Menin mediates Tat-induced neuronal apoptosis in Tat-treated cells and in brain frontal cortex of SIV-infected macaques

神经元凋亡是人类免疫缺陷病毒相关神经认知紊乱(HumanImmunodeficiencyVirus-AssociatedNeurocognitiveDisorder，HAND)的主要病理特征。神经元凋亡与HIV-1Tat蛋白（简称Tat）有关，但具体机制尚不十分清楚。最近的研究表明：Tat的反式激活需要多发性内分泌肿瘤Ⅰ型（MEN1）肿瘤抑制蛋白menin参与，提示menin可能参与到Tat诱导的神经元损伤中。本研究从细胞实验、SIV感染恒河猴动物模型两个层面，使用Westernblot、TUNEL染色、qRT-PCR、免疫组化二重染色等实验方法，深入探究menin是否可以介导Tat诱导的神经...Neuronal apoptosis is the main pathological feature in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND). Neuronal apoptosis is associated with HIV-1 transactivator of transcription (Tat) protein, but the mechanism of apoptosis remains poorly unclear. Recent studies suggested that the transactivation of HIV-1 Tat required multiple endocrine neoplasia type 1 (MEN1) tumor ...学位：理学硕士院系专业：医学院_微生物学学号：2452014115347

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中枢神经系统（CNS）由大量的神经细胞组成,星形胶质细胞是其中分布最广的一类神经胶质细胞,具有营养支持、调节神经递质及影响突触功能等多种生理功能。星形胶质细胞高表达基因-1（AEG-1）是一种原癌基因,对多种CNS肿瘤细胞的增殖、发展及转移有重要影响。本文从AEG-1对CNS肿瘤的诊断、治疗和预后评估方面的作用进行综述,寻找新的标志物用于CNS肿瘤的诊断和治疗

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JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies