Children in residential care in México:Understanding profiles, trajectories and outcomes

Residential care continues to be the primary child protection measure for children in Mexico given the limited access to family placements and family support programmes. Legislation regulating residential care homes was not enacted until 2014. The first census of children in care was conducted in 2015. Prior to that year, key information such as how many children were placed in residential care, who was caring after them, what kinds of living conditions they faced, and their families histories was not well documented. To date, there remains a lack of reliable information on the number of children in residential care but it is estimated to be approximately 26,000. The lack of oversight has contributed to serious violations of children's rights. This article presents an overview of residential care in Mexico, including profiles of the children, families, and professionals involved. It also outlines the residential care process and various factors involved in decision-making, with special attention to children from minoritized groups. We conclude that residential care in Mexico still presents a myriad of challenges and obstacles to providing comprehensive care for children

Stories in Mexico and the United States About the Border: The Rhetoric and the Realities

Our goal in this article is to demonstrate how perspective, political agenda, and personal experiences affect how stories about the Mexico-U.S. Border are framed. The framing is shaped by audience and emotional appeal, as well as political agenda. Stories framed and portrayed as personal experiences and stock narratives about a group or country can shape the attitude, experience, and behavior of others. Our discussion will: 1) examine the concept of using word choices and metaphors as devices in storytelling to frame political, economic and social issues, which are meant to evoke certain emotional responses among specific audiences in the immigration debates; 2) describe the legal history of the border as a legal and social construct as background for the stories that are told about immigration; 3) demonstrate with examples of stories published in Mexico and the U.S. that portray how some stories about the border are being framed in the U.S. and in Mexico by identifying word choices, metaphors, audience, social and/or political connections and emotional responses provoked in these narratives, particularly examples of stories published in Mexico; 4) examine the traditional mental frames created by the border stories that do not describe the effect of U.S. policies and practices on a cross-national indigenous community; and finally 5) demonstrate how the members of the transnational tribal communities have worked to tell their own stories about the lived realities of their border experiences

FireDB—a database of functionally important residues from proteins of known structure

The FireDB database is a databank for functional information relating to proteins with known structures. It contains the most comprehensive and detailed repository of known functionally important residues, bringing together both ligand binding and catalytic residues in one site. The platform integrates biologically relevant data filtered from the close atomic contacts in Protein Data Bank crystal structures and reliably annotated catalytic residues from the Catalytic Site Atlas. The interface allows users to make queries by protein, ligand or keyword. Relevant biologically important residues are displayed in a simple and easy to read manner that allows users to assess binding site similarity across homologous proteins. Binding site residue variations can also be viewed with molecular visualization tools. The database is available a

Child protection in Mexico:A review of policy, system structure and current challenges

In 2014 Mexico created the General Law for the Protection of Children and Adolescents, which establishes a new organization of the child protection system that legally complies with the requirements of international treaties. Since this change, the focus of attention of policy makers, civil society organizations and society in general has been on child protection. However, not many studies have addressed the Mexican child protection system. This research aims to present the evolution of the system, its structure, remaining gaps and provide suggestions for policy, research, and practice. We conclude that the system is legally well embedded, however, it is necessary to strengthen the institutions with economic resources and trained personnel to carry out adequate practices to implement the system that is legally portrayed. There is a need to update the available information on the situation of children in order to evaluate the system and carry out appropriate research that will serve as a basis for new practices

Procesos de transición hacia el retiro deportivo: una revisión sistemática usando la herramienta PRISMA

The phenomena of sports retreat is a topic relatively new in sports science, for this reason it is addressed currently ideas about the process towards the sports retreat as the last stage in a professional sport career and competitive longevity in long-term athletes. The objective of this systematic revision is to identify researches which involve the way how they assume the transition process towards the sports retreat and the detraining of athletes.   To carry out this work, it was necessary an examination of the data. Scopus, Ebsco and Sciencedirect along august 2022.  The analysis was done through a combination of the terms: Detraining, Retirement and Sport using the inclusion criteria. Published review articles in the last ten years, In English or Spanish that allow access to complete texts. During the search 16.642 articles were found. After applying different filters and keeping in mind the title and the research objectives, 165 of them were taken into consideration, which were examined with the application of the check list suggested by the PRISMA tool. It provided us 17 articles to be considered in this research. From these, two of them come from systematic revision, one of them with PRISMA methodology, besides four quantitative and 11 qualitative. El fenómeno del retiro deportivo es una temática relativamente nueva en el campo de las ciencias del deporte, por ello se abordan ideas actuales acerca del proceso hacia el retiro deportivo, como la última etapa dentro de sus carreras profesionales y longevidad competitiva en deportistas de alto rendimiento. El objetivo de esta revisión sistemática es identificar las investigaciones que hablan sobre la manera como se asume el proceso de transición hacia el retiro deportivo y desentrenamiento en los deportistas. Para ello se realizó una búsqueda en las bases de datos. Scopus, Ebsco y Sciencedirect durante el mes de agosto del año 2022. La consulta se realizó combinando los términos: Detraining, Retirement y Sport utilizando los criterios de inclusión. Artículos de revisión, publicados en los últimos diez años, en idiomas inglés o español y que se tuviera acceso al texto completo. Durante la búsqueda se encontraron 16.642 artículos. Luego de aplicar los diferentes filtros teniendo en cuenta el título y los objetivos de la investigación se tuvieron en cuenta 165 de ellos, a los cuales se les aplicaron de nuevo los ítems incluidos en el check list de la herramienta PRISMA teniendo como resultado 17 artículos para ser contemplados en esta investigación. De estos, dos son de revisión sistemática, 1 de ellos con metodología PRISMA, además cuatro cuantitativas y once de carácter cualitativo

Osteogenic effects of simvastatin-loaded mesoporous titania thin films

The use of statins in the field of bone regeneration is under current investigation due to the existing demand for non-toxic anabolic agents capable of enhancing bone formation in cases of substantial loss. Simvastatin, a coenzyme currently prescribed in clinics to inhibit cholesterol biosynthesis, has been proven to promote osteogenic differentiation by stimulating bone formation and inhibiting osteoclasts activity. We present the loading of simvastatin in mesoporous TiO2 thin films toward combining the pro-osteogenic properties of this molecule with the demonstrated bioactivity of titania. TiO2 thin films processing and characterization were carried out, as well as evaluation of MC3T3-E1 pre-osteoblasts viability when directly incubated with different concentrations of simvastatin, followed by the analysis of osteogenic activity promoted by simvastatin upon loading in the thin films. The accessible porosity of 36% quantified on the 95 ± 5 nm thick mesoporous thin films, together with pore diameters of 5.5 nm, necks between pores of 2.8 nm and interpore distances of 12 ± 2 nm allow the loading of the simvastatin molecule, as confirmed by FTIR spectroscopy. Simvastatin was found to promote MC3T3-E1 pre-osteoblasts viability at concentrations ≤0.01 g l−1, with a cytotoxicity threshold of 0.05 g l−1. We additionally found that film loadings with 0.001 g l−1 simvastatin promotes statistically higher MC3T3-E1 pre-osteoblast proliferation whereas a higher concentration of 0.01 g l−1 leads to statistically higher osteogenic activity (ALP synthesis), after 21 days of incubation, as compared to unloaded films. These results demonstrate the potential of simvastatin local administration based on bioactive mesoporous thin films to promote pro-osteogenic properties. By focusing this strategy on the coating of metallic prostheses, the supply of simvastatin to the target tissue can be favored and risks of systemic side effects will be reduced while enhancing the osteointegration of the implants.Fil: Lopez Alvarez, Miriam. Universidad de Vigo; EspañaFil: López Puente, Vanesa. Universidad de Vigo; EspañaFil: Rodriguez Valencia, Cosme. Universidad de Vigo; EspañaFil: Angelome, Paula Cecilia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Liz Marzan, Luis M. Ikerbasque; EspañaFil: Serra, Julia. Universidad de Vigo; EspañaFil: Pastoriza Santos, Isabel. Universidad de Vigo; EspañaFil: Gonzalez, Pio. Universidad de Vigo; Españ

CFD Analysis of Bed Textural Characteristics on TBR Behavior: Kinetics, Scaling-up, Multiscale Analysis and Wall Effects

A simulation of a trickle bed reactor aided by computational fluid dynamics was implemented. With a Eulerian approach, geometrical characteristics were explicitly considered and two simultaneous heterogeneous reactions were included, hydrodesulphurization (HDS) and hydrodenitrogenation (HDN). This was performed in order to achieve the following: (1) attain further insight into a proper scaling‐up procedure to be able to obtain the same hydrodynamics and kinetics behavior in two reactors of different length and diameter scales; (2) develop a multiscale analysis regarding the communication of information between scales through the construction of a porous microstructure model from which the geometrical information of the microscale is captured by the effective transport coefficients (which affect the overall reactor behavior); (3) investigate the effect of operation conditions variations on hydrodynamics and kinetics; (4) and assess the deviations and further differences observed from average to punctual conversion values and the assumptions from kinetic literature models through a preliminary multiscale analysis. The CFD results were validated against experimental pressure drops data as well as HDS and HDN conversions theoretical data. An excellent agreement was found. The model produces a significant improvement in hydrodynamic parameters prediction, achieving 5 times better accuracy in predicting pressure drops and 50% improvement in holdup prediction. The fully coupled model predicts HDS conversion with 96% accuracy and HDN conversion with 94% accuracy. Results suggest that the best way to obtain similar kinetic and hydrodynamic behavior in TBRs with different length and diameter length scales is by equaling the liquid holdup (εγ) or the mass velocities (L‐G)

Aplicación de la metodología Lean Warehouse para mejorar la gestión de almacén en la empresa LAPIZ Y COLORES, Piura – 2023

La presente tesis obtuvo datos de fuentes primarias recopilados de la empresa LAPIZ Y COLORES SERVICIOS GENERALES E.I.R.L. El propósito de esta investigación fue aplicar la metodología Lean Warehouse para mejorar la gestión de almacén de la empresa LAPIZ Y COLORES, Piura – 2023. Para ello, se detectó que no existía un control de inventarios, ni una adecuada gestión de almacén, esto generaba pérdidas de stock, exceso de inversión de capital, insatisfacción del cliente, entregas poco estables, entre otros. Lo que produjo que la empresa se encuentre en condiciones desordenadas y deficientes, ocasionando una inadecuada gestión de almacén. El diseño de la investigación fue experimental, según su finalidad fue de tipo aplicada y con enfoque cuantitativo. Para solucionar la problemática mencionada se aplicaron herramientas de la metodología Lean Warehouse, como el Kardex, inventario ABC y clasificación ABC, mediante su aplicación se pudo obtener un mejor control de las entradas, salidas y stock de cada producto, por ende, ayudó a tomar mejores decisiones al momento de realizar su adquisición, asimismo, a conocer y organizar cada uno de los productos de mayor y menor importancia en el área de almacén