In-situ co-amorphization of olanzapine in pellets

Poster presented at the 13th PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Rotterdam, The Netherlands, 28-31 March 2022N/

System analysis of metabolism in Helicobacter pylori

Systems biology integrates different levels of information for understanding biological systems. The availability of the genome sequence of Helicobacter pylori has allowed the construction of a genome-scale metabolic model for this organism. In order to study the behaviour of H. pylori and understand the mechanisms associated with infection using systems biology tools and controlled cultivation conditions, fermentations in a chemically defined medium were performed and several conditions were tested. The experimental data obtained were compared with simulated data generated by the existing model. The simultaneous use of both approaches allows to correct the in silico model and, on the other hand, to rationally adjust the medium components. The improvement of the genome-scale metabolic model will allow the identification of potential targets in order to design more effective drugs for the inactivation of H. pylori

Electroconvulsive therapy for Patients with Intellectual Disability. When and how?

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Electroconvulsive therapy for Depression in Anorexia Nervosa. A review

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Family farmers as agents of resilience in the Western Region of Santa Catarina (Brazil)

This article analyses how the resilience of family farmers has contributed to the development of the western region of Santa Catarina, Brazil. Despite having largest agro-industrial complex in Latin America, the region has faced cyclical crisis and challenges in recent decades. In fact, the quality of life of the rural population - the region is the main strongholds of family farming in Brazil - has not improved. Rural exodus, an aging population and the impairment of environmental quality are some of the evidences that point to the limits of the adopted agribusiness model. Family farmers and their organizations have responded to this socioeconomic environment of uncertainty with adaptive strategies based on local resilience, such as pluriactivity, productive diversification, transformation of raw materials in the property and production for own consumption. These strategies have served not only for the social reproduction of the group but also have contributed to a renewed regional dynamismEste artículo analiza cómo la resiliencia de las explotaciones agrarias familiares contribuye al desarrollo de la región occidental del Estado de Santa Catarina en Brasil. A pesar de acoger un complejo agroindustrial con larga tradición en America Latina, la región ha sufrido crisis cíclicas en las recientes décadas. De hecho, la calidad de vida de la población rural no ha mejorado en esta región, que es la más importante del Brasil en agricultura familiar. La emigración rural, el envejecimiento de la población y la no consideración de la calidad ambiental son algunas de las evidencias que fijan los límites del modelo de los "agro-negocios". Los agricultores familiares y sus organizaciones han respondido a esta situación de incertidumbre socioeconómica adoptando estrategias que se basan en la resiliencia local, tales como la pluriactividad, la diversificación productiva, la transformación de materias primas en la explotación y produciendo para el autoconsumo. Estas estrategias han servido, no únicamente para la reproducción social del grupo, sino también para revitalizar el dinamismo en esta región

Alongamento in vitro de brotações de Eucalyptus benthamii Maiden & Cambage x Eucalyptus dunnii Maiden.

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Avaliação preliminar de variedades de tangeleiros em Barcarena, Pará.

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Atividade anti-protozoários de Croton cajucara Benth. e do 7-Hidroxi-calameneno.

O objetivo deste trabalho foi avaliar a atividade anti-protozoários de óleos essenciais obtidos de 5 diferentes acessos de sacaca e do 7-hidroxi-calameneno isolado desses óleos contra parasitas do gênero Leishmania e Trypanosoma