Investigation of creep, fracture, and bending of lead and lead alloys for cable sheathing-series 1946

Cover title.Prepared as part of an investigation conducted by the Engineering Experiment Station, University of Illinois at Urbana-Champaign

A new direction in British choral composition : Jonathan Dove and Bob Chilcott

This project investigates a new style of choral composition developing in Great Britain through the analyses of two contemporary compositions: It Sounded as if the Streets Were Running by Jonathan Dove and The Making of the Drum by Bob Chilcott. The paper examines the background of the composers and the possible influences on their compositional style. Salient features in the music of these composers include: coherent non-­‐traditional tonalities, non-­‐traditional tonal shifts, motivic ostinatos, and rhythmic complexity. It is asserted that through the analyses and comparisons to other contemporary composers that Dove and Chilcott are at the forefront of an emerging style of British choral composition.Thesis (M.M.)School of Musi

Influences of mobility on the academic progress of pupils in the fourth and sixth grades of Quantico Post Elementary School

The purpose of this study is to determine to what extent mobility­ of pupils at the elementary school level affects their academic achievement. Is there correlation between the number of moves and retardation in academic achievement? It has boon the opinion of the teachers and administrators of the Quantico Post Elementary School that the pupils who are forced to transfer so frequently are handicapped by the many changes. They have found it necessary at all grade levels to do a great deal of individual work as they have found these pupils to be very retarded in specific skills and fundamentals

Readerly Curiosity: theorizing narrative experience in the Greek novel

This thesis proposes that the ancient Greek novels theorize their readers from within themselves. The novels self-consciously promote and construct a reader who is curious, or polypragmôn, and lead this reader towards a recognition of that fact. The reader becomes aware of his or her experience of reading as a process. Drawing on Plutarch's suggestion that the best way to turn curiosity into a force for good is to turn it on oneself, this thesis puts forward the idea that the novels lead a curious reader to engage with his or her encounter with the text, to identify him or herself as curious, and in so doing come to a position of self-analysis. Attention is drawn to the experience of reading, and the lessons that can be learnt from it, by the embedding of narratives within the novels. Embedded or partial narratives can suggest alternative storylines and encourage the curious reader to pry and collaborate with the narrator. The experience of interior space maps the reader's encounter with the novel, constructing him or her as curious as s/he is encouraged to peep through gaps in doors, follow the narrator through doors, and think about his or her status as voyeur and eavesdropper. Deceptive narratives lead the reader to follow suggested storylines and to interrogate the text to try to discover the 'truth' that may lie behind the narrative. Finally, the presence of female characters incites the curious reader to find out what s/he can about them, pushing the narrative to its limit. In going through this process of interrogating the text and actively striving to find out more by reading between the lines, the reader becomes aware of reading as a process, and of his or her curiosity, thus becoming able to analyse him or herself. The novels thus promote a theory of how their readers approach them

Development of Technologies and Test Formats for Credibility Assessment

From introduction: "Because Credibility Assessment is a relatively new and developing field there are different ways of describing it and what it encompasses. For ihe purposes of this paper Credibility Assessment is defined as the process of determining the reliability and validity of information, regardless of source. "(...

Comparison of Utah and DoDPI Scoring Accuracy: Equating Veracity Decision Rule, Chart Rule, and Number of Data Channels Used

The performance of scorers using the University of Utah and Department of Defense Polygraph Institute (DoD PI) physiological detection of deception chart evaluation rules were compared to discover if differences in laboratory-based decision accuracy rates are due to chart evaluation rules. Four scorers (two based at the DoD PI , two based at the University of Utah) evaluated the charts from 100 polygraph examinations (50 deceptive, 50 nondeceptive). We attempted to isolate scorer ability by equating the rules for making veracity decisions, number of charts used, and number of data channels considered. There was no evidence, when these variables were held constant, that scorers differed on the proportion of correct, incorrect, or no opinion decisions rendered. Results suggest no differences in chart scoring ability among scorers based at the two institutions. Observed differences in accuracies for Utah and DoDPI scoring systems may be due to differences in veracity decision rules, the number of charts evaluated, the inclusion of the photo-plethysmograph data channel, or a combination of these factors. The greatest accuracy was obtained by all scorers using the University of Utah chart evaluation rules

Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors

Hsp90 is a molecular chaperone responsible for the assembly and regulation of many cellular client proteins. In particular, Trap1, a mitochondrial Hsp90 homologue, plays a pivotal role in maintaining mitochondrial integrity, protecting against apoptosis in cancer cells. The N (N-terminal)-M (middle) domain of human Trap1 was crystallized in complex with Hsp90 inhibitors (PU-H71 and BIIB-021) by the hanging-drop vapour-diffusion method at pH 6.5 and 293 K using 15% PEG 8K as a precipitant. Diffraction data were collected from crystals of the Trap1-PU-H71 (2.7 A) and Trap1-BIIB-021 (3.1 A) complexes to high resolution at a synchrotron-radiation source. Preliminary X-ray diffraction analysis revealed that both crystals belonged to space group P41212 or P43212, with unit-cell parameters a = b = 69.2, c = 252.5 A, and contained one molecule per asymmetric unit according to Matthews coefficient calculations.open1

Different Poses for Ligand and Chaperone in Inhibitor Bound Hsp90 and GRP94: Implications for Paralog-specific Drug Design

Hsp90 chaperones contain an N-terminal ATP binding site that has been effectively targeted by competitive inhibitors. Despite the myriad of inhibitors, none to date have been designed to bind specifically to just one of the four mammalian hsp90 paralogs, which are cytoplasmic Hsp90α and β, ER GRP94, and mitochondrial Trap-1. Given that each of the hsp90 paralogs is responsible for chaperoning a distinct set of client proteins, specific targeting of one hsp90 paralog may result in higher efficacy and therapeutic control. Specific inhibitors may also help elucidate the biochemical roles of each hsp90 paralog. Here we present side by side comparisons of the structures of yeast Hsp90 and mammalian GRP94, bound to the pan-hsp90 inhibitors Geldanamycin and Radamide. These structures reveal paralog specific differences in the Hsp90 and GRP94 conformations in response to Geldanamycin binding. We also report significant variation in the pose and disparate binding affinities for the Geldanamycin-Radicicol chimera Radamide when bound to the two paralogs, which may be exploited in the design of paralog-specific inhibitors