From Homo Sovieticus to Homo Zapiens: Viktor Pelevin's Consumer Dystopia

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72149/1/j.1467-9434.2008.00500.x.pd

Stress, stress responses and coping strategies among bachelor nursing students

Introductions: Inability to use effective coping strategies to minimize stress due to high academic and clinical expectations may affect nursing students’ health, academic and clinical performance. The aim of this study was to assess the level of stress, stress responses and use of coping strategies among bachelor nursing students. Methods: This-cross-sectional study included bachelor nursing program students selected by stratified random sampling technique from four nursing colleges affiliated to Tribhuvan University in Kathmandu Valley, Nepal, during August 18th to September 15th 2017. Data were collected using structured self-administered questionnaire. Perceived stress scale, physio-psycho-social responses scale and coping check lists were used to assess stress, stress responses and coping strategies of bachelor nursing students.               Results: There were total 284 participating nursing students, 240 (84.5%) had moderate level of stress and 20 (7%) high level of stress. The common source of stress were assignments and workload (2.37±0.63), and clinical environment (2.16±0.74). Students’ physio-psycho-social responses during stress, 109 (38.4%) reported best emotional health, 125 (44%) best social behavioral and 189 (66.7%) best physical health. Coping strategies were, problem focused 175 (61.6%), social support coping 173 (60.9%), and avoidance coping 165 (58.1%). There was a positive correlation between stress and coping (r=0.138).Conclusions: More than 3/4th of bachelor nursing students reported moderate level of stress, problem focused coping strategies was commonly used and half of the students maintained good level of physio-psychosocial health during stress. Keywords: coping strategies, nursing students, stress, stress responses

Evidence-based practice at Patan Academy of Health Sciences, Nepal: knowledge, attitude, behavior and barriers

Introduction: Evidence based practice (EBP) is the use of current best evidence in making decisions about the care of individual patients. The aim of this study was to explore the practices, attitudes, knowledge and perceived barriers in relation to EBP among faculty members at Patan Academy of Health Sciences (PAHS), Nepal. Methods: This was a cross-sectional survey study. Participants were faculty members (both clinical and non-clinical) at PAHS. The main outcomes were attitude towards the usefulness of EBP, the frequency of use of EBP in practice, and the barriers to carrying out EBP. Results: One hundred and seventy-two faculty members participated in this survey. Ninety five percent knew it was used for clinical decision making and the majority used it for teaching. Senior faculty spent more time on searching for evidence and reading compared to junior faculty. There was no difference between clinical and non-clinical departments. The main barriers to EBP were inadequate teaching learning support by 49% (85/172) followed by inadequate time 30% (52/172). Conclusions: The study showed that faculty at PAHS had a generally positive attitude towards EBP. EBP could be better facilitated by proper teaching and allocation of dedicated time. Keywords: evidence-based practice, faculties, health sciences, attitude- knowledge-behavio

Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma

Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity

Head and Neck Squamous Cell Carcinoma Detection and Surveillance: Advances of Liquid Biomarkers

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150578/1/lary27725.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150578/2/lary27725_am.pd

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the author name has been updated in the original publication. The authors also reported an error in the Methods section of the original article. In this Correction the incorrect and correct versions of the affected sentence are indicated. The original article has not been updated with regards to the error in the Methods section.https://deepblue.lib.umich.edu/bitstream/2027.42/144529/1/12967_2018_Article_1552.pd