Optimization and implementation of the wavelet based algorithms for embedded biomedical signal processing

Existing biomedical wavelet based applications exceed the computational, memory and consumption resources of low-complexity embedded systems. In order to make such systems capable to use wavelet transforms, optimization and implementation techniques are proposed. The Real Time QRS Detector and De-noising Filter are developed and implemented in 16-bit fixed point microcontroller achieving 800 Hz sampling rate, occupation of less than 500 bytes of data memory, 99.06% detection accuracy, and 1 mW power consumption. By evaluation of the obtained results it is found that the proposed techniques render negligible degradation in detection accuracy of -0.41% and SNR of -2.8%, behind 2-4 times faster calculation, 2 times less memory usage and 5% energy saving. The same approach can be applied with other signals where the embedded implementation of wavelets can be beneficial

Reasoning with linguistic preferences using NPN logic

Negative-positive-neutral logic provides an alternative framework for fuzzy cognitive maps development and decision analysis. This paper reviews basic notion of NPN logic and NPN relations and proposes adaptive approach to causality weights assessment. It employs linguistic models of causality weights activated by measurement-based fuzzy cognitive maps' concepts values. These models allow for quasi-dynamical adaptation to the change of concepts values, providing deeper understanding of possible side effects. Since in the real-world environments almost every decision has its consequences, presenting very valuable portion of information upon which we also make our decisions, the knowledge about the side effects enables more reliable decision analysis and directs actions of decision maker

Predicting resurgery in intensive care - a data mining approach

Every day the surgical interventions are associated with medicine, and the area of critical care medicine is no exception. The goal of this work is to assist health professionals in predicting these interventions. Thus, when the Data Mining techniques are well applied it is possible, with the help of medical knowledge, to predict whether a particular patient should or not should be re-operated upon the same problem. In this study, some aspects, such as heart disease and age, and some data classes were built to improve the models created. In addition, several scenarios were created, with the objective can predict the resurgery patients. According the primary objective, the resurgery patients prediction, the metric used was the sensitivity, obtaining an approximate result of 90%.This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT - Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2013." This work is also supported by the Deus ex Machina (DEM): Symbiotic technology for societal efficiency gains - NORTE-01-0145-FEDER-00002

Semi-automatic generation of quizzes and learning artifacts from Linked Data

In this position paper, we illustrate how Linked Data can be effectively used in a Technology-enhanced Learning scenario. Specifically, we aim at using structured data to semi-automatically generate artifacts to support learning delivery and assessment: natural language facts, Q&A systems and quizzes, also used with a gaming favour, can be creatively generated to help teachers and learners to support and improve the learning path. Moreover, those artifacts can in turn be published on the Web as Linked Data, thus directly contributing to make the Web a global data space also for learning purposes

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases