7 research outputs found
Etiologia, Tratamento e Prognóstico da Pericardite Aguda
Introduction: Acute pericarditis is a common inflammatory
condition of the pericardium usually assumed to be viral or idiopathic. Despite recent treatment improvements, information
is scarce regarding etiology and prognosis. Our aim was to
determine the incidence of pericarditis with a known etiology
and assess clinical prognostic predictors.
Material and Methods: A clinical retrospective analysis of
hospitalized patients with acute pericarditis was conducted
from 2012 to 2016. Population was characterized according to etiology, clinical presentation, treatment and prognosis.
Outcomes of interest, evaluated at one year after hospital discharge, were pericarditis recurrence, hospitalization, constriction and overall mortality.
Results: A total of 94 patients were enrolled, median age
46 years (inter-quartile range 32-61), 65% were male. Idiopathic etiology was responsible for 68% of cases. A specific
etiology was found in the remaining 32% of patients, being
the most frequent autoimmune disease (12%) and malignancy
(5%). Idiopathic pericarditis was associated with myopericarditis (p = 0.049) and a known etiology with pericardial effusion
(p = 0.001) and cardiac tamponade (p = 0.027). Recurrence of
pericarditis was found in 13% of patients. Corticosteroid treatment in patients with an identified etiology was not associated
with an increase in recurrence (p = 0.220). Overall 1-year mortality was 9%. A defined etiology was the only independent
predictor of mortality at multivariate analysis (OR 40.3; 95% CI
1.9 – 137.2; p = 0.016).
Conclusion: Up to one third of hospitalized patients with
acute pericarditis have an identified cause of pericarditis and
these patients are at increased risk of mortality.Introdução: A pericardite aguda é uma síndrome frequente
caracterizada pela inflamação do pericárdio e usualmente
atribuído a etiologia viral/idiopática. Apesar dos avanços no
tratamento, existe informação limitada em relação a etiologia e
prognóstico. O objetivo do nosso trabalho foi identificar a prevalência de pericardite aguda com etiologia especifica e avaliar
marcadores clínicos de prognóstico.
Material e Métodos: Estudo retrospetivo de doentes hospitalizados por pericardite aguda entre 2012-2016. A população foi caracterizada quanto a etiologia, apresentação clínica,
tratamento e prognóstico. Para avaliação de prognóstico
foram avaliadas recorrência de pericardite, pericardite constritiva e mortalidade global um ano após alta hospitalar.
Resultados: Foram incluídos 94 doentes com idade mediana 46 anos (IIQ 32-61), 65% eram do sexo masculino. A
etiologia idiopática foi responsável por 68% dos casos. Etiologia especifica foi identificada em 32% dos doentes, sendo
mais frequente doença autoimune (12%) e neoplasia (5%). A
pericardite idiopática foi mais associada a miopericardite (p
= 0,049), enquanto a etiologia específica se associou a derrame pericárdico (p = 0,001) e a tamponamento pericárdico
(p = 0,027). A recorrência de pericardite ocorreu em 13% dos
doentes. O tratamento com corticosteroides em doentes com
etiologia definida não se associou com aumento de recorrência (p = 0,220). A mortalidade global a um ano foi de 9%.
A etiologia definida de pericardite aguda revelou-se o único
preditor independente de mortalidade na análise multivariada
(OR 40,3; 95% CI 1,9 – 137,2; p = 0,016).
Conclusão: Cerca de um terço dos doentes hospitalizados
por pericardite aguda têm uma causa específica identificável
de pericardite e estes doentes apresentam risco aumentado
de mortalidadeinfo:eu-repo/semantics/publishedVersio
Experiential learning through students non-profit organizations: ESTIEM case study
European Students of Industrial Engineering and Management (ESTIEM) is a non-profit organization of Industrial Engineering and Management (IEM) students that was founded in 1990 to support common activities and relations across Europe. Through it, students engage in activities that promote a combination of technological understanding with management skills. Belonging to this type of organization during their graduation time, gives students a plethora of competences that are learned beyond the classes, outside the university walls. These competences are acquired through experiential learning. The objective of this paper is to present ESTIEM creation, evolution and organization. Also, projects participation, events organization and meetings organized are presented as outcomes of ESTIEM students' engagement. This paper intends also to explore how the participation on this type of organization allows students to develop competences and contribute to the IEM student's education. Following the key competencies for lifelong learning recommended by the Council of European Union, some examples of key competences acquired from the experience of the authors are given. Results showed that being member of ESTIEM allows them to develop such competences and they felt better prepared for the labour market.This work has been supported by FCT Fundação para a Ciência e Tecnologia within the R&D Units Project
Scope: UIDB/00319/2020 and UIDB/04058/2020
Bleomycin-Induced Lung Injury
Bleomycin is a chemotherapeutic agent commonly used to treat curable diseases such as germinative tumors and Hodgkin’s lymphoma. The major limitation of bleomycin therapy is pulmonary toxicity, which can be life threatening in up to 10% of patients receiving the drug. The mechanism of bleomycin-induced pneumonitis (BIP) involves oxidative damage, relative deficiency of the deactivating enzyme bleomycin hydrolase, genetic susceptibility, and the elaboration of inflammatory cytokines. Ultimately, BIP can progress to lung fibrosis. The diagnosis of BIP is established by the combination of systemic symptoms, radiological and histological findings, and respiratory function tests abnormalities, while other disorders should be excluded. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. In general, the clinical picture is extremely complex. A greater understanding of the BIP pathogenesis may lead to the development of new agents capable of preventing or even treating the injury already present. Physicians who prescribe bleomycin must be aware of the potential pulmonary toxicity, especially in the presence of risk factors. This review will focus on BIP, mainly regarding recent advances and perspectives in diagnosis and treatment