Clinical Research on “Gui” Acupuncture Method for Chronic Non-specific Low Back Pain

目的：比较“龟刺”与常规针刺方法治疗慢性非特异性腰痛的疗效差异，为临床上治疗本病提供新的治疗思路和方法。 方法：本研究采用随机分组单盲对照法对所选病例进行前瞻性研究，受试者来源于厦门大学附属中山医院演武分院六楼针灸科门诊，收集符合纳入标准的60例慢性非特异性腰痛患者，随机分为治疗组与对照组，每组30例。治疗组按照周然宓教授所创“龟刺”法的选穴与操作标准，对照组按照石学敏主编《针灸学》中治疗腰痛的选穴与操作标准分别进行治疗。两组均以治疗10次为一个疗程，隔两天治疗1次，每周治疗2次，共治疗1个疗程，为期5周。采用视觉模拟评分法（VAS）以及Oswestry功能障碍指数（ODI）对患者治疗前后的...Objective: To compare the difference between the “Gui” acupuncture method and routine acupuncture method in the clinical efficacy on chronic nonspecific low back pain. In order to carrying forward Professor Zhou’s academic thoughts and provide a way of thinking for the clinical treatment of this disease. Methods: A prospective study of the selected cases were performed by using a randomized, sing...学位：医学硕士院系专业：医学院_针灸推拿学学号：2452013115355

Research progress on the objectification, quantitation and standardization of tongue manifestation in traditional Chinese medicine

舌诊是中医诊断学的重要组成部分,舌象在中医临床治疗中具有重要的诊断意义与辨证价值。传统中医舌象易受主客观因素影响,难以客观化、定量化、标准化,严; 重制约舌象临床应用及发展。随着医学、计算机等现代技术的迅猛发展,中医舌象客观量化研究取得了长足进步,并被应用于基础及临床研究。文章对近几年中医舌; 象采集分析系统、舌象定量化研究、现代仪器应用与舌象基础研究进行概述,为舌象应用于临床治疗提供客观、科学的思路与方法。Tongue diagnosis is an important part of traditional Chinese medicine; (TCM), and the tongue manifestation is also important in the diagnosis; and syndrome differentiation in TCM clinical treatment. However, due to; the lack of objective, quantitative and standardized valuation, with it; being susceptible to subjective and objective factors, the application; and development of traditional tongue diagnosis is limited for a long; period. Recently, with the rapid development of medical and other modern; technology, the objectification, quantitation and standardization of TCM; tongue manifestation have been received great progress, including the; progress in basic and clinical researches. Recent researches on the; tongue image acquisition and analysis system, the quantitation of tongue; manifestation, the application of modern instruments and the basic; research in tongue manifestation were reviewed to provide certain; objective and scientific ideas and methods for TCM tongue manifestation.教育部新世纪优秀人才支持计划; 中国博士后科学基金面上项

1984 Vol. 33 No. 3

https://engagedscholarship.csuohio.edu/lawpublications_gavel1980s/1009/thumbnail.jp

基于调控脑肠轴探索解毒化瘀汤改善阿尔茨海默病小鼠认知功能的机制

目的研究解毒化瘀汤(黄连解毒汤加味方)对阿尔茨海默病(AD)模型小鼠学习、记忆障碍的影响及调控机制。方法侧脑室定位注射寡聚化Aβ42制备AD小鼠模型,灌胃给予黄连解毒汤、低剂量或高剂量解毒化瘀汤3周,多奈哌齐灌胃作为阳性对照。3周后,水迷宫、T迷宫、Y迷宫等检测小鼠学习、记忆功能;超高效液相色谱质谱联用(UPLC-Q-TOF/MS)分析比较黄连解毒汤原方和解毒化瘀汤的化学成分组成;飞行时间质谱联用技术(GC-TOF/MS)检测不同组别小鼠海马代谢物质的变化;16S rDNA检测不同组别小鼠肠道菌群多样性变化;Western印迹和免疫组化等手段检测信号通路表达变化。结果相较黄连解毒汤组,高剂量解毒化瘀汤显著改善了AD模型小鼠的学习、记忆障碍。UPLC-Q-TOF/MS结果显示,与黄连解毒汤相比,在解毒化瘀汤中,谷氨酸和天冬氨酸等氨基酸含量更丰富。分子生物学结果提示,解毒化瘀汤上调了AD模型小鼠海马NMDA受体亚基(NR1,NR2A和NR2B)的表达。基于GC-TOF/MS的代谢组学检测结果表明,相较黄连解毒汤,解毒化瘀汤显著提高了AD模型小鼠海马的腺苷水平。结合分子生物学,解毒化瘀汤同时也上调了腺苷下游的ATPase/AMPK信号通路。16S rDNA肠道菌群检测结果表明,解毒化瘀汤调控了AD模型小鼠肠道Firmicutes,Bacteroidetes,Proteobacteria等菌属的多样性。通过对代谢组学和肠道菌群进行的相关性分析,最终鉴定出Dorea是响应解毒化瘀汤上调AD模型小鼠海马腺苷水平的肠道菌属。结论相较黄连解毒汤原方,解毒化瘀汤显著改善AD模型小鼠的学习、记忆障碍,通过调控NMDA/ATPase/AMPK信号通路上调AD模型小鼠海马腺苷和肠道Dorea菌属水平,重塑大脑和肠道的沟通。上述研究提示,解毒化瘀汤可能是治疗AD的新型有效药物。国家自然科学基金(81704130)广州市科技计划项目(201904010238)福建省自然科学基金(2017J05139)广东省自然科学基金(2017A030310643)广州医科大学科研启动经费(B185006002047

Applied research on SiO_2 deposited by PECVD

研究了PECVD腔内压力、淀积温度和淀积时间等工艺条件对SiO2薄膜的结构、淀积速率和抗腐蚀性等性能的影响。结果表明,利用剥离工艺,并采用AZ5214E光刻胶作为剥离掩模成功制作了约2μm厚的包裹在金属铝柱周围的SiO2隔热掩模。The silicon oxide thin films are deposited on Silicon substrate by PECVD.The influence of the process parameters such as temperature, reactant and time on the quality,deposited rate and etchant-resistant characteristics of the silicon oxide thin films are discussed.The experimental result indicates that 2μm-thick silicon oxide adiabatic films can be prepared successfully by using lift-off technology with AZ5214E photoresist lift-off mask,which is wrapped around the aluminum pillar

A design of high precision and high power electroplating power source

针对传统电镀电源体积大、实现方式复杂以及输出纹波大的特点,提出了一种新型的dC/dC变换器,采用双闭环PWM实时控制方式,具有恒电流和恒电压两种工作方式。用该方法设计了一组9.6 kW电源模块,实验表明,电源输出纹波系数小于1%,效率达到90%。The tradition electroplating power is large and the output ripple is big.This paper provides a circuit scheme that use high-frequency switch power supply.The double close-loop PWM control is adopted in control circuit.The power supply has two kinds of working patter,which are constant current mode and constant voltage mode.A group of 9.6 KW power supply module are designed.According to the experiments,the power output ripple coefficient is less than 1%,and the efficiency is 90%.厦门市科技计划项目(3502Z20123013

Polishing of Laser Lift-off-Induced GaN Surface

激光剥离(llO)技术是研制新型氮化镓(gAn)基谐振腔结构光电子器件的关键技术。然而llO后的gAn表面往往具有较大的粗糙度,而制作谐振腔结构器件需要很高的表面平整度,因此需要对llO后的gAn表面进行抛光。分别采用金刚石粉抛光液和胶粒二氧化硅抛光液进行机械抛光和化学机械抛光(CMP),并对比了两种方法获得的抛光结果,研究发现前者会在抛光后的gAn表面引入划痕,而采用后者可以得到亚纳米级平整度的表面。进一步的实验结果表明,胶粒二氧化硅抛光液同样适用于图形化衬底外延片激光剥离后的gAn表面抛光。Laser lift-off( LLO) is a key technology in development of new GaN-based resonant-cavity optoelectronic devices.For cavity-dependent devices,a smooth surface is highly required.However,the GaN surface after LLO is usually rough,and the polishing is necessary.The mechanical polishing of diamond powder and the chemical mechanical polishing of colloidal silica were compared.It is found that diamond powder leads to scratches on the GaN surface whereas colloidal silica leads to smooth surface with sub-nanometer roughness.The experiment results indicate that polishing with colloidal silica solutions can be applied to smoothen the LLO-produced GaN surface from an epitaxial wafer grown on patterned-sapphire substrate.国家自然科学基金资助项目(61274052;61106044); 中国科学院纳米器件与应用重点实验室开放课题资助项目(14ZS02

氯胺酮辅助硬膜外麻醉诱发喉痉挛1例

病例男,48岁,体重62kg,ASAⅠ级,3d前有上呼吸道感染病史,既往无其他疾病及药物过敏史,因急性阑尾炎拟在硬膜外麻醉下急诊行阑尾切除术。患者于术前30MIn肌注苯巴比妥钠100Mg和阿托品0.5Mg,入室后常规心电监护、吸氧、开放上肢静脉后,取左侧卧位,于T12~l1行硬膜外穿刺。穿刺置管顺利,注射试验剂量2%利多卡因5Ml,观察5MIn无全脊麻征象后追加1%利罗合剂10Ml,10MIn后测麻醉平面T8~l2。手术开始15MIn后,当提起阑尾、

Biological mechanism underlying the formation of greasy fur

腻苔是一种临床常见的病理性舌苔,主湿浊、痰饮、食积等,在中医临床诊断与治疗中有重要的临床意义与辨证价值,研究腻苔形成的现代生物学机制有重要的理论; 和实践意义。文章从舌表面脱落细胞学、微生态学、相关蛋白与基因表达及物质代谢等方面对腻苔形成的生物学机制进行了综述,并对腻苔与肠道微生态的关系,腻; 苔与现代医学疾病的关系进行了阐述,以期从现代生物医学角度对腻苔形成的物质基础、发生机制、变化规律及与相关疾病的关系作相关阐明,为疾病的中医诊断与; 治疗提供借鉴和帮助。Greasy fur is a common pathological tongue coating and is mainly seen in; the clinical practice in traditional Chinese medicine (TCM), such as in; the dampness turbidity, the phlegm and fluid retention, the dyspepsia or; food accumulation, and so on. Greasy fur shows important clinical; significance and differentiation value in TCM diagnosis and treatment,; there is also great theoretical and practical significance in the; studying of the modern biomedical mechanism underlying the formation of; the greasy fur. Here we summarized the formation mechanism of the greasy; fur from the aspects of the shedding cytology of the tongue surface, the; microecology, the expression of the relative genes and proteins and the; metabolism. The relationship between the greasy fur and the intestinal; microecology, and between the greasy fur and the diseases were also; discussed in this paper. Through summarizing these related research; literatures, we want to elucidate the material basis, the occurrence; mechanism and the changing rules of the greasy fur from the perspective; of the modern biomedicine, and to elucidate its relationship with some; related modern medicine diseases, thus to provide references and; assistance for the disease diagnosis and treatment in TCM clinic.国家重点研发计划重点专项; 教育部新世纪优秀人才支持计划; 国家自然科学基金项