High-speed, in-band performance measurement instrumentation for next generation IP networks

Facilitating always-on instrumentation of Internet traffic for the purposes of performance measurement is crucial in order to enable accountability of resource usage and automated network control, management and optimisation. This has proven infeasible to date due to the lack of native measurement mechanisms that can form an integral part of the network‟s main forwarding operation. However, Internet Protocol version 6 (IPv6) specification enables the efficient encoding and processing of optional per-packet information as a native part of the network layer, and this constitutes a strong reason for IPv6 to be adopted as the ubiquitous next generation Internet transport. In this paper we present a very high-speed hardware implementation of in-line measurement, a truly native traffic instrumentation mechanism for the next generation Internet, which facilitates performance measurement of the actual data-carrying traffic at small timescales between two points in the network. This system is designed to operate as part of the routers' fast path and to incur an absolutely minimal impact on the network operation even while instrumenting traffic between the edges of very high capacity links. Our results show that the implementation can be easily accommodated by current FPGA technology, and real Internet traffic traces verify that the overhead incurred by instrumenting every packet over a 10 Gb/s operational backbone link carrying a typical workload is indeed negligible

Modulation of programmed cell death pathways by the hepatitis C virus

10.2741/3709Frontiers in Bioscience162608-1

The Role of Protein Kinase D1 in HIV-1 Replication

PKD家族由PKD1，PKD2h和PKD3组成，通常主要分布在胞浆，但在刺激条件下，可转位到各亚细胞结构。这些激酶在生理和病理过程中，具有广泛而重要的作用。包括线粒体氧化应激，T细胞受体信号，心肌基因表达和心肌收缩，细胞凋亡和肿瘤发生等。它们的功能还涉及许多细胞生物学过程，例如高尔基体组织，蛋白运输，高尔基体囊泡分泌以及其他各种细胞信号途径等。 本研究中，我们发现，Hela细胞虽然不表达内源性PKD1，但却能异位表达外源导入的PKD1，并且可以刺激HIV-LTR荧光虫酶报告基因的蛋白表达。然而对HIV-LTR启动子进行各种删除突变，并不能抑制PKD1所刺激的HIV-LTR荧光虫酶报告基因的蛋...The Protein kinase D (PKD) enzymes, which comprise of three isoforms (PKD1/PKDμ, PKD2 and PKD3/PKDυ), are generally localized to the cytosol, but in stimulated cells, they are translocated to various subcellular compartments. These enzymes play numerous roles in a variety of normal and pathological processes including transcriptional response to mitochondrial oxidative stress, T-cell receptor sign...学位：工学硕士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2172007115410

CHARACTERIZATION OF FACTORS INVOLVED IN HOST-VIRAL INTERACTIONS AND HOW THEY CONTRIBUTE TO HEPATITIS C VIRUS-INDUCED CELL DEATH

Ph.DDOCTOR OF PHILOSOPH

The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2

10.1016/j.virusres.2012.12.005Virus Research 1721-224-3

Cloud computing—effect of evolutionary algorithm on load balancing

© Springer International Publishing Switzerland 2015 In cloud computing due to the multi-tenancy of the resources, there is an essential need for effective load management to ensure an efficient load sharing. Depends on the structure of the tasks, different algorithms could be applied to distribute the load. Workflow scheduling as one of those load distribution algorithms, is specifically designed to schedule the dependent tasks on available resources. Considering a job as an elastic network of dependent tasks, this paper describes how evolutionary algorithm, with its mathematical apparatus, could be applied as workflow scheduling in cloud computing. In this research, the impact of Generalized Spring Tensor Model on workflow load balancing, in context of mathematical patterns have been studied. This research can establish patterns in cloud computing which can be applied in designing the heuristic workflow load balancing algorithms to identify the load patterns of the cloud network. Furthermore, the outcome of this research can help the end users to recognize the threats of tasks failure in processing the e-business and e-since data in cloud environment

The mechanisms and factors that induce trained immunity in arthropods and mollusks

Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens’ reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity