Angle-resolved photoemission spectroscopy with quantum gas microscopes

Quantum gas microscopes are a promising tool to study interacting quantum many-body systems and bridge the gap between theoretical models and real materials. So far they were limited to measurements of instantaneous correlation functions of the form $\langle \hat{O}(t) \rangle$, even though extensions to frequency-resolved response functions $\langle \hat{O}(t) \hat{O}(0) \rangle$ would provide important information about the elementary excitations in a many-body system. For example, single particle spectral functions, which are usually measured using photoemission experiments in electron systems, contain direct information about fractionalization and the quasiparticle excitation spectrum. Here, we propose a measurement scheme to experimentally access the momentum and energy resolved spectral function in a quantum gas microscope with currently available techniques. As an example for possible applications, we numerically calculate the spectrum of a single hole excitation in one-dimensional $t-J$ models with isotropic and anisotropic antiferromagnetic couplings. A sharp asymmetry in the distribution of spectral weight appears when a hole is created in an isotropic Heisenberg spin chain. This effect slowly vanishes for anisotropic spin interactions and disappears completely in the case of pure Ising interactions. The asymmetry strongly depends on the total magnetization of the spin chain, which can be tuned in experiments with quantum gas microscopes. An intuitive picture for the observed behavior is provided by a slave-fermion mean field theory. The key properties of the spectra are visible at currently accessible temperatures.Comment: 16+7 pages, 10+2 figure

Disparities in Child and Adolescent Mental Health and Mental Health Services in the U.S.

This is one of a series of five papers outlining the particular domains and dimensions of inequality where new research may yield a better understanding of responses to this growing issue.Mental health is recognized as a central determinant of individual well-being, family relationships, and engagement in society, yet there are considerable variations in mental health and mental health care according to race and ethnicity among youth in the U.S.In their report, Margarita Alegría and colleagues investigate disparities in mental health and mental health services for minority youth. Taking a developmental perspective, the authors explore four areas that may give rise to inequalities in mental health outcomes, highlight specific protective factors and barriers to care, and, finally, outline an agenda for future research

Black Hole Feedback On The First Galaxies

We study how the first galaxies were assembled under feedback from the accretion onto a central black hole (BH) that is left behind by the first generation of metal-free stars through self-consistent, cosmological simulations. X-ray radiation from the accretion of gas onto BH remnants of Population III (Pop III) stars, or from high-mass X-ray binaries (HMXBs), again involving Pop III stars, influences the mode of second generation star formation. We track the evolution of the black hole accretion rate and the associated X-ray feedback starting with the death of the Pop III progenitor star inside a minihalo and following the subsequent evolution of the black hole as the minihalo grows to become an atomically cooling galaxy. We find that X-ray photoionization heating from a stellar-mass BH is able to quench further star formation in the host halo at all times before the halo enters the atomic cooling phase. X-ray radiation from a HMXB, assuming a luminosity close to the Eddington value, exerts an even stronger, and more diverse, feedback on star formation. It photoheats the gas inside the host halo, but also promotes the formation of molecular hydrogen and cooling of gas in the intergalactic medium and in nearby minihalos, leading to a net increase in the number of stars formed at early times. Our simulations further show that the radiative feedback from the first BHs may strongly suppress early BH growth, thus constraining models for the formation of supermassive BHs.Astronom

Equation of state sensitivities when inferring neutron star and dense matter properties

Understanding the dense matter equation of state at extreme conditions is an important open problem. Astrophysical observations of neutron stars promise to solve this, with NICER poised to make precision measurements of mass and radius for several stars using the waveform modelling technique. What has been less clear, however, is how these mass-radius measurements might translate into equation of state constraints and what are the associated equation of state sensitivities. We use Bayesian inference to explore and contrast the constraints that would result from different choices for the equation of state parametrization; comparing the well-established piecewise polytropic parametrization to one based on physically motivated assumptions for the speed of sound in dense matter. We also compare the constraints resulting from Bayesian inference to those from simple compatibility cuts. We find that the choice of equation of state parametrization and particularly its prior assumptions can have a significant effect on the inferred global mass-radius relation and the equation of state constraints. Our results point to important sensitivities when inferring neutron star and dense matter properties. This applies also to inferences from gravitational wave observations

GATA2 mutations in myeloid malignancies: Two zinc fingers in many pies

The GATA family of transcription factors are zinc finger (ZF) DNA‐binding proteins that regulate transcription during development and cell differentiation. GATA2 plays an essential role in the regulation of hematopoiesis. As a result, mutations in this gene or alterations in its expression level or function have been linked to a variety of human hematologic disorders. In this review, we summarize the findings and developments over the recent years regarding the clinical correlations and functional properties of distinct GATA2 mutations in hematopoietic malignancies, with particular focus on the mutational hotspots in the ZF domains

Viable tax constitutions

Taxation is only sustainable if the general public complies with it. This observation is uncontroversial with tax practitioners but has been ignored by the public finance tradition, which has interpreted tax constitutions as binding contracts by which the power to tax is irretrievably conferred by individuals to government, which can then levy any tax it chooses. However, in the absence of an outside party enforcing contracts between members of a group, no arrangement within groups can be considered to be a binding contract, and therefore the power of tax must be sanctioned by individuals on an ongoing basis. In this paper we offer, for the first time, a theoretical analysis of this fundamental compliance problem associated with taxation, obtaining predictions that in some cases point to a re-interptretation of the theoretical constructions of the public finance tradition while in others call them into question

Diagnostic applications of next generation sequencing: working towards quality standards

Over the past 6 years, next generation sequencing (NGS) has been established as a valuable high-throughput method for research in molecular genetics and has successfully been employed in the identification of rare and common genetic variations. All major NGS technology companies providing commercially available instruments (Roche 454, Illumina, Life Technologies) have recently marketed bench top sequencing instruments with lower throughput and shorter run times, thereby broadening the applications of NGS and opening the technology to the potential use for clinical diagnostics. Although the high expectations regarding the discovery of new diagnostic targets and an overall reduction of cost have been achieved, technological challenges in instrument handling, robustness of the chemistry and data analysis need to be overcome. To facilitate the implementation of NGS as a routine method in molecular diagnostics, consistent quality standards need to be developed. Here the authors give an overview of the current standards in protocols and workflows and discuss possible approaches to define quality criteria for NGS in molecular genetic diagnostics

NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum

The treatment of Neospora caninum infection in the bovine host is still at an experimental stage. In contrast to the in vivo situation, a wide range of compounds have been intensively investigated in cell-culture-based assays. Tools to demonstrate efficacy of treatment have remained conventional including morphological and cell biological criteria. In this work, we present a molecular assay that allows the distinction between live and dead parasites. Live parasites can be detected by measuring the mRNA level of specific genes, making use of the specific mRNA available in live cells. The NcGra2 gene of N. caninum, which is known to be expressed in both tachyzoites and bradyzoites, was used to establish a quantitative real-time RT-PCR, for monitoring parasite viability. Validation of the system in vitro was achieved using Neospora-infected cells that had been treated for 2-20 days with 30μg/ml toltrazuril. NcGRA2-RT-real time PCR demonstrated that a 10-day toltrazuril-treatment exerted parasitostatic activity, as assessed by the presence of NcGRA2-transcripts, whereas after a 14-day treatment period no NcGRA2-transcripts were detected, showing that the parasites were no longer viable. Concurrently, extended culture for a period of 4 weeks in the absence of the drug following the 14-day toltrazuril treatment did not lead to further parasite proliferation, confirming the parasiticidal effect of the treatment. This assay has the potential to be widely used in the development of novel drugs against N. caninum, with a view to distinguishing between parasiticidal and parasitostatic efficacy of given compound