Path-Independence of Work Done Theorem Is Invalid in Center-Bound Force Fields

Abstract: The notion of work done, and the corresponding to it concept of potential energy, was incompletely defined making the path independence theorem of work done by center-bound force fields invalid for other than radial/conservative forces. Hence nonradial effects along equipotential surfaces, whose presence was suggested by experiments, can exist. New, mathematically complete representation of work done by center-bound force fields (generated by a single source) is offered

Equipotential Energy Exchange Depends on Density of Matter

Abstract: Potential energy exchanged for work done by radial/center-bound gravitational force field along equipotential surfaces (where the radial potential remains unchanged by definition), depends also on density of matter of the source mass that is responsible for generating the locally dominant field. To the extent that equipotential hence nonradial parts of trajectory paths (of the objects that move within the field) are exposed to the (nonrotating) field’s influence, the moving objects’ energy is lost (regardless of direction of the nonradial part of their motion) and transferred to the field. Mathematically derived, with the use of (new) synthetic mathematics, a new law governing nonradial exchange of potential energy generalizes the previous law that has been derived from physical considerations and had already been confirmed by several experiments and observations

MATHEMATICAL EXPANSION OF SPECIAL THEORY OF RELATIVITY ONTO ACCELERATIONS

The special theory of relativity (STR) is operationally expanded onto orthogonal accelerations: normal  and binormal  that complement the instantaneous tangential speed  and thus can be structurally extended into operationally complete 4D spacetime without defying the STR. Thus the former classic Lorentz factor, which defines proper time differential  can be expanded onto  within a trihedron moving in the Frenet frame (T,N,B). Since the tangential speed  which was formerly assumed as being always constant, expands onto effective normal and binormal speeds ensuing from the normal and binormal accelerations, the expanded formula conforms to the former Lorentz factor. The obvious though previously overlooked fact that in order to change an initial speed one must apply accelerations (or decelerations, which are reverse accelerations), made the Einstein’s STR incomplete for it did not apply to nongravitational selfpropelled motion. Like a toy car lacking accelerator pedal, the STR could drive nowhere. Yet some scientists were teaching for over 115 years that the incomplete STR is just fine by pretending that gravity should take care of the absent accelerator. But gravity could not drive cars along even surface of earth. Gravity could only pull the car down along with the physics that peddled the nonsense while suppressing attempts at its rectification. The expanded formula neither defies the STR nor the general theory of relativity (GTR) which is just radial theory of gravitation. In fact, the expanded formula complements the STR and thus it supplements the GTR too. The famous Hafele-Keating experiments virtually confirmed the validity of the expanded formula proposed here

Quantitation of the cellular content of saliva and buccal swab samples

Buccal swabs and saliva are the two most common oral sampling methods used for medical research. Often, these samples are used interchangeably, despite previous evidence that both contain buccal cells and blood leukocytes in different proportions. For some research, such as epigenetic studies, the cell types contributing to the analysis are highly relevant. We collected such samples from twelve children and twenty adults and, using Papanicolaou staining, measured the proportions of epithelial cells and leukocytes through microscopy. To our knowledge, no studies have compared cellular heterogeneity in buccal swab and saliva samples from adults and children. We confirmed that buccal swabs contained a higher proportion of epithelial cells than saliva and that children have a greater proportion of such cells in saliva compared to adults. At this level of resolution, buccal swabs and saliva contained similar epithelial cell subtypes. Gingivitis in children was associated with a higher proportion of leukocytes in saliva samples but not in buccal swabs. Compared to more detailed and costly methods such as flow cytometry or deconvolution methods used in epigenomic analysis, the procedure described here can serve as a simple and low-cost method to characterize buccal and saliva samples. Microscopy provides a low-cost tool to alert researchers to the presence of oral inflammation which may affect a subset of their samples. This knowledge might be highly relevant to their specific research questions, may assist with sample selection and thus might be crucial information despite the ability of data deconvolution methods to correct for cellular heterogeneity

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22-35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health