Europe Eats the World: How the EUs Food Production and Consumption Impact the Planet

Despite being the world's largest exporter of agri-food products in economic terms, the EU carries a significant trade deficit when measured for what actually matters in nutritional terms, such as calories and proteins. The EU consumes more than its fair share and our current high levels of food production are only possible thanks to massive imports of resources

La biología sintética como desafío para comprender la autonomía de lo vivo

We here offer an alternative view of synthetic biology, quite distant from the engineering approaches that currently set the main research agenda of the field. Our analysis centres on those lines of work, both theoretical and experimental, whose primary objective is understanding the living phenomenon per se. A detailed review of several cases of artificial in vitro implementation of 'self-productive' chemical systems will help us reflect on the enormous challenge of transforming a descriptive scientific discipline, like biology, into an enterprise that comprises and fosters investigations articulated around the notion of synthesis or fabrication. The challenge is huge because of the intrinsic metabolic nature of biological systems, what makes our efforts to control or build them de novo much harder, forcing us to develop intervention/implementation platforms at the molecular level that do not threaten that inherent autonomous dimension of the living.En este artículo se ofrece una visión de la biología sintética alternativa a los planteamientos ingenieriles que marcan gran parte de la agenda de investigación del campo. Nuestro análisis se centra en enfoques, teóricos y experimentales, cuyo objetivo fundamental es la comprensión del fenómeno de la vida per se. Una revisión detallada de varios casos de implementación artificial, in vitro, de sistemas químicos ‘auto-productivos’ nos ayudará a reflexionar sobre el enorme reto que supone transformar una disciplina científica eminentemente descriptiva, como la biología, en un proyecto que incluya y potencie líneas de investigación basadas en la idea de síntesis o fabricación. El reto es mayúsculo debido al carácter intrínsecamente metabólico de los sistemas biológicos, lo cual hace que nuestro empeño en controlarlos o en construirlos de novo sea mucho más dificultoso, forzándonos a desarrollar plataformas de intervención/implementación a nivel molecular que no pongan en compromiso esa inherente dimensión autónoma de lo vivo

In search of conceptual bridges: a review of Krohs, U. & Kroes, P. "Functions in Biological and Artificial Worlds"

International audienc

"Minimal metabolism": A key concept to investigate the origins and nature of biological systems

The systems view on life and its emergence from complex chemistry has remarkably increased the scientific attention on metabolism in the last two decades. However, during this time there has not been much theoretical discussion on what constitutes a metabolism and what role it actually played in biogenesis. A critical and updated review on the topic is here offered, including some references to classical models from last century, but focusing more on current and future research. Metabolism is considered as intrinsically related to the living but not necessarily equivalent to it. More precisely, the idea of "minimal metabolism", in contrast to previous, top-down conceptions, is formulated as a heuristic construct, halfway between chemistry and biology. Thus, rather than providing a complete or final characterization of metabolism, our aim is to encourage further investigations on it, particularly in the context of life's origin, for which some concrete methodological suggestions are provided.This work was carried out as part of a Horizon 2020 Marie Curie ITN ("ProtoMet"-Grant Agreement no. 813873 with the European Commission), within which NL obtained a PhD fellowship. KR-M also acknowledges support from the Basque Government (Grant IT 122819) and the Spanish Ministry of Science and Innovation (PID2019-104576GB-I00

Reflections on the origin of life : more than an 'evolutionary' problem

This paper argues that the question of the origin of life cannot be explained by appealing exclusively to Darwinian evolutionary mechanisms, as many experts tend to assume, but requires a profound change in perspective. Accordingly, we highlight the fact that, in order to operate as a diversification force (and indirectly, a force for a potential increase in complexity), natural selection requires a number of conditions to be met in order for it to be possible: specifically, self-sustained and self-(re-)productive chemical organisation within a sufficiently large phenotypic space (that is, a wide range of functions). Therefore, we suggest an extension of the «self-organising» paradigm towards a «self-(re-)productive» one as an alternative to the main proposals regarding the origin of life, based on molecular populations (typically RNA) subject to Darwinian evolution. Such a paradigm would adequately portray the specificity of the biological phenomenon (particularly, its metabolic and cellular dimension) and would be relevant before, during, and after natural selection started to operate

Editorial: ‘Inter-Identities’ in Life, Mind, and Society

The main funding for this research was received by the Ministry of Economy and Competitiveness (Spain) FFI2014-52173-P Research Project on Inter-Identities (PIs: AE and KR-M). AE and KR-M also acknowledge funding from the Basque Government Research Groups IT 1228-19 to IAS Research on Life, Mind and Society

Structural and functional interaction between polyamine related molecules and biological membranes

La comunicación describe el conocimiento actual sobre las interacciones de biomoléculas relacionadas con el metabolismo de poliaminas con las estructuras y funciones de las membranas biológicasChanges induced by PA on nucleic acid (NA) conformation and synthesis is proven to be a major reason for PA essentiality (1-3). However, PA interactions with other polyanions, for instance polyanionic membrane lipid bilayers and glyosaminoglycans have received less attention (3-4). The functional importance of these interactions still is an obscure but interesting area of cell and molecular biology, especially in mammalian cells for which specific PA transport systems are not fully characterized (5). In mammals, activity and turnover of the polyamine (PA) synthesis key enzyme is controlled by a set of proteins: Antizymes (OAZ1-3) and antizyme inhibitors (AZIN1 and 2). It is demonstrated that AOZ modulate polyamine uptake (6), and that PA transport to mitochondria is linked to the respiratory chain state and modulates mitochondrial permeability transition (7). Antizyme expression variants have been located in mitochondria, being proposed as a proapoptotic factor (7-8). AZIN 2 is only expressed in a reduced set of tissues that includes mast cells, where it is associated to mast cell granules membrane (9). This fact, together to the abnormalities observed in bone marrow derived mast cell granules when they are differentiated under restricted PA synthesis conditions (10 and unpublished results), point out to important roles of PA and their related proteins in structure and function of mast cell granules. We will also present novel biophysical results on tripartite interactions of PA that remark the interest of the characterization of PA interactions with lipid bilayers for biomedicine and biotechnology. Thus, the information reported in this paper integrates previously reported information with our still unpublished results, all indicating that PA and their related proteins also are important factors for structure and dynamics of biological membranes and their associated functions essential in human physiology; for instance, solute interchange with the environment (uptake and secretion), oxidative metabolism and apoptosis. The importance of these involved processes for human homeostasis claim for further research efforts. 1. Ruiz-Chica J, Medina MA, Sánchez-Jiménez F and Ramírez FJ (2001) Fourier Transform Raman study of the structural specificities on the interaction between DNA and biogenic polyamines. Biophysical J. 80:443-454. 2. Lightfoot HL, Hall J (2014) Endogenous polyamine function--the RNA perspective. Nucleic Acids Res. 42:11275-11290. 3. Igarashi K, Kashiwagi K (2010) Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 42:39-51. 4. Finger S, Schwieger C, Arouri A, Kerth A, Blume A (2014) Interaction of linear polyamines with negatively charged phospholipids: the effect of polyamine charge distance. Biol Chem. 395:769-778. 5. Poulin R, Casero RA, Soulet D. (2012) Recent advances in the molecular biology of metazoan polyamine transport. Amino Acids. 42:711-723. 6. Kahana C (2009) Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Essays Biochem. 4:47-61. 7. Agostinelli E, Marques MP, Calheiros R, Gil FP, Tempera G, Viceconte N, Battaglia V, Grancara S, Toninello A (2010) Polyamines: fundamental characters in chemistry and biology. Amino Acids 38:393-403. 8. Liu GY, Liao YF, Hsu PC, Chang WH, Hsieh MC, Lin CY, Hour TC, Kao MC, Tsay GJ, Hung HC (2006) Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases' cascade. Apoptosis 11:1773-1788. 9. Kanerva K, Lappalainen J, Mäkitie LT, Virolainen S, Kovanen PT, Andersson LC (2009). Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion. PLoS One 31:e6858. 10. García-Faroldi G, Rodríguez CE, Urdiales JL, Pérez-Pomares JM, Dávila JC, Pejler G, Sánchez-Jiménez F, Fajardo I (2010) Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS One 30:e15071.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech