Decreased numerical density of kainate receptor-positive neurons in the orbitofrontal cortex of chronic schizophrenics

We utilised postmortem brain tissue to quantify sections of left and right orbitofrontal cortex (area 11) from nine schizophrenic and eight control patients from the Charing Cross Prospective Schizophrenia Study immunostained for the presence of the kainate receptor (GluR5/6/7). The numerical density of neurons immunopositive for kainate receptor was measured. Other sections from the same blocks were stained with cresyl violet to determine the total neuronal numerical density. All measurements were made blind: diagnoses were only revealed by a third party after measurements were completed. There was a significant reduction (21%) in numerical density of kainate receptor-positive neurons in both cortices in the schizophrenic group (488cells/mm2) compared to that in the control group (618cells/mm2) (P=0.033). Nissl-stained tissue showed no significant difference in total neuronal numerical density between control and schizophrenic groups. These observations suggest that there are actually fewer kainate receptor-positive neurons in schizophrenic orbitofrontal cortex. There was no correlation of reduced kainate receptor-positive cell number with age at death, postmortem interval, or other possibly confounding neuropathology. Our results support the concept of there being reduced glutamatergic activity in frontal cortex in schizophreni

Metamagnetism in the 2D Hubbard Model with easy axis

Although the Hubbard model is widely investigated, there are surprisingly few attempts to study the behavior of such a model in an external magnetic field. Using the Projector Quantum Monte Carlo technique, we show that the Hubbard model with an easy axis exhibits metamagnetic behavior if an external field is turned on. For the case of intermediate correlations strength $U$, we observe a smooth transition from an antiferromagnetic regime to a paramagnetic phase. While the staggered magnetization will decrease linearly up to a critical field $B_c$, uniform magnetization develops only for fields higher than $B_c$.Comment: RevTeX 5 pages + 2 postscript figures (included), accepted for PRB Rapid Communication

Switching of Geometric Phase in Degenerate Systems

The geometric and open path phases of a four-state system subject to time varying cyclic potentials are computed from the Schr\"{o}dinger equation. Fast oscillations are found in the non-adiabatic case. For parameter values such that the system possesses degenerate levels, the geometric phase becomes anomalous, undergoing a sign switch. A physical system to which the results apply is a molecular dimer with two interacting electrons. Additionally, the sudden switching of the geometric phase promises to be an efficient control in two-qubit quantum computing.Comment: 15 pages, 4 figures,accepted by Physics Letters A (2000

On the nature of continuous physical quantities in classical and quantum mechanics

Within the traditional Hilbert space formalism of quantum mechanics, it is not possible to describe a particle as possessing, simultaneously, a sharp position value and a sharp momentum value. Is it possible, though, to describe a particle as possessing just a sharp position value (or just a sharp momentum value)? Some, such as Teller (Journal of Philosophy, 1979), have thought that the answer to this question is No -- that the status of individual continuous quantities is very different in quantum mechanics than in classical mechanics. On the contrary, I shall show that the same subtle issues arise with respect to continuous quantities in classical and quantum mechanics; and that it is, after all, possible to describe a particle as possessing a sharp position value without altering the standard formalism of quantum mechanics.Comment: 26 pages, LaTe

Pair Fluctuations in Ultra-small Fermi Systems within Self-Consistent RPA at Finite Temperature

A self-consistent version of the Thermal Random Phase Approximation (TSCRPA) is developed within the Matsubara Green's Function (GF) formalism. The TSCRPA is applied to the many level pairing model. The normal phase of the system is considered. The TSCRPA results are compared with the exact ones calculated for the Grand Canonical Ensemble. Advantages of the TSCRPA over the Thermal Mean Field Approximation (TMFA) and the standard Thermal Random Phase Approximation (TRPA) are demonstrated. Results for correlation functions, excitation energies, single particle level densities, etc., as a function of temperature are presented.Comment: 22 pages, 13 figers and 3 table

Accessing the dynamics of large many-particle systems using Stochastic Series Expansion

The Stochastic Series Expansion method (SSE) is a Quantum Monte Carlo (QMC) technique working directly in the imaginary time continuum and thus avoiding "Trotter discretization" errors. Using a non-local "operator-loop update" it allows treating large quantum mechanical systems of many thousand sites. In this paper we first give a comprehensive review on SSE and present benchmark calculations of SSE's scaling behavior with system size and inverse temperature, and compare it to the loop algorithm, whose scaling is known to be one of the best of all QMC methods. Finally we introduce a new and efficient algorithm to measure Green's functions and thus dynamical properties within SSE.Comment: 11 RevTeX pages including 7 figures and 5 table

Legal coercion, respect & reason-responsive agency

Legal coercion seems morally problematic because it is susceptible to the Hegelian objection that it fails to respect individuals in a way that is ‘due to them as men’. But in what sense does legal coercion fail to do so? And what are the grounds for this requirement to respect? This paper is an attempt to answer these questions. It argues that (a) legal coercion fails to respect individuals as reason-responsive agents; and (b) individuals ought to be respected as such in virtue of the fact that they are human beings. Thus it is in this sense that legal coercion fails to treat individuals with the kind of respect ‘due to them as men’.The Leverhulme Trust (ECF-2012-032); AHRC (AH/H015655/1

Magnetism and Pairing in Hubbard Bilayers.

We study the Hubbard model on a bilayer with repulsive on-site interactions, $U$, in which fermions undergo both intra-plane ($t$) and inter-plane ($t_z$) hopping. This situation is what one would expect in high-temperature superconductors such as YBCO, with two adjacent CuO$_2$ planes. Magnetic and pairing properties of the system are investigated through Quantum Monte Carlo simulations for both half- and quarter-filled bands. We find that in all cases inter-planar pairing with $d_{x^2-z^2}$ symmetry is dominant over planar pairing with $d_{x^2-y^2}$ symmetry, and that for $t_z$ large enough pair formation is possible through antiferromagnetic correlations. However, another mechanism is needed to make these pairs condense into a superconducting state at lower temperatures. We identify the temperature for pair formation with the spin gap crossover temperature. [Submitted to Phys. Rev. B]Comment: 7 pages, uuencoded self-unpacking PS file with text and figures