阳离子铝酞菁红区荧光探针测定硫酸软骨素

目的建立以阳离子铝酞菁为红区荧光探针定量测定硫酸软骨素(CS)的新方法。方法在pH5.0的Britton-Robinson(B-R)缓冲溶液中,阳离子铝酞菁与CS发生相互作用形成离子缔合物而导致荧光猝灭。在610 nm波长光的激发下,随着CS的加入,探针的特征发射峰(676 nm)处的荧光强度逐步减弱。结果在最佳条件下,荧光强度差值(ΔIf)与CS浓度(C,μg/mL)在0.2~1.3μg/mL内呈良好的线性关系,工作曲线为ΔIf=406.67C-36.23,r=0.997。建立了溶剂沉淀法成功地进行了样品的前处理,实现了实际样品(滴眼液)的准确测定。结论该法简便、快速、抗金属离子及小分子干扰的能力较强,可用于复杂实际样品中CS的含量测定

Application study on phthalocyanine red fluorescent probes in the detection of biological macromolecules

荧光分析法应用的领域日益广泛，具有良好的发展前景。而红区荧光试剂在分析科学中的开发与应用是现代荧光分析法的一个重要的领域。阳离子铝酞菁化合物易于合成，化学性质稳定，荧光量子产率高，长波激发和红区发射，结构可修饰性强，是一类理想的荧光试剂。本论文主要应用荧光分析法的基本原理，以生物大分子为研究对象，建立酞菁红区荧光探针检测多种生物大分子的荧光分析法。 第一章前言。介绍荧光分析法和荧光探针的应用进展，概述了酞菁类化合物的光谱性质及其作为荧光探针在生物分析检测中的应用。将荧光探针按照其的性质分类分为有机荧光探针，量子点荧光探针和高分子荧光探针，分别介绍三种荧光探针在生物医学研究中的应用，显示出明...The applications of fluorescence analysis,with good prospects for development, are being increasingly used. While an important area of modern fluorescence analysis is the development and application of red fluorescent reagent in analytic science. Cationic aluminum phthalocyanine compounds are ideal fluorescent reagents,because of easy way of synthesis, stable chemical property, a high fluorescence...学位：理学硕士院系专业：药学院_药物化学学号：2452009115305

主观记忆减退老年人脑结构与功能的可塑性

主观记忆减退(subjective memory complaints,SMC)期是阿尔兹海默病(Alzheimer’s disease,AD)发病进程的最初始阶段。影像学证据显示,虽然主观记忆减退老年人在行为测验上的成绩还没表现出明显下降,但其大脑可能已经发生了生理病理性改变。在主观记忆减退期开展有针对性干预是预防和延缓AD发生的有效切入点,但针对主观记忆减退老年人脑结构与功能的可塑性研究尚处于起步阶段。将主观记忆减退的脑机制研究和脑可塑性研究相结合,在深入阐明其生理病理机制的基础上采取有针对性的干预措施,对于理解脑老化和预防AD具有重要意义

Brain plasticity of structural and functional in elderly with subjective memory complaints

主观记忆减退(subjective memory complaints,SMC)期是阿尔兹海默病(Alzheimer&rsquo;s disease,AD)发病进程的最初始阶段。影像学证据显示,虽然主观记忆减退老年人在行为测验上的成绩还没表现出明显下降,但其大脑可能已经发生了生理病理性改变。在主观记忆减退期开展有针对性干预是预防和延缓AD发生的有效切入点,但针对主观记忆减退老年人脑结构与功能的可塑性研究尚处于起步阶段。将主观记忆减退的脑机制研究和脑可塑性研究相结合,在深入阐明其生理病理机制的基础上采取有针对性的干预措施,对于理解脑老化和预防AD具有重要意义。</p

Residual stress analysis of thin film photovoltaic cells subjected to massive micro-particle impact

Residual stresses play a crucial role in both light-electricity conversion performances and the lifespan of photovoltaic (PV) cells. In this paper, the residual stress of triple junction cells (i.e. GaInP/GaInAs/Ge) induced by laser-driven massive micro-particle impact is analyzed with a novel method based on backscattering Raman spectroscopy. The impact process, which induces damage to the PV cells and brings the residual stress, is also investigated by optical microscopy (OM) and Scanning Electron Microscopy (SEM). The results show that the PV cells would exhibit various damage patterns. At the same time, strong residual stresses up to hundreds of MPa introduced in the damaged PV cells after impact have been analysis, providing an effective perspective to better understand the damage behavior and residual stress features of PV cells during their service life

气候变化对中国的影响利弊

气候变化对自然生态系统、自然资源、三次产业、社会系统及自然灾害等领域的影响包括:气候变化对自然生态系统结构和功能产生深刻影响,如东北多年冻土区植被生产力下降,而青藏高原则升高;气候变化导致华北、东北大部分地区降水减少以及许多北方河流径流量减少;由于气候变化,人们生产生活对能源的需求发生变化;气候变化导致的极端事件增加(包括频次与强度)、水资源短缺等问题对人体健康、疾病传播、重大工程等具有重要影响;气候变化背景下,热量资源的改善有助于延长农作物生育期,但极端事件增加也会造成农业生产的不稳定;气候变化不仅可通过影响农业和自然资源而间接地对第二、三产业产生影响,而且气候变化减缓措施(如碳税、碳关税、碳交易等)的采用也将对社会经济产生广泛而深刻的影响。进一步,通过分析可发现,气候变化的影响具有显著的区域差异性,而且总体上利弊共存,但弊大于利。基于此,本文提出要趋利避害,科学应对气候变化,实现"整体最优、长期受益"的有序适应目标;要强调定量适应,提出可操作性方案和可预期目标,并分析适应措施的不确定性;而且为提高我国未来综合竞争力,今后应采取更加主动的应对策略,如逐渐调整产业结构,加大减排技术研发,积极应对碳税、碳关税和碳市场对中国社会经济发展的影响等

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel