The Role and Mechanism of Dihydroartemisinin in the Development of Non-Small Cell Lung Carcinoma

背景及目的 肺癌是最常见的恶性肿瘤，在全世界范围内，也是肿瘤导致死亡的首位原因。非小细胞肺癌是肺癌最常见的一种类型。非小细胞肺癌细胞对凋亡的抵抗性是抗肿瘤治疗的一大主要的障碍。因此，目前研究关注的热点是那些能提高治疗抵抗非小细胞肺癌细胞凋亡的新型复合物的发展。双氢青蒿素是一种重要的青蒿素衍生物，是从中草药植物青蒿素中提取出来的天然产物。作为一种非常有效的抗疟疾药物，双氢青蒿素（DHA）在全世界范围内已经是治疗抗疟原虫的一线治疗药。近期研究发现DHA对乳腺癌，乳头瘤病毒导致的宫颈癌，肝癌和胰腺癌有着良好的效果，此外，DHA对肺癌可以通过诱导凋亡达到抗肿瘤的作用，而没有明显的副作用。并且，电离辐...Abstract Background and Objective Lung cancer is the most common malignant tumor and the leading cause of cancer-relatedmortality worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lungcancer. Resistance of NSCLC cells to apoptosis is a major obstacle in anticancer treatment. Accordingly,current researches focus on the development of innovative compounds that promotethe apo...学位：医学硕士院系专业：医学院_外科学学号：2452013115350

Effects of La~(3+) on H~+ Transmembrane Gradient and Membrane Potential in Rice Seedling Roots

The effects of LaCl 3 on membrane potential and transmembrane proton gradient for rice ( Oryza sativa ) seedling roots were studied. Highly purified plasma membranes were isolated by aqueous two phase partitioning method. Both the gradient of transmembrane proton and membrane potential were stimulated by certain low concentration of LaCl 3 and depressed by high concentration of LaCl 3. The optimal concentration of La 3+ was around 40～60 μmol·L -1 for transmembrane proton gradient and membran...国家自然科学基金 ( 39970 438;39870 630 )资助项目 ;; 福建省自然科学基金 (C970 0 2 )资助项

Nutrient requirements and development of formulated diets of mud crab,Scylla sp.

【中文摘要】 青蟹属(Scylla)有锯缘青蟹(Scylla serrata),拟穴青蟹(S.paramamosain),紫螯青蟹(S.tranquebarica)和榄绿青蟹(S.olivacea)等4个种。我国以拟穴青蟹占绝对优势,它有个体大、生长快、适应性强、肉味鲜美、营养丰富等特点,已成为具有重要经济价值的海水养殖蟹类之一。随着青蟹人工育苗技术的突破、养殖技术的改进和多种养蟹形式的开发,养蟹业得到了蓬勃发展,其养殖规模不断扩大,产量不断提高,据统计,2004年全国青蟹养殖产量已达10.85万吨。养蟹产业的形成和持续发展必然要走健康养殖的道路,而健康养殖除了供应高质量苗种和保持良好的养殖环境外,必须供应量足质优的饲料,以满足青蟹的营养需求。然而,尽管我国青蟹养殖已有100多年的历史,但对其营养需求研究和配合饲料研发起步较晚,国外的相关研究也较少,故目前市场上尚未生产出能满足其正常生长发育所需营养需求的配合饲料,养蟹所用的饲料主要是天然低质鱼、虾、贝类等。鲜杂鱼等天然生物饵料资源有限,供应不稳定,使用不方便(需要冷冻保存),营养不全面,自身携带病原菌,且投喂后容易腐烂分解,败坏水质,易导致病害蔓延,难以满足日益扩大的养蟹... 【英文摘要】 The mud crab,Scylla sp.,is an important crustacean species farmed on a commercial scale in China.They are polycultured with fish or shrimp,but mud crabs are now monocultured in increasing density to supply the growing market.This trend has made diet development more important.Information on the nutrients required for growth of mud crabs is vital for the formulation of an effective feed.This paper reviews the current knowledge on Scylla sp.nutrition with special reference to developments during the last deca...国家“八六三”计划项目(2002AA603013); 厦门大学高层次人才引进科研启动项目; 厦门大学“九八五”计划科技创新项目“青蟹亲体脂肪酸营养与幼体发育关系研究

凡纳滨对虾亲虾性腺成熟节律和交配率

在水温(27±2)℃、盐度29±2、pH 7.8~8.5、光强1 000 lx的条件下,对来自中国台湾省的体质量为35~45 g的凡纳滨对虾(Litopenaeus vannameiBoone 1931)亲虾的性腺成熟节律和交配进行了为期73 d的繁育实验,样品为1 300对,3个批次。结果表明,雌虾术后卵巢成熟率分4期:Ⅰ期(1~9 d)入池适应术后效应期;Ⅱ期(10~16 d)低成熟率期,Ⅲ期(17~51 d)成熟率渐上升期,Ⅳ(52~73 d)平稳期;雄虾精荚形成率分3期:Ⅰ期(1~12 d)入池适应与术后效应期;Ⅱ期(13~51 d)平缓上升期,Ⅲ期(52~73 d)平稳期。在95%的概率保证程度下,雌亲虾卵巢成熟率为9.73%,波动区间9.14%~11.53%;雄虾精荚形成率6.63%,波动区间5.87%~7.38%;平均交配率为61.43%,波动区间58.85%~64.00%。在繁殖过程中,雌虾卵巢再成熟时间间隔9.68 d,可多次成熟的次数19.49次,雄虾精荚再形成时间15.10 d,可多次形成的次数为12.50次。此外还就影响雌虾卵巢成熟和雄虾精荚形成的因素以及如何提高交配率进行了详细的讨论... 【英文摘要】 Beginning in 1988,Litopenaeus vannamei was introduced into China,and 1998 on a commercial scale.China now has a large and flourishing industry for Litopenaeus vannamei,with Mainland China producing more than 270?000 metric tonnes in 2002,300?000 metric tonnes(71 percent of the country's total shrimp production) in 2003,and 367?500 metric tonnes(78.5 percent of the country's total shrimp production) in 2004,which is higher than the current production of the whole of the Americas.The intensive culture of Lito...福建省自然科学基金项目(B9910003

Combined Use of Thoracoscopy and Laparoscopy in Total Laryngectomy for Cervical Esophageal Carcinoma

目的探讨胸、腹腔镜联合全喉切除治疗颈段食管的可行性和疗效。方法 2009年1月~2014年7月胸、腹腔镜联合全喉切除治疗33例颈段食管癌。胸腔镜下分离食管、腹腔镜下管胃成形、全喉切除、气管永久造口、胃咽吻合术。结果胸部手术时间40~66 MIn,平均53 MIn;腹部手术时间35~51 MIn,平均44 MIn;颈部手术时间128~150 MIn,平均139 MIn。术中出血量130~270 Ml,平均150 Ml。术后住院时间8~14 d,平均12 d。病理均为鳞状细胞癌,其中高分化2例,中分化19例,中-低分化7例,低分化5例。切缘病理学检查无癌组织残留。31例淋巴结转移。并发症:吻合口漏2例,喉返神经损伤3例,肺部感染6例,胃排空障碍2例,吻合口狭窄1例,无死亡病例。33例随访1个月~5年,术后1、3、5年生存率分别为87.9%、54.5%、45.5%。结论颈段食管癌应采取积极的手术治疗,胃咽吻合术是颈段食管癌切除后较为理想的修复手段。Objective To investigate clinical feasibility and efficacy of combined use of thoracoscopy and laparoscopy in total laryngectomy for cervical esophageal carcinoma.Methods Clinical data of 33 patients with cervical esophageal carcinoma undergoing surgical treatment in our department from January 2009 to July 2014 were analyzed retrospectively.The esophagus was separated under thoracoscopy.And laparoscopic gastroplasty,total laryngectomy,tracheal permanent colostomy,and gastric pharyngeal anastomosis were performed.Results The thoracoscopic operation time was 40- 66 min( mean,53 min),the laparoscopic operation time was 35- 51 min( mean,44 min),and the cervical operation time was 128- 150 min( mean,139 min).The blood loss was 130- 270 ml( mean,150 ml).The postoperative hospital stay was 8- 14 d( mean,12 d).Pathological examinations showed squamous cell carcinoma in all the cases,including 2 cases of highly differentiated carcinoma,19 cases of moderately differentiated carcinoma,7 cases of moderately or lowly differentiated carcinoma,and 5 cases of lowly differentiated carcinoma.No residual cancer was found at cutting edges pathologically.Among the 33 cases,lymph node metastasis was found in 31 cases.Complications included 2 cases of anastomotic fistula,3 cases of recurrent laryngeal nerve injury,6 cases of pulmonary infection,2cases of delayed gastric emptying,and 1 case of anastomotic stenosis.There was no death.All the patients were followed up for 1months to 5 years.The survival rates at 1,3,and 5 postoperative year were 87.9%,54.5%,and 45.5%,respectively.Conclusions Cervical esophageal carcinoma should be surgically treated actively.Gastric pharyngeal anastomosis is an ideal option for the repair of cervical esophageal cancer resection

创新土地产权的关键

创新土地产权的关键刘春雷，李宇乔在传统体制下，土地产权主体的单一性及产权的完整性，抑制了人们对土地货币评价，造成土地资源短缺与浪费并存，一些用地单位低效率使用土地，多占少用或占而不用的现象相当普遍。国有土地收益流失严重。究其原因，在于传统的土地产权制..

视觉词形加工:从脑区到神经通路

视觉词形加工是阅读机制中的重要环节。基于获得性阅读障碍的早期阅读"神经病学模型"对视觉词形加工的神经通路进行了描述。近年来,随着脑功能成像技术的发展和左梭状回中部视觉词形区的发现,研究者们对原有视觉词形加工的神经通路加以补充和修订,并提出了新的模型。该文对视觉词形加工障碍患者的神经心理学研究和正常人视觉词形加工的脑功能成像研究进行了总结,并讨论了研究的局限性,对今后该领域的发展方向进行展望