控股股东股权质押与企业投资行为——基于金融投资和实业投资的视角

本文以2007—2017年我国沪深两市非金融上市公司的半年度数据为研究对象,从金融投资和实业投资的视角,考察了控股股东股权质押对上市公司投资行为的影响。实证研究发现,控股股东股权质押比例与上市公司的金融投资水平呈U形关系,与上市公司的实业投资水平呈倒U形关系。这说明不同质押比例下控股股东出于不同的动机做出的改变和调整上市公司的投资决策,对金融投资和实业投资产生非线性影响。以上结论在尽可能控制内生性问题以及一系列稳健性检验后依然成立。进一步研究发现:产权性质、控制权转移风险以及金融资产与经营资产收益率差对控股股东股权质押比例与上市公司投资行为之间的关系具有重要的调节作用。本研究揭示了控股股东股权质押在公司投资策略方面的经济后果,低质押比例的控股股东更有可能支持上市公司,而高质押比例的控股股东更可能损害上市公司提供了增量证据

Syndrome Index System Screening Based on Expert Questionnaire of Correspondence Between Traditional Chinese Medicine Syndrome and Symptom of Sub-health

目的:筛选亚健康中医证候指标,建立亚健康证-症对应关系。方法:采用专家问卷调查,考核专家权威系数、协调系数,运用均值,等级和,满分比等方法对亚健康脾气虚证、心气虚证、肺气虚证、肝气郁结证、火证和湿证6个中医证候对应的63个症状进行筛选。共有40位专家参与此次问卷调查。结果:问卷回收率为87.5%,34份有效问卷参与统计分析。问卷单个领域和总体的权威系数均≥0.8,问卷单个领域和总体的专家协调系数检验均具有统计学意义(P<0.01),问卷总体的专家协调系数为0.479。经过筛选,最后筛选出6个亚健康证候所对应的43项症状指标。结论:在保证专家群体具有较高权威性、协调性的情况下,运用专家问卷调查法,结合相关数理评价指标对亚健康中医证候指标体系进行筛选是有效的可行的。Objective: To screen the sub-health traditional Chinese medicine( TCM) syndrome indexes,and establish the corresponding relationship between sub-health syndromes-symptoms. Method: Expert questionnaire survey was used to test the authority coefficient and the coordination coefficient of experts,with use of means,sum of ranks,ratio of full marks to screen 63 symptoms included in the 6 TCM syndromes of spleen-Qi deficiency,heart-Qi deficiency,lung-Qi deficiency,liver stagnation,fire syndrome and dampness syndrome. A total of 40 experts were involved in the questionnaire survey. Result: The questionnaire recovery rate was 87. 5%,and 34 valid questionnaires were involved in statistical analysis. The overall and individual questionnaire authority coefficient was 0. 8 or higher,with statistical significance in overall and individual questionnaire coordination coefficient( P < 0. 01). The overall experts coordination coefficient was 0. 479. After screening,finally 43 symptoms in 6 sub-health syndromes were selected. Conclusion: Under the condition of a high degree of authority and coordination for the experts group,it is effective and feasible to screen the sub-health TCM syndrome indexes by using expert questionnaire survey combined with the relevant mathematical evaluation indexes.国家自然科学基金项目(81403324);; 广东省中医药管理局科研课题(20141211

Effects of Ciji Hua'ai Baosheng Decoction on peripheral blood cells and spleen hematopoietic growth factors of tumor chemotherapy model mice with H22 hepatoma carcinoma cells

目的:研究慈济化癌保生汤(CHBT)对H22肝癌化疗小鼠外周血细胞以及脾脏造血生长因子红细胞生成素(EPO)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)以及造血功能的作用。方法:将肝癌H22细胞悬液(2×107/m L)接种于Kunming种小鼠右前腋皮下,约7d后,全部形成移植瘤,环磷酰胺(CTX)按200mg/kg(0.2m L/10g)腹腔注射,建立H22肝癌小鼠化疗模型。随机分为模型组,CTX(0.033g/kg)组,CHBT高、中、低剂量(117、58.5、29.25g/kg)组,连续给药10d,采用全自动血细胞分析仪检测外周血红细胞、白细胞、血小板和血红蛋白,运用酶联免疫吸附测定法检测脾组织EPO和GM-CSF含量。结果:与模型组和CTX组比较,CHBT高、中、低剂量组红细胞、白细胞、血小板数量明显升高(P<0.05,P<0.01);CHBT高、中剂量组血红蛋白升高(P<0.05,P<0.01);CHBT各剂量组EPO、GM-CSF含量升高(P<0.01,P<0.05)。结论:慈济化癌保生汤能促进化疗后EPO和GM-CSF的生成并增强活性,刺激血细胞的产生,维持外周血象稳定性。Objective: To investigate the effects of Ciji Hua'ai Baosheng Decoction(CHBT) on peripheral blood cells, spleen hematopoietic growth factors such as erythropoietin(EPO) and granulocyte-macrophage colony stimulating factor(GM-CSF), and blood-producing function of tumor chemotherapy model mice with H22 hepatoma carcinoma cells. Methods: The suspension of H22 hepatoma carcinoma cells(2×107/m L) were subcutaneously injected into the right anterior armpit of Kunming mice. After 7 days, all mice formed the transplanted tumors, and then the cytoxan(CTX) at the dosage of 200mg/kg were intraperitoneally injected into the mice to establish the tumor chemotherapy model. The mice were randomly divided into model group, CTX(0.033g/kg) group, CHBT high, middle and low dose(117, 58.5, 29.25g/kg) groups. The experiment groups were treated for 10 days. The levels of red blood cells, white blood cells, platelet and hemoglobin in peripheral blood were detected by automatic blood cell analyzer. The contents of EPO and GM-CSF in spleen tissue were assayed by enzyme-linked immunosorbent assay. Results: Compared with model group and CTX group, the levels of red blood cells, white blood cells and platelet in high, middle and low dose CHBT groups were increased significantly(P<0.05, P<0.01), the levels of hemoglobin in CHBT high and middle dose groups were increased(P<0.05, P<0.01), the contents of EPO and GM-CSF in CHBT high, middle and low dose groups were increased significantly(P<0.05, P<0.01). Conclusion: The CHBT in given concentration could promote the production of EPO and GM-CSF after tumor chemotherapy and stimulate the hemocytogenesis to maintain the stability of peripheral haemogram, which may be the possible mechanism of CHBT ameliorating the haemogram of cancer after chemotherapy.国家自然科学青年基金项目(No.81202659);; 厦门市重大科技计划项目(No.3502Z20100006);; 福建省自然科学基金项目(No.2014J01373);; 厦门市科技计划项目(No.3502Z20153027)~

中医“状态辨治”构建的必要性及其应用举隅

中医\"状态辨治\"思维及其相关理论的构建,对突破单纯辨病或辨证或辨症思维方式有建设性意义,对完善中医辨证论治体系不无裨益。文章着眼于把生命从出生、成长到死亡的起伏看成不同的状态,从状态角度辨治,力求达到从定性到定量的精准治疗;同时提出中医治疗就是人体\"土壤改造\"的过程,帮助理解状态辨治。最后通过列举1则状态辨治的验案以期理解中医\"状态辨治\"的内涵。厦门市重大科技计划项目(No.3502Z20100006);;厦门市科技计划高校创新项目(No.3502 Z20153027)~

Academic and clinical experience of professor WANG Yan-hui in treatment for cancer with heavy prescription

文章总结了厦门大学医学院王彦晖教授治疗癌症的临床经验,突出了其善用重剂治疗癌症的特色。王彦晖教授认为,癌症本质上是实证,痰浊和瘀血贯穿于癌症病程的全过程,在癌症的病理病机中,痰瘀是相对不变的,而气滞、寒热、肺虚、脾虚、肾虚等病理病机则是可变的;癌症的治疗,王教授善用重剂,非常重视化痰散结和活血化瘀的治法,并注意处理好祛邪与扶正的关系、调理好寒热和气机升降出入的状态;王教授认为,应该重视中医药在癌症预防方面的独特作用。最后,文章以两个典型病案展示了王彦晖教授治疗癌症的学术特色。The academic and clinical experience of WANG Yan-hui, the professor of medical college of Xiamen University, treated the cancer with heavy prescription was introduced in this paper.Professor WANG Yan-hui thought that excess syndrome was the essential syndrome of cancer and the pathogenic effect of phlegm and blood stasis was throughout its whole process.In the pathological mechanism of cancer, phlegm and blood stasis were relatively invariable, on the contrary the others such as qi stagnation, coldness and heat, lung deficiency, spleen deficiency, kidney deficiency and so on were variable.In the treatment of cancer, heavy prescription was used by professor WANG, who paid attention to reduce phlegm and resolve masses, promote blood circulation to remove blood stasis, the balance of eliminating evil and strengthening the body resistance, the regulation of coldness and heat and the ascent, descent, going out and in of qi.Professor WANG thought that the distinctive effect of Chinese medicine in the treatment of cancer should be valued.Finally, two typical cases were selected for showing the academic characteristic of professor WANG in the treatment of cancer.厦门市重大科技计划项目(No.3502Z20100006)~

秦子文对中药药性及相关理论认识

文章对清末湖北名医秦子文《玲珑医鉴》抄本中以歌括呈现的中药药性及相关理论进行了一定的总结,并认为该书作者秦子文对中药基本理论不仅有独到的见解,而且补充和完善了相关用药理论,如四性分类法、五脏六腑虚实寒热引经用药等。希望通过总结秦子文对中药理论的部分认识,能够为临床用药发挥指导作用并对相关研究有所启发

Effects of Taohong Siwu Decoction on the expression of pathological angiogenesis correlation factors including VEGF,KDR and Flt-1 in hepatic fibrosis mice

目的:从整体水平研究复方桃红四物汤对四氯化碳所致肝纤维化模型小鼠肝组织血管内皮生长因子(VEGF)、含激酶插入区受体(KDR)及Flt-1蛋白与mRNA表达的影响。方法:昆明小鼠60只,随机分组为空白组,模型组,秋水仙碱组,桃红四物汤高、中、低(17.00、8.50、4.25g/kg)剂量组,采用左侧腹股沟处皮下注射四氯化碳花生油溶液建立小鼠肝纤维化模型,给药6周后,运用酶联免疫吸附测定(ELISA)法检测肝组织VEGF蛋白含量;蛋白印迹法(Western blot)测定小鼠肝脏KDR、Flt-1蛋白的表达;逆转录PCR(RT-PCR)法测定小鼠肝脏VEGF、KDR及Flt-1 mRNA表达。结果:桃红四物汤治疗后,桃红四物汤高、中剂量组肝组织VEGF蛋白表达量较模型组降低(P<0.05,P<0.01),中药高剂量组肝组织KDR与Flt-1蛋白表达较模型组显著降低(P<0.05);而桃红四物汤高、中剂量组肝组织VEGF、KDR与Flt-1 mRNA表达较模型组、秋水仙碱组明显减少(P<0.01),并且呈现一定的量效正相关。结论:桃红四物汤能够降低肝纤维化病理血管生成相关因子的表达,减缓病理性的微血管生成可能是其改善肝纤维化的机制之一。Objective:To investigate the effects of Taohong Siwu Decoction(THSWD) on protein and mRNA expression of vascular endothelial growth factor(VEGF),kinase insert domain containing receptor(KDR) and Flt-1 in hepatic fibrosis model mice caused by CCI_4.Methods:Sixty Kunming mice were randomly divided into blank,model,colchicine(control)and three THSWD(17.00,8.50,4.25g/kg) groups,with 10 mice in each group.Except the blank group,the other groups' mice were subcutaneously injected with carbon tetrachloride(CCI_4)-arachis oil solution in left inguen to establish hepatic fibrosis mouse model.After administration for six weeks,the content of VEGF protein in liver tissue was measured by enzyme-linked immunosorbent assay(ELISA),protein expressions of KDR and Flt-1 in liver tissue were detected by Western blotting,and mRNA expressions of VEGF,KDR and Flt-1 in liver tissue were measured by reverse transcription polymerase chain reaction(RT-PCR).Results:After treatment,the content of VEGF protein in THSWD(17.00,8.50g/kg) groups were lower than that in model group(P<0.05,P<0.01).The protein expressions of liver tissue KDR and Flt-1 in THSWD(17.00g/kg) group were less than that in model group(P<0.05).The mRNA expressions of liver tissue VEGF,KDR and Flt-1 were significantly lower than that in both model and colchicine groups(P<0.01),which showed a certain positive correlation between dose and effect.Conclusion:Taohong Siwu Decoction could decrease the expression of pathological angiogenesis correlation factors of hepatic fibrosis,thus helpful to induce the formation of pathological capillary vessels,which may be one of the possible mechanisms of ameliorating hepatic fibrosis.国家自然科学青年基金项目(No.81202659);; 福建省自然科学基金项目(No.2014J01373);; 厦门大学新聘教师科研启动基金项目(No.ZK1014);; 福建省大学生创新创业训练项目(No.DC2013174)~

Effects of Shenling Baizhu Powder on expression of apoptosis related proteins of tumor chemotherapy model mice with H22 hepatocellular carcinoma cells

目的:研究参苓白术散(SLBZP)对H22肝癌移植瘤小鼠化疗后肿瘤凋亡相关因子Caspase -3、; Caspase-9、X染色体连锁凋亡抑制因子(XIAP)、血小板源生长因子-BB(PDGF-BB)、血管生成素-1(Ang-1)、血管生成素-2; (Ang-2)表达的影响。方法:SPF级昆明小鼠64只,将肝癌H22细胞悬液(2*10~7/mL)接种于小鼠右前腋皮下,1周全部形成移植瘤后,行; 环磷酰胺(CTX,0.20g/kg,0.2mL/10g)腹腔注射,建立肿瘤化疗模型。随机分组为8组:模型组,CTX(0.02g/kg)组,SLB; ZP高、中、低(6.00、3.00、1.50g/kg)剂量组,SLBZP高、中、低剂量+CTX(0.02g/kg)组,给药14d后,运用蛋白印迹; 法(Western blot)测定小鼠瘤组织中Caspase-3、; Caspase-9、XIAP蛋白表达;酶联免疫吸附(ELISA)测定小鼠血清PDGF-BB、Ang-1、Ang-2表达。结果:SLBZP联合治疗; 各组抑瘤作用明显,CT X组,SLBZP高剂量组,SLBZP高、中剂量+C T X组抑瘤率分别为52.39%、; 45.84%、58.41%、52.77%。与模型组比较,各治疗组血清PDGF-BB、Ang-1、Ang-2及瘤组织中XIAP表达呈现出被下调的趋; 势,瘤组织中Caspase-3、Caspase-9表达呈现出被上调的趋势,且以SLBZP高剂量加CTX组变化幅度最为显著(P<0.01,P<0.; 05)。结论:SLBZP联合化疗可以更有效调节H22肝癌移植瘤小鼠肿瘤凋亡相关因子的表达,促进肿瘤细胞凋亡可能是其改善化疗的机制之一。Objective: To investigate the effects of Shenling Baizhu Powder (SLBZP); on expression of apoptosis related proteins such as Caspase-3,; Caspase-9, X-linked inhibitor of apoptosis (XIAP), PDGF-BB, Ang-1, Ang-2; of tumor chemotherapy model mice with H22 hepatocellular carcinoma; cells. Methods: Sixty-four Kunming mice were subcutaneously injected; with suspension of H22 hepatocellular carcinoma cells (2*10~7/mL) into; the right anterior armpit. After 1 week, all transplanted tumors were; formed and the mice were received intraperitoneal injection with cytoxan; (CTX) with the dosage of 0.2g/kg to establish the tumor chemotherapy; model. Then mice were randomly divided into eight groups. CTX group was; treated with CTX (0.02g/kg), the model group was treated with; physiologic saline, three SLBZP groups were treated with SLBZP (6.00,; 3.00, 1.50g/kg), and other three groups were treated with SLBZP (6.00,; 3.00, 1.50g/kg) plus CTX (0.02g/kg). After all groups were treated for; 14 days, Western blot was used to detect the expression of Caspase-3,; Caspase-9 and XIAP proteins in tumor tissue, and protein expression of; PDGF-BB, Ang-1, Ang-2 in blood was measured by enzyme-linked; immunosorbent assay (ELISA). Results: The combined treatment group had; obvious effect on tumor inhibition. Tumor inhibitory ratios in CTX; alone, SLBZP (H), SLBZP (H) plus CTX, and SLBZP (M) plus CTX groups were; 52.39%, 45.84%, 58.41% and 52.77% respectively. Compared to the model; group, the protein expressions of PDGF-BB, Ang-1, Ang-2, and XIAP in; tumor tissue were obviously lower than those in all treated groups. And; the expressions of Caspase-3 and Caspase-9 in tumor tissue showed a; trend of up-regulation. And the effect in SLBZP (H) plus CTX group was; the most significant (P<0.01, P<0.05). Conclusion: SLBZP can more; effectively adjust the expression of apoptosis related proteins of tumor; in mice with H22 hepatocellular carcinoma cells, and promoting tumor; apoptosis may be one of the possible mechanisms of SLBZP to improve; chemotherapy in treating hepatic cancer.国家自然科学青年基金项目; 福建省自然科学基金项目; 福建省大学生创新创业训练项

《黄帝内经》胃本源理论临床意义及对消化系统肿瘤防治的作用

文章通过对《黄帝内经》经文"胃者,五脏之本也"的深入理解,从生理和病理角度,论述了胃对于正常机体、疾病的产生、病情判断及临床用药等方面的重要作用与指导意义;并从胃五脏本源的角度对消化系统恶性肿瘤食管癌、胃癌、大肠癌、原发性肝癌、胆管癌、胰腺癌的认识和防治进行了理论阐述

癌症“种子土壤说”新论

\"种子土壤\"理论最初被应用于肿瘤转移相关学说,文章根据癌症的发生、发展和转移等规律,从另一个全新的角度来定义\"种子土壤说\",呈现直观又形象的癌症解读,并且将这种理论应用于指导癌症的诊断、预防和治疗,体现出在未来中医和西医的融合必将会是医学发展的大势所趋。厦门市重大科技计划项目(No.3502Z20100006);;厦门市科技计划高校创新项目(No.3502Z20153027)~