Evaluation of structural stressmethod and master curve for fatigue life prediction of a weldedjoint

Este artigo apresenta um estudo dos métodos da tensão estrutural hot spot e do método da curva mestre (Battelle) para a determinação da vida à fadiga de uma junta soldada do tipo T. Ambos os métodos utilizam o conceito de tensão estrutural, determinada, normalmente, através de modelos de elementos finitos. Utilizando diferentes tipos de modelos de elementos finitos de casca, os resultados obtidos pelos 2 métodos foram comparados com os obtidos experimentalmente, verificando‐se diferenças significativas entre os métodos. Os níveis de carregamento influenciaram decisivamente na precisão de ambas as metodologias, sendo que, para o caso em estudo, o método hot spot demonstrou ser mais preciso. O maior diferencial constatado para o método de Battelle foi a correção do parâmetro da tensão estrutural, visto que, sem essa correção, as tensões no pé da solda foram muito similares às obtidas pelo método hot spot. Comparando a curva mestre de comportamento à fadiga do método de Battelle com a curva do método hot spot, ambas em função da tensão nominal aplicada no ensaio, verificou‐se que o método hot spot é conservador. Para os diferentes modelos numéricos estudados, apenas uma técnica de modelagem forneceu resultados dispersos das demais. Pelo método de Battelle, o comportamento da componente de flexão da tensão variou consideravelmente de um modelo para o outro, denotando que, sobre um carregamento mais complexo, poderá haver uma variabilidade maior na vida à fadiga calculada.This paper presents a study on the structural hot spot stress method and the master curve method (Battelle) for evaluating the fatigue life of a T‐shaped welded joint. Both methods are based on the concept of structural stress, which is usually determined using finite element models. Using different types of shell finite element models, the results obtained by the two methods were compared to experimental data, verifying significant differences between the studied methods. The loading level had a great deal of influence over the accuracy of both methodologies, but on the other hand the hot spot method revealed to be more precise for the analyzed joint. The main differential for the Batelle method was the correction of the stress amplitude into an equivalent structural stress parameter, since, without this correction, the stresses on the weld toe were very similar between the Battelle and the hot spot methods. Comparing the master curve for the fatigue behavior of the Battelle method to the fatigue curve of hot spot method, with both curves expressed in terms of the nominal stress applied in the experiment, it was verified that the hot spot method is conservative. Among the different modeling techniques used, only one provided results that are not in agreement with the others. Using the Battelle method, the behavior of the bending stress component varied considerably according to the employed numerical model, indicating that can be a greater variability in the expected fatigue life for joints under more complex loading configuration.Peer Reviewe

Fatalities due to intestinal obstruction following the ingestion of foreign bodies

Two fatalities due to an occlusive ileus following the ingestion of foreign bodies in patients with psychiatric disorders are described. A severely mentally handicapped young man developed a temperature and died 1 h after admission to a surgical ward. At autopsy, not, vert, similar 2000 cm3 of foreign material, including broken glass and porcelain, branches, buttons, parts of clothing and other material were found in the gastrointestinal tract, leading to a complete obstruction of the distal intestine and colon with resulting faecal vomiting. The other case was even more unusual as a hair fetishist had swallowed a thick strand of his own hair, 50 cm long, also resulting in mechanical obstruction of the distal intestine

Optoelectronic applications of solution-processable sulfide semiconductors

Solar cells and photodetectors rely on similar physical principles based on the interaction of light and matter. Both types of optoelectronic devices are indispensable in a wide range of technological applications, from large-scale renewable power conversion to everyday consumer items. In this thesis, the use of facile solution-processable semiconductors in solar cells and light sensors is studied with a focus on antimony sulfide (Sb$_2$S$_3$) and antimony sulfoiodide (SbSI). The improvement of the photovoltaic performance in Sb$_2$S$_3$ sensitized solar cells upon the controlled partial oxidation of the absorber layer is investigated. A reduction in charge carrier recombination is the reason for the improved efficiency, caused by the oxidation process. Further, a new chemical bath deposition method for antimony sulfide is developed. Carried out at room temperature, this technique eliminates the necessity of cooling equipment during the deposition process. The antimony sulfide from this method decreases the density of trap states compared to the conventional deposition. Power-conversion efficiencies of up to $\eta=5.1\,\%$ are achieved in antimony sulfide sensitised solar cells using the new room temperature deposition method. Finally, antimony sulfide is used as a precursor to form films of antimony sulfoiodide (SbSI) micro-crystals in a facile physical vapour process. These films are then used to fabricate photodetectors. With PMMA as an insulating spacer layer, the devices are built in a sandwich-type architecture. Optoelectronic characterisation shows that these devices have the shortest response and recovery times reported for SbSI photodetectors to date

Numerical simulation of the road bus structure submitted a offset frontal impact against a rigid wall

Neste trabalho se apresenta um estudo paramétrico do impacto semifrontal em um ônibus, no qual se avalia independentemente a influência de cada variável envolvida neste tipo acidente. O cenário de impacto semifrontal é sem dúvida um dos mais severos acidentes envolvendo ônibus, pois parte da lateral do ônibus é totalmente danificada, podendo deixar um elevado número de vítimas. A simulação numérica utiliza um modelo de análise explícita formado por elementos de vigas que utiliza uma lei constitutiva elasto‐plástica, a qual leva em conta a influência da taxa de deformação. Com este modelo se realiza um estudo paramétrico das variáveis globais que permitem caracterizar este tipo de cenário. Também são avaliados de forma qualitativa acidentes deste tipo acontecidos nas estradas brasileiras. A discussão dos resultados é finalmente apresentada e serve como um primeiro passo na busca de melhorias a serem introduzidas nas estruturas dos ônibus, objetivando minimizar os danos.This paper presents a parametric study of the offset frontal impact on a bus, in which is assessed independently an influence of each variable involved in this accident type. The scenario of offset frontal impact is surely one of the most severe accidents involving buses, once the same has part of your lateral totally damaged and can leave a large number of victims. The numerical simulation model uses an explicit analysis formed by beams elements which uses elastic‐plastic constitutive law, which takes into account the influence of strain rate. With this model a parametric study of global variables that can characterize this type of scenario is realized. Also are evaluated qualitatively real accidents happened on Brazilian roads. The discussion is finally presented, and serves as a first step in the search for improvements to be made to the structures of the bus, aiming to minimize the damage.Peer Reviewe

Finding History: A Curatorial Analysis

https://scholarworks.moreheadstate.edu/student_scholarship_posters/1034/thumbnail.jp

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus

A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus. Efficiency of expression was investigated in the Escherichia coli strain CAG456. The synthesized protein was sequestered in an insoluble form in inclusion bodies and was purified to homogeneity by one-step affinity chromatography based on the specific complex formation of the histidine-hexapeptide and a chelating matrix which was charged with Ni2+ ions. The antigenic nature of the purified recombinant preproinsulin fusion protein was evaluated by ELISA screening for insulin autoantibodies in selected sera from patients with recent-onset type 1 (insulin-dependent) diabetes mellitus classified by the existence of additional autoantibodies reactive against glutamic acid decarboxylase. 14% of the tested sera (n=43) conttained insulin autoantibodies which strongly recognized the recombinant human preproinsulin. Comparable measurements with both recombinant human preproinsulin and mature insulin suggested that the observed autoantigenicity of preproinsulin was mediated by the C-peptide or/and signal peptide

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy

Frameshift mutations in the TTN gene encoding titin are a major cause for inherited forms of dilated cardiomyopathy (DCM), a heart disease characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure. To date, there are no specific treatment options for DCM patients but heart transplantation. Here, we show the beneficial potential of reframing titin transcripts by antisense oligonucleotide (AON)-mediated exon skipping in human and murine models of DCM carrying a previously identified autosomal-dominant frameshift mutation in titin exon 326. Correction of TTN reading frame in patient-specific cardiomyocytes derived from induced pluripotent stem cells rescued defective myofibril assembly and stability and normalized the sarcomeric protein expression. AON treatment in Ttn knock-in mice improved sarcomere formation and contractile performance in homozygous embryos and prevented the development of the DCM phenotype in heterozygous animals. These results demonstrate that disruption of the titin reading frame due to a truncating DCM mutation canbe restored by exon skipping in both patient cardiomyocytes invitro and mouse heart invivo, indicating RNA-based strategies as a potential treatment option for DCM

Disseminated Effects in Agent Based Models: A Potential Outcomes Framework and Application to Inform Pre-Exposure Prophylaxis Coverage Levels for HIV Prevention

Pre-exposure prophylaxis (PrEP) for HIV prevention may not only benefit the individual who uses it, but also their uninfected sexual risk contacts. We developed an agent-based model using a novel trial emulation approach to quantify disseminated effects of PrEP use among men who have sex with men in Atlanta, USA from 2015 to 2017. Components (subsets of agents connected through partnerships in a sexual network, but not sharing partnerships with any other agents) were first randomized to an intervention coverage level or control, then within intervention components, eligible agents were randomized to PrEP. We estimated direct and disseminated (indirect) effects using randomization-based estimators and reported corresponding 95% simulation intervals across scenarios ranging from 10% to 90% coverage in the intervention components. A population of 11,245 agents was simulated with an average of 1,551 components identified. Comparing agents randomized to PrEP in 70% coverage components to control agents, there was a 15% disseminated risk reduction in HIV incidence (95% simulation intervals = 0.65, 1.05). Individuals not on PrEP may receive a protective benefit by being in a sexual network with higher PrEP coverage. Agent-based models are useful to evaluate possible direct and disseminated effects of HIV prevention modalities in sexual networks

Lifting paddle wheel : full-size protype craft development.

This report describes the construction, testing and analysis of a large scale lifting paddlewheel craft. No large scale vehicle of this style exists to date; a small scale version has previously been successful. A 4wd farm bike provided the basis for the prototype with modifications for use in an aquatic environment. Following open water tests, ongoing developmental work was carried out. This included the analysis and prediction of the crafts performance, operation of the lifting paddlewheels and comparison of the successful small scale craft to that of the prototype constructed. The prototype did not operate as the lifting paddlewheels were intended. Predictions initially showed a deficit in power comparable with the craft comparison which showed a large difference in the power to weight of the crafts. Modifications to increase the power and following tests proved to also be unproductive. Analysis of the farm bike prototype dynamics showed a possibility of successful operation should certain criteria be met