儿童食管烧伤研究进展

19世纪末20世纪初,随着强碱、强酸性清洁剂进入市场,儿童误食导致食管化学性烧伤时有发生,尤其是在发展中国家[1]。儿童食管烧伤多发于5岁及以下的儿童[2],常见的5类儿童误食物分别是化妆品/个人护理产品(13.5%),止痛药(9.7%),日用品清洁物质(9.7%),异物/玩具/杂物(7.5%)和外用制剂(6.9%)。本文将从儿童食管烧伤的病理机制、临床特点、治疗进展和并发症处理等方面作一综述

The correlation between body mass index,waist-to-hip ratio,waist circumference chronic hepatitis B with nonalcoholic fatty liver diseases

目的探讨体质量指数(bMI)、腰臀比(WHr)与慢性乙型肝炎(CHb)并非酒精性脂肪性肝病(nAfld)的相关性。方法研究对象为厦门大学附属东南医院肝病中心住院的110例nAfld患者和143例CHb并nAfld患者,选取同期健康体检者23例为对照组。采用方差分析(AnOVA)、bOnfErrOnI法,比较三组间bMI、WHr、腰围(WC)、空腹血糖(fbg)、胆固醇(TCHO)、甘油三酯(Tg)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(AlT)、碱性磷酸酶(AlP)、谷氨酰转移酶(ggT)的差别,分析各项指标与CHb并nAfld的相关性。结果与对照组相比,nAfld组和CHb并nAfld组的bMI、WHr、WC、Tg、AST、AlT、ggT水平均显著增加(P0.05)。结论 CHb并nAfld患者的发病机制与血脂紊乱相关,尤其是高Tg血症,临床中监测WHr与WC有助于CHb并nAfld的早期诊断。Objective To explore the correlation between body mass index (BMI),waist to hip ratio (WHR) and chronic hepatitis B (CHB) patients with nonalcoholic fatty liver diseases (NAFLD).Methods A total of 110 subjects with NAFLD and 143 CHB patients with NAFLD were enrolled in Dongnan Affiliated Hospital of Xiamen University,and 23 normal subjects were selected as control group.Differences of BMI,WHR,waist circumference (WC),fasting plasma glucose (FPG),total cholesterol (TCHO),triglyceride (TG),aspartate aminotransferase (AST),alanine aminotransferase (ALT),alkaline phosphatase (ALP),gamma-glutamyl transpeptidase (GGT) among three groups were analyzed by ANOVA and Bonferroni correction methods.Results Compared with the control group,the levels of BMI,WHR,WC,TG,AST,ALT,GGT were significantly higher in CHB patients with NAFLD and NAFLD patients (P< 0.05).WHR and WC of NAFLD patients were higher than that of CHB patients with NAFLD.There was no significant difference in other indexes.Conclusions The hepatic steatosis changes in CHB patients with NAFLD are mainly caused by the metabolic factors.WHR and WC may be helpful for early diagnosis in CHB patients with NAFLD.福建省漳州市科技计划资助项目(No.Z04094

非活动性HBsAg携带者并妊娠期急性脂肪肝一例报道

妊娠急性脂肪肝(ACuTE fATTy lIVEr Of PrEgnAnCy,AflP)多发生于妊娠28~40周,临床上并不少见,近年报道该病例有增多趋势[1];AflP起病急、病势凶险,病死率及早期诊断与治疗措施密切相关;随着乙肝疫苗的广泛接种,我国HbSAg阳性率显著降低,但仍高达7.18%[1],育龄期孕妇HbSAg阳性率达8.16%[2],高于普通人群的HbSAg阳性率,非活动性HbSAg携带者并AflP临床上较为少见,本文报道1例如下。一、病历摘要患者,女,20岁,因“停经24周,乏力

慢性乙型肝炎伴劳-蒙-毕综合征1例

患者,男性,10岁,因“乏力、食欲不振、尿黄8月余“于2010年5月入院。患儿父母诉患儿自幼双手六指畸形,右侧隐睾,于3岁时曾行左侧畸形手指矫正术,7岁发现智力落后于同龄儿、生长缓慢,9岁行右侧睾丸复位固定术。患者为第1胎第1产,父母非近亲结婚,母孕期间曾有“上呼吸道感染“病史,否认家族中有其他遗传病病史

妊娠急性脂肪肝2例报告

病例1:女,27岁。停经36周伴瘙痒、呕吐、腹泻、尿少15 d。查体:皮肤、巩膜重度黄染,未见肝掌、蜘蛛痣,静脉穿刺部位片状瘀斑、心率86次/MIn、律齐、未闻及杂音,双下肺闻及少许干湿啰音;腹部膨隆,双下肢轻度水肿。实验室检查:血常规:WbC 18.65x109/l、n 0.885、PlT 82x109/l;生化:glu 3.6 MMOl/l、urEA 8.16 MMOl/l、r

慢性乙型肝炎合并非酒精性脂肪性肝病患者体质量指数与血脂水平的研究

目的研究慢性乙型肝炎(CHb)合并非酒精性脂肪性肝病(nAfld)患者体质量指数(bMI)和血脂与其发病的关系。方法选取经临床和病理确诊的CHb并nAfld患者80例为病例组,另选取同期住院的47例CHb患者为对照组;测量身高、体质量,同时检测两组患者的总胆固醇(TC)、甘油三酯(Tg),采用病例对照研究的方法,lOgISTIC回归分析bMI、TC、Tg与CHb并nAfld的相关性。结果两组患者的bMI、TC、Tg水平的差异有统计学意义(P<0.05);bMI、TC及Tg均为CHb并nAfld的危险因素(P<0.05);经lOgISTIC回归分析,bMI、Tg与CHb并nAfld有相关性(P<0.01)。结论 TC对CHb并nAfld的发病无明显影响,bMI和Tg均为CHb并nAfld的独立影响因子;Tg在预测CHb并nAfld的发生上比bMI更具有优势。福建省漳州市科技计划资助项目(Z04094);09军区面上B类(09MB131

City-Regional Governance from the Perspective of Comparison:Conception Clarification, Theory Development and Research Progress

“治理“是国际上处理区域事务的基本理念,强调多利益协调、多元协同等理念,大都市区治理是区域治理的重要尺度层面,也最能体现“政府、市场、公民社会“三者关系。在剖析治理、区域治理及大都市区治理等概念基础上,梳理了大都市区治理理论的发展脉络,进一步研究国内外大都市区治理的主要内容,并进行比较与评述。国内外大都市区治理理念一致,但由于国情差别,研究领域、关注重点、治理机制和具体实践差别较大。国外较为注重“多元利益协调“基础上大都市区治理问题研究,充分考虑各方面诉求,并关注地区社会公平、公共资源和环境问题;国内较注重“政府间关系“基础上的大都市区治理研究、本土化探讨等,实践中均以政府为主导,对其他利益诉求考虑不充分。"Governance" is a basic concept in regional affairs around the world which emphasizes different interests and multiparty coordination.City-regional governance is an important dimension of regional governance, which can best embody the relations between "the government, market and civil society".On the basis of analyzing the concept of the governance, regional governance and city-regional governance, the paper hackle the development and main content of city-regional governance at home and abroad connotation, then do comparison and analysis.City-regional governance theory is consistent at home and abroad connotation.But due to national differences, there are great differences in governance mechanism, research focus and practice method.The research pays more attention to "multiple interest coordination" of city-regional governance issues, fully considers all aspects of the demands and concerns of social justice areas, public resources and environmental issues aboard.The domestic research pays more attention on city-regional governance and localization discussing on "intergovernmental relations" view.It's based on government-led in practice,and lacking of other interest demands.国家自然科学基金青年项目(51208444); 教育部人文社会科学研究青年基金项目(11YJCZH058); 中央高校基本科研业务费项目(20720140519

过滤、吸附及灭活病毒的纳米催化材料的快速筛选方法

本发明涉及催化材料，具体地说是一种过滤、吸附及灭活病毒的纳米催化材料的快速筛选方法，具体操作为：1)以100～1000个碱基的核酸分子片段作为探针，采用喷洒或浸泡的方式将核酸分子吸附于催化剂上，然后用不少于探针原液9倍的水进行洗脱，筛选出吸附能力强的、即吸附量为原液重量60％)以上的催化剂；2)将上述步骤选取的催化剂对目标病毒进行吸附、洗脱，对催化剂用水或生理盐水一次或多次洗脱，然后对洗脱液中的病毒进行传统的活性检测；筛选出对病毒的过滤、吸附及灭活作用好的、即吸附量为原液重量95％的催化剂。本发明首先以核酸分子作为探针，建立了对纳米催化材料吸附性能和抗水性能进行快速筛选和评价的方法。带填