気管支喘息におけるCD163発現マクロファージの重要性

久留米大学2019年

乳幼児揺さぶられ症候群に関する研究の動向 ―テキストマイニングを用いた抄録内容の分析―

目的　子ども虐待の一種である乳幼児揺さぶられ症候群（SBS/AHT）に関する研究の動向を可視化する． 方法　2009年～2018年の10年間に発表された原著論文のうち，「乳幼児揺さぶられ症候群」をキーワード にして検索し，33件を研究対象とした．対象論文の抄録をデータとし，テキストマイニングを用いて頻出 語の抽出，多次元尺度構成法およびクラスター分析を行った． 結果　「脳の損傷」「検査」など27語が頻出語として抽出され，「虐待予防」の頻出回数は少なかった．また， 多次元尺度構成法およびクラスター分析では「虐待」と「揺さぶり」が近く，「揺さぶり」と「父親」に 類似性がみられた． 考察　SBS/AHTに関する研究の内容では，症例対照研究が多く病態や具体的な診断方法が多かった． SBS/AHTの対策への課題として，予防に関する研究が少ないことが考えられた．今後は「揺さぶり」へ の類似性がみられた父親も対象に含め，SBS/AHTによる虐待予防研究を推進していくことが必要である

Synergetic responses after administration of interleukin-2 and Interferon-alpha combined with gamma knife radiosurgery in a patient with multiple lung and brain metastases : a case report

51歳男性.患者は右胸部痛を主訴に近医を受診, 胸部X線・CTにて右胸水, 多発性肺腫瘍を指摘され, 著者らの施設へ紹介入院となった.胸部CTでは上記所見とともに左腎腫瘍が発見され, 精査の結果, 左腎癌の肺転移と診断し, 根治的左腎摘除術を施行した.病理組織学的にClear cell carcinomaで, 術後, 肺転移に対しIFN-α投与を開始したが, 1ヵ月後より四肢の痺れが出現した.頭部CT・MRIにて脳転移と診断し, gamma knife radiosurgeryを行ったところ, 脳転移は消失した.肺転移はIFN-αとIL-2の併用投与にて消失が得られたが, 治療中うつによる自殺企図をおこした.INF-αまたはIL-2による副作用と診断し, 両薬剤を中止し, 抗うつ剤投与にて精神状態の安定が得られたA 51-year-old man with left renal tumor and multiple lung metastases was admitted to our hospital for treatment. Left nephrectomy was performed, and pathological diagnosis was renal cell carcinoma (clear cell carcinoma, G2, pT3a). Initially, Interferon-alpha (IFN-alpha) therapy was started for lung metastases. About 40 days after surgery, head magnetic resonance imaging revealed brain metastases, and therefore gamma knife radiosurgery(GKS) was performed. Since chest computed tomography showed no change in lung metastases, we tried a combination of interleukin-2 (IL-2) and IFN-alpha therapy to elininate those metastases. As a result, neither lung nor brain metastases could be detected at the 4th month follow-up examination. At 5 months after the IL-2 and IFN-alpha therapy, the patient attempted suicide. Therefore, the IL-2 and IFN-alpha therapy was stopped and an antidepressant was prescribed. Now 11 months after withdrawal of the IL-2 and IFN-alpha, the patient's mental condition remains stable. No recurrence of the cancer has been detected by CT

The ASCA Medium Sensitivity Survey (the GIS Catalog Project): Source Counts and Evidence for Emerging Population of Hard Sources

We present first results from the ASCA Medium Sensitivity Survey (AMSS; or the GIS catalog project). From the serendipitous fields amounting to 106 degE-2, we determined the Log N - Log S relations in the 0.7-7 keV and 2-10 keV bands with the best statistical accuracy obtained so far, over the flux range from 1 x 10E-11 to 5 x 10E-14 and 7 x 10E-14 erg sE-1 cmE-2, respectively. When the sources detected in the 0.7-7 keV band are divided into two subsamples with higher and lower spectral hardness, the former exhibits a significantly steeper slope than the latter at fluxes below ~10E-12 erg sE-1 cmE-2 (0.7-7 keV). The average spectrum of sources becomes continuously harder toward fainter fluxes, from a photon index of 2.1 in the 0.7-10 keV range at the flux of ~10E-11 to 1.6 at ~10E-13 erg sE-1 cmE-2 (0.7-7 keV). This is consistent with the comparison of source counts between the 2-10 keV and the 0.7-2 keV band, and solves the puzzle of their discrepancy reported previously. Our results demonstrate rapid emergence of hard X-ray sources with a decreasing flux from \~10E-12 to ~10E-13 erg sE-1 cmE-2 (2-10 keV).Comment: 10 pages, 3 figures (including 2 color figures). Accepted for publication in ApJ