7 research outputs found
Primjena traneksamiÄne kiseline u dermatologiji
Tranexamic acid is a synthetic derivative of the amino acid lysine, an antifibrinolytic
that is primarily used to reduce bleeding in surgery, trauma, and dental procedures. Its anti-inflammatory
and anti-angiogenic properties, as well as its ability to suppress melanogenesis have enabled it to be used
in dermatology in the treatment of skin conditions such as melasma, acne, post-inflammatory hyperpigmentation,
rosacea and angioedema. Tranexamic acid can be used by various routes of administration
including oral, topical and intradermal injection, and in combination with other treatment methods. This
review article presents evidence for the effectiveness of tranexamic acid in the treatment of various skin
disorders.TraneksamiÄna kiselina sintetski je derivat aminokiseline lizina, antifibrinolitika koji se prvenstveno rabi za smanjenje
krvarenja u kirurŔkim zahvatima, traumi i stomatoloŔkim zahvatima. Njegova protuupalna i antiangiogena svojstva, kao i
njegova sposobnost suzbijanja melanogeneze omoguÄili su mu upotrebu u dermatologiji u lijeÄenju kožnih stanja kao Å”to su
melazma, akne, poslijeupalna hiperpigmentacija, rozacea i angioedem. TraneksamiÄnu kiselinu moguÄe je primijeniti na razliÄite
naÄine: oralno, lokalno i intradermalno te u kombinaciji s drugim metodama lijeÄenja. Ovaj pregledni Älanak prikazuje
dokaze o uÄinkovitosti traneksamiÄne kiseline u lijeÄenju razliÄitih kožnih poremeÄaja
PrecipitirajuÄi Äimbenici i simptomi u bolesnika s dijabetiÄkom ketoacidozom
The aim of the study was to determine the most common precipitating factors and
symptoms of diabetic ketoacidosis and the possible difference according to age, gender and severity of
diabetic ketoacidosis. Medical records from January 1, 2017 until December 31, 2019 were reviewed
and patients diagnosed with diabetic ketoacidosis were selected. The study included 52 patients, median
age 34 (interquartile range 21-56) years. There was no statistically significant difference between
male and female gender. The severity of diabetic ketoacidosis was moderate in the majority of cases
(65.4%; p=0.005). The most common precipitating factor was infection (61.7%). In patients with
moderate diabetic ketoacidosis, respiratory infections were more common, while gastrointestinal infections
were more common in severe diabetic ketoacidosis (33% and 25%, respectively; p=0.03). Nausea
(median age 32 years; p=0.004) and vomiting (median age 31 years; p=0.01) were more common in
younger age groups, while altered mental status was more common in the older age group (median age
61 years; p=0.001). Infection was the most common precipitating factor. The most common symptoms
in younger age groups were nausea and vomiting, and altered mental status in the older age group.Cilj istraživanja je bio utvrditi najÄeÅ”Äe precipitirajuÄe Äimbenike i simptome dijabetiÄke ketoacidoze te postoji li razlika
s obzirom na dob, spol i stupanj dijabetiÄke ketoacidoze. Pregledana je medicinska dokumentacija od 1. sijeÄnja 2017. do 31.
prosinca 2019. godine te su izdvojeni bolesnici s dijagnozom dijabetiÄke ketoacidoze. U istraživanje je ukljuÄeno 52 bolesnika.
Medijan dobi bio je 34 godine (interkvartilni raspon 21-56 godina). Nije postojala statistiÄki znaÄajna razlika muÅ”kog i
ženskog spola. U najveÄem broju sluÄajeva radilo se o umjerenom stupnju dijabetiÄke ketoacidoze (65,4%; p=0,005). NajÄeÅ”Äi
precipitirajuÄi Äimbenik bila je infekcija (61,7%). Kod umjerenog stupnja najÄeÅ”Äe se radilo o respiracijskim infekcijama, a
u teÅ”kom stupnju o gastrointestinalnim infekcijama (33% i 25%; p=0,03). U mlaÄim dobnim skupinama ÄeÅ”Äe su se pojavljivale
muÄnina (medijan dobi 32 godine; p=0,004) i povraÄanje (medijan dobi 31 godina; p=0,01), a u starijoj dobnoj skupini
poremeÄaj svijesti (medijan dobi 61 godina; p=0,001). Infekcije su bile najÄeÅ”Äi precipitirajuÄi Äimbenik dijabetiÄke ketoacidoze.
NajÄeÅ”Äi simptomi u mlaÄim dobnim skupinama bili su muÄnina i povraÄanje, a u starijoj dobnoj skupini poremeÄaj
svijesti
Serum glucose, sodium and potassium concentrations in patients with diabetic ketoacidosis
Aim To investigate possible differences in serum glucose and sodium and potassium concentrations with respect to age, gender and severity of diabetic ketoacidosis.
Methods Medical records from 1 January 2017 to 31 December 2019 were reviewed and patients with the diagnosis of diabetic ketoacidosis were selected.
Results The study included 52 patients. Glucose concentration was significantly higher in the age group of 25-44 and >65 years compared to the group of 18-24 years (p=0.02). Sodium concentration was significantly higher in the age group 18-24 and >65 years compared to groups 25-44 and 45-65 years (p=0.002). Females had significantly higher sodium concentration than males (p=0.002). Potassium concentration was significantly higher in the age group 25-44 years compared to other groups (p=0.01). Males had significantly higher potassium concentration (p =0.01).
Conclusion This study showed that significant differences exist in electrolyte concentration between specific age groups, male and female gender as well as DKA severity. Knowing these differences could help clinicians to promptly recognize and treat electrolyte derangements, leading to better outcome of patients with DKA
Maternal outcomes in gestational diabetes
Uvod: Gestacijski dijabetes mellitus (GDM) je najÄeÅ”Äi metaboliÄki poremeÄaj u trudnoÄi, a definira se kao netolerancija na glukozu otkrivena tijekom trudnoÄe, najÄeÅ”Äe u drugom i treÄem trimestru. Ukoliko bolest nije dobro kontrolirana moguÄa je pojava razliÄitih nepovoljnih ishoda trudnoÄe kao Å”to su arterijska hipertenzija, preeklampsija, polihidroamnion, oligohidroamnion, porod carskim rezom i prijevremeni porod. Ustroj studije: presjeÄna studija s povijesnim podatcima Cilj: Ispitati povezanost majÄinskih ishoda s terapijom, vremenom OGTT-a, prethodnim GDM-om, ukupnim dobitkom na tjelesnoj masi tijekom trudnoÄe i majÄinim ITM-om. Metode i ispitanici: Pacijentice lijeÄene u KBC Osijek pod dijagnozom GDM, u razdoblju od 2016. do 2020. VeliÄina uzorka je 400 ispitanica. Podaci su prikupljeni iz BolniÄkog informacijskog sustava. Rezultati su prikazani tablicama, apsolutnim i relativnim frekvencijama, a znaÄajnost razlika hi-kvadrat testom s 95 % intervalom pouzdanosti. StatistiÄka znaÄajnost Äe biti prihvaÄena uz p < 0,05. Rezultati: Nisu pokazane statistiÄki znaÄajne razlike izmeÄu promatranih ishoda trudnoÄe i terapije, vremena provoÄenja OGTT-a i prethodnog GDM-a. Majke koje su tijekom trudnoÄe dobile viÅ”e od 15 kg znaÄajno su viÅ”e imale arterijsku hipertenziju u odnosu na majke koje su dobile manje od 15 kg (P < 0,001). ZakljuÄak: U prikazanom ispitivanju terapija GDM nije znaÄajno utjecala na majÄinske ishode trudnoÄe, kao niti vrijeme uÄinjenog OGTT-a ili prisutvo prethodnog GDM-a u anamnezi. Pojava arterijske hipertenzije bila je ÄeÅ”Äa u bolesnica s ukupnim dobitkom na tjelesnoj masi veÄim od 15 kg. Arterijska hipertenzija, preeklampsija i porod carskim rezom bili su ÄeÅ”Äi u majki s viskom ITM-om.Introduction: Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, and is defined as glucose intolerance detected during pregnancy, most commonly in the second and third trimesters. If the disease is not well controlled, various adverse pregnancy outcomes such as arterial hypertension, preeclampsia, polyhydroamnion, oligohydroamnion, cesarean delivery and premature birth are possible. Study structure: cross-sectional study with historical data Objective: To examine the association of maternal outcomes with therapy, time of OGTT, previous history of GDM, and weight gain during pregnancy Methods and subjects: Women treated at Clinical Hospital Center Osijek under the diagnosis of GDM, in the period from 2016. to 2020. The sample size is 400 respondents. Data were collected from patients medical histories. The results are shown in tables, absolute and relative frequencies, and the significance of the differences by the chi-square test with a 95 % confidence interval. Statistical significance will be accepted with p < 0.05. Results: There were no statistically significant differences between the observed outcomes of pregnancy and therapy, the time of OGTT and previous GDM. Mothers who gained more than 15 kg during pregnancy had significantly more arterial hypertension compared to mothers who gained less than 15 kg (P < 0.001). Conclusion: In this study, GDM therapy did not significantly affect maternal pregnancy outcomes, nor did the time of OGTT performed or the presence of a history of previous GDM. The occurrence of arterial hypertension was more common in patients with a total weight gain greater than 15. Arterial hypertension, preeclampsia, and cesarean delivery were more common in mothers with high BMI
Maternal outcomes in gestational diabetes
Uvod: Gestacijski dijabetes mellitus (GDM) je najÄeÅ”Äi metaboliÄki poremeÄaj u trudnoÄi, a definira se kao netolerancija na glukozu otkrivena tijekom trudnoÄe, najÄeÅ”Äe u drugom i treÄem trimestru. Ukoliko bolest nije dobro kontrolirana moguÄa je pojava razliÄitih nepovoljnih ishoda trudnoÄe kao Å”to su arterijska hipertenzija, preeklampsija, polihidroamnion, oligohidroamnion, porod carskim rezom i prijevremeni porod. Ustroj studije: presjeÄna studija s povijesnim podatcima Cilj: Ispitati povezanost majÄinskih ishoda s terapijom, vremenom OGTT-a, prethodnim GDM-om, ukupnim dobitkom na tjelesnoj masi tijekom trudnoÄe i majÄinim ITM-om. Metode i ispitanici: Pacijentice lijeÄene u KBC Osijek pod dijagnozom GDM, u razdoblju od 2016. do 2020. VeliÄina uzorka je 400 ispitanica. Podaci su prikupljeni iz BolniÄkog informacijskog sustava. Rezultati su prikazani tablicama, apsolutnim i relativnim frekvencijama, a znaÄajnost razlika hi-kvadrat testom s 95 % intervalom pouzdanosti. StatistiÄka znaÄajnost Äe biti prihvaÄena uz p < 0,05. Rezultati: Nisu pokazane statistiÄki znaÄajne razlike izmeÄu promatranih ishoda trudnoÄe i terapije, vremena provoÄenja OGTT-a i prethodnog GDM-a. Majke koje su tijekom trudnoÄe dobile viÅ”e od 15 kg znaÄajno su viÅ”e imale arterijsku hipertenziju u odnosu na majke koje su dobile manje od 15 kg (P < 0,001). ZakljuÄak: U prikazanom ispitivanju terapija GDM nije znaÄajno utjecala na majÄinske ishode trudnoÄe, kao niti vrijeme uÄinjenog OGTT-a ili prisutvo prethodnog GDM-a u anamnezi. Pojava arterijske hipertenzije bila je ÄeÅ”Äa u bolesnica s ukupnim dobitkom na tjelesnoj masi veÄim od 15 kg. Arterijska hipertenzija, preeklampsija i porod carskim rezom bili su ÄeÅ”Äi u majki s viskom ITM-om.Introduction: Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, and is defined as glucose intolerance detected during pregnancy, most commonly in the second and third trimesters. If the disease is not well controlled, various adverse pregnancy outcomes such as arterial hypertension, preeclampsia, polyhydroamnion, oligohydroamnion, cesarean delivery and premature birth are possible. Study structure: cross-sectional study with historical data Objective: To examine the association of maternal outcomes with therapy, time of OGTT, previous history of GDM, and weight gain during pregnancy Methods and subjects: Women treated at Clinical Hospital Center Osijek under the diagnosis of GDM, in the period from 2016. to 2020. The sample size is 400 respondents. Data were collected from patients medical histories. The results are shown in tables, absolute and relative frequencies, and the significance of the differences by the chi-square test with a 95 % confidence interval. Statistical significance will be accepted with p < 0.05. Results: There were no statistically significant differences between the observed outcomes of pregnancy and therapy, the time of OGTT and previous GDM. Mothers who gained more than 15 kg during pregnancy had significantly more arterial hypertension compared to mothers who gained less than 15 kg (P < 0.001). Conclusion: In this study, GDM therapy did not significantly affect maternal pregnancy outcomes, nor did the time of OGTT performed or the presence of a history of previous GDM. The occurrence of arterial hypertension was more common in patients with a total weight gain greater than 15. Arterial hypertension, preeclampsia, and cesarean delivery were more common in mothers with high BMI
Sindikalna dejavnost v policiji
Diplomsko delo obravnava delovanje sindikatov v policiji. Kot vsi vemo, je PSS nastal že v Äasu osamosvojitve in je pred kratkim praznoval 20-letnico svojega delovanja, medtem ko je SPS nastal v Äasu mandata Pahorjeve vlade oziroma takratne ministrice za notranje zadeve gospe Katarine Kresal. S tem, ko je nastal Å”e en sindikat, ki ga je takratno ministrstvo podpiralo in po zadnjih dogodkih tudi sedanje, pa so se zaÄeli problemi tudi med zaposlenimi. V nekaterih sredinah so Älani SPS izvajali pritiske na Älane PSS, kaj poÄnejo v tem starem sindikatu (PSS) ipd. Tudi zadnji dogodki kažejo, da je vladi in MNZ vÅ”eÄ, ker sta PSS in SPS skregana med seboj in le redko sodelujeta. Analiza statistiÄnih podatkov nadalje pokaže, da tudi policisti in policistke niso zadovoljni s tem, da obstajata dva delujoÄa sindikata. Prav tako je bilo iz analize ugotovljeno, da je kar 42.7 % anketirancev mnenja, da sindikata med seboj slabo sodelujeta.
Äe na kratko povzamemo celotno nalogo, lahko zapiÅ”emo, da je sindikat organizacija v katerem so vÄlanjeni Älani, ki imajo doloÄene pravice, kot so pravica do stavke, koalicijska svoboda, delavski boj, soodloÄanje, pogajanja in kolektivno pogodbo. Glavna naloga sindikata je, da se bori za pravice policistov, s Äimer se je strinjajo tudi 72,5 % anketirancev. Glede na pravice in ugodnosti, ki jih pridobijo Älani sindikata, je bilo iz analize ugotovljeno, da je kar 85.5 % policistk in policistov vÄlanjenih v sindikat. Vsak sindikat ima tudi svojega sindikalnega zaupnika, ki deluje na obmoÄju celotne regije ali pa na doloÄeni policijski postaji. Naloga sindikalnega zaupnika je, da obveÅ”Äa svoje Älane o trenutnem dogajanju. Pri tem je statistiÄna analiza pokazala, da se kar 34,5 % anketirancev popreÄno strinjajo s tem, da sindikalni zaupniki dobro opravljajo svoje delo. Prav tako je bilo iz analize ugotovljeno, da se 33,6 % anketirancev prav tako povpreÄno strinjajo s tem, da sindikalni zaupniki obveÅ”Äajo Älane o trenutnih dogodkih. 35,5 % pa je vseh tistih, ki so mnenja, da sindikat povpreÄno zastopa interese svojih Älanov.
Lahko reÄemo, da sindikat in sindikalni zaupniki dobro opravljajo svoje delo.This thesis discusses activity of trade unions in the police. Like we all know PSS was formed during the time of independence and has recently celebrated the twentieth anniversary of its operation, while SPS was formed during the mandate of Pahor government and the then Minister of Interior Mrs. Katarina Kresal. When another trade union in police was founded it was suported by the then Ministry and after recent events also from the current Ministry. This has caused problems between employees. In some environments the members of SPS exert pressure on the members of PSS saying what they are doing in this old trade union (PSS) etc. Last events show that Government and MNZ like the fact PSS and SPS are at odds with each other and rarely cooperate.
The analysis of statistical data further shows that police officers are not satisfied with the fact that there are two functioning trade unions. Analysis shows that 42.7% of respondents thinks that cooperation between trade unions is not good.
If we briefly summarize the entire task we can say that the trade union is organisation in which they are members, which have certain rights, such as the right to strike,freedom coalition, aworking class fight, co-decision, negotiations and collective agreement. The main task od the trade union is to fight for the rights of the police officers. With that agree72.5% of the respondents. Depending on the rights and benefits, which acquire trade union members from the analysis is found that as many as 85.5% of policeofficers are members of a trade union. Each trade union ha salso his labor confidant which works in the area of the entire redion or at a particular police station. The task of the labor confident is to inform its members about the current events. The statistical analysis shows that 34,5% of respondents agree that trade union representatives are good at their work. It was also found from the analysis that 33,6% of the respondents agree that trade union representatives infrom members abaut current events. There is 35,5% of all those who share the opinion that the trade union on average represents the interests of its members. We can say that the trade union and trade union representatives are good at their work
Precipitating Factors and Symptoms in Patients with Diabetic Ketoacidosis
The aim of the study was to determine the most common precipitating factors and
symptoms of diabetic ketoacidosis and the possible difference according to age, gender and severity of
diabetic ketoacidosis. Medical records from January 1, 2017 until December 31, 2019 were reviewed
and patients diagnosed with diabetic ketoacidosis were selected. The study included 52 patients, median
age 34 (interquartile range 21-56) years. There was no statistically significant difference between
male and female gender. The severity of diabetic ketoacidosis was moderate in the majority of cases
(65.4%; p=0.005). The most common precipitating factor was infection (61.7%). In patients with
moderate diabetic ketoacidosis, respiratory infections were more common, while gastrointestinal infections
were more common in severe diabetic ketoacidosis (33% and 25%, respectively; p=0.03). Nausea
(median age 32 years; p=0.004) and vomiting (median age 31 years; p=0.01) were more common in
younger age groups, while altered mental status was more common in the older age group (median age
61 years; p=0.001). Infection was the most common precipitating factor. The most common symptoms
in younger age groups were nausea and vomiting, and altered mental status in the older age group