Publication Design Workbook: A Real-World Design Guide

A book review of Publication Design Workbook by Timothy Samara

Aprendizaje colaborativo basado en tecnologías multimedia

Uno de los objetivos del Espacio Europeo de Educación Superior (EEES) es la incorporación de metodologías docentes innovadoras que conviertan al alumno en una parte activa del proceso de aprendizaje. Una de estas metodologías que fomentan la participación del alumno en el proceso de adquisición de conocimientos es la de aprendizaje colaborativo, que permite a los alumnos, además de facilitar la comprensión y asimilación de los contenidos y la adquisición de las competencias propias de la asignatura, adquirir nuevas competencias relacionadas con el trabajo en grupo. El uso de tecnologías multimedia para desarrollar y presentar el trabajo realizado, combinado con tecnologías web, aumenta el grado de motivación e implicación de los alumnos, y las posibilidades de divulgación de los contenidos. En este artículo se describe la experiencia docente llevada a cabo en la asignatura de Arquitectura de Redes de Computadores de la Universidad de Valencia. Los alumnos divididos en grupos han realizado objetos digitales de aprendizaje, los cuales han sido divulgados libremente a través de la red, logrando con ello, además del aprendizaje colaborativo dentro del propio grupo, también un aprendizaje intergrupal. Los grupos obtienen retroalimentación acerca de su trabajo en base a los comentarios y evaluaciones realizados por alumnos externos al grupo de trabajo y por los profesores de la asignatura.SUMMARY -- One of the targets of the European Space of Higher Education is the use of innovative teaching methodologies to convert students into active participants during the learning process. One of these methodologies is the collaborative learning, which promotes the students participation throughout the process of knowledge acquisition. The collaborative learning allows students to acquire new skills related to working groups, as well as to reinforce and acquire skills of the own subject. The use of web multimedia technologies increases students’ motivation, students’ integration and the possibilities of broadcasting the outcomes of the work. This paper shows the teaching experience performed in a subject about Computer Network Architecture in the University of Valencia. In this subject, students divided into groups have defined teaching digital objects that have been spread through internet, allowing a collaborative learning inside each working group and among other groups. This way, each group can receive feedback from comments and evaluations performed by students of other groups and by the teachers

Identificación de genes y polimorfismos asociados a fenotipos óseos

El deterioro óseo sucede principalmente como consecuencia del envejecimiento en ambos sexos y particularmente con la depleción estrogénica que ocurre durante la menopausia en la mujer. Este deterioro en la calidad ósea puede desembocar finalmente en el desarrollo de patologías óseas como la osteoporosis, y en última instancia en el fenotipo clínico de peor pronóstico, la fractura ósea por fragilidad. Ambos fenotipos, la osteoporosis y la fractura por fragilidad, se consideran patologías complejas o multifactoriales; esto es, influenciadas por múltiples factores entre los que se encuentran factores genéticos, epigenéticos o ambientales. En la caracterización de los factores genéticos que intervienen en estos fenotipos se han venido utilizando múltiples aproximaciones, cada vez más costosas, pero que, en conjunto, no han llegado a explicar más que un pequeño porcentaje de la varianza fenotípica total observada. En los últimos años se ha demostrado que la interacción de los sistemas óseo, inmune y hematopoyético trasciende de la de meros compañeros de nicho, pues sus células principales ocupan el mismo espacio-tiempo en la médula ósea, lo que hace posible múltiples interacciones entre ellas. Ésto ha hecho necesaria la creación de una nueva disciplina de estudio, que se ha bautizado como Osteoinmunología. El objetivo principal de este trabajo de Tesis Doctoral ha sido la caracterización genética de los fenotipos mencionados y para ello se han realizado distintos abordajes, algunos de ellos muy novedosos. El abordaje más clásico es el de los estudios de asociación bajo hipótesis previa, también conocidos como estudios de genes candidatos. En el presente trabajo se ha usado esta aproximación y así, se ha intentado la replicación de estudios previos de otros investigadores, pero también se han elegido para su estudio genes candidatos relacionados con la osteoinmunología como CD40 y CD40L. Sin embargo, el presente trabajo no se ha limitado a identificar una posible asociación genética, sino que, además, se ha centrado en intentar determinar la funcionalidad de los polimorfismos, integrando los resultados desde una aproximación global, en la que se pretende abordar el problema desde una perspectiva traslacional e integradora. Fruto de estos abordajes se ha conseguido corroborar o describir por primera vez la asociación a fenotipos óseos de polimorfismos en los genes CD40, CD40L, y LRP5, entre otros. Un abordaje novedoso del presente trabajo ha sido el uso de aproximaciones traslacionales desde modelos animales y celulares para la identificación de nuevos genes candidatos para su estudio en nuestra cohorte de mujeres. Así, la aproximación traslacional desde el modelo animal de pérdida ósea acelerada, como es el ratón sometido a ovariectomía, ha aportado nuevos genes candidatos y ha subrayado el papel crucial de la célula B en la regulación de la homeostasis ósea debida al déficit de estrógenos, lo que nos ha servido de modelo de lo que sucede en la menopausia. Por este motivo se ha realizado por primera vez un estudio en el que se ha analizado la expresión génica diferencial mediante microarrays entre células B de médula ósea de ratonas ovariectomizadas y SHAM. De esta manera se han asociado por primera vez a fenotipos óseos polimorfismos en los genes CD80, CD86 y MMP9. Estos resultados apuntan a que el papel de la célula B en la regulación de la homeostasis ósea no está ni mucho menos esclarecido. Por último, en el presente trabajo se ha tratado de caracterizar la fractura por fragilidad desde un punto de vista más clínico, mediante la determinación de parámetros clásicos, pero también de novedosas determinaciones de miRNAs séricos, lo que nos ha llevado a describir diversos parámetros que pueden postularse como potenciales biomarcadores del riesgo de fractura como el nivel de fosfato o de HDL o tres miRNAs séricos, en especial miR-21-5p

User Interface Design for Searching Biomedical Literature

Biomedical bibliographic sources are crucial resources for the work of physicians, biologists, and bioinformatics. Many of the genetic-medical diagnoses depend on the findings in these bibliographic sources. Despite the importance and value of the information stored in these repositories, the user interface (UI) of these resources does not provide the adequate mechanisms to interact with the content, converting the query and interpretation of the information into complex and time-consuming tasks. In this sense, improving the usability of these UIs becomes a challenge since this means facilitating the interaction, analysis and comparison of biomedical information, and, consequently, improving the productivity of professionals in this domain. This paper presents a UI design for the search of biomedical bibliography that incorporates solutions to the usability problems documented and detected by a study of the literature. The proposed design becomes a usability heuristic for UI designers facing the development of UIs in this domain

Challenges for Model-Driven Development of Strategically Aligned Information Systems

[EN] Model-Driven Development (MDD) has been proposed as an alternative to the traditional development of information systems, given its ability to integrate different stakeholders into the information system engineering process. Currently, longtime researched MDD methods and modern no-code and low-code platforms support the generation of the working code of the information system and services. However, in today's continuously changing environment, organisations need to align the information systems and services with the business structure, strategy, and processes they support. This article shows the design challenges for integrating business strategy information into a model-driven development method. We applied a set of mechanism experiments on an MDD method composed of three modelling frameworks with demonstrated semantic consistency, that covers the organisational, business process, and information system levels to identify information loss and transformation coverage issues that prevent the generation of information systems and services that are strategically aligned. The challenges were discussed with experts, confirming the relevance of avoiding the overlapping between the strategic and business process concepts, providing organisational-level constructs to express strategic ends and means, and considering the organisational structure in the modular design of business process and information systems and services.This work was supported in part by the Spanish State Research Agency and the Generalitat Valenciana under Project MICIN/AEI/10.13039/501100011033, Project GV/2021/072, and Project INNEST/2021/57 by Agencia Valenciana de Innovacion (AVI); in part by the European Regional Development Fund (ERDF), the European Union Next Generation, and Plan de Recuperacion, Transformacion y Resiliencia (PRTR); and in part by the National Agency for Research and Development (ANID)/Scholarship Program/Doctorado Becas Chile under Grant 2020-72210494.Noel-Lopez, R.; Panach, JI.; Pastor López, O. (2022). Challenges for Model-Driven Development of Strategically Aligned Information Systems. IEEE Access. 10:38237-38253. https://doi.org/10.1109/ACCESS.2022.316222538237382531

Improvement of usability in user interfaces for massive data analysis: an empirical study

[EN] Big Data challenges the conventional way of analyzing massive data and creates the need to improve the usability of existing user interfaces (UIs) in order to deal with massive amounts of data. How the UIs facilitate the search for information and helps in the end-user's decision-making depends on developers and designers, who have no guides for producing usable UIs. We have proposed a set of interaction patterns for designing massive data analysis UIs by studying 27 real case studies of massive data analysis. We evaluate if the proposed patterns improve the usability of the massive data analysis UIs in the context of literature search. We conducted two replications of the same controlled experiment, one with 24 undergraduate students experienced in scientific literature search and the other with eight researchers who are experienced in biomedical literature search. The experiment, which was planned as a repeated measures design, compares UIs that have been enhanced with the proposed patterns versus original UIs in terms of three response variables: effectiveness, efficiency, and satisfaction. The outcomes show that the use of interaction patterns in UIs for massive data analysis yields better and more significant effects for the three response variables, enhancing the discovery and visualization of the data. The use of the proposed interaction design patterns improves the usability of the UIs that deal with massive data. The patterns can be considered as guides for helping designers and developers to design usable UIs for massive data analysis web applications.The authors thank the members of the PROS Center Genome group for productive discussions. In addition, it is also important to highlight that the Secretaría Nacional de Educación, Ciencia y Tecnología (SENESCYT) and the Escuela Politécnica Nacional from Ecuador have supported this work. 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