James Weldon Johnson and the Speech Lab Recordings

Through my work editing the collection, I seek to bring these recordings to public attention and also to situate them in their context among the rest of the recordings in the Speech Lab Recordings,4 taking note too of the material conditions of their production.Not

Les archives sonores de la poésie: production – conservation – utilisation

As recent reports by the United States Library of Congress have shown, many historical sound recordings are in danger of degradation or destruction, due to the decomposition of the media upon which they are inscribed (Library of Congress; CLIR and Library of Congress). Reel-to-reel tapes, which have a stated shelf-life of 25 years, threaten to disintegrate into chips and powder as they await digitization in sometimes less-than-ideal archival storage. The same is true of acetate transcription ..

Les archives sonores de la poésie: production – conservation – utilisation

As recent reports by the United States Library of Congress have shown, many historical sound recordings are in danger of degradation or destruction, due to the decomposition of the media upon which they are inscribed (Library of Congress; CLIR and Library of Congress). Reel-to-reel tapes, which have a stated shelf-life of 25 years, threaten to disintegrate into chips and powder as they await digitization in sometimes less-than-ideal archival storage. The same is true of acetate transcription ..

Sound Pedagogy – Teaching the Audible Dimensions of Poetry: A Conversation (plus clips and sample syllabus) with Chris Mustazza

In 2018 I had the opportunity to visit one of Chris Mustazza's interdisciplinary literature classes taught at the University of Pennsylvania, a course called Poetry Audio Lab: Modernism & Sound Studies. I was amazed at how seamlessly he had woven questions of poetics, performance, media history, and digital approaches to listening and analysis into his syllabus. As one of the early experimenters in teaching poetry through a major audio poetry archive (PennSound), and as a regular collaborator with Al Filreis, another innovator in this area who draws upon the audio archive in his wide-reaching ModPo MOOC, talking to Chris about teaching proved a unique opportunity to think about rationale, methods and effects of teaching poetry with sound

Role of ozone therapy in the treatment of osteonecrosis of the jaws in multiple myeloma patients.

Current treatments for bisphosphonate-associated osteonecrosis of the jaw (ONJ) in multiple myeloma patients have limited efficacy. The biological effects of ozone indicate it may be therapeutic for ONJ. We, here, report the efficacy of a 15-day course of antibiotics, surgery and ozone therapy in 12 MM patients with ONJ

The evolution of the illegal market of falsified medicines and the experience of the Italian OMCL: from control to research.

Abstrac

[Dmt 1 ]N/OFQ(1–13)‐NH 2 : a potent nociceptin/orphanin FQ and opioid receptor universal agonist

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95271/1/bph2115.pd

Structural Requirements of N-Substituted Spiropiperidine Analogues as Agonists of Nociceptin/Orphanin FQ Receptor

The nociceptin/orphanin FQ (NOP) receptor is involved in a wide range of biological functions, including pain, anxiety, depression and drug abuse. Especially, its agonists have great potential to be developed into anxiolytics. In this work, both the ligand- and receptor-based three-dimensional quantitative structure–activity relationship (3D-QSAR) studies were carried out using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques on 103 N-substituted spiropiperidine analogues as NOP agonists. The resultant optimal ligand-based CoMSIA model exhibited Q2 of 0.501, R2ncv of 0.912 and its predictive ability was validated by using an independent test set of 26 compounds which gave R2pred value of 0.818. In addition, docking analysis and molecular dynamics simulation (MD) were also applied to elucidate the probable binding modes of these agonists. Interpretation of the 3D contour maps, in the context of the topology of the active site of NOP, provided insight into the NOP-agonist interactions. The information obtained from this work can be used to accurately predict the binding affinity of related agonists and also facilitate the future rational design of novel agonists with improved activity