Climate model boundary conditions for four Cretaceous time slices

International audienceGeneral circulation models (GCMs) are useful tools for investigating the characteristics and dynamics of past climates. Understanding of past climates contributes significantly to our overall understanding of Earth's climate system. One of the most time consuming, and often daunting, tasks facing the paleoclimate modeler, particularly those without a geological background, is the production of surface boundary conditions for past time periods. These boundary conditions consist of, at a minimum, continental configurations derived from plate tectonic modeling, topography, bathymetry, and a vegetation distribution. Typically, each researcher develops a unique set of boundary conditions for use in their simulations. Thus, unlike simulations of modern climate, basic assumptions in paleo surface boundary conditions can vary from researcher to researcher. This makes comparisons between results from multiple researchers difficult and, thus, hinders the integration of studies across the broader community. Unless special changes to surface conditions are warranted, researcher dependent boundary conditions are not the most efficient way to proceed in paleoclimate investigations. Here we present surface boundary conditions (land-sea distribution, paleotopography, paleobathymetry, and paleovegetation distribution) for four Cretaceous time slices (120 Ma, 110 Ma, 90 Ma, and 70 Ma). These boundary conditions are modified from base datasets to be appropriate for incorporation into numerical studies of Earth's climate and are available in NetCDF format upon request from the lead author. The land-sea distribution, bathymetry, and topography are based on the 1°×1° (latitude × longitude) paleo Digital Elevation Models (paleoDEMs) of Christopher Scotese. Those paleoDEMs were adjusted using the paleogeographical reconstructions of Ronald Blakey (Northern Arizona University) and published literature and were then modified for use in GCMs. The paleovegetation distribution is based on published data and reconstructions and consultation with members of the paleobotanical community and is represented as generalized biomes that should be easily translatable to many vegetation-modeling schemes

Magmatism at an ultra-slow spreading rift: high-resolution geomorphological studies of a Red Sea Rift segment in Hadarba Deep

The mid-ocean rift in the Red Sea is one of the youngest rifting systems on Earth. Only recently, state-of-the-art methods and modern deep-sea instruments have been used to explore this young and unique volcanic system. During the first autonomous underwater vehicle surveys of the Red Sea Rift in Spring 2022, we collected multibeam bathymetry, backscatter, sub-bottom profiler data, and water column data over a 9 km long ridge segment in the Hadarba Deep between 22.49°N and 22.56°N to investigate the volcano-tectonic processes of this ultra-slow spreading segment (12 mm/year spreading rate). The high-resolution hydroacoustic data was used to (1) delineate and quantify the geometry of tectonic structures and individual lava flows, (2) define lava flow morphology and eruption style, (3) estimate relative ages of flows and features, and (4) retrace the evolution of the volcanic activity. In addition, the geochemistry of several young lava flows provides information on the relation between the different magma that supply these eruptions. About 90 eruptive units with variable sedimentary cover have been identified within the 43 km2 mapped region. The oldest lava flows are buried under 3 to 4.2 m of sediment, indicating ages of up to ~30 ka based on average sedimentation rate estimates (~14 cm/ka), while the youngest eruptions are covered by<10 cm of sediment, and are thus younger than 700 years. Three volcanic phases have been identified based on changes in flow morphology and distribution, and tectonic pattern. All three axial phases have an average eruptive frequency of ~100-250 years. The segment displays an overall low tectonic extension (<10% of the total extension) and low vertical offset. Our geomorphological maps, analyses, and statistics reveal a moderately faulted, ultra-slow spreading MOR segment in the Red Sea with a surprisingly large amount of magmatic extension, implying that the segment has been underlined by a large magma supply for at least 15 ka. All these observations provide valuable implications for the formation history of the Red Sea Rift and the formation of ultra-slow spreading crust

Predictors of self-perceived cultural responsiveness in entry-level physiotherapy students in Australia and Aotearoa New Zealand

Background: Ensuring physiotherapy students are well prepared to work safely and effectively in culturally diverse societies upon graduation is vital. Therefore, determining whether physiotherapy programs are effectively developing the cultural responsiveness of students is essential. This study aimed to evaluate the level of self-perceived cultural responsiveness of entry level physiotherapy students during their training, and explore the factors that might be associated with these levels. Methods: A cross sectional study of physiotherapy students from nine universities across Australia and Aotearoa New Zealand was conducted using an online self-administered questionnaire containing three parts: The Cultural Competence Assessment tool, Altemeyer’s Dogmatism scale, and the Marlowe-Crowne social desirability scale- short form. Demographic data relating to university, program, and level of study were also collected. Data was analysed using one-way ANOVA, t-tests and multiple regression analysis. Results: A total of 817 (19% response rate) students participated in this study. Overall, students had a moderate level of self-perceived cultural responsiveness (Mean (SD) = 5.15 (0.67)). Fewer number of weeks of clinical placement attended, lower levels of dogmatism, and greater social desirability were related to greater self-perceived cultural responsiveness. Additionally, fourth year undergraduate students perceived themselves to be less culturally responsive than first and second year students (p < 0.05). Conclusions: These results provide educators with knowledge about the level of self-perceived cultural responsiveness in physiotherapy students, and the factors that may need to be assessed and addressed to support the development of culturally responsive practice

The deepest record of the octocoral Acanthogorgia from the Red Sea

Octocorals (Cnidaria: Anthozoa) have a global distribution and form benthic assemblages along the depth gradient, from shallow to deep waters. They often occur below SCUBA diving limits, where they can become dominant habitat builders and aggregate different taxa. During a cruise in February 2023, one octocoral specimen was collected at 1453 m depth at Kebrit Deep, in the northern Saudi Arabian Red Sea axis, an area with extremely high temperature and salinity profiles at depth. Morphological analysis coupled with DNA barcoding using two mitochondrial markers (COI and mtMuts), revealed that the coral belongs to Acanthogorgia, a genus of azooxanthellate octocorals known to occur from 3 to 2300 m depths in cold, temperate and tropical waters. In the Red Sea, the genus was previously only known from shallower waters. Hence, we report the deepest record of the genus Acanthogorgia from the warm and saline Red Sea basin. This finding provides novel insights on deep-water octocoral diversity in the Red Sea, a still scantily explored area of the world, while emphasizing the need for further explorations at depth

Mixed signature of activation and dysfunction allows human decidual CD8(+) T cells to provide both tolerance and immunity

Stemcel biology/Regenerative medicine (incl. bloodtransfusion

A Decade of Experience With Alemtuzumab Therapy for Severe or Glucocorticoid-Resistant Kidney Transplant Rejection

Alemtuzumab is used as lymphocyte-depleting therapy for severe or glucocorticoid-resistant kidney transplant rejection. However, the long-term efficacy and toxicity of alemtuzumab therapy are unclear. Therefore, all cases of alemtuzumab anti-rejection therapy between 2012 and 2022 in our institution were investigated. Graft survival, graft function, lymphocyte depletion, serious infections, malignancies, and patient survival were analyzed and compared with a reference cohort of transplanted patients who did not require alemtuzumab anti-rejection therapy. A total of 225 patients treated with alemtuzumab were identified and compared with a reference cohort of 1,668 patients. Over 60% of grafts was salvaged with alemtuzumab therapy, but graft survival was significantly poorer compared to the reference cohort. The median time of profound T- and B lymphocyte depletion was 272 and 344 days, respectively. Serious infection rate after alemtuzumab therapy was 54.1/100 person-years. The risk of death (hazard ratio 1.75, 95%-CI 1.28–2.39) and infection-related death (hazard ratio 2.36, 95%-CI 1.35–4.11) were higher in the alemtuzumab-treated cohort. In conclusion, alemtuzumab is an effective treatment for severe kidney transplant rejection, but causes long-lasting lymphocyte depletion and is associated with frequent infections and worse patient survival outcomes.</p

Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology

BACKGROUND: Blood-based biomarkers for Alzheimer's disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta(1-42/1-40), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) to identify cerebral amyloidosis and/or disease severity. METHODS: We included individuals with a positive (n = 176: 63 ± 7 years, 87 (49%) females) or negative (n = 76: 61 ± 9 years, 27 (36%) females) amyloid PET status, with syndrome diagnosis subjective cognitive decline (18 PET+, 25 PET-), mild cognitive impairment (26 PET+, 24 PET-), or AD-dementia (132 PET+). Plasma Abeta(1-42/1-40), GFAP, and NfL were measured by Simoa. We applied two-way ANOVA adjusted for age and sex to investigate the associations of the plasma markers with amyloid PET status and syndrome diagnosis; logistic regression analysis with Wald's backward selection to identify an optimal panel that identifies amyloid PET positivity; age, sex, and education-adjusted linear regression analysis to investigate associations between the plasma markers and neuropsychological test performance; and Spearman's correlation analysis to investigate associations between the plasma markers and medial temporal lobe atrophy (MTA). RESULTS: Abeta(1-42/1-40) and GFAP independently associated with amyloid PET status (p = 0.009 and p  0.33, p < 0.001). Abeta(1-42/1-40) showed a moderate negative correlation with MTA (Spearman's rho = - 0.24, p = 0.001). DISCUSSION AND CONCLUSIONS: Combination of plasma Abeta(1-42/1-40) and GFAP provides a valuable tool for the identification of amyloid PET status. Furthermore, plasma GFAP and NfL associate with various disease severity measures suggesting potential for disease monitoring

A 46,XY female DSD patient with bilateral gonadoblastoma, a novel SRY missense mutation combined with a WT1 KTS splice-site mutation

Patients with Disorders of Sex Development (DSD), especially those with gonadal dysgenesis and hypovirilization are at risk of developing malignant type II germ cell tumors/cancer (GCC) (seminoma/dysgerminoma and nonseminoma), with either carcinoma in situ (CIS) or gonadoblastoma (GB) as precursor lesion. In 10-15% of 46,XY g