isoform hCA IX. All isoforms investigated here were inhibited by the newly synthesised 1,3-diaryltriazene sulfonamide derivatives from the micromolar to the nanomolar range. The cytosolic isoforms were inhibited with Kis in the range of 92.3–8371.1 nM (hCA I), 4.3–9194.0 nM (hCA II), and 15.6–9477.8 nM (hCA VII), respectively. For the membrane-bound tumour-associated isoform hCA IX, the KI-s ranged between 50.8 and 9268.5 nM. The structure–activity relationship (SAR) with these newly synthesised metanilamide derivatives are discussed in detail

Poly(N-vinyl-2-pyrrolidone) Stabilized Nanoclusters as Highly Efficient and Reusable Catalyst for the Dehydrogenation of Dimethly Ammonia-Borane

Addressed herein, we report a highly efficient and facile synthesis of palladium, nickel nanoparticles supported on poly(N-vinyl-2-pyrrolidone) (PdNi@PVP NPs) for the dehydrogenation of DMAB. PdNi@PVP nanoclusters have been synthesized from the reduction of precursors of metals (Pd and Ni) by the microwave assistance method at room temperature with an average particle size of 3.05 +/- 0.38 nm. This newly produced monodisperse PdNi@PVP nanoclusters exhibits high durability, reusability, and catalytic performance even after the fourth cycle of dehydrogenation of DMAB reactions. On the other hand, the structure morphology and properties of the nanoclusters were characterized using different analytical methods such as UV-Vis, XPS, XRD, TEM, and the HR-TEM techniques. Besides, the PdNi@PVP NPs catalyst showed good catalytic effectiveness with a high turnover frequency of 561.0 h(-1) and low Ea value of 37.11 +/- 2 kJ mol(-1) for DMAB dehydrocoupling in ambient conditions

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides

In this study, a series of 10 novel copper (II) and silver complexes of 1,3-diaryltriazene-substituted sulfonamides was synthesised. All the synthesised ligands and their metal complexes were assessed for in vitro cytotoxicity against human colorectal adenocarcinoma (DLD-1), cervix carcinoma (HeLa), breast adenocarcinoma (MDA-MB-231), colon adenocarcinoma (HT-29), endometrial adenocarcinoma (ECC-1), prostate cancer (DU-145 and PC-3), normal embryonic kidney (HEK-293), normal prostate epithelium (PNT-1A), and normal retinal pigment epithelium (ARPE-19) cells. Most of the metal complexes from the series showed to be more active against all cancerous cells than the uncomplexed 1,3-diaryltriazene-substituted sulfonamides, and lower cytotoxic effects observed on normal cells. Most of the Cu (II) and Ag (I) metal complexes from the presented series showed high cytotoxic activity against HeLa cells with IC50 values ranging from 2.08 to >300 µM. Specifically, compound L3-Ag showed one of the highest cytotoxicity against all cancer cell lines with IC50 values between 3.30 to 16.18 µM among other tested compounds